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1. 发明授权

US5876971A Thrombin inhibitor from the saliva of protostomia 失效
标题翻译：凝血酶抑制剂来自原肠the唾液
公开(公告)号：US5876971A
公开(公告)日：1999-03-02
申请号：US448438
申请日：1995-08-24
申请人： Christiane Noeske-Jungblut , Wolf-Dieter Schleuning , Alejandro Alagon , Lourival Possani , Delia Cuevas-Aguierre , Peter Donner , Bernard Haendler , Ulrike Hechler
发明人： Christiane Noeske-Jungblut , Wolf-Dieter Schleuning , Alejandro Alagon , Lourival Possani , Delia Cuevas-Aguierre , Peter Donner , Bernard Haendler , Ulrike Hechler
IPC分类号： C12N15/09 , A61K35/12 , A61K35/56 , A61K35/64 , A61K38/00 , A61K38/55 , A61K38/57 , A61P7/02 , A61P9/10 , C07H21/04 , C07K1/14 , C07K14/435 , C07K14/81 , C12N1/21 , C12N5/10 , C12N9/99 , C12N15/15 , C12P21/00 , C12P21/02 , A61K38/16 , C07K1/36
CPC分类号： C07K14/811 , A61K38/00
摘要： The invention relates to a natural protein or a protein that can be synthetically produced, which is a thrombin inhibitor and can be isolated from the saliva of insects which suck the blood of mammals. Preferred is the Triatoma pallidipennis insect. The protein is used for the treatment of thromboses or unstable angina or arteriosclerosis, or for the prevention of a reblockage of vessels after PTCA/PTA or for the prevention of blood clotting in hemodialysis.
摘要翻译： PCT No.PCT / DE93 / 01172 Sec。 371日期1995年8月24日 102（e）日期1995年8月24日PCT提交1993年12月3日PCT公布。公开号WO94 / 13807 日期1994年6月23日本发明涉及可以合成产生的天然蛋白质或蛋白质，其是凝血酶抑制剂，并且可以从吸入哺乳动物的血液的昆虫的唾液中分离出来。优选的是Triatoma pallidipennis昆虫。该蛋白质用于治疗血栓形成或不稳定性心绞痛或动脉硬化，或用于预防PTCA / PTA后血管再阻塞或用于预防血液透析中血液凝固。

2. 发明申请

US20090142356A1 Pharmaceutical Composition of F(ab')2 Antibody Fragments and a Process for the Preparation Thereof 有权
标题翻译： F（ab'）2抗体片段的药物组合物及其制备方法
公开(公告)号：US20090142356A1
公开(公告)日：2009-06-04
申请号：US12326687
申请日：2008-12-02
申请人： Juan LOPEZ DE SILANES , Rita G. MANCILLA NAVA , Jorge F. PANIAGUA SOLIS , Alejandro ALAGON CANO , Walter GARCIA UBBELOHDE
发明人： Juan LOPEZ DE SILANES , Rita G. MANCILLA NAVA , Jorge F. PANIAGUA SOLIS , Alejandro ALAGON CANO , Walter GARCIA UBBELOHDE
IPC分类号： A61K39/395 , A61P37/06
CPC分类号： C07K16/065 , A61K2039/505 , C07K16/18 , C07K16/241 , C07K16/249 , C07K2317/54 , Y10S424/809
摘要： The present invention is directed to a pharmaceutical composition comprising F(ab′)2 antibody fragments that are preferably free from albumin and of whole antibodies and also substantially free of pyrogens, and an effective amount of a pharmaceutically acceptable carrier. It is also directed to a method for the production of a pharmaceutical composition comprising F(ab′)2 antibody fragments using serum or blood plasma of a mammal that has been previously immunized as a source of antibodies. The serum or blood plasma is digested with an enzyme pepsin, followed by separation and purification until the pharmaceutical composition of F(ab′)2 fragments is free of albumin and complete antibodies, and substantially free of pyrogens.
摘要翻译：本发明涉及包含优选不含白蛋白和完全抗体也基本上不含热原的F（ab'）2抗体片段和有效量的药学上可接受的载体的药物组合物。还涉及使用先前已被免疫作为抗体来源的哺乳动物的血清或血浆来制备包含F（ab'）2抗体片段的药物组合物的方法。用酶胃蛋白酶消化血清或血浆，然后分离和纯化，直到F（ab'）2片段的药物组合物不含白蛋白和完全抗体，基本上不含热原。

