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1. 发明申请

US20160324944A1 Methods and compositions relating to p62/SQSTM1 for the treatment and prevention of inflammation-associated diseases 审中-公开
标题翻译：与p62 / SQSTM1相关的治疗和预防炎症相关疾病的方法和组合物
公开(公告)号：US20160324944A1
公开(公告)日：2016-11-10
申请号：US15108653
申请日：2014-12-29
申请人： Franco VENANZI , Antonio CONCETTI , Maria Giovanna SABBIETI , Dimitrios AGAS , Vladimir GABAI , Victor SHIFRIN , Michael SHERMAN , Alexander SHNEIDER , CURELAB ONCOLOGY, INC.
发明人： Alexander Shneider , Franco Venanzi , Dimitrios Agas , Antonio Concetti , Maria Giovanna Sabbieti , Vladimir Gabai , Michael Sherman , Victor Shifrin
IPC分类号： A61K39/00 , A61K45/06
CPC分类号： C07K14/545 , A61K31/436 , A61K31/519 , A61K31/573 , A61K38/1709 , A61K39/0005 , A61K39/0008 , A61K45/06 , A61K2039/53 , A61K2039/55566 , A61P25/28 , A61P29/00 , A61P37/06 , C07K14/47 , C07K14/523 , C07K14/525 , C07K14/5412 , C07K16/245 , C07K16/248 , C12N15/62 , A61K2300/00
摘要： Provided herein are novel p62 compositions for the modulation of expression of a proinflammatory cytokines, osteogenic transcription factors, a bone resorptive factors and endogenous p62. Consequently, such p62 compositions are useful for prophylaxis and treatment of inflammatory diseases and related methods. In certain embodiments the inflammatory diseases are not cancer-related. In various embodiments, the inflammatory diseases include, but are not limited to osteoporosis, obesity, metabolic syndrome, type 2 diabetes, fat liver, inflammatory bowel disease, chronic pancreatitis, asthma, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis (RA), osteoarthritis, multiple sclerosis (MS), psoriasis, congestive heart failure (CHF), atherosclerosis, neurodegenerative diseases (ALS, Parkinson, Alzheimer's, Huntington disease), depression, schizophrenia, gout, asbestosis and silicosis.
摘要翻译：本文提供了用于调节促炎细胞因子，成骨转录因子，骨吸收因子和内源性p62的表达的新型p62组合物。因此，这种p62组合物可用于预防和治疗炎性疾病及相关方法。在某些实施方案中，炎性疾病不是癌症相关的。在各种实施方案中，炎性疾病包括但不限于骨质疏松症，肥胖症，代谢综合征，2型糖尿病，脂肪肝，炎性肠病，慢性胰腺炎，哮喘，慢性阻塞性肺病（COPD），类风湿性关节炎（RA），骨关节炎，多发性硬化症（MS），牛皮癣，充血性心力衰竭（CHF），动脉粥样硬化，神经退行性疾病（ALS，帕金森病，阿尔茨海默病，亨廷顿病），抑郁症，精神分裂症，痛风，石棉沉滞症和矽肺病。

2. 发明申请

US20070122430A1 Influenza vaccine compositions and methods of use thereof 审中-公开
标题翻译：流感疫苗组合物及其使用方法
公开(公告)号：US20070122430A1
公开(公告)日：2007-05-31
申请号：US11498320
申请日：2006-08-01
申请人： Alexander Shneider , Peter Ilyinskii , Galini Thoidis
发明人： Alexander Shneider , Peter Ilyinskii , Galini Thoidis
IPC分类号： A61K39/395 , A61K39/12
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/53 , A61K2039/552 , A61K2039/57 , A61K2039/70 , C07K14/005 , C12N2760/16122 , C12N2760/16134
摘要： Compositions of anti-influenza vaccine containing nucleic acids encoding influenza proteins NP, M1 and NS-1 and methods of inducing a protective immune response using these compositions. Also included is the enhancement of antigenic presentation or increasing immunogenicity of an influenza NP, M1 and/or NS-1 polypeptide by modifying the three dimensional structure of the polypeptide.
摘要翻译：含有编码流感蛋白NP，M1和NS-1的核酸的抗流感疫苗的组合物以及使用这些组合物诱导保护性免疫应答的方法。还包括通过修饰多肽的三维结构来增强抗原呈递或增加流感NP，M1和/或NS-1多肽的免疫原性。

