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1. 发明授权

US06624178B2 Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof 失效
公开(公告)号：US06624178B2
公开(公告)日：2003-09-23
申请号：US10214704
申请日：2002-08-09
申请人： Alangudi Sankaranarayanan
发明人： Alangudi Sankaranarayanan
IPC分类号： A61K31444
CPC分类号： C07D213/77 , A61K31/4425 , A61K31/4436 , A61K31/444 , A61K45/06 , C07D213/82 , C07D213/87 , C07D409/14 , A61K2300/00
摘要： The invention discloses novel compounds of the pyridinium series useful for the management of diabetes and aging-related vascular complications, including kidney disease, nerve damage, atherosclerosis, retinopathy, dermatological disorders and discoloration of teeth, by breaking preformed AGE, of the general formula I, or pharmaceutically acceptable salts thereof, wherein, R1, R2, R3, X and m are as defined in the specification.

2. 发明授权

US06281246B1 Pharmaceutical composition with sotalol combination and their use in treatment of cardiac ailments 有权
公开(公告)号：US06281246B1
公开(公告)日：2001-08-28
申请号：US09739276
申请日：2000-12-19
申请人： Alangudi Sankaranarayanan
发明人： Alangudi Sankaranarayanan
IPC分类号： A61K3118
摘要： The invention discloses a safer Antiarrhythmic drug with controlled Beta Adrenergic activity which comprises a combination of dextro- and laevo-rotatory isomers of sotalol as active ingredients, pharmaceutical compositions with said combination as active ingredients and its preparation and use of the said combination in the treatment of cardiac ailments in mammals including human beings.

3. 发明授权

US06232331B1 Benzofuroxan derivatives, their therapeutic uses and pharmaceutical compositions 失效
标题翻译：苯并呋喃衍生物，其治疗用途和药物组合物
公开(公告)号：US06232331B1
公开(公告)日：2001-05-15
申请号：US09690805
申请日：2000-10-18
申请人： Alangudi Sankaranarayanan
发明人： Alangudi Sankaranarayanan
IPC分类号： A61K3141
CPC分类号： A61K31/4245 , C07D271/12
摘要： The invention discloses use of a compound of the benzofuroxan series for treatment of cardiovascular disorders represented by the general formula (I) and pharmaceutically acceptable salts thereof wherein: R is halogen, acetoxy, —X—R′, —C(O)NR″R′″, or —C(O)Cl; X is oxygen, sulfur, —C(O)—, or —C(O)O—; R′ is hydrogen, straight chain or branched lower alkyl (C1-C8); R″ and R′″ are independently hydrogen, straight chain or branched lower alkyl (C1-C8) or R″ and R′″ are linked together with or without a heteroatom selected from the group consisting of oxygen and nitrogen wherein substitution on nitrogen is with hydrogen or lower alkyl. The invention further discloses pharmaceutical compositions containing compounds of general formula I as active ingredients. The invention also discloses a method of treatment of mammal, including man, of coronary heart disease by administration of an effective amount of a compound of formula I as defined above.
摘要翻译：本发明公开了苯并呋喃酮系列化合物用于治疗由通式（I）表示的心血管疾病及其药学上可接受的盐的用途，其中：R为卤素，乙酰氧基，-X-R'，-C（O）NR' R'是-C（O）Cl; X是氧，硫，-C（O） - 或-C（O）O-; R'是氢，直链或支链的低级烷基（C1- C8）; R“和R”'独立地是氢，直链或支链的低级烷基（C1-C8）或R“和R”'与或不具有选自氧的杂原子连接在一起和氮，其中在氮上取代为氢或低级烷基。本发明还公开了含有通式I化合物作为活性成分的药物组合物。本发明还公开了一种通过给药治疗冠状动脉心脏病的哺乳动物（包括人）的方法有效量的如上定义的式I化合物。

4. 发明申请

US20070167493A1 Novel compounds for the management of aging-related and diabetic vascular complications, process for their preparation, therapeutic and cosmetic uses thereof 审中-公开
标题翻译：用于治疗老化和糖尿病性血管并发症的新型化合物，其制备方法，其治疗和美容用途
公开(公告)号：US20070167493A1
公开(公告)日：2007-07-19
申请号：US11727909
申请日：2007-03-29
申请人： Alangudi Sankaranarayanan
发明人： Alangudi Sankaranarayanan
IPC分类号： A61K31/44
CPC分类号： C07D409/14 , C07D413/14
摘要： The invention discloses a new clause of a five membered heterocylic ring compounds of general formula I and its pharmaceutically or cosmetically acceptable salts, wherein R1, R2, R3, R4, R5, A, B, X and Y are as defined in the specification. The invention also discloses a process for preparation of these compound and their therapeutic and cosmetic applications particularly in the management of aging related and diabetic vascular complications. The compounds in question act by triple action of an AGE (Advanced Glycation Endproducts) breaker, AGE inhibitor and free radical scavenger which make them most suitable in different therapeutic and cosmetic applications. The invention also discloses pharmaceuticals and cosmetic compositions comprising these compounds and method of treatment of diseases caused by accumulation of AGE and/or free radicals in the body cells.
摘要翻译：本发明公开了通式I的五元杂环环化合物及其药学上或化妆品上可接受的盐的新条款，其中R1，R2，R3，R4，R5，A，B，X和Y如说明书中所定义。本发明还公开了一种制备这些化合物及其治疗和美容应用的方法，特别是用于治疗老化和糖尿病性血管并发症。所述化合物通过AGE（高级糖化终产物）破坏剂，AGE抑制剂和自由基清除剂的三重作用起作用，使其最适合于不同的治疗和美容应用。本发明还公开了包含这些化合物的药物和化妆品组合物以及治疗由身体细胞中AGE和/或自由基的积累引起的疾病的方法。