3. 发明授权

US08512706B2 Compositions of F(ab′)2 antibody fragments 有权
标题翻译： F（ab'）2抗体片段的组成
公开(公告)号：US08512706B2
公开(公告)日：2013-08-20
申请号：US13298778
申请日：2011-11-17
申请人： Juan López De Silanes , Rita Guadalupe Mancilla Nava , Jorge F. Paniagua-Solís , Alejandro Alagon Cano , Walter J. García-Ubbelohde
发明人： Juan López De Silanes , Rita Guadalupe Mancilla Nava , Jorge F. Paniagua-Solís , Alejandro Alagon Cano , Walter J. García-Ubbelohde
IPC分类号： A61K39/395
CPC分类号： C07K16/065 , A61K2039/505 , C07K16/18 , C07K16/241 , C07K16/249 , C07K2317/54 , Y10S424/809
摘要： The present invention is directed to a pharmaceutical composition comprising F(ab′)2 antibody fragments that are preferably free from albumin and of whole antibodies and also substantially free of pyrogens, and an effective amount of a pharmaceutically acceptable carrier. It is also directed to a method for the production of a pharmaceutical composition comprising F(ab′)2 antibody fragments using scrum or blood plasma of a mammal that has been previously immunized as a source of antibodies. The serum or blood plasma is digested with an enzyme pepsin, followed by separation and purification until the pharmaceutical composition of F(ab′)2 fragments is free of albumin and complete antibodies, and substantially free of pyrogens.
摘要翻译：本发明涉及包含优选不含白蛋白和完全抗体也基本上不含热原的F（ab'）2抗体片段和有效量的药学上可接受的载体的药物组合物。还涉及使用先前已被免疫作为抗体来源的哺乳动物的scrum或血浆来制备包含F（ab'）2抗体片段的药物组合物的方法。用酶胃蛋白酶消化血清或血浆，然后分离和纯化，直到F（ab'）2片段的药物组合物不含白蛋白和完全抗体，基本上不含热原。

