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1. 发明授权

US06730310B2 Wash-off vitamin E compositions 有权
标题翻译：洗去维生素E组合物
公开(公告)号：US06730310B2
公开(公告)日：2004-05-04
申请号：US09902314
申请日：2001-07-10
申请人： Zeenat F. Nabi , Thomas Gregory Polefka , Nadia Soliman , Amir Tavakkol
发明人： Zeenat F. Nabi , Thomas Gregory Polefka , Nadia Soliman , Amir Tavakkol
IPC分类号： A61K700
CPC分类号： A61Q19/10 , A61K8/42 , A61K8/463 , A61K8/671 , A61K8/676 , A61K8/678 , A61K8/731 , A61K8/922 , A61K2800/522 , A61Q17/00 , A61Q19/00 , Y10S514/844 , Y10S514/858
摘要： A topical composition suitable for application to skin comprising an amount of antioxidant action vitamin and vitamin precursor sufficient to bring about an effect selected from the group consisting of a level of vitamin on the skin significantly above the amount of vitamin on normal vitamin untreated skin for a period of treating four hours after application of the said vitamin containing composition, a reduction of lipid peroxide levels brought about by an insult to the skin wherein the skin is treated with the said vitamin containing composition prior to said insult, a level of skin vitamin which is significantly above the level of vitamin on the skin brought about by oral ingestion of the vitamin, or a combination of any of a, b, or c.
摘要翻译：一种适用于皮肤的局部组合物，其包含一定量的抗氧化作用维生素和维生素前体，其足以产生选自以下的效果：皮肤上的维生素水平显着高于正常维生素未处理的皮肤上的维生素量，用于在施用所述含维生素组合物后4小时处理的时间段，通过对所述皮肤的侮辱引起的脂质过氧化物水平的降低，其中在所述侮辱之前用所述含维生素组合物处理皮肤，皮肤维生素水平明显高于通过口服摄取维生素或a，b或c中任何一种的组合引起的皮肤上的维生素水平。

2. 发明申请

US20050209339A1 Methods for the treatment of sinusitis 审中-公开
标题翻译：治疗鼻窦炎的方法
公开(公告)号：US20050209339A1
公开(公告)日：2005-09-22
申请号：US10519041
申请日：2003-07-01
申请人： Ercem Atillasoy , Steven Bradford , Lynn Day , Pascal Pfister , Amir Tavakkol
发明人： Ercem Atillasoy , Steven Bradford , Lynn Day , Pascal Pfister , Amir Tavakkol
IPC分类号： A61P11/02 , A61K31/135 , A61K31/137 , A61P31/10
CPC分类号： A61K31/137 , A61K31/135
摘要： The invention provides a method of treating chronic rhinosinusitis such as allergic fungal sinusitis comprising daily oral administration of a composition from more than 500 mg to about 800 mg, preferably about 625 mg or 725 mg terbinafine base equivalent as hydrochloride, or a molar equivalent in other acid addition salt or free base form, for a duration effective to reduce the symptoms of, or eliminate chronic rhinosinusitis; it further concerns the use of terbinafine in the manufacture of a corresponding medicament, and packs containing a plurality of corresponding compositions and medicaments.
摘要翻译：本发明提供了一种治疗慢性鼻鼻窦炎如过敏性真菌性鼻窦炎的方法，其包括每日口服给予组合物从500mg至约800mg，优选约625mg或725mg特比萘芬碱当量作为盐酸盐或其他摩尔当量酸加成盐或游离碱形式，持续有效减少或消除慢性鼻鼻窦炎的症状; 它还涉及特比萘芬在制备相应的药物中的用途，以及包含多种相应的组合物和药物的包装。