3. 发明申请

US20060198759A1 Universal test-tube rack for chemical and biochemical sample preparation 审中-公开
标题翻译：通用试管架，用于化学和生化样品制备
公开(公告)号：US20060198759A1
公开(公告)日：2006-09-07
申请号：US11071008
申请日：2005-03-03
申请人： Alexander Shneider , Yakov Katsman
发明人： Alexander Shneider , Yakov Katsman
IPC分类号： B01L9/00
CPC分类号： B01L9/06 , B01L3/5021 , B01L3/5085 , B01L2300/0803 , B01L2300/123 , B04B5/0414 , B04B2005/0435
摘要： A universal test-tube rack is configured for mounting on each of a plurality of apparatus for sample preparation. A centrifugal spinning vortex induction apparatus includes a combination centrifuge/vortex including a motor with a rotational drive system on which the portable test-tube rack can be mounted for rotation and oscillation. A feed station, flotation ring and holder can also be provided, each serving as a mount for the test-tube rack, wherein the test-tube rack can be proceed from station to station with the test tubes and samples remaining in the rack and with the relative configuration and orientation of the test tubes remaining substantially the same throughout the process.
摘要翻译：通用试管架被配置为安装在用于样品制备的多个装置中的每一个上。离心式旋转涡流诱导装置包括组合离心机/涡流，其包括具有旋转驱动系统的马达，便携式试管架可安装在该旋转驱动系统上用于旋转和振荡。还可以提供进料站，浮选环和保持器，每个用作试管架的安装座，其中试管架可以从站到站进行，试管和样品保留在机架中并与在整个过程中试管的相对构型和取向基本相同。

4. 发明申请

US20140095969A1 Method of Referencing and Citing Scientific Papers 审中-公开
标题翻译：引用和引用科学论文的方法
公开(公告)号：US20140095969A1
公开(公告)日：2014-04-03
申请号：US13410376
申请日：2012-03-02
申请人： Alexander Shneider , Andrey Chursov , Alex Litvinenko , Vita Shcherbinina
发明人： Alexander Shneider , Andrey Chursov , Alex Litvinenko , Vita Shcherbinina
IPC分类号： G06F17/24
CPC分类号： G06F17/243 , G06Q10/06
摘要： The number of citations in scientific papers referencing an individual scientist plays a key role in their professional life and in scientific communities. Today's exponentially growing number of scientific publications makes it nearly impossible for authors to reflect all papers that may deserve citations. Often, authors learn about a paper they would have cited only after their work is published, and the situation cannot be corrected. We have invented a method which allows authors to appropriately reference the work of others by enabling the addition of citations to papers which have already been published. This method is implemented via the Internet system and contains one or more of the following elements: Post-Publication Citation List, Citations Under Discussion List, Non-Citators List, and a system enabling dialog between parties.
摘要翻译：参考个人科学家的科学论文的引用次数在其职业生涯和科学界都发挥着关键作用。今天科学出版物数量呈指数级增长，使作者几乎不可能反映所有可能引用的论文。通常，作者了解他们在发表作品后才会引用的论文，而且情况无法纠正。我们发明了一种方法，允许作者通过对已经发表的论文添加引用来适当地引用他人的作品。该方法通过互联网系统实现，并包含一个或多个以下元素：出版后引文列表，讨论列表引用，非引用列表，以及启用对话之间的对话系统。

