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1. 发明授权

US5849509A Nuclear matrix proteins 失效
标题翻译：核基质蛋白
公开(公告)号：US5849509A
公开(公告)日：1998-12-15
申请号：US488036
申请日：1995-06-07
申请人： Donald S. Coffey , Alan W. Partin , Robert H. Getzenberg
发明人： Donald S. Coffey , Alan W. Partin , Robert H. Getzenberg
IPC分类号： G01N33/53 , A61K31/70 , A61K39/395 , A61K48/00 , A61P35/00 , C07K14/435 , C07K14/47 , C07K14/82 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08 , C12Q1/68 , G01N33/574 , G01N33/577
CPC分类号： G01N33/57434 , C07K14/47 , Y10S436/813
摘要： Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell. Also provided are substantially purified polypeptides and nucleotide sequences encoding the NMPs of the invention.
摘要翻译：提供以组织中定义的表达为特征的核基质蛋白（NMP）。这些NMP是诊断和监测细胞恶性肿瘤阶段的有用标志物。还提供了基本纯化的多肽和编码本发明的NMP的核苷酸序列。

2. 发明授权

US06025128A Prediction of prostate cancer progression by analysis of selected predictive parameters 失效
标题翻译：通过分析选择的预测参数预测前列腺癌进展
公开(公告)号：US06025128A
公开(公告)日：2000-02-15
申请号：US315210
申请日：1994-09-29
申请人： Robert W Veltri , Michael P. Bacus , M. Craig Miller , Kaveh Ashenayi , Donald P. Coffey , Alan W. Partin , Jonathan I. Epstein
发明人： Robert W Veltri , Michael P. Bacus , M. Craig Miller , Kaveh Ashenayi , Donald P. Coffey , Alan W. Partin , Jonathan I. Epstein
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/68 , G01N33/574 , Y10S436/813
摘要： A method for screening individuals at risk for prostate cancer progression is disclosed. The method is useful for evaluating cells from patients at risk for recurrence of prostate cancer following surgery for prostate cancer. Specifically, the method uses specific Markovian nuclear texture factors, alone or in combination with other biomarkers, to determine whether the cancer will progress or lose organ confinement. In addition, methods of predicting the development of fatal metastatic disease by statistical analysis of selected biomarkers is also disclosed. The invention also contemplates a method that uses a neural network to analyze and interpret cell morphology data. Utilizing Markovian factors and other biomarkers as parameters, the network is first trained with a sets of cell data from known progressors and known non-progressors. The trained network is then used to predict prostate cancer progression in patient samples.
摘要翻译：公开了一种筛选患有前列腺癌进展风险的个体的方法。该方法可用于评估前列腺癌手术后前列腺癌复发风险的患者细胞。具体来说，该方法单独或与其他生物标志物组合使用特定的马科夫核质构因子，以确定癌症是否进展或丧失器官限制。此外，还公开了通过选择的生物标志物的统计分析预测致命转移性疾病的发展的方法。本发明还考虑使用神经网络来分析和解释细胞形态学数据的方法。利用马尔科夫因子和其他生物标志物作为参数，网络首先被训练有来自已知进化者和已知非进展者的一组细胞数据。然后将训练好的网络用于预测患者样品中的前列腺癌进展。

3. 发明授权

US6030793A Nuclear matrix proteins 有权
公开(公告)号：US6030793A
公开(公告)日：2000-02-29
申请号：US256428
申请日：1999-02-23
申请人： Donald S. Coffey , Alan W. Partin , Robert H. Getzenberg
发明人： Donald S. Coffey , Alan W. Partin , Robert H. Getzenberg
IPC分类号： G01N33/53 , A61K31/70 , A61K39/395 , A61K48/00 , A61P35/00 , C07K14/435 , C07K14/47 , C07K14/82 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08 , C12Q1/68 , G01N33/574 , G01N33/577 , C07K16/18 , C12Q1/00
CPC分类号： G01N33/57434 , C07K14/47 , Y10S436/813
摘要： Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell and treating cell proliferative disorders associated with the NMP. Also provided are substantially purified polypeptides and nucleotide sequences encoding the NMPs of the invention.