5. 发明授权

US07223777B2 Compounds for the management of aging-related and diabetic vascular complications, process for their preparation, therapeutic and cosmetic uses thereof 失效
标题翻译：用于治疗老化相关和糖尿病血管并发症的化合物，其制备方法，其治疗和美容用途
公开(公告)号：US07223777B2
公开(公告)日：2007-05-29
申请号：US10116135
申请日：2002-04-05
申请人： Alangudi Sankaranarayanan
发明人： Alangudi Sankaranarayanan
IPC分类号： A61K31/4439 , C07D401/04
CPC分类号： C07D409/14 , C07D413/14
摘要： The invention discloses a new clause of a five membered heterocylic ring compounds of general formula I and its pharmaceutically or cosmetically acceptable salts, wherein R1, R2, R3, R4, R5, A, B, X and Y are as defined in the specification. The invention also discloses a process for preparation of these compound and their therapeutic and cosmetic applications particularly in the management of aging related and diabetic vascular complications. The compounds in question act by triple action of an AGE (Advanced Glycation Endproducts) breaker, AGE inhibitor and free radical scavenger which make them most suitable in different therapeutic and cosmetic applications. The invention also discloses pharmaceuticals and cosmetic compositions comprising these compounds and method of treatment of diseases caused by accumulation of AGE and/or free radicals in the body cells.
摘要翻译：本发明公开了通式I的五元杂环环化合物及其药学上或化妆品上可接受的盐的新条款，其中R1，R2，R3，R4，R5，A，B，X和Y如说明书中所定义。本发明还公开了一种制备这些化合物及其治疗和美容应用的方法，特别是用于治疗老化和糖尿病性血管并发症。所述化合物通过AGE（高级糖化终产物）破坏剂，AGE抑制剂和自由基清除剂的三重作用起作用，使其最适合于不同的治疗和美容应用。本发明还公开了包含这些化合物的药物和化妆品组合物以及治疗由身体细胞中AGE和/或自由基的积累引起的疾病的方法。

6. 发明授权

US07138416B2 Compounds and therapeutic uses thereof 失效
标题翻译：化合物及其治疗用途
公开(公告)号：US07138416B2
公开(公告)日：2006-11-21
申请号：US10408276
申请日：2003-04-08
申请人： Alangudi Sankaranarayanan
发明人： Alangudi Sankaranarayanan
IPC分类号： A61K31/41 , A61K31/44 , A61K31/4015 , C07D277/06
CPC分类号： C07D401/12 , C07D207/16 , C07D277/06 , C07D403/06 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The invention discloses a novel series of compound represented by general formula (I), its derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, pharmaceutically acceptable salts, and solvates wherein X, n, k, z, R1, R2, R3, R4, R5 and R6 are as defined in the specification that are useful in (i) normalizing elevated blood glucose levels in diabetics, (ii) treating disorders related to glucose intolerance and (iii) for scavenging free radicals in mammals.
摘要翻译：本发明公开了一种新的一系列由通式（I）表示的化合物，其衍生物，类似物，互变异构体，立体异构体，多晶型物，药学上可接受的盐和溶剂合物，其中X，n，k，z，R1，R2，R3，R4 R5和R6如说明书中所定义，可用于（i）使糖尿病患者的血糖水平升高，（ii）治疗与葡萄糖不耐受有关的疾病和（iii）对哺乳动物中的自由基进行清除。