5. 发明申请

US20140161824A1 METHODS AND COMPOSITIONS RELATING TO P62 FOR THE TREATMENT AND PROPHYLAXIS OF CANCER 有权
标题翻译：与P62相关的治疗和预防癌症的方法和组成
公开(公告)号：US20140161824A1
公开(公告)日：2014-06-12
申请号：US14236829
申请日：2012-08-08
申请人： Alexander Shneider , Franco Venanzi , Michael Sherman , Victor Shifrin
发明人： Alexander Shneider , Franco Venanzi , Michael Sherman , Victor Shifrin
IPC分类号： A61K39/00 , A61N5/10 , A61K45/06
CPC分类号： A61K39/0011 , A61K9/0019 , A61K31/337 , A61K31/407 , A61K31/4748 , A61K31/475 , A61K31/513 , A61K31/519 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K38/1709 , A61K38/1793 , A61K38/19 , A61K45/06 , A61K48/00 , A61K2039/53 , A61N5/10 , A61K2300/00
摘要： Provided herein are novel p62 compositions for the prophylaxis and treatment of cancer and related methods. The invention also provides modified p62 compositions that increase the anti-cancer activity of p62.
摘要翻译：本文提供了用于预防和治疗癌症的新型p62组合物及相关方法。本发明还提供增加p62的抗癌活性的改良的p62组合物。

6. 发明申请

US20050013826A1 Vaccine compositions and methods 审中-公开
标题翻译：疫苗组合物和方法
公开(公告)号：US20050013826A1
公开(公告)日：2005-01-20
申请号：US10866484
申请日：2004-06-11
申请人： Alexander Shneider , Michael Sherman
发明人： Alexander Shneider , Michael Sherman
IPC分类号： A61K20060101 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/38 , C07K5/103 , C07K14/11 , C07K17/00 , C12N15/74
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/5256 , A61K2039/53 , C07K5/1013 , C12N2710/14143 , C12N2740/16122 , C12N2740/16222 , C12N2760/16122
摘要： Methods of enhancing antigenic presentation or increasing immunogenicity of a polypeptide accomplished by modifying the three dimensional structure of a polypeptide.
摘要翻译：通过修饰多肽的三维结构来增强多肽的抗原呈递或提高多肽的免疫原性的方法。

7. 发明授权

US09717781B2 Methods and compositions relating to P62 for the treatment and prophylaxis of cancer 有权
公开(公告)号：US09717781B2
公开(公告)日：2017-08-01
申请号：US14236829
申请日：2012-08-08
申请人： Alexander Shneider , Franco Venanzi , Michael Sherman , Victor Shifrin
发明人： Alexander Shneider , Franco Venanzi , Michael Sherman , Victor Shifrin
IPC分类号： A61K31/713 , A61K47/42 , A61K39/00 , A61K45/06 , A61K31/337 , A61K31/407 , A61K31/475 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K38/17 , A61K38/19 , A61N5/10 , A61K9/00 , A61K48/00
CPC分类号： A61K39/0011 , A61K9/0019 , A61K31/337 , A61K31/407 , A61K31/4748 , A61K31/475 , A61K31/513 , A61K31/519 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K38/1709 , A61K38/1793 , A61K38/19 , A61K45/06 , A61K48/00 , A61K2039/53 , A61N5/10 , A61K2300/00
摘要： Provided herein are novel p62 compositions for the prophylaxis and treatment of cancer and related methods. The invention also provides modified p62 compositions that increase the anti-cancer activity of p62.

