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    • 6. 发明授权
    • Biodegradable polymers with sulfenamide bonds for drug delivery applications
    • 具有亚磺酰胺键的生物可降解聚合物用于药物递送应用
    • US09345776B2
    • 2016-05-24
    • US13984228
    • 2012-02-10
    • Ned B. BowdenDenison J. KuruvillaAliasger K. SalemJun Yoo
    • Ned B. BowdenDenison J. KuruvillaAliasger K. SalemJun Yoo
    • A61K47/34C08G75/30C08G73/00
    • A61K47/34C08G73/00C08G75/30Y10T428/2982
    • The present invention provides methods for preparing polysulfenamides having a repeating unit of formula (4): wherein R1 is selected from the group consisting of alkyl, alkenyl, alkynyl, haloalkyl, alkoxyalkyl, hydroxyalkyl, ether, cycloether, aryl, heteroaryl, arylalkyl, heteroarylalkyl, hydroxyaryl, arylether, cycloalkyl, heterocycloalkyl, hydroxycycloalkyl, halocycloalkyl, and aminocycloalkyl. Each of R4, R5 and R6 are independently selected from the group consisting of alkyl, alkenyl, alkynyl, haloalkyl, alkoxyalkyl, hydroxyalkyl, ether, cycloether, aryl, heteroaryl, arylalkyl, heteroarylalkyl, hydroxyaryl, arylether, cycloalkyl, heterocycloalkyl, hydroxycycloalkyl, halocycloalkyl, and aminocycloalkyl. Microparticles comprising polysulfenamides can be used as delivery vehicles for a variety of biological applications.
    • 本发明提供了制备具有式(4)重复单元的聚亚麻酰胺的方法:其中R1选自烷基,烯基,炔基,卤代烷基,烷氧基烷基,羟基烷基,醚,环醚,芳基,杂芳基,芳基烷基,杂芳基烷基 ,羟基芳基,芳基醚,环烷基,杂环烷基,羟基环烷基,卤代环烷基和氨基环烷基。 R4,R5和R6各自独立地选自烷基,烯基,炔基,卤代烷基,烷氧基烷基,羟基烷基,醚,环醚,芳基,杂芳基,芳基烷基,杂芳基烷基,羟基芳基,芳基醚,环烷基,杂环烷基,羟基环烷基,卤代环烷基 和氨基环烷基。 包含聚亚麻酰胺的微粒可用作各种生物应用的递送载体。