7. 发明授权

US06608094B2 Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof 有权
标题翻译：用于治疗老化相关和糖尿病血管并发症的化合物，其制备方法及其治疗用途
公开(公告)号：US06608094B2
公开(公告)日：2003-08-19
申请号：US09939702
申请日：2001-08-28
申请人： Alangudi Sankaranarayanan
发明人： Alangudi Sankaranarayanan
IPC分类号： A61K314436
CPC分类号： C07D213/77 , A61K31/4425 , A61K31/4436 , A61K31/444 , A61K45/06 , C07D213/82 , C07D213/87 , C07D409/14 , Y10S977/915 , A61K2300/00
摘要： Novel compounds of the pyridinium series useful for the management of diabetes and aging-related vascular and neurovascular complications, including kidney disease, nerve damage, atherosclerosis, retinopathy, inflammatory disorders, immunological disorders, oxidative stress, dermatological disorders and discoloration of teeth, by breaking preformed AGE, of the general formula I, or pharmaceutically acceptable salts thereof, wherein, R1, R2, R3, X and m are as defined in the specification. Also disclosed is a method for preparation of the compounds of general formula (I) and pharmaceutical composition containing one or more compounds as defined above as active ingredients. Also disclosed is a method of treatment of a diabetic patient by administering the compounds as defined above, either singly or in combination with drugs for antidiabetic therapy.
摘要翻译：用于治疗糖尿病和老化相关的血管和神经血管并发症的新型化合物，包括肾脏疾病，神经损伤，动脉粥样硬化，视网膜病变，炎性疾病，免疫学障碍，氧化应激，皮肤病学和牙齿变色预制的AGE，通式I或其药学上可接受的盐，其中R1，R2，R3，X和m如说明书中所定义。还公开了制备通式（I）的化合物和含有一种或多种如上所定义的化合物作为活性成分的药物组合物的方法。还公开了通过单独施用如上定义的化合物或与用于抗糖尿病治疗的药物组合来治疗糖尿病患者的方法。

8. 发明授权

US06462057B1 Compounds for the management of aging-related and diabetic vascular complications, process for their preparation and therapeutic uses thereof 有权
标题翻译：用于治疗老化相关和糖尿病血管并发症的化合物，其制备方法及其治疗用途
公开(公告)号：US06462057B1
公开(公告)日：2002-10-08
申请号：US09598410
申请日：2000-06-21
申请人： Alangudi Sankaranarayanan
发明人： Alangudi Sankaranarayanan
IPC分类号： A61K314436
CPC分类号： C07D213/77 , A61K31/4425 , A61K31/4436 , A61K31/444 , A61K45/06 , C07D213/82 , C07D213/87 , C07D409/14 , A61K2300/00
摘要： The invention discloses novel compounds of the pyridinium series useful for the management of diabetes and aging-related vascular complications, including kidney disease, nerve damage, atherosclerosis, retinopathy, dermatological disorders and discoloration of teeth, by breaking preformed AGE, of the general formula I, or pharmaceutically acceptable salts thereof, wherein, R1, R2, R3, X and m are as defined in the specification.
摘要翻译：本发明公开了用于治疗糖尿病和衰老相关血管并发症的新颖化合物，其包括肾脏疾病，神经损伤，动脉粥样硬化，视网膜病变，皮肤病学和牙齿变色，通过破坏预先形成的AGE，通式I 或其药学上可接受的盐，其中R1，R2，R3，X和m如说明书中所定义。

9. 发明授权

US06248895B1 Benzofuroxan compound, method of preparation, pharmaceutical composition and method of treatment using the same 失效
标题翻译：苯并呋喃复合物，制备方法，药物组合物及其使用方法
公开(公告)号：US06248895B1
公开(公告)日：2001-06-19
申请号：US09565917
申请日：2000-05-05
申请人： Alangudi Sankaranarayanan
发明人： Alangudi Sankaranarayanan
IPC分类号： C07D27112
CPC分类号： A61K31/4245 , C07D271/12
摘要： The invention discloses a novel compound of the benzofuroxan series used for cardiovascular disorders represented by the general formula (I) and pharmaceutically acceptable salts thereof wherein: R is —O—(CH2)n-X-R′; n=1 to 6; X is —NHC(O)—, or oxygen; R′ is lower alkyl (C1-C8), aromatic, heteroaromatic, substituted or unsubstituted saturated heterocyclic ring with one or two hetero atoms such as nitrogen or oxygen wherein substitution is with lower alkyl; or R is selected from wherein R″ is hydrogen, nitro, lower alkyl or—C(O)—R′″ wherein R′″ is hydrogen, lower alkyl or aryl. The invention also discloses process for the preparation of compounds of general formula I. The invention also discloses the use of the compounds of general formula I as defined above, as NO donors and/or in coronary heart diseases, and pharmaceutical compositions containing compounds of general formula I as active ingredients. The invention also discloses a method of treatment of mammal, including man, of coronary heart disease by administration of an effective amount of a compound of formula I as defined above.
摘要翻译：本发明公开了一种用于由通式（I）表示的心血管疾病的苯并呋喃系列的新化合物及其药学上可接受的盐，其中R为-O-（CH 2）n X-R'; n = 1-6; X为 - NHC（O） - 或氧; R'是具有一个或两个杂原子如氮或氧的芳族，杂芳族，取代或未取代的饱和杂环，其中用低级烷基取代;或R 选自R“是氢，硝基，低级烷基或-C（O）-R”，其中R“'是氢，低级烷基或芳基。本发明还公开了制备通式本发明还公开了如上定义的通式I化合物作为NO供体和/或冠心病的用途，以及含有通式I化合物作为活性成分的药物组合物。本发明还公开了一种治疗哺乳动物，包括男性，冠心病通过施用有效量的如上定义的式I化合物的疾病。

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