8. 发明申请

US20160364524A1 METHODS FOR INTRODUCING MUTATIONS THAT ALTER THE PROBABILITY OF INTRANUCLEIC ACID BASE PAIRING OF A CONSERVED STRUCTURED NUCLEOTIDE AND RELATED COMPOSITIONS 审中-公开
标题翻译：引入突变体的方法，该突变体是一种保守的结构化核苷酸和相关组合物的内在酸碱基配对的概率
公开(公告)号：US20160364524A1
公开(公告)日：2016-12-15
申请号：US15121560
申请日：2015-02-26
申请人： Andrey CHURSOV , Alexander SHNEIDER , CureLab, Inc.
发明人： Andrey Chursov , Alexander Shneider
IPC分类号： G06F19/22 , A61K39/145 , C12N7/00 , G06F17/18
CPC分类号： G16B30/00 , A61K39/145 , A61K2039/5254 , C12N7/00 , C12N2760/16122 , C12N2760/16134 , G06F17/18 , G16B20/00
摘要： The present invention relates generally to methods for introducing mutations that alter the probability of intranucleic acid base pairing of a conserved structured nucleotide in a nucleic acid. The present invention also provide methods for making mutant pathogenic organisms suitable as live attenuated vaccines, animal and human diagnostics, and for identifying suitable drug targets.
摘要翻译：本发明一般涉及用于引入改变核酸中保守结构核苷酸的核酸内碱基配对的概率的突变的方法。本发明还提供了用于制备适合作为活减毒疫苗，动物和人类诊断以及用于鉴定合适的药物靶标的突变病原生物的方法。

9. 发明申请

US20070116717A1 INFLUENZA VACCINE COMPOSITIONS AND METHODS 审中-公开
标题翻译：流感疫苗组合物和方法
公开(公告)号：US20070116717A1
公开(公告)日：2007-05-24
申请号：US11380554
申请日：2006-04-27
申请人： Alexander Shneider , Peter Ilyinskii , Galini Thoidis
发明人： Alexander Shneider , Peter Ilyinskii , Galini Thoidis
IPC分类号： A61K39/395 , A61K39/12
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/53 , A61K2039/552 , A61K2039/57 , A61K2039/70 , C07K14/005 , C12N2760/16122 , C12N2760/16134
摘要： Compositions of anti-influenza vaccine containing nucleic acids encoding influenza proteins NP, M1 and NS-1 and methods of inducing an immune response using these compositions. Also included is the enhancement of antigenic presentation or increasing immunogenicity of an influenza NP, M1 and/or NS-1 polypeptide by modifying the three dimensional structure of the polypeptide.
摘要翻译：含有编码流感蛋白NP，M1和NS-1的核酸的抗流感疫苗的组合物以及使用这些组合物诱导免疫应答的方法。还包括通过修饰多肽的三维结构来增强抗原呈递或增加流感NP，M1和/或NS-1多肽的免疫原性。

10. 发明申请

US20060177936A1 Apparatus and methods for chemical and biochemical sample preparation 审中-公开
标题翻译：化学和生物化学样品制备的装置和方法
公开(公告)号：US20060177936A1
公开(公告)日：2006-08-10
申请号：US11052425
申请日：2005-02-07
申请人： Alexander Shneider , Yakov Katsman
发明人： Alexander Shneider , Yakov Katsman
IPC分类号： G01N35/00
CPC分类号： B04B5/0414 , B01F9/0003 , B01F11/0002 , B01F11/0008 , B01L7/02 , B01L9/06 , B04B2011/046 , G01N35/00 , Y10T436/111666
摘要： A universal test-tube rack is configured for mounting on each of a plurality of apparatus for sample preparation. A centrifugal spinning vortex induction apparatus includes a combination centrifuge/vortex including a motor with a rotational drive system on which the portable test-tube rack can be mounted for rotation and oscillation. A feed station, flotation ring and holder can also be provided, each serving as a mount for the test-tube rack, wherein the test-tube rack can be proceed from station to station with the test tubes and samples remaining in the rack and with the relative configuration and orientation of the test tubes remaining substantially the same throughout the process.
摘要翻译：通用试管架被配置为安装在用于样品制备的多个装置中的每一个上。离心式旋转涡流诱导装置包括组合离心机/涡流，其包括具有旋转驱动系统的马达，便携式试管架可安装在该旋转驱动系统上用于旋转和振荡。还可以提供进料站，浮选环和保持器，每个用作试管架的安装座，其中试管架可以从站到站进行，试管和样品保留在机架中并与在整个过程中试管的相对构型和取向基本相同。

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