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1. 发明授权

US08813750B2 Self-sizing adjustable endotracheal tube 有权
标题翻译：自动调节气管插管
公开(公告)号：US08813750B2
公开(公告)日：2014-08-26
申请号：US12859567
申请日：2010-08-19
申请人： Michael P. O'Neil , Joel C. Colburn , Gary L. Crumback , Charles E. Porges , Alfred Chung , David Hyde
发明人： Michael P. O'Neil , Joel C. Colburn , Gary L. Crumback , Charles E. Porges , Alfred Chung , David Hyde
IPC分类号： A61M16/00 , A62B9/06
CPC分类号： A61M16/04 , A61M16/0427 , A61M16/0431 , A61M16/0434 , A61M16/044 , A61M16/0443 , A61M16/0459 , A61M16/0463 , A61M16/0484 , A61M25/0026 , A61M2205/0266 , Y10T29/49826
摘要： There is disclosed an endotracheal tube which has a minimal cross-sectional profile for easy viewing of anatomical features during intubation. After the tube is placed into the trachea, the tube is adapted to increase the diameter. In this manner the tube diameter may be expanded to allow for decreased Work of Breathing (WOB) for patient, while not having so large a diameter as to cause tracheal discomfort.
摘要翻译：公开了一种气管内管，其具有最小的横截面轮廓，以便于在插管期间容易地观察解剖特征。在将管置于气管中之后，管适于增加直径。以这种方式，管直径可以被扩张以允许减少患者的呼吸作用（WOB），而没有如此大的直径导致气管不适。

2. 发明申请

US20060099604A1 Fluorescent affinity tag to enhance phosphoprotein detection and characterization 失效
公开(公告)号：US20060099604A1
公开(公告)日：2006-05-11
申请号：US10984617
申请日：2004-11-09
申请人： Stanley Stevens , Alfred Chung
发明人： Stanley Stevens , Alfred Chung
IPC分类号： C12Q1/68 , G01N33/53 , C07D311/88 , C07H21/04
CPC分类号： G01N33/533 , C07D493/10 , C07H21/04 , G01N33/582 , Y10T436/24
摘要： The invention relates to target-associative tags incorporating cysteamine as the target-associative moiety. The invention further relates to a method for producing a target-associative tag by addition of cysteamine as the target-associative moiety to another molecule or entity having a property or properties useful in discriminating or selecting between members of a set, where such properties could include, for example, fluorescence, mass, affinity, reactivity, size, absorbance, magnetism, subatomic spin characteristics, or an ability to associate specifically or preferentially with certain structures. The invention further relates to a method for analyzing, identifying, or purifying phosphorylated proteins or phosphorylated protein fragments using a tag having the properties of both fluorescence and affinity.

3. 发明授权

US4745124A Orally effective anti-hypertensive agents 失效
标题翻译：口服有效的抗高血压药
公开(公告)号：US4745124A
公开(公告)日：1988-05-17
申请号：US515474
申请日：1983-07-20
申请人： James W. Ryan , Alfred Chung
发明人： James W. Ryan , Alfred Chung
IPC分类号： A61K38/00 , C07D207/16 , C07D207/22 , C07D207/50 , C07K5/068 , C07K5/078 , A61K31/40 , A61K31/41 , C07D207/00 , C07D211/72
CPC分类号： C07K5/06173 , C07D207/16 , C07D207/22 , C07D207/50 , C07K5/06086 , A61K38/00
摘要： Novel thiolester compounds are disclosed which are orally effective angiotensin converting enzyme inhibitors useful in the treatment of mammalian hypertension. They have the formula,R.sub.1 -A.sub.1 -S-Z,wherein Z denotes -B-A.sub.2, R.sub.1 is H or an acyl group, A.sub.1 is a carboxylic acid containing at least one amino or imino -N-, A.sub.2 is a carboxylic acid containing at least one amino or imino -N- or a lower alkyl ester or amide thereof, B is a 2-4 carbon backbone chain in mercapto linkage to S which includes a carbonyl or sulfonyl group joined in carboxamido or sulfonamido linkage, respectively, to A.sub.2.Preferably A.sub.2 includes a 4-6 membered C-N ring or a 5 membered ring of one N, one S and 3 C atoms.
摘要翻译：公开了新颖的硫醇酯化合物，其是可用于治疗哺乳动物高血压的口服有效的血管紧张素转换酶抑制剂。它们具有式R1-A1-SZ，其中Z表示-B-A2，R1是H或酰基，A1是含有至少一个氨基或亚氨基-N-的羧酸，A2是含有至少一个氨基或亚氨基-N-或其低级烷基酯或酰胺，B是与S巯基连接的2-4碳主链，其包括分别连接到甲酰氨基或亚磺酰氨基键的羰基或磺酰基。优选地，A2包括一个N，一个S和3个C原子的4-6元C-N环或5元环。