4. 发明授权

US08287860B2 Immunogen and antivenom against violin spider venom 有权
标题翻译：针对小提琴蜘蛛毒液的免疫原和抗蛇毒素
公开(公告)号：US08287860B2
公开(公告)日：2012-10-16
申请号：US11574488
申请日：2005-08-29
申请人： Alejandro Olvera Rodriguez , Roberto Pablo Stock Silberman , Blanca Margarita Ramos Cerrillo , Rosana Sanchez-Lopez , Alejandro Alagon Cano
发明人： Alejandro Olvera Rodriguez , Roberto Pablo Stock Silberman , Blanca Margarita Ramos Cerrillo , Rosana Sanchez-Lopez , Alejandro Alagon Cano
IPC分类号： A61K39/395 , A61K39/00 , A61K38/46 , A61K38/54 , C12N9/14 , C12N9/16 , C07K16/40
CPC分类号： C12N9/16 , C07K14/43518
摘要： The invention relates to the isolation, characterization and expression of DNA fragments encoding sphingomyelinases D from three species of Loxosceles genus spiders, namely L. boneti, L reclusa and L. laeta, and the toxoids thereof. The invention also relates to the production of active sphingomyelinases D and the toxoids thereof using recombinant means and to the use of same as an immunogen for the production in vertebrates of antibodies that neutralise the corresponding venom and the respective fragments F(ab′)2. The invention further relates to the use of recombinant sphingomyelinases D as part of an antigen matrix which can be used in the immunopurification of antibodies and the fragments thereof or as part of any diagnostic device used to obtain clinical confirmation that the causal agent of poisoning in a patient is a spider of the Loxosceles genus. In addition, the invention includes molecular vectors for the expression of the DNA fragments, strains comprising same, which can express Loxosceles sphingomyelinases D, and methods for the expression thereof. AA Porcentaje de identidad de aminoacidos entre necrotoxinas de diferentes especies de Loxosceles. especie BBLb1Lr1Lr2LaLiLl-H17Ll-H13Ll-1Ll-2 Lb1— Lr191— Lr28490— La868887— Li82848880— Ll-H175760605959— Ll-H13576061586080— Ll-156595958599980— Ll-25760615959829482— AA . . . AMINO ACID PERCENTAGE OF IDENTITY BETWEEN NECROTOXINS OF DIFFERENT LOXOSCELES SPECIES BB . . . SPECIES
摘要翻译：本发明涉及编码来自三种类型的松属蜘蛛蜘蛛（即，usa usa usa usa usa usa usa usa encoding encoding encoding encoding encoding encoding encoding of of of of of of of of of of of的DNA片段的分离，表征和表达。本发明还涉及使用重组方法生产活性鞘磷脂酶D及其类毒素，并且使用其作为免疫原用于在中和相应毒液和各自片段F（ab'）2的抗体的脊椎动物中的产生。本发明还涉及重组鞘磷脂酶D作为抗原基质的一部分的用途，所述抗原基质可用于抗体及其片段的免疫纯化，或作为用于获得临床确认中毒中毒原因的任何诊断装置的一部分病人是柳科属的蜘蛛。此外，本发明包括用于表达DNA片段的分子载体，包含其的可以表达软骨鞘磷脂酶D的菌株及其表达方法。 AA Porcentaje de identidad de aminoacidos entre necrotoxinas de differentes especies de Loxosceles。 especie BB Lb1 Lr1 Lr2 La Li Ll-H17 L1-H13 L1-1 L1-2 Lb1 -Lr1 91 -Lr2 84 90-La 86 88 87 - Li 82 84 88 80 -LI-H17 57 60 60 59 59 - H13 57 60 61 58 60 80 - L1-1 56 59 59 58 59 99 80 - L1-2 57 60 61 59 59 82 94 82 - AA。。。氨基酸含量不同于不同脂蛋白类别的NECROTOXIN之间的氨基酸百分比。。。种类

5. 发明授权

US08541551B2 Immunogen and antivenom against violin spider venom 有权
标题翻译：针对小提琴蜘蛛毒液的免疫原和抗蛇毒素
公开(公告)号：US08541551B2
公开(公告)日：2013-09-24
申请号：US13610516
申请日：2012-09-11
申请人： Alejandro Olvera Rodriguez , Roberto Pablo Stock Silberman , Blanca Margarita Ramos Cerrillo , Rosana Sanchez-Lopez , Alejandro Alagon Cano
发明人： Alejandro Olvera Rodriguez , Roberto Pablo Stock Silberman , Blanca Margarita Ramos Cerrillo , Rosana Sanchez-Lopez , Alejandro Alagon Cano
IPC分类号： A61K38/43 , C07K14/435 , C12N9/16
CPC分类号： C12N9/16 , C07K14/43518
摘要： The invention relates to the isolation, characterization and expression of DNA fragments encoding sphingomyelinases D from three species of Loxosceles genus spiders, namely L. boneti., L. reclusa and L. laeta, and the toxoids thereof. The invention also relates to the production of active sphingomyelinases D and the toxoids thereof using recombinant means and to the use of same as an immunogen for the production in vertebrates of antibodies that neutralize the corresponding venom and the respective fragments F(ab′)2. The invention further relates to the use of recombinant sphingomyelinases D as part of an antigen matrix which can be used in the immunopurification of antibodies and the fragments thereof or as part of any diagnostic device used to obtain clinical confirmation that the causal agent of poisoning in a patient is a spider of the Loxosceles genus. In addition, the invention includes molecular vectors for the expression of the DNA fragments, strains comprising same, which can express Loxosceles sphingomyelinases D, and methods for the express thereof.
摘要翻译：本发明涉及从三种洛克索斯属蜘蛛（即，bon usa，L. reclusa和L. laeta）及其类毒素中分离，表征和编码编码鞘磷脂酶D的DNA片段的分离，表征和表达。本发明还涉及使用重组方法生产活性鞘磷脂酶D及其类毒素，并且使用其作为免疫原用于在中和相应毒液和各自片段F（ab'）2的抗体的脊椎动物中的产生。本发明还涉及重组鞘磷脂酶D作为抗原基质的一部分的用途，所述抗原基质可用于抗体及其片段的免疫纯化，或作为用于获得临床确认中毒中毒原因的任何诊断装置的一部分病人是柳科属的蜘蛛。此外，本发明包括用于表达DNA片段的分子载体，包含它们的菌株，其可以表达软骨鞘磷脂酶D，以及用于表达它们的方法。

