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1. 发明授权

US08622240B2 Reclosable pour systems for containers 失效
标题翻译：用于集装箱的可重新浇注系统
公开(公告)号：US08622240B2
公开(公告)日：2014-01-07
申请号：US13200300
申请日：2011-09-22
申请人： Amy Johnson Krasucki , Edgar Merino , Brian Scott Canady
发明人： Amy Johnson Krasucki , Edgar Merino , Brian Scott Canady
IPC分类号： B65D5/72
CPC分类号： B65D5/725
摘要： Reclosable pour systems useful on any suitable container and containers comprising the reclosable pour systems are disclosed. The system features a pour opening comprising a hinged flap and a tab that enables latchable reclosing and reopening of the pour opening, to allow the pouring of a flowable material contained within the container. A unitary blank capable of being cut and folded to produce a container comprising the reclosable pour system, as well as methods of manufacture and use of a container comprising the reclosable pour system, are also disclosed.
摘要翻译：公开了可用于任何合适的容器和容器的可重新封闭的浇注系统，该容器和容器包括可重新封闭的浇注系统。该系统具有倾倒开口，该倾倒开口包括铰接的翼片和突出部，其使得能够闭合重新闭合并重新打开倾倒开口，以允许倾倒容纳在容器内的可流动材料。还公开了一种能够被切割和折叠以生产包括可重新封闭的倾倒系统的容器的整体坯料，以及包括可再闭合倾倒系统的容器的制造和使用方法。

2. 发明授权

US08586300B2 Genetic polymorphisms and infertility 有权
标题翻译：遗传多态性与不育症
公开(公告)号：US08586300B2
公开(公告)日：2013-11-19
申请号：US12934236
申请日：2009-03-25
申请人： Steven H. Zeisel , Amy Johnson
发明人： Steven H. Zeisel , Amy Johnson
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： Methods of screening for a cause of low sperm motility and/or for mitochondrial impairment in subjects are provided, comprising determining a genotype of the subject with respect to at least one choline metabolism gene and comparing the genotype of the subject with at least one reference choline metabolism genotype associated with low sperm motility and/or impaired mitochondrial function, wherein a similarity between the subject and reference genotypes indicates a cause of low sperm motility and/or impaired mitochondrial function in the subject. In another aspect, methods for treating subjects having low sperm motility and/or impaired mitochondrial function are provided, comprising administering to the subject an effective amount of a choline metabolism supplement composition to at least partially ameliorate the low sperm motility and/or impaired mitochondrial function.
摘要翻译：提供筛选受试者的精子活力低和/或线粒体损伤的原因的方法，包括确定受试者相对于至少一种胆碱代谢基因的基因型，并将受试者的基因型与至少一种参考胆碱代谢基因型与低精子运动性和/或受损的线粒体功能相关，其中受试者和参考基因型之间的相似性表示受试者中精子活力低和/或受损的线粒体功能的原因。在另一方面，提供了用于治疗具有低精子活力和/或线粒体功能受损的受试者的方法，包括向所述受试者施用有效量的胆碱代谢补充组合物，以至少部分地改善低精子活力和/或线粒体功能受损。

3. 发明申请

US20180140602A1 COMBINATION OF CHIMERIC ANTIGEN RECEPTOR THERAPY AND AMINO PYRIMIDINE DERIVATIVES 审中-公开
公开(公告)号：US20180140602A1
公开(公告)日：2018-05-24
申请号：US15564463
申请日：2016-04-07
申请人： Daniela Angst , John Byrd , Jason Dubovsky , Joseph A. Fraietta , Francois Gessier , Saar Gill , Amy Johnson , Carl H. June , Marcela Maus , Natarajan Muthusamy , David L. Porter , Marco Ruella , Anna Vulpetti , Mariusz Wasik , Novartis AG , The Trustees of the University of Pennsylvania
发明人： Daniela Angst , John Byrd , Jason Dubovsky , Joseph A. Fraietta , Francois Gessier , Saar Gill , Amy Johnson , Carl H. June , Marcela Maus , Natarajan Muthusamy , David L. Porter , Marco Ruella , Anna Vulpetti , Mariusz Wasik
IPC分类号： A61K31/505 , A61K35/17 , C07K16/28 , A61K31/506 , C07K16/30 , A61P35/00 , A61P35/02
CPC分类号： A61K31/505 , A61K31/506 , A61K35/17 , A61K45/06 , A61K2035/124 , A61K2039/505 , A61K2039/545 , A61P35/00 , A61P35/02 , C07K16/2803 , C07K16/30 , C07K2317/24 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C12N5/0636 , A61K2300/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a BTK inhibitor, e.g., an amino pyrimidine derivative described herein. The invention also provides kits and compositions described herein.

