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1. 发明授权

US08198020B2 Compositions and methods for enhancing phagocytosis or phagocyte activity 有权
标题翻译：用于增强吞噬作用或吞噬细胞活性的组合物和方法
公开(公告)号：US08198020B2
公开(公告)日：2012-06-12
申请号：US10923940
申请日：2004-08-23
申请人： Cedric Francois , Pascal Deschatelets , Paul Olson , Alec Machiels
发明人： Cedric Francois , Pascal Deschatelets , Paul Olson , Alec Machiels
IPC分类号： C12Q1/70 , C12Q1/00 , G01N33/53 , G01N33/567 , G01N33/574
CPC分类号： B82Y5/00 , A61K47/544 , A61K47/62 , A61K47/6911 , A61K47/6913
摘要： The present invention provides a system for enhancing clearance or destruction of undesirable cells or noncellular molecular entities by tagging such cells or noncellular molecular entities with a marker that targets the cells or noncellular molecular entities for phagocytosis (phagocytic marker). The target cells can be, for example, endothelial cells, tumor cells, leukocytes, or virus-infected cells. In certain embodiments of the invention the tagging is accomplished by administering a composition comprising an antibody or ligand linked to the phagcytotic marker, wherein the antibody or ligand binds to a cell type specific marker present on or in the cell surface of a target cell. In preferred embodiments of the invention, the phagocytic marker comprises phosphatidylserine or a group derived from phosphatidylserine, thrombospondin-1, annexin I, or a derivative of any of these.
摘要翻译：本发明提供了一种用于通过用靶向细胞或非细胞分子实体进行吞噬作用（吞噬标记）的标记来标记这样的细胞或非细胞分子实体来增强不需要的细胞或非细胞分子实体的清除或破坏的系统。靶细胞可以是例如内皮细胞，肿瘤细胞，白细胞或病毒感染的细胞。在本发明的某些实施方案中，标记通过施用包含与噬菌体标记物连接的抗体或配体的组合物来实现，其中所述抗体或配体结合存在于靶细胞的细胞表面上或细胞表面的细胞类型特异性标志物。在本发明的优选实施方案中，吞噬标记物包含磷脂酰丝氨酸或衍生自磷脂酰丝氨酸，血小板反应素-1，膜联蛋白I或其任何衍生物的基团。

2. 发明申请

US20050113297A1 Compositions and methods for enhancing phagocytosis or phagocyte activity 有权
标题翻译：用于增强吞噬作用或吞噬细胞活性的组合物和方法
公开(公告)号：US20050113297A1
公开(公告)日：2005-05-26
申请号：US10923940
申请日：2004-08-23
申请人： Cedric Francois , Pascal Deschatelets , Paul Olson , Alec Machiels
发明人： Cedric Francois , Pascal Deschatelets , Paul Olson , Alec Machiels
IPC分类号： A61K38/17 , A61K47/48 , C12N5/08
CPC分类号： B82Y5/00 , A61K47/544 , A61K47/62 , A61K47/6911 , A61K47/6913
摘要： The present invention provides a system for enhancing clearance or destruction of undesirable cells or noncellular molecular entities by tagging such cells or noncellular molecular entities with a marker that targets the cells or noncellular molecular entities for phagocytosis (phagocytic marker). The target cells can be, for example, endothelial cells, tumor cells, leukocytes, or virus-infected cells. In certain embodiments of the invention the tagging is accomplished by administering a composition comprising an antibody or ligand linked to the phagcytotic marker, wherein the antibody or ligand binds to a cell type specific marker present on or in the cell surface of a target cell. In preferred embodiments of the invention, the phagocytic marker comprises phosphatidylserine or a group derived from phosphatidylserine, thrombospondin-1, annexin I, or a derivative of any of these.
摘要翻译：本发明提供了一种用于通过用靶向细胞或非细胞分子实体进行吞噬作用（吞噬标记）的标记来标记这样的细胞或非细胞分子实体来增强不需要的细胞或非细胞分子实体的清除或破坏的系统。靶细胞可以是例如内皮细胞，肿瘤细胞，白细胞或病毒感染的细胞。在本发明的某些实施方案中，标记通过施用包含与噬菌体标记物连接的抗体或配体的组合物来实现，其中所述抗体或配体结合存在于靶细胞的细胞表面上或细胞表面的细胞类型特异性标志物。在本发明的优选实施方案中，吞噬标记物包含磷脂酰丝氨酸或衍生自磷脂酰丝氨酸，血小板反应素-1，膜联蛋白I或其任何衍生物的基团。

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