3. 发明授权

US5871909A Human cellular retinoic acid binding protein I and II DNA and methods of use 失效
标题翻译：人细胞视黄酸结合蛋白I和II DNA及其使用方法
公开(公告)号：US5871909A
公开(公告)日：1999-02-16
申请号：US241664
申请日：1994-05-11
申请人： Anders .ANG.strom , John J. Voorhees , Ulrika Pettersson , Amir Tavakkol
发明人： Anders .ANG.strom , John J. Voorhees , Ulrika Pettersson , Amir Tavakkol
IPC分类号： C07K14/705 , C12N15/12 , C12Q1/68 , G01N33/566 , G01N33/68 , C12N15/63
CPC分类号： C07K14/70567 , C12Q1/6897 , G01N33/566 , G01N33/6872 , G01N2333/70567 , G01N2500/00
摘要： The sequences encoding two isoforms of human cellular retinoid acid binding proteins, CRABP-I and CRABP-II, have been cloned and sequenced and are set forth with their corresponding amino acid sequences. The identification of human CRABP nucleic and amino acid sequences provides the basis for the construction of recombinant human CRABP vectors and expression constructs. Human CRABP can also be synthesized or produced ex vivo, e.g. in bacterial or other production systems. Ligand binding assays, including recombinant and chimeric receptor reporter assays, and direct and competition hybridization assays employing the human CRABP sequences herein described can be used to test drugs for retinoid induction and tissue specificity for pathologies in which retinoids are implicated. Immunoassays utilizing antibodies or binding fragments produced to human CRABP can also be used to test patient tissues for the presence and levels of CRABP for diagnosis and to monitor treatment. The identification of the nucleic and amino acids sequences for human CRABP-I and CRABP-II also contributes to the elucidation of the function and interaction of the retinoid-binding proteins.
摘要翻译：编码人类细胞类视黄醇酸结合蛋白（CRABP-1和CRABP-II）的两种同工型的序列已被克隆和测序，并且以相应的氨基酸序列进行阐述。人类CRABP核酸和氨基酸序列的鉴定提供了构建重组人类CRABP载体和表达构建体的基础。人类CRABP也可以离体合成或产生，例如，在细菌或其他生产系统中。配体结合测定法，包括重组和嵌合受体报告基因测定，以及使用本文描述的人类CRABP序列的直接和竞争杂交测定法，可用于测试类维生素A诱导的药物和其中涉及类维生素A的病理学的组织特异性。利用针对人类CRABP产生的抗体或结合片段的免疫测定法也可用于测试患者组织中CRABP的存在和水平以进行诊断和监测治疗。人CRABP-1和CRABP-II的核酸和氨基酸序列的鉴定也有助于阐明类视黄醇结合蛋白的功能和相互作用。

4. 发明授权

US5654137A Human CRABP-I and CRABP-II 失效
标题翻译：人类CRABP-I和CRABP-II
公开(公告)号：US5654137A
公开(公告)日：1997-08-05
申请号：US468709
申请日：1995-06-06
申请人： Anders Astrom , John J. Voorhees , Ulrika Pettersson , Amir Tavakkol
发明人： Anders Astrom , John J. Voorhees , Ulrika Pettersson , Amir Tavakkol
IPC分类号： C07K14/705 , C12N15/12 , C12Q1/68 , G01N33/566 , G01N33/68 , C12Q1/70 , C12N5/10
CPC分类号： C07K14/70567 , C12Q1/6897 , G01N33/566 , G01N33/6872 , G01N2333/70567 , G01N2500/00
摘要： The sequences encoding two isoforms of human cellular retinoid acid binding proteins, CRABP-I and CRABP-II, have been cloned and sequenced and are set forth with their corresponding amino acid sequences. The identification of human CRABP nucleic and amino acid sequences provides the basis for the construction of recombinant human CRABP vectors and expression constructs. Human CRABP can also be synthesized or produced ex vivo, e.g. in bacterial or other production systems. Ligand binding assays, including recombinant and chimeric receptor reporter assays, and direct and competition hybridization assays employing the human CRABP sequences herein described can be used to test drugs for retinoid induction and tissue specificity for pathologies in which retinoids are implicated. Immunoassays utilizing antibodies or binding fragments produced to human CRABP can also be used to test patient tissues for the presence and levels of CRABP for diagnosis and to monitor treatment. The identification of the nucleic and amino acids sequences for human CRABP-I and CRABP-II also contributes to the elucidation of the function and interaction of the retinoid-binding proteins.
摘要翻译：编码人类细胞类视黄醇酸结合蛋白（CRABP-1和CRABP-II）的两种同工型的序列已被克隆和测序，并且以相应的氨基酸序列进行阐述。人类CRABP核酸和氨基酸序列的鉴定提供了构建重组人类CRABP载体和表达构建体的基础。人类CRABP也可以离体合成或产生，例如，在细菌或其他生产系统中。配体结合测定法，包括重组和嵌合受体报告基因测定，以及使用本文所述的人类CRABP序列的直接和竞争杂交测定法，可用于测试类视黄醇诱导药物和组胺特异性，其中涉及类维生素A。利用针对人类CRABP产生的抗体或结合片段的免疫测定法也可用于测试患者组织中CRABP的存在和水平以进行诊断和监测治疗。人CRABP-1和CRABP-II的核酸和氨基酸序列的鉴定也有助于阐明类视黄醇结合蛋白的功能和相互作用。

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