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1. 发明授权

US5648341A Method of treating pulmonary inflammation by continuous administration of an adenosine-containing solution 失效
标题翻译：通过连续施用含腺苷溶液治疗肺部炎症的方法
公开(公告)号：US5648341A
公开(公告)日：1997-07-15
申请号：US144803
申请日：1993-10-28
申请人： Alf Sollevi
发明人： Alf Sollevi
IPC分类号： C07H19/167 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P11/00 , A61P29/00 , A61P31/04 , A61P31/12
CPC分类号： A61K31/70
摘要： The described invention relates to a method of treatment of a pulmonary inflammatory reaction brought about by e.g. bacteraemia, physical trauma or viral infection, with activation of polymorphonuclear white blood cells, said method comprising continuous intravenous infusion of adenosine at a rate effective for such treatment, preferably 2 to 50 .mu.g/ml/min, more preferably 5-20 .mu.g/kg/min in a central vein.
摘要翻译：所述本发明涉及一种治疗由例如血液透析引起的肺部炎性反应的方法。细菌血症，物理创伤或病毒感染，多形核白细胞激活，所述方法包括以对这种治疗有效的速率连续静脉内输注腺苷，优选为2〜50μg/ ml / min，更优选为5-20μg / kg / min。

2. 发明授权

US5534504A Treating myocardial infarction by administration of a thrombolytic agent together with adenosine 失效
标题翻译：通过与腺苷一起施用溶栓剂治疗心肌梗死
公开(公告)号：US5534504A
公开(公告)日：1996-07-09
申请号：US361995
申请日：1994-12-21
申请人： Alf Sollevi
发明人： Alf Sollevi
IPC分类号： C07H19/16 , A61K31/70
CPC分类号： A61K31/70 , A61K31/7076 , C07H19/16
摘要： This invention is concerned with the use of adenosine as an agent for the treatment of human beings. More particularly, this invention is concerned with the administration of adenosine to human patients by continuous intravenous infusion for, inter alia, control of blood pressure, use as a selective vasodilator, decreasing pulmonary vascular resistance, treating acute pulmonary hypertension in conjunction with idiopathic respiratory distress syndrome, in diagnosing pulmonary hypertension in conjunction with cardiac septum defects, in percutaneous transluminal angioplasty (PTCA), in coronary thrombolysis (CTL) and in radionucleide scintography.
摘要翻译：本发明涉及使用腺苷作为治疗人的药剂。更具体地说，本发明涉及通过连续静脉输注向人类患者施用腺苷，特别是控制血压，用作选择性血管扩张剂，降低肺血管阻力，结合特发性呼吸窘迫治疗急性肺动脉高压综合征，诊断肺动脉高压联合心脏隔膜缺陷，经皮腔内血管成形术（PTCA），冠状动脉溶栓（CTL）和放射核素扫描。

3. 发明授权

US5449665A Continuous intravenous infusion of adenosine to human patients undergoing percutaneous transluminal angioplasty 失效
标题翻译：连续静脉输注腺苷到接受经皮冠状动脉成形术的人类患者
公开(公告)号：US5449665A
公开(公告)日：1995-09-12
申请号：US167745
申请日：1993-12-15
申请人： Alf Sollevi
发明人： Alf Sollevi
IPC分类号： C07H19/16 , A61K31/70
CPC分类号： A61K31/70 , A61K31/7076 , C07H19/16
摘要： This invention is concerned with the use of adenosine as an agent for the treatment of human beings. More particularly, this invention is concerned with the administration of adenosine to human patients by continuous intravenous infusion for, inter alia, control of blood pressure, use as a selective vasodilator, decreasing pulmonary vascular resistance, treating acute pulmonary hypertension in conjunction with idiopathic respiratory distress syndrome, in diagnosing pulmonary hypertension in conjunction with cardiac septum defects, in percutaneous transluminal angioplasty (PTCA), in coronary thrombolysis (CTL) and in radionucleide scintography.
摘要翻译：本发明涉及使用腺苷作为治疗人的药剂。更具体地说，本发明涉及通过连续静脉输注向人类患者施用腺苷，特别是控制血压，用作选择性血管扩张剂，降低肺血管阻力，结合特发性呼吸窘迫治疗急性肺动脉高压综合征，诊断肺动脉高压联合心脏隔膜缺陷，经皮腔内血管成形术（PTCA），冠状动脉溶栓（CTL）和放射核素扫描。

4. 发明授权

US5231086A Continuous administration adenosine to increase myocardial blood flow 失效
标题翻译：持续给予腺苷以增加心肌血流量
公开(公告)号：US5231086A
公开(公告)日：1993-07-27
申请号：US821395
申请日：1992-01-14
申请人： Alf Sollevi
发明人： Alf Sollevi
IPC分类号： C07H19/16
CPC分类号： A61K31/70 , A61K31/7076 , C07H19/16
摘要： This invention is concerned with the use of adenosine as an agent for the treatment of human beings. More particularly, this invention is concerned with the administration of adenosine to human patients by continuous intravenous infusion for, inter alia, control of blood pressure, use as a selective vasodilator, decreasing pulmonary vascular resistance, treating acute pulmonary hypertension in conjunction with idiopathic respiratory distress syndrome, in diagnosing pulmonary hypertension in conjunction with cardiac septum defects, in percutaneous transluminal angioplasty (PTCA), in coronary thrombolysis (CTL) and in radionucleide scintography.
摘要翻译：本发明涉及使用腺苷作为治疗人的药剂。更具体地说，本发明涉及通过连续静脉输注向人类患者施用腺苷，特别是控制血压，用作选择性血管扩张剂，降低肺血管阻力，结合特发性呼吸窘迫治疗急性肺动脉高压综合征，诊断肺动脉高压联合心脏隔膜缺陷，经皮腔内血管成形术（PTCA），冠状动脉溶栓（CTL）和放射核素扫描。

