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1. 发明授权

US08099151B2 System and method for magnetic-resonance-guided electrophysiologic and ablation procedures 有权
标题翻译：磁共振引导电生理和消融手术的系统和方法
公开(公告)号：US08099151B2
公开(公告)日：2012-01-17
申请号：US11314241
申请日：2005-12-22
申请人： Henry R Halperin , Ronald D. Berger , Ergin Atalar , Elliot R McVeigh , Albert Lardo , Hugh Calkins , Joao Lima
发明人： Henry R Halperin , Ronald D. Berger , Ergin Atalar , Elliot R McVeigh , Albert Lardo , Hugh Calkins , Joao Lima
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/415 , A61B5/418 , A61B18/1492 , A61B90/36 , A61B2017/00039 , A61B2017/00053 , A61B2090/374 , G01R33/285 , G01R33/34084 , G01R33/4808 , G01R33/5601
摘要： A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures includes an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures, such as ablation of cardiac arrhythmias. The combined electrophysiology and imaging antenna catheter may further include an ablation tip, and be used as an intracardiac device to deliver energy to selected areas of tissue and visualize the resulting ablation lesions. The antenna utilized in the combined electrophysiology and imaging catheter for receiving MR signals is preferably of the coaxial or “loopless” type. High-resolution images from the antenna may be combined with low-resolution images from surface coils of the MR scanner to produce a composite image. A system for eliminating the pickup of RF energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance. Other ablative methods can be used such as laser, ultrasound, and low temperatures.
摘要翻译：使用磁共振成像来提高电生理过程精度的系统和方法包括侵入性组合电生理学和成像天线导管，其包括用于接收磁共振信号的RF天线和用于接收电位的诊断电极。组合的电生理学和成像天线导管与磁共振成像扫描仪组合使用以在电生理诊断或治疗过程（例如心律失常消融）中引导和提供可视化。组合的电生理学和成像天线导管还可以包括消融尖端，并且用作心内装置以将能量传递到组织的选定区域并且可视化所得到的消融损伤。在组合的电生理学和成像导管中用于接收MR信号的天线优选地是同轴的或“无绒毛”的。来自天线的高分辨率图像可以与来自MR扫描器的表面线圈的低分辨率图像组合以产生合成图像。用于消除RF能量的拾取的系统，其中心内线通过滤波失谐，使得它们变得非常低效的天线。提供RF滤波系统，用于抑制MR成像信号，同时不衰减RF消融电流。可以提供转向装置用于在MR引导下转导侵入性导管。可以使用其他烧蚀方法，如激光，超声和低温。

2. 发明申请

US20060100506A1 System and method for magnetic-resonance-guided electrophysiologic and ablation procedures 有权
标题翻译：磁共振引导电生理和消融手术的系统和方法
公开(公告)号：US20060100506A1
公开(公告)日：2006-05-11
申请号：US11314241
申请日：2005-12-22
申请人： Henry Halperin , Ronald Berger , Ergin Atalar , Elliot McVeigh , Albert Lardo , Hugh Calkins , Joao Lima
发明人： Henry Halperin , Ronald Berger , Ergin Atalar , Elliot McVeigh , Albert Lardo , Hugh Calkins , Joao Lima
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/415 , A61B5/418 , A61B18/1492 , A61B90/36 , A61B2017/00039 , A61B2017/00053 , A61B2090/374 , G01R33/285 , G01R33/34084 , G01R33/4808 , G01R33/5601
摘要： A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures includes an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures, such as ablation of cardiac arrhythmias. The combined electrophysiology and imaging antenna catheter may further include an ablation tip, and be used as an intracardiac device to deliver energy to selected areas of tissue and visualize the resulting ablation lesions. The antenna utilized in the combined electrophysiology and imaging catheter for receiving MR signals is preferably of the coaxial or “loopless” type. High-resolution images from the antenna may be combined with low-resolution images from surface coils of the MR scanner to produce a composite image. A system for eliminating the pickup of RF energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance. Other ablative methods can be used such as laser, ultrasound, and low temperatures.
摘要翻译：使用磁共振成像来提高电生理过程精度的系统和方法包括侵入性组合电生理学和成像天线导管，其包括用于接收磁共振信号的RF天线和用于接收电位的诊断电极。组合的电生理学和成像天线导管与磁共振成像扫描仪组合使用以在电生理诊断或治疗过程（例如心律失常消融）中引导和提供可视化。组合的电生理学和成像天线导管还可以包括消融尖端，并且用作心内装置以将能量传递到组织的选定区域并且可视化所得到的消融损伤。在组合的电生理学和成像导管中用于接收MR信号的天线优选地是同轴的或“无绒毛”的。来自天线的高分辨率图像可以与来自MR扫描器的表面线圈的低分辨率图像组合以产生合成图像。用于消除RF能量的拾取的系统，其中心内线通过滤波失谐，使得它们变得非常低效的天线。提供RF滤波系统，用于抑制MR成像信号，同时不衰减RF消融电流。可以提供转向装置用于在MR引导下转导侵入性导管。可以使用其他烧蚀方法，如激光，超声和低温。