6. 发明申请

US20110177078A1 Immunogen and Antivenom Against Violin Spider Venom 有权
标题翻译：免疫原和抗毒素对小提琴蜘蛛毒液
公开(公告)号：US20110177078A1
公开(公告)日：2011-07-21
申请号：US11574488
申请日：2005-08-29
申请人： Alejandro Olvera Rodriguez , Roberto Pablo Stock Silberman , Blanca Margarita Ramos Cerrillo , Rosana Sanchez-Lopez , Alejandro Alagon Cano
发明人： Alejandro Olvera Rodriguez , Roberto Pablo Stock Silberman , Blanca Margarita Ramos Cerrillo , Rosana Sanchez-Lopez , Alejandro Alagon Cano
IPC分类号： A61K39/395 , C07K16/18 , A61P39/02 , C07K14/435
CPC分类号： C12N9/16 , C07K14/43518
摘要： The invention relates to the isolation, characterisation and expression of DNA fragments encoding sphingomyelinases D from three species of Loxosceles genus spiders, namely L. boneti, L reclusa and L. laeta, and the toxoids thereof. The invention also relates to the production of active sphingomyelinases D and the toxoids thereof using recombinant means and to the use of same as an immunogen for the production in vertebrates of antibodies that neutralise the corresponding venom and the respective fragments F(ab′)2. The invention further relates to the use of recombinant sphingomyelinases D as part of an antigen matrix which can be used in the immunopurification of antibodies and the fragments thereof or as part of any diagnostic device used to obtain clinical confirmation that the causal agent of poisoning in a patient is a spider of the Loxosceles genus. In addition, the invention includes molecular vectors for the expression of the DNA fragments, strains comprising same, which can express Loxosceles sphingomyelinases D, and methods for the expression thereof. AA Porcentaje de identidad de aminoacidos entre necrotoxinas de diferentes especies de Loxosceles. especie BBLb1Lr1Lr2LaLiLl-H17Ll-H13Ll-1Ll-2 Lb1— Lr191— Lr28490— La868887— Li82848880— Ll-H175760605959— Ll-H13576061586080— Ll-156595958599980— Ll-25760615959829482— AA . . . AMINO ACID PERCENTAGE OF IDENTITY BETWEEN NECROTOXINS OF DIFFERENT LOXOSCELES SPECIES BB . . . SPECIES
摘要翻译：本发明涉及编码来自三种类型的松属蜘蛛蜘蛛（即，usa usa usa usa usa usa usa usa encoding encoding encoding encoding encoding encoding encoding of of of of of of of of of of of的DNA片段的分离，表征和表达。本发明还涉及使用重组方法生产活性鞘磷脂酶D及其类毒素，并且使用其作为免疫原用于在中和相应毒液和各自片段F（ab'）2的抗体的脊椎动物中的产生。本发明还涉及重组鞘磷脂酶D作为抗原基质的一部分的用途，所述抗原基质可用于抗体及其片段的免疫纯化，或作为用于获得临床确认中毒中毒原因的任何诊断装置的一部分病人是柳科属的蜘蛛。此外，本发明包括用于表达DNA片段的分子载体，包含其的可以表达软骨鞘磷脂酶D的菌株及其表达方法。 AA Porcentaje de identidad de aminoacidos entre necrotoxinas de differentes especies de Loxosceles。 especie BB Lb1 Lr1 Lr2 La Li Ll-H17 L1-H13 L1-1 L1-2 Lb1 -Lr1 91 -Lr2 84 90-La 86 88 87 - Li 82 84 88 80 -LI-H17 57 60 60 59 59 - H13 57 60 61 58 60 80 - L1-1 56 59 59 58 59 99 80 - L1-2 57 60 61 59 59 82 94 82 - AA。。。氨基酸含量不同于不同脂蛋白类别的NECROTOXIN之间的氨基酸百分比。。。种类