4. 发明申请

US20150283178A1 TREATMENT OF CANCER USING ANTI-CD19 CHIMERIC ANTIGEN RECEPTOR 审中-公开
标题翻译：使用抗CD19基因抗原受体治疗癌症
公开(公告)号：US20150283178A1
公开(公告)日：2015-10-08
申请号：US14680860
申请日：2015-04-07
申请人： Carl H. June , David L. Porter , Marcela Maus , Mariusz Wasik , Saar Gill , Joseph Fraietta , Marco Ruella , John Byrd , Jason Dubovsky , Amy Johnson , Natarajan Muthusamy , Saad Kenderian , Joan Mannick , David Glass , Leon Murphy , Jennifer Brogdon , William Raj Sellers
发明人： Carl H. June , David L. Porter , Marcela Maus , Mariusz Wasik , Saar Gill , Joseph Fraietta , Marco Ruella , John Byrd , Jason Dubovsky , Amy Johnson , Natarajan Muthusamy , Saad Kenderian , Joan Mannick , David Glass , Leon Murphy , Jennifer Brogdon , William Raj Sellers
IPC分类号： A61K35/17 , A61K31/519 , C07K16/30 , A61K31/53 , C07K14/725 , C07K16/28 , A61K31/436 , A61K39/395 , A61K45/06
CPC分类号： A61K35/17 , A61K31/436 , A61K31/519 , A61K31/53 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/5156 , A61K2039/5158 , C07K14/7051 , C07K16/2803 , C07K2317/14 , C07K2317/24 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2319/03 , C12N5/0636 , C12N2501/599 , C12N2501/727 , C12N2510/00 , A61K2300/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a kinase inhibitor, e.g., a kinase inhibitor described herein. The invention also provides kits and compositions described herein.
摘要翻译：本发明提供了用于治疗与CD19表达相关的疾病的组合物和方法，例如通过如本文所述施用包含本文所述的CD19 CAR的重组T细胞与激酶抑制剂，例如本文所述的激酶抑制剂组合。本发明还提供了本文所述的试剂盒和组合物。

5. 发明申请

US20120074159A1 Reclosable pour systems for containers 失效
标题翻译：用于集装箱的可重新浇注系统
公开(公告)号：US20120074159A1
公开(公告)日：2012-03-29
申请号：US13200300
申请日：2011-09-22
申请人： Amy Johnson Krasucki , Edgar Merino , Brian Scott Canady
发明人： Amy Johnson Krasucki , Edgar Merino , Brian Scott Canady
IPC分类号： B65D5/72 , B31B1/90 , B65D43/16
CPC分类号： B65D5/725
摘要： Reclosable pour systems useful on any suitable container and containers comprising the reclosable pour systems are disclosed. The system features a pour opening comprising a hinged flap and a tab that enables latchable reclosing and reopening of the pour opening, to allow the pouring of a flowable material contained within the container. A unitary blank capable of being cut and folded to produce a container comprising the reclosable pour system, as well as methods of manufacture and use of a container comprising the reclosable pour system, are also disclosed.
摘要翻译：公开了可用于任何合适的容器和容器的可重新封闭的浇注系统，该容器和容器包括可重新封闭的浇注系统。该系统具有倾倒开口，该倾倒开口包括铰接的翼片和突出部，其使得能够闭合重新闭合并重新打开倾倒开口，以允许倾倒容纳在容器内的可流动材料。还公开了一种能够被切割和折叠以生产包括可重新封闭的倾倒系统的容器的整体坯料，以及包括可再闭合倾倒系统的容器的制造和使用方法。