4. 发明授权

US4695577A Anti-hypertensive agents 失效
公开(公告)号：US4695577A
公开(公告)日：1987-09-22
申请号：US64901
申请日：1979-08-14
申请人： James W. Ryan , Alfred Chung
发明人： James W. Ryan , Alfred Chung
IPC分类号： A61K38/00 , C07D207/16 , C07D207/22 , C07D207/50 , C07K5/068 , C07K5/078 , A61K31/40 , A61K31/41 , C07D207/00 , C07D211/72
CPC分类号： C07K5/06173 , C07D207/16 , C07D207/22 , C07D207/50 , C07K5/06086 , A61K38/00
摘要： Novel compounds are disclosed as potent inhibitors of angiotensin converting enzyme and as orally effective antihypertensive agents. The compounds have the general formula: ##STR1##

5. 发明授权

US4692437A Anti-hypertensive agents 失效
标题翻译：抗高血压药
公开(公告)号：US4692437A
公开(公告)日：1987-09-08
申请号：US156749
申请日：1980-06-05
申请人： James W. Ryan , Alfred Chung
发明人： James W. Ryan , Alfred Chung
IPC分类号： A61K38/55 , A61K20060101 , A61K31/40 , A61K31/401 , A61K31/405 , A61K38/00 , A61P9/12 , A61P43/00 , C07C20060101 , C07C67/00 , C07C325/00 , C07C327/20 , C07D207/16 , C07D207/22 , C07D207/50 , C07D403/12 , C07K1/113 , C07K5/06 , C07K5/068 , C07K5/078 , C07K5/08 , C07K14/81 , A61K31/425 , C07D207/00 , C07D277/04
CPC分类号： C07D207/16 , C07D207/22 , C07D207/50 , C07K5/06086 , C07K5/06173 , A61K38/00 , Y10S930/12
摘要： Inhibitors of angiotensin converting enzyme which are physiologically acceptable salts of compounds which have the formula: ##STR1## wherein R is hydrogen, formyl, acetyl, propanoyl, butanoyl, phenylacetyl, phenylpropanoyl, benzoyl, cyclopentanecarbonyl, tert-butyloxycarbonyl, cyclopentanecarbonyl-L-lysyl, pyro-L-glutamyl-L-lysyl, L-lysyl, L-arginyl or pyro-L-glutamyl;A is phenylalanyl, glycyl, alanyl, tryptophyl, tyrosyl, isoleucyl, leucyl, histidyl, or valyl, the .alpha.-amino group thereof being in amide linkage with R;R.sub.1 is hydrogen or methyl;R.sub.2 is L-proline, L-3,4-dehydroproline, D,L-3,4-dehydroproline, L-3-hydroxyproline, L-4-hydroxyproline, L-thiazolidine-4-carboxylic acid, or L-5-oxo-proline, the imino group thereof being in imide linkage with the adjacent ##STR2## and, n is 0 or 1, such that when n is O, R.sub.1 is methyl are disclosed as useful anti-hypertensive agents.
摘要翻译：其中R为氢，甲酰基，乙酰基，丙酰基，丁酰基，苯乙酰基，苯基丙酰基，苯甲酰基，环戊烷羰基，叔丁氧基羰基，环戊烷羰基-L-赖氨酰基的化合物的生理上可接受的盐的血管紧张素转换酶抑制剂，pyro-L-谷氨酰-L-赖氨酰，L-赖氨酰，L-精氨酰或焦-L-谷氨酰; A是与R的酰胺键合的苯丙氨酰基，甘氨酰基，丙氨酰基，色氨酸，酪氨酰基，异亮氨酰基，亮氨酰基，组氨酰基或缬氨酰基; R1是氢或甲基; R2是L-脯氨酸，L-3,4-脱氢脯氨酸，D，L-3,4-脱氢脯氨酸，L-3-羟脯氨酸，L-4-羟基脯氨酸，L-噻唑烷-4-羧酸或L-5- 氧基 - 脯氨酸，其亚氨基与相邻的“IMAGE”具有酰亚胺键，并且n为0或1，使得当n为O时，R 1为甲基作为有用的抗高血压剂公开。