7. 发明申请

US20090155850A1 Horse:Human Chimeric Antibodies 审中-公开
标题翻译：马：人类嵌合抗体
公开(公告)号：US20090155850A1
公开(公告)日：2009-06-18
申请号：US12090166
申请日：2006-10-27
申请人： Juan C. Almagro , Alejandro Alagon-Cano , Jorge P. Solis , Sylvia L. Smith , Alvaro Velandia
发明人： Juan C. Almagro , Alejandro Alagon-Cano , Jorge P. Solis , Sylvia L. Smith , Alvaro Velandia
IPC分类号： C12P21/00 , C07K16/18 , C12N9/96
CPC分类号： C07K16/18 , C07K2317/24 , C07K2317/622
摘要： The present invention provides a plurality of chimeric single chain variable region (scFv) antibodies. The chimeric scFv antibodies individually comprise variable regions from both horse and non-horse antibodies. Methods of making and using the plurality are also provided.
摘要翻译：本发明提供了多个嵌合单链可变区（scFv）抗体。嵌合scFv抗体单独包含来自马和非马抗体的可变区。还提供了制造和使用多个的方法。

8. 发明申请

US20130071399A1 Immunogen and Antivenom Against Violin Spider Venom 有权
标题翻译：免疫原和抗毒素对小提琴蜘蛛毒液
公开(公告)号：US20130071399A1
公开(公告)日：2013-03-21
申请号：US13610516
申请日：2012-09-11
申请人： Alejandro Olvera Rodriguez , Roberto Pablo Stock Silberman , Blanca Margarita Ramos Cerrillo , Rosana Sanchez-Lopez , Alejandro Alagon Cano
发明人： Alejandro Olvera Rodriguez , Roberto Pablo Stock Silberman , Blanca Margarita Ramos Cerrillo , Rosana Sanchez-Lopez , Alejandro Alagon Cano
IPC分类号： C07K14/435 , A61K39/395 , A61P37/04 , A61K39/00
CPC分类号： C12N9/16 , C07K14/43518
摘要： The invention relates to the isolation, characterisation and expression of DNA fragments encoding sphingomyelinases D from three species of Loxosceles genus spiders, namely L. boneti., L. reclusa and L. laeta, and the toxoids thereof. The invention also relates to the production of active sphingomyelinases D and the toxoids thereof using recombinant means and to the use of same as an immunogen for the production in vertebrates of antibodies that neutralise the corresponding venom and the respective fragments F(ab′)2. The invention further relates to the use of recombinant sphingomyelinases D as part of an antigen matrix which can be used in the immunopurification of antibodies and the fragments thereof or as part of any diagnostic device used to obtain clinical confirmation that the causal agent of poisoning in a patient is a spider of the Loxosceles genus. In addition, the invention includes molecular vectors for the expression of the DNA fragments, strains comprising same, which can express Loxosceles sphingomyelinases D, and methods for the express thereof.
摘要翻译：本发明涉及从三种洛克索斯属蜘蛛（即，bon usa，L. reclusa和L. laeta）及其类毒素中分离，表征和编码编码鞘磷脂酶D的DNA片段的分离，表征和表达。本发明还涉及使用重组方法生产活性鞘磷脂酶D及其类毒素，并且使用其作为免疫原用于在中和相应毒液和各自片段F（ab'）2的抗体的脊椎动物中的产生。本发明还涉及重组鞘磷脂酶D作为抗原基质的一部分的用途，所述抗原基质可用于抗体及其片段的免疫纯化，或作为用于获得临床确认中毒中毒原因的任何诊断装置的一部分病人是柳科属的蜘蛛。此外，本发明包括用于表达DNA片段的分子载体，包含它们的菌株，其可以表达软骨鞘磷脂酶D，以及用于表达它们的方法。