4. 发明授权

US5874539A Antibodies to nuclear matrix proteins 失效
标题翻译：核基质蛋白抗体
公开(公告)号：US5874539A
公开(公告)日：1999-02-23
申请号：US459023
申请日：1995-06-02
申请人： Donald S. Coffey , Alan W. Partin , Robert H. Getzenberg
发明人： Donald S. Coffey , Alan W. Partin , Robert H. Getzenberg
IPC分类号： G01N33/53 , A61K31/70 , A61K39/395 , A61K48/00 , A61P35/00 , C07K14/435 , C07K14/47 , C07K14/82 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08 , C12Q1/68 , G01N33/574 , G01N33/577 , C07K16/18
CPC分类号： G01N33/57434 , C07K14/47 , Y10S436/813
摘要： Antibodies directed to nuclear matrix proteins (NMP) are provided. Such antibodies are useful markers in diagnosing and monitoring the stage of malignancy of a cell.
摘要翻译：提供了针对核基质蛋白（NMP）的抗体。这些抗体是诊断和监测细胞恶性肿瘤阶段的有用标志物。

5. 发明授权

US5962237A Method of enriching rare cells 失效
标题翻译：丰富稀有细胞的方法
公开(公告)号：US5962237A
公开(公告)日：1999-10-05
申请号：US832468
申请日：1997-04-02
申请人： Paul O. P. Ts'o , Zheng-Pin Wang , Stephen A. Lesko , William G. Nelson , Alan W. Partin
发明人： Paul O. P. Ts'o , Zheng-Pin Wang , Stephen A. Lesko , William G. Nelson , Alan W. Partin
IPC分类号： C12N15/09 , C12N5/06 , C12N5/08 , C12N5/10 , C12Q1/68 , G01N33/48 , G01N33/569 , G01N33/574 , B01D33/15 , G01N9/30 , G01N33/53
CPC分类号： G01N33/57407 , G01N33/56966 , G01N33/57434 , G01N33/57438 , G01N33/57488
摘要： A method for enriching cancer cells such as prostate cancer cells in a bodily fluid sample is disclosed comprising (a) obtaining the sample comprising cancer cells and non-rare cells; (b) subjecting the sample to multiple density gradient separation comprising a first density gradient and a second density gradient, wherein the second density gradient is greater than the first density gradient, and producing a first fluid comprising an increased concentration of cancer cells of a first density, and a second fluid comprising an increased concentration of cancer cells of a second density, wherein the second density is greater than the first density; wherein subjecting the sample to multiple density gradient separation includes producing a plasma layer, a first interface layer, a first gradient layer, a second interface layer, a second gradient layer, and a cell pellet; wherein producing the first fluid includes combining the first interface layer and the first gradient layer and forming a first suspension; and wherein producing the second fluid includes combining the second interface layer and the second gradient layer and forming a second suspension; (c) subjecting said second fluid comprising the second suspension to a binding agent that binds non-rare cells; and (d) removing the bound non-rare cells from the second fluid to provide a second fluid enriched with the greater density cancer cells.
摘要翻译：公开了一种在体液样品中富集癌细胞如前列腺癌细胞的方法，其包括（a）获得包含癌细胞和非罕见细胞的样品; （b）对样品进行多密度梯度分离，其包括第一密度梯度和第二密度梯度，其中所述第二密度梯度大于所述第一密度梯度，并且产生第一流体，所述第一流体包含增加浓度的第一并且包括第二密度增加的癌细胞浓度的第二流体，其中所述第二密度大于所述第一密度; 其中对样品进行多重密度梯度分离包括产生等离子体层，第一界面层，第一梯度层，第二界面层，第二梯度层和细胞沉淀物; 其中制备所述第一流体包括组合所述第一界面层和所述第一梯度层并形成第一悬浮液; 并且其中制备所述第二流体包括组合所述第二界面层和所述第二梯度层并形成第二悬浮液; （c）使包含第二悬浮液的所述第二流体接合结合非稀有细胞的结合剂; 和（d）从第二流体中除去结合的非稀有细胞以提供富含更大密度的癌细胞的第二种液体。

6. 发明授权

US5824490A Method for detecting prostate cancer using a reagent which binds prostate cancer-1 protein 失效
标题翻译：使用结合前列腺癌1蛋白的试剂检测前列腺癌的方法
公开(公告)号：US5824490A
公开(公告)日：1998-10-20
申请号：US455558
申请日：1995-05-31
申请人： Donald S. Coffey , Alan W. Partin , Robert H. Getzenberg
发明人： Donald S. Coffey , Alan W. Partin , Robert H. Getzenberg
IPC分类号： G01N33/53 , A61K31/70 , A61K39/395 , A61K48/00 , A61P35/00 , C07K14/435 , C07K14/47 , C07K14/82 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08 , C12Q1/68 , G01N33/574 , G01N33/577
CPC分类号： G01N33/57434 , C07K14/47 , Y10S436/813
摘要： Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. Also provided is an in vitro method for detecting prostate cancer in a sample employing a reagent that reacts with the NMP designated PC-1 (prostate cancer-1).
摘要翻译：提供以组织中定义的表达为特征的核基质蛋白（NMP）。还提供了使用与指定为PC-1的NMP（前列腺癌-1）反应的试剂的样品中检测前列腺癌的体外方法。

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