3. 发明授权

US07155271B2 System and method for magnetic-resonance-guided electrophysiologic and ablation procedures 有权
公开(公告)号：US07155271B2
公开(公告)日：2006-12-26
申请号：US10424093
申请日：2003-04-28
申请人： Henry R. Halperin , Ronald D. Berger , Ergin Atalar , Elliot R. McVeigh , Albert Lardo , Hugh Calkins , Joao Lima
发明人： Henry R. Halperin , Ronald D. Berger , Ergin Atalar , Elliot R. McVeigh , Albert Lardo , Hugh Calkins , Joao Lima
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/415 , A61B5/418 , A61B18/1492 , A61B90/36 , A61B2017/00039 , A61B2017/00053 , A61B2090/374 , G01R33/285 , G01R33/34084 , G01R33/4808 , G01R33/5601
摘要： A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures is disclosed. The system in its preferred embodiment provides an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures. The invention is particularly applicable to catheter ablation, e.g., ablation of atrial fibrillation. In embodiments which are useful for catheter ablation, the combined electrophysiology and imaging antenna catheter may further include an ablation tip, and such embodiment may be used as an intracardiac device to both deliver energy to selected areas of tissue and visualize the resulting ablation lesions, thereby greatly simplifying production of continuous linear lesions. The invention further includes embodiments useful for guiding electrophysiologic diagnostic and therapeutic procedures other than ablation. Imaging of ablation lesions may be further enhanced by use of MR contrast agents. The antenna utilized in the combined electrophysiology and imaging catheter for receiving MR signals is preferably of the coaxial or “loopless” type. High-resolution images from the antenna may be combined with low-resolution images from surface coils of the MR scanner to produce a composite image. The invention further provides a system for eliminating the pickup of RF energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance. Other ablative methods can be used such as laser, ultrasound, and low temperatures.

4. 发明授权

US09301705B2 System and method for magnetic-resonance-guided electrophysiologic and ablation procedures 有权
标题翻译：磁共振引导电生理和消融手术的系统和方法
公开(公告)号：US09301705B2
公开(公告)日：2016-04-05
申请号：US13341266
申请日：2011-12-30
申请人： Henry R. Halperin , Ronald D. Berger , Ergin Atalar , Elliott R. McVeigh , Albert Lardo , Hugh Caikins , Joao Lima
发明人： Henry R. Halperin , Ronald D. Berger , Ergin Atalar , Elliott R. McVeigh , Albert Lardo , Hugh Caikins , Joao Lima
IPC分类号： A61B5/05 , A61B5/055 , A61B5/00 , A61B18/14 , A61B19/00 , G01R33/28 , G01R33/34 , A61B17/00 , G01R33/48 , G01R33/56
CPC分类号： A61B5/055 , A61B5/415 , A61B5/418 , A61B18/1492 , A61B90/36 , A61B2017/00039 , A61B2017/00053 , A61B2090/374 , G01R33/285 , G01R33/34084 , G01R33/4808 , G01R33/5601
摘要： A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures includes an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures, such as ablation of cardiac arrhythmias. The combined electrophysiology and imaging antenna catheter may further include an ablation tip, and be used as an intracardiac device to deliver energy to selected areas of tissue and visualize the resulting ablation lesions.
摘要翻译：使用磁共振成像来提高电生理过程精度的系统和方法包括侵入性组合电生理学和成像天线导管，其包括用于接收磁共振信号的RF天线和用于接收电位的诊断电极。组合的电生理学和成像天线导管与磁共振成像扫描仪组合使用以在电生理诊断或治疗过程（例如心律失常消融）中引导和提供可视化。组合的电生理学和成像天线导管还可以包括消融尖端，并且用作心内装置以将能量传递到组织的选定区域并且可视化所得到的消融损伤。