9. 发明授权

US08075893B2 Pharmaceutical composition of F(ab′)2 antibody fragments and a process for the preparation thereof 有权
标题翻译： F（ab'）2抗体片段的药物组合物及其制备方法
公开(公告)号：US08075893B2
公开(公告)日：2011-12-13
申请号：US12326687
申请日：2008-12-02
申请人： Juan López De Silanes , Rita Guadalupe Mancilla Nava , Jorge F. Paniagua-Solís , Alejandro Alagon Cano , Walter J. García-Ubbelohde
发明人： Juan López De Silanes , Rita Guadalupe Mancilla Nava , Jorge F. Paniagua-Solís , Alejandro Alagon Cano , Walter J. García-Ubbelohde
IPC分类号： A61K39/395 , C07K1/30
CPC分类号： C07K16/065 , A61K2039/505 , C07K16/18 , C07K16/241 , C07K16/249 , C07K2317/54 , Y10S424/809
摘要： The present invention is directed to a pharmaceutical composition comprising F(ab′)2 antibody fragments that are preferably free from albumin and of whole antibodies and also substantially free of pyrogens, and an effective amount of a pharmaceutically acceptable carrier. It is also directed to a method for the production of a pharmaceutical composition comprising F(ab′)2 antibody fragments using serum or blood plasma of a mammal that has been previously immunized as a source of antibodies. The serum or blood plasma is digested with an enzyme pepsin, followed by separation and purification until the pharmaceutical composition of F(ab′)2 fragments is free of albumin and complete antibodies, and substantially free of pyrogens.
摘要翻译：本发明涉及包含优选不含白蛋白和完全抗体也基本上不含热原的F（ab'）2抗体片段和有效量的药学上可接受的载体的药物组合物。还涉及使用先前已被免疫作为抗体来源的哺乳动物的血清或血浆来制备包含F（ab'）2抗体片段的药物组合物的方法。用酶胃蛋白酶消化血清或血浆，然后分离和纯化，直到F（ab'）2片段的药物组合物不含白蛋白和完全抗体，基本上不含热原。

10. 发明授权

US6008019A Plasminogen activator from saliva of the vampire bat 失效
标题翻译：吸血蝙蝠唾液中的纤溶酶原激活剂
公开(公告)号：US6008019A
公开(公告)日：1999-12-28
申请号：US456833
申请日：1995-06-01
申请人： Berthold Baldus , Peter Donner , Wolf-Dieter Schleuning , Alejandro Alagon , Werner Boidol , Jorn Reiner Kratzschmar , Bernard Jacques Haendler , Gernot Langer
发明人： Berthold Baldus , Peter Donner , Wolf-Dieter Schleuning , Alejandro Alagon , Werner Boidol , Jorn Reiner Kratzschmar , Bernard Jacques Haendler , Gernot Langer
IPC分类号： A61K38/00 , C12N1/21 , C12N9/72 , C12N9/64 , C12N5/10 , C12N15/12
CPC分类号： C12N9/6456 , A61K38/00
摘要： The present invention relates to novel thrombolitic v-PA's which dissolve blood clots in the human body and thus are suitable for the treatment of cardial infarction, for example.
摘要翻译：本发明涉及溶解人体血栓的新型血栓栓塞型v-PA，例如适用于治疗心梗。

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