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1. 发明公开

US20240139228A1 PHARMACEUTICAL COMPOSITION AND APPLICATIONS THEREOF 审中-公开
公开(公告)号：US20240139228A1
公开(公告)日：2024-05-02
申请号：US18484291
申请日：2023-10-10
申请人： Alan Y. LU , Huanlong QIN , Menghan LIU , Patrick Y. LU
发明人： Alan Y. LU , Huanlong QIN , Menghan LIU , Patrick Y. LU
IPC分类号： A61K31/7105 , A61K47/10 , A61K47/42 , A61K48/00 , A61P35/00
CPC分类号： A61K31/7105 , A61K47/10 , A61K47/42 , A61K48/00 , A61P35/00 , C12Q2600/178 , G01N33/57419
摘要： A pharmaceutical composition, comprises micro RNAs with or without chemical modification, and a carder suitable for delivery in vivo, the carrier is a branched histidine-lysine polypeptide or modified compound thereof. The pharmaceutical composition is capable of inhibiting the growth of colon cancer by inducing programmed death of cancer cell and further be used for the manufacture of a targeted drug for colorectal cancer treatment.

2. 发明申请

US20130345284A1 siRNA Compositions and Methods for Treatment of HPV and Other Infections 有权
标题翻译：用于治疗HPV和其他感染的siRNA组合物和方法
公开(公告)号：US20130345284A1
公开(公告)日：2013-12-26
申请号：US13752568
申请日：2013-01-29
申请人： Alan Y. Lu , Patrick Y. Lu , David M. Evans , John J. Xu
发明人： Alan Y. Lu , Patrick Y. Lu , David M. Evans , John J. Xu
IPC分类号： C12N15/113
CPC分类号： C12N15/1131 , C12N2310/14 , C12N2310/17 , C12N2320/31
摘要： The invention provides siRNA compositions that (1) interfere with viral replication of human papillomavirus (HPV), herpes simplex virus (HSV), and human immunodeficiency virus (HIV) in mucosal tissues, such as genital tissues, and (2) treat fungal infections. The compositions include siRNA molecules that target HPV, complexed with a dendrimer that treats and prevents genital herpes (HSV) and HIV. The compositions also include siRNA molecules that target HPV, complexed with a histidine-lysine (HK) polymer that treats and prevent fungus infection. The combined formulations of siRNA and dendrimer provide treatment of the infections from HPVs, HSVs, and HIVs. The combined formulations of siRNA and HK polymer provide treatment of HPVs and fungus infections.
摘要翻译：本发明提供了siRNA组合物，其（1）干扰人乳头状瘤病毒（HPV），单纯疱疹病毒（HSV）和人类免疫缺陷病毒（HIV）在粘膜组织如生殖器官组织中的病毒复制，和（2）治疗真菌感染。组合物包括靶向HPV的siRNA分子，与治疗和预防生殖器疱疹（HSV）和HIV的树突状细胞复合。组合物还包括靶向HPV的siRNA分子，与治疗和预防真菌感染的组氨酸 - 赖氨酸（HK）聚合物复合。 siRNA和树枝状大分子的组合制剂提供了对HPV，HSV和HIV感染的治疗。 siRNA和HK聚合物的组合制剂提供对HPV和真菌感染的治疗。

3. 发明申请

US20130123330A1 Dual Targeted siRNA Therapeutics for Treatment of Diabetic Retinopathy and Other Ocular Neovascularization Diseases 审中-公开
标题翻译：用于治疗糖尿病性视网膜病变和其他眼部新血管形成疾病的双靶向siRNA治疗剂
公开(公告)号：US20130123330A1
公开(公告)日：2013-05-16
申请号：US13549514
申请日：2012-07-15
申请人： Patrick Y. Lu , John J. Xu , Alan Y. Lu
发明人： Patrick Y. Lu , John J. Xu , Alan Y. Lu
IPC分类号： A61K31/713
CPC分类号： A61K31/713 , A61K2300/00
摘要： The present invention relates to compositions and methods for treating diabetic retinopathy and other ocular neovascularization diseases. In one embodiment, the composition comprises at least two different siRNA duplexes and a pharmaceutically acceptable carrier. One of the duplexes binds to an mRNA molecule that encodes VEGF, and the other binds to an mRNA molecule that encodes VEGFR2. In another embodiment, the composition further comprises an siRNA duplex that binds to an mRNA molecule that encodes TGFβ1.
摘要翻译：本发明涉及用于治疗糖尿病性视网膜病变和其它眼部新血管形成疾病的组合物和方法。在一个实施方案中，组合物包含至少两种不同的siRNA双链体和药学上可接受的载体。双链体之一与编码VEGF的mRNA分子结合，另一个与编码VEGFR2的mRNA分子结合。在另一个实施方案中，组合物还包含与编码TGFbeta1的mRNA分子结合的siRNA双链体。

4. 发明授权

US09506063B2 SiRNA compositions and methods for treatment of HPV and other infections 有权
标题翻译：用于治疗HPV和其他感染的SiRNA组合物和方法
公开(公告)号：US09506063B2
公开(公告)日：2016-11-29
申请号：US13752568
申请日：2013-01-29
申请人： Alan Y. Lu , Patrick Y. Lu , David M. Evans , John J. Xu
发明人： Alan Y. Lu , Patrick Y. Lu , David M. Evans , John J. Xu
IPC分类号： C12N15/113
CPC分类号： C12N15/1131 , C12N2310/14 , C12N2310/17 , C12N2320/31
摘要： The invention provides siRNA compositions that (1) interfere with viral replication of human papillomavirus (HPV), herpes simplex virus (HSV), and human immunodeficiency virus (HIV) in mucosal tissues, such as genital tissues, and (2) treat fungal infections. The compositions include siRNA molecules that target HPV, complexed with a dendrimer that treats and prevents genital herpes (HSV) and HIV. The compositions also include siRNA molecules that target HPV, complexed with a histidine-lysine (HK) polymer that treats and prevent fungus infection. The combined formulations of siRNA and dendrimer provide treatment of the infections from HPVs, HSVs, and HIVs. The combined formulations of siRNA and HK polymer provide treatment of HPVs and fungus infections.
摘要翻译：本发明提供了siRNA组合物，其（1）干扰人乳头状瘤病毒（HPV），单纯疱疹病毒（HSV）和人类免疫缺陷病毒（HIV）在粘膜组织如生殖器官组织中的病毒复制，和（2）治疗真菌感染。组合物包括靶向HPV的siRNA分子，与治疗和预防生殖器疱疹（HSV）和HIV的树突状细胞复合。组合物还包括靶向HPV的siRNA分子，与治疗和预防真菌感染的组氨酸 - 赖氨酸（HK）聚合物复合。 siRNA和树枝状大分子的组合制剂提供了对HPV，HSV和HIV感染的治疗。 siRNA和HK聚合物的组合制剂提供对HPV和真菌感染的治疗。

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