5. 发明申请

US20080058635A1 MRI-GUIDED THERAPY METHODS AND RELATED SYSTEMS 有权
公开(公告)号：US20080058635A1
公开(公告)日：2008-03-06
申请号：US11924877
申请日：2007-10-26
申请人： Henry Halperin , Ronald Berger , Ergin Atalar , Elliot McVeigh , Albert Lardo , Hugh Calkins , Joao Lima
发明人： Henry Halperin , Ronald Berger , Ergin Atalar , Elliot McVeigh , Albert Lardo , Hugh Calkins , Joao Lima
IPC分类号： A61B5/055 , A61B18/12
CPC分类号： A61B5/055 , A61B5/415 , A61B5/418 , A61B18/1492 , A61B90/36 , A61B2017/00039 , A61B2017/00053 , A61B2090/374 , G01R33/285 , G01R33/34084 , G01R33/4808 , G01R33/5601
摘要： A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures is disclosed. The system in its preferred embodiment provides an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures. The invention is particularly applicable to catheter ablation, e.g., ablation of atrial fibrillation. In embodiments which are useful for catheter ablation, the combined electrophysiology and imaging antenna catheter may further include an ablation tip, and such embodiment may be used as an intracardiac device to both deliver energy to selected areas of tissue and visualize the resulting ablation lesions, thereby greatly simplifying production of continuous linear lesions. The invention further includes embodiments useful for guiding electrophysiologic diagnostic and therapeutic procedures other than ablation. Imaging of ablation lesions may be further enhanced by use of MR contrast agents. The antenna utilized in the combined electrophysiology and imaging catheter for receiving MR signals is preferably of the coaxial or “loopless” type. High-resolution images from the antenna may be combined with low-resolution images from surface coils of the MR scanner to produce a composite image. The invention further provides a system for eliminating the pickup of RF energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance. Other ablative methods can be used such as laser, ultrasound, and low temperatures.

6. 发明申请

US20120101364A1 SYSTEM AND METHOD FOR MAGNETIC-RESONANCE-GUIDED ELECTROPHYSIOLOGIC AND ABLATION PROCEDURES 审中-公开
标题翻译：用于磁共振导向电生理和消除程序的系统和方法
公开(公告)号：US20120101364A1
公开(公告)日：2012-04-26
申请号：US13341266
申请日：2011-12-30
申请人： Henry R. HALPERIN , Ronald D. Berger , Ergin ATALAR , Elliott R. McVeigh , Albert LARDO , Hugh CAIKINS , Joao LIMA
发明人： Henry R. HALPERIN , Ronald D. Berger , Ergin ATALAR , Elliott R. McVeigh , Albert LARDO , Hugh CAIKINS , Joao LIMA
IPC分类号： A61B18/14 , A61B5/02 , A61B5/055
CPC分类号： A61B5/055 , A61B5/415 , A61B5/418 , A61B18/1492 , A61B90/36 , A61B2017/00039 , A61B2017/00053 , A61B2090/374 , G01R33/285 , G01R33/34084 , G01R33/4808 , G01R33/5601
摘要： A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures includes an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures, such as ablation of cardiac arrhythmias. The combined electrophysiology and imaging antenna catheter may further include an ablation tip, and be used as an intracardiac device to deliver energy to selected areas of tissue and visualize the resulting ablation lesions.
摘要翻译：使用磁共振成像来提高电生理过程精度的系统和方法包括侵入性组合电生理学和成像天线导管，其包括用于接收磁共振信号的RF天线和用于接收电位的诊断电极。组合的电生理学和成像天线导管与磁共振成像扫描仪组合使用以在电生理诊断或治疗过程（例如心律失常消融）中引导和提供可视化。组合的电生理学和成像天线导管还可以包括消融尖端，并且用作心内装置以将能量传递到组织的选定区域并且可视化所得到的消融损伤。