6. 发明申请

US20110034476A1 GENETIC POLYMORPHISMS AND INFERTILITY 有权
标题翻译：遗传多态性与感染性
公开(公告)号：US20110034476A1
公开(公告)日：2011-02-10
申请号：US12934236
申请日：2009-03-25
申请人： Steven H. Zeisel , Amy Johnson
发明人： Steven H. Zeisel , Amy Johnson
IPC分类号： A61K31/519 , A61K31/14 , C12Q1/68 , A61P15/08
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： Methods of screening for a cause of low sperm motility and/or for mitochondrial impairment in subjects are provided, comprising determining a genotype of the subject with respect to at least one choline metabolism gene and comparing the genotype of the subject with at least one reference choline metabolism genotype associated with low sperm motility and/or impaired mitochondrial function, wherein a similarity between the subject and reference genotypes indicates a cause of low sperm motility and/or impaired mitochondrial function in the subject. In another aspect, methods for treating subjects having low sperm motility and/or impaired mitochondrial function are provided, comprising administering to the subject an effective amount of a choline metabolism supplement composition to at least partially ameliorate the low sperm motility and/or impaired mitochondrial function.
摘要翻译：提供筛选受试者的精子活力低和/或线粒体损伤的原因的方法，包括确定受试者相对于至少一种胆碱代谢基因的基因型，并将受试者的基因型与至少一种参考胆碱代谢基因型与低精子运动性和/或受损的线粒体功能相关，其中受试者和参考基因型之间的相似性表示受试者中精子活力低和/或受损的线粒体功能的原因。在另一方面，提供了用于治疗具有低精子活力和/或线粒体功能受损的受试者的方法，包括向所述受试者施用有效量的胆碱代谢补充组合物，以至少部分地改善低精子活力和/或线粒体功能受损。

7. 发明申请

US20100017223A1 Electronic donor medical records management system 审中-公开
标题翻译：电子捐赠医疗记录管理系统
公开(公告)号：US20100017223A1
公开(公告)日：2010-01-21
申请号：US12380966
申请日：2009-03-03
申请人： Amy Johnson , Mike Hooks , Mathew Shuster
发明人： Amy Johnson , Mike Hooks , Mathew Shuster
IPC分类号： G06Q50/00 , G06F3/01
CPC分类号： G06Q50/22 , G16H10/60
摘要： There are disclosed an electronic donor medical records management system and a method of managing electronic donor medical records in a system. In an embodiment, the system includes a recovery agency site having a first electronic chart component configured to allow a recovery agency to add online donor charts directly to the system; and a medical records site having a second electronic chart component configured to allow processing of the online donor charts. In one embodiment, the method includes navigating a browser to a recovery agency site related to a donor; selecting an add donor link; selecting a prefix to identify a recovery agency; entering a recovery agency donor number; selecting necessary documents to be uploaded and associated with a donor chart; clicking a checkbox for review; and clicking a save donor button. Other embodiments are also disclosed.
摘要翻译：公开了一种电子捐赠者医疗记录管理系统和一种在系统中管理电子捐赠者医疗记录的方法。在一个实施例中，系统包括具有第一电子图表组件的恢复机构站点，其被配置为允许恢复机构将在线捐助者图表直接添加到系统; 以及具有被配置为允许处理在线捐助者图表的第二电子图表组件的医疗记录站点。在一个实施例中，该方法包括将浏览器导航到与捐赠者相关的恢复机构站点; 选择添加捐助者链接; 选择一个前缀来识别恢复机构; 进入恢复机构捐赠人数; 选择要上传并与捐助者图表相关联的必要文件; 点击复选框进行审核; 并点击保存捐赠者按钮。还公开了其他实施例。

8. 发明申请

US20070010968A1 Dedicated process diagnostic device 失效
标题翻译：专用过程诊断装置
公开(公告)号：US20070010968A1
公开(公告)日：2007-01-11
申请号：US11440582
申请日：2006-05-25
申请人： Randy Longsdorf , Scott Nelson , Dale Davis , Richard Nelson , Amy Johnson , Gregory Brown
发明人： Randy Longsdorf , Scott Nelson , Dale Davis , Richard Nelson , Amy Johnson , Gregory Brown
IPC分类号： G06F11/30 , G06F15/00 , G21C17/00
CPC分类号： G01F1/50 , G01F15/00 , G05B19/0428 , G05B2219/24033 , G08C19/02
摘要： A field mountable dedicated process diagnostic device is used for diagnosing operation of an industrial control or monitoring system. An input is configured to receive at least one process signal related to operation of the industrial process. A memory contains diagnostic program instructions configured to implement a diagnostic algorithm using the process signal. The diagnostic algorithm is specific to the industrial process. A microcontroller performs the diagnostic program instructions and responsively diagnoses operation of the process based upon the process signal.
摘要翻译：现场安装的专用过程诊断装置用于诊断工业控制或监控系统的操作。输入被配置为接收与工业过程的操作相关的至少一个过程信号。存储器包含配置为使用过程信号实现诊断算法的诊断程序指令。诊断算法特定于工业过程。微控制器执行诊断程序指令并且基于过程信号响应地诊断过程的操作。

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