5. 发明授权

US5731296A Selective vasodilation by continuous adenosine infusion 失效
标题翻译：通过连续腺苷输注选择性血管舒张
公开(公告)号：US5731296A
公开(公告)日：1998-03-24
申请号：US31666
申请日：1993-03-15
申请人： Alf Sollevi
发明人： Alf Sollevi
IPC分类号： C07H19/16 , A61K31/70
CPC分类号： A61K31/70 , A61K31/7076 , C07H19/16
摘要： This invention is concerned with the use of adenosine as an agent for the treatment of human beings. More particularly, this invention is concerned with the administration of adenosine to human patients by continuous intravenous infusion for, inter alia, control of blood pressure, use as a selective vasodilator, decreasing pulmonary vascular resistance, treating acute pulmonary hypertension in conjunction with idiopathic respiratory distress syndrome, in diagnosing pulmonary hypertension in conjunction with cardiac septum defects, in percutaneous transluminal angioplasty (PTCA), in coronary thrombolysis (CTL) and in radionucleide scintography.
摘要翻译：本发明涉及使用腺苷作为治疗人的药剂。更具体地说，本发明涉及通过连续静脉输注向人类患者施用腺苷，特别是控制血压，用作选择性血管扩张剂，降低肺血管阻力，结合特发性呼吸窘迫治疗急性肺动脉高压综合征，诊断肺动脉高压联合心脏隔膜缺陷，经皮腔内血管成形术（PTCA），冠状动脉溶栓（CTL）和放射核素扫描。

6. 发明授权

US5691318A Method of treating hyperexcited sensory nerve function 失效
标题翻译：治疗超感觉神经功能的方法
公开(公告)号：US5691318A
公开(公告)日：1997-11-25
申请号：US732492
申请日：1996-10-31
申请人： Alf Sollevi
发明人： Alf Sollevi
IPC分类号： A61K45/00 , A61K31/70 , A61K31/7076 , A61K49/00 , A61P25/00 , A61P25/02
CPC分类号： A61K31/70 , A61K31/7076
摘要： The described invention relates to the treatment of hyperexcited sensory nerve functions, e.g., neuropathia in human subjects, comprising parenteral administration of an amount of an adenosine receptor agonist to said subjects. It is demonstrated that an adenosine receptor agonist can alleviate or normalize hyperexcited sensory nerve functions such as the perception of touch, temperature, vibration, pain, pressure and disturbances in other sensory functions.
摘要翻译： PCT No.PCT / SE95 / 00474 Sec。 371日期：1996年10月31日 102（e）日期1996年10月31日PCT提交1995年4月28日PCT公布。公开号WO95 / 29680 PCT 日期1995年11月9日所述发明涉及治疗超受激感觉神经功能，例如人受试者的神经病变，包括向所述受试者肠胃外施用一定数量的腺苷受体激动剂。证明腺苷受体激动剂可以缓解或归一化过度兴奋的感觉神经功能，例如触觉，温度，振动，疼痛，压力和其他感觉功能紊乱的感觉。

7. 发明授权

US5104859A Continuous administration of adenosine to reduce pulmonary vascular resistance 失效
标题翻译：连续给予腺苷以减少肺血管阻力
公开(公告)号：US5104859A
公开(公告)日：1992-04-14
申请号：US630413
申请日：1990-12-19
申请人： Alf Sollevi
发明人： Alf Sollevi
IPC分类号： C07H19/16
CPC分类号： A61K31/70 , C07H19/16
摘要： This invention is concerned with the use of adenosine as an agent for the treatment of human beings. More particularly, this invention is concerned with the administration of adenosine to human patients by continuous intravenous infusion for, inter alia, control of blood pressure, use as a selective vasodilator, decreasing pulmonary vascular resistance, treating acute pulmonary hypertension in conjunction with idiopathic respiratory distress syndrome, in diagnosing pulmonary hypertension in conjunction with cardiac septum defects, in percutaneous transluminal angioplasty (PTCA), in coronary thrombolysis (CTL), and in radionucleide scintography.
摘要翻译：本发明涉及使用腺苷作为治疗人的药剂。更具体地说，本发明涉及通过连续静脉输注向人类患者施用腺苷，特别是控制血压，用作选择性血管扩张剂，降低肺血管阻力，结合特发性呼吸窘迫治疗急性肺动脉高压综合征，诊断肺动脉高压联合心脏隔膜缺陷，经皮腔内血管成形术（PTCA），冠状动脉溶栓（CTL）和放射核素扫描。

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