7. 发明授权

US07822460B2 MRI-guided therapy methods and related systems 有权
标题翻译： MRI指导治疗方法及相关系统
公开(公告)号：US07822460B2
公开(公告)日：2010-10-26
申请号：US11924877
申请日：2007-10-26
申请人： Henry R. Halperin , Ronald D. Berger , Ergin Atalar , Elliot R. McVeigh , Albert Lardo , Hugh Calkins , Joao Lima
发明人： Henry R. Halperin , Ronald D. Berger , Ergin Atalar , Elliot R. McVeigh , Albert Lardo , Hugh Calkins , Joao Lima
IPC分类号： A61B5/05 , G01V3/00
CPC分类号： A61B5/055 , A61B5/415 , A61B5/418 , A61B18/1492 , A61B90/36 , A61B2017/00039 , A61B2017/00053 , A61B2090/374 , G01R33/285 , G01R33/34084 , G01R33/4808 , G01R33/5601
摘要： A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures is disclosed. The system in its preferred embodiment provides an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures. The invention further provides a system for eliminating the pickup of RF energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance.
摘要翻译：公开了一种使用磁共振成像来提高电生理过程精度的系统和方法。该系统在其优选实施例中提供了一种侵入性组合电生理学和成像天线导管，其包括用于接收磁共振信号的RF天线和用于接收电位的诊断电极。组合的电生理和成像天线导管与磁共振成像扫描仪结合使用以在电生理诊断或治疗过程中引导和提供可视化。本发明还提供一种用于消除射频能量的拾取的系统，其中心内线通过滤波失谐，使得它们变得非常低效的天线。提供RF滤波系统，用于抑制MR成像信号，同时不衰减RF消融电流。可以提供转向装置用于在MR引导下转导侵入性导管。

8. 发明授权

US06701176B1 Magnetic-resonance-guided imaging, electrophysiology, and ablation 有权
公开(公告)号：US06701176B1
公开(公告)日：2004-03-02
申请号：US09428990
申请日：1999-10-29
申请人： Henry R. Halperin , Ronald D. Berger , Ergin Atalar , Elliot R. McVeigh , Albert Lardo , Hugh Calkins , Joao Lima
发明人： Henry R. Halperin , Ronald D. Berger , Ergin Atalar , Elliot R. McVeigh , Albert Lardo , Hugh Calkins , Joao Lima
IPC分类号： A61B5055
CPC分类号： A61B5/055 , A61B5/415 , A61B5/418 , A61B18/1492 , A61B90/36 , A61B2017/00039 , A61B2017/00053 , A61B2090/374 , G01R33/285 , G01R33/34084 , G01R33/4808 , G01R33/5601
摘要： A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures is disclosed. The system in its preferred embodiment provides an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures. The invention is particularly applicable to catheter ablation, e.g., ablation of atrial fibrillation. In embodiments which are useful for catheter ablation, the combined electrophysiology and imaging antenna catheter may further include an ablation tip, and such embodiment may be used as an intracardiac device to both deliver energy to selected areas of tissue and visualize the resulting ablation lesions, thereby greatly simplifying production of continuous linear lesions. The invention further includes embodiments useful for guiding electrophysiologic diagnostic and therapeutic procedures other than ablation. Imaging of ablation lesions may be further enhanced by use of MR contrast agents. The antenna utilized in the combined electrophysiology and imaging catheter for receiving MR signals is preferably of the coaxial or “loopless” type. High-resolution images from the antenna may be combined with low-resolution images from surface coils of the MR scanner to produce a composite image. The invention further provides a system for eliminating the pickup of RF energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance. Other ablative methods can be used such as laser, ultrasound, and low temperatures.

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