6. 发明授权

US4335041A High sensitivity assays for angiotensin converting enzyme 失效
标题翻译：血管紧张素转换酶的高灵敏度测定
公开(公告)号：US4335041A
公开(公告)日：1982-06-15
申请号：US191029
申请日：1980-09-26
申请人： James W. Ryan , Alfred Chung
发明人： James W. Ryan , Alfred Chung
IPC分类号： C07K5/087 , C12Q1/37 , C07C103/52
CPC分类号： C12Q1/37 , C07K5/0812
摘要： A method for measuring the activity of angiotensin converting enzyme is disclosed. In this assay, benzoylphenylalanylalanyproline or a radioisotope labelled form thereof is used as the substrate for the angiotensin converting enzyme.
摘要翻译：公开了一种测定血管紧张素转换酶活性的方法。在该测定中，使用苯甲酰苯丙氨酰脯氨酸或其放射性同位素标记形式作为血管紧张素转化酶的底物。

7. 发明授权

US4327178A Urinary kallikrein assay: specific substrates and assay method 失效
标题翻译：尿激肽释放酶测定：特异性底物和测定方法
公开(公告)号：US4327178A
公开(公告)日：1982-04-27
申请号：US249645
申请日：1981-03-31
申请人： James W. Ryan , Alfred Chung
发明人： James W. Ryan , Alfred Chung
IPC分类号： C12Q1/37 , C12Q1/38 , C12Q1/36
CPC分类号： C12Q1/37 , Y10S530/802
摘要： Substrates and method for the assay of urinary kallikrein are provided. The substrates have the general formula ##STR1## wherein R is H, acetyl, benzoyl, cyclopentylcarbonyl, succinyl, R.sub.1 --Ser.sub.1 or R.sub.1 --Phe--Ser where R.sub.1 is H, acetyl, benzoyl, cyclopentylcarbonyl or succinyl,X is H, tritium, 3-iodo or 4-iodo, andn is 0 or 1.Radioactive label may be incorporated in the anilide or benzylamide moiety. Hydrolysis catalyzed by urinary kallikrein yields labeled aniline or benzylamine as product.The assay method includes mixing the enzyme with substrate in a buffered solution, pH 7.5-10.5, the substrate being present preferably at a concentration substantially below K.sub.m. After incubating to allow the reaction to proceed, the reaction is terminated and the radioactive hydrolysis product is separated and counted.Also disclosed are compounds of the type ##STR2## wherein R, R.sub.1 and n are as defined above. X is 3--OH or 4--OH. Y.sub.1 is 3-iodo if X is 4--OH or 6-iodo if X is 3--OH. Y.sub.2 may be H or 5-iodo if Y.sub.1 is 3-iodo, or 4-iodo if Y.sub.1 is 6-iodo.
摘要翻译：提供尿激肽释放酶的底物和方法。底物具有通式：其中R为H，乙酰基，苯甲酰基，环戊基羰基，琥珀酰基，R1-Ser1或R1-Phe-Ser，其中R1为H，乙酰基，苯甲酰基，环戊基羰基或琥珀酰基，X为H，氚， 3-碘或4-碘，n为0或1.放射性标记可以并入苯胺或苄基酰胺部分。通过尿激肽释放酶催化水解产生标记的苯胺或苄胺作为产物。测定方法包括将酶与底物在缓冲溶液（pH7.5-10.5）中混合，底物优选以基本上低于Km的浓度存在。孵育后使反应进行，终止反应，分离并计数放射性水解产物。还公开了类型“IMAGE”的化合物，其中R，R 1和n如上所定义。 X是3-OH或4-OH。如果X为3-OH，X为4-羟基或6-碘，则Y1为3-碘。如果Y1是3-碘，Y2可以是H或5-碘，如果Y1是6-碘，Y2可以是4-碘。

8. 发明授权

US4260682A High sensitivity assays for angiotensin converting enzyme 失效
标题翻译：血管紧张素转换酶的高灵敏度测定
公开(公告)号：US4260682A
公开(公告)日：1981-04-07
申请号：US26592
申请日：1979-04-04
申请人： James W. Ryan , Alfred Chung
发明人： James W. Ryan , Alfred Chung
IPC分类号： C07K5/083 , C12Q1/34 , C12Q1/36
CPC分类号： C07K5/0806 , C12Q1/34 , G01N2333/948 , G01N2333/96486
摘要： A method for measuring the activity of angiotensin converting enzyme is disclosed. In this assay, benzoylphenylalanylalanylproline or a radioisotope labelled form thereof is used as the substrate for the angiotensin converting enzyme.
摘要翻译：公开了一种测定血管紧张素转换酶活性的方法。在该测定中，使用苯甲酰基苯丙氨酰丙氨酰脯氨酸或其放射性同位素标记形式作为血管紧张素转化酶的底物。

9. 发明授权

US4690940A Anti-hypertensive agents 失效
标题翻译：抗高血压药
公开(公告)号：US4690940A
公开(公告)日：1987-09-01
申请号：US64902
申请日：1979-08-14
申请人： James W. Ryan , Alfred Chung
发明人： James W. Ryan , Alfred Chung
IPC分类号： A61K38/00 , C07D207/16 , C07D207/22 , C07D207/50 , C07K5/068 , C07K5/078 , A61K31/40 , A61K31/41 , C07D207/00 , C07D211/72
CPC分类号： C07K5/06173 , C07D207/16 , C07D207/22 , C07D207/50 , C07K5/06086 , A61K38/00
摘要： Novel Compounds are disclosed as potent inhibitors of angiotensin converting enzyme and as orally effective antihypertensive agents. The compounds have the general formula: ##STR1##
摘要翻译：公开了新型化合物作为血管紧张素转换酶的有效抑制剂和口服有效的抗高血压药。化合物具有以下通式：

10. 发明授权

US4690937A Anti-hypertensive agents 失效
公开(公告)号：US4690937A
公开(公告)日：1987-09-01
申请号：US64897
申请日：1979-08-14
申请人： James W. Ryan , Alfred Chung
发明人： James W. Ryan , Alfred Chung
IPC分类号： A61K38/00 , C07D207/16 , C07D207/22 , C07D207/28 , C07D207/50 , C07D277/06 , C07K5/068 , C07K5/078 , A61K31/40 , A61K31/41 , C07D207/00 , C07D211/72
CPC分类号： C07D207/28 , C07D207/16 , C07D207/22 , C07D207/50 , C07D277/06 , C07K5/06086 , C07K5/06173 , A61K38/00
摘要： Novel inhibitors of ACE are disclosed as potent inhibitors of angiotensin converting enzyme and as orally effective anti-hypertensive agents. The compounds have the general formula: ##STR1##

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