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1. 发明授权

US06713078B2 Retrocyclins: antiviral and antimicrobial peptides 有权
标题翻译：逆转录酶：抗病毒和抗菌肽
公开(公告)号：US06713078B2
公开(公告)日：2004-03-30
申请号：US10141645
申请日：2002-05-06
申请人： Robert I. Lehrer , Alan J. Waring , Alexander M. Cole , Teresa B. Hong
发明人： Robert I. Lehrer , Alan J. Waring , Alexander M. Cole , Teresa B. Hong
IPC分类号： A01N2500
CPC分类号： C07K14/4723 , A61K38/00 , C07K7/64
摘要： Retrocyclin peptides are small antimicrobial agents with potent activity against bacteria and viruses. The peptides are nonhemolytic, and exhibit minimal in vitro cytotoxicity. A pharmaceutical composition comprising retrocyclin as an active agent is administered therapeutically to a patient suffering from a bacterial and/or viral infection, or to an individual facing exposure to a bacterial and/or viral infection, especially one caused by the HIV-1 retrovirus or other sexually-transmitted pathogens.
摘要翻译：逆转录肽是针对细菌和病毒的有效活性的小抗微生物剂。肽是非溶血性的，并且表现出最小的体外细胞毒性。包含逆转录酶作为活性剂的药物组合物治疗性地给予患有细菌和/或病毒感染的患者或面临暴露于细菌和/或病毒感染的个体，特别是由HIV-1逆转录病毒或其他性传播病原体。

2. 发明授权

US06492328B2 Novispirins: antimicrobial peptides 有权
公开(公告)号：US06492328B2
公开(公告)日：2002-12-10
申请号：US09840009
申请日：2001-04-19
申请人： Robert I. Lehrer , Alan J. Waring , Brian F. Tack
发明人： Robert I. Lehrer , Alan J. Waring , Brian F. Tack
IPC分类号： A61K3800
CPC分类号： C07K7/08 , A61K38/00 , Y02A50/473
摘要： Novispirin peptides are antimicrobial agents with potent activity against Gram-negative bacteria. The peptides are nonhemolytic, exhibit reduced in vitro cytotoxicity relative to other antimicrobial peptides, and were well-tolerated in vivo after intravenous injection. Novispirins also bind lipopolysaccharide (LPS), a property that may mitigate symptoms associated with Gram-negative bacterial infection. A pharmaceutical composition comprising novispirin as an active agent is administered to a patient suffering from or predisposed to a microbial infection, particularly Gram-negative bacterial infections.

3. 发明申请

US20100055164A1 SYNTHETIC LUNG SURFACTANT AND USE THEREOF 有权
标题翻译：合成肺表面活性剂及其用途
公开(公告)号：US20100055164A1
公开(公告)日：2010-03-04
申请号：US12374458
申请日：2007-07-20
申请人： Robert H. Notter , Zhengdong Wang , Adrian L. Schwan , Zhongyi Wang , Jason A. Davy , Alan J. Waring , Frans Walther , Larry M. Gordon
发明人： Robert H. Notter , Zhengdong Wang , Adrian L. Schwan , Zhongyi Wang , Jason A. Davy , Alan J. Waring , Frans Walther , Larry M. Gordon
IPC分类号： A61K38/00 , A61K9/127 , A61K38/16 , A61K31/662 , C07K14/00 , C07K1/00 , C07F9/28 , A61P11/00
CPC分类号： C07F9/091 , A61K9/0082 , C07F9/4006 , C07F9/4075 , C07K14/001 , C07K14/785
摘要： The present invention relates to synthetic lung surfactant compositions that contain one or more of phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active proteins or peptides, more preferably a combination of at least two or all three of these materials. Novel phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active peptides are also disclosed herein. Uses of the surfactant compositions of the present invention to treat endogenous surfactant dysfunctional or deficient lung tissue, to prepare synthetic peptides for use in the surfactant compositions, and to deliver therapeutic agents are also disclosed.
摘要翻译：本发明涉及含有一种或多种磷脂酶抗性磷酸甘油衍生物，磷脂酶抗性磷酸胆碱衍生物和表面活性蛋白质或肽的合成肺表面活性剂组合物，更优选至少两种或全部三种这些材料。本文还公开了新型磷脂酶抗性磷酸甘油衍生物，磷脂酶抗性磷酸胆碱衍生物和表面活性肽。还公开了本发明的表面活性剂组合物用于治疗内源性表面活性物质功能障碍或缺乏肺组织，制备用于表面活性剂组合物的合成肽和递送治疗剂的用途。

4. 发明授权

US07314858B2 Retrocyclins: antiviral and antimicrobial peptides 有权
标题翻译：逆转录酶：抗病毒和抗菌肽
公开(公告)号：US07314858B2
公开(公告)日：2008-01-01
申请号：US10982145
申请日：2004-11-05
申请人： Robert I. Lehrer , Alan J. Waring , Alexander M. Cole , Teresa B. Hong
发明人： Robert I. Lehrer , Alan J. Waring , Alexander M. Cole , Teresa B. Hong
IPC分类号： A61K38/00 , C07K7/00 , C07K7/04 , C07K7/64
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K7/64
摘要： Retrocyclin peptides are small antimicrobial agents with potent activity against bacteria and viruses. The peptides are nonhemolytic, and exhibit minimal in vitro cytotoxicity. A pharmaceutical composition comprising retrocyclin as an active agent is administered therapeutically to a patient suffering from a bacterial and/or viral infection, or to an individual facing exposure to a bacterial and/or viral infection, especially one caused by the HIV-1 retrovirus or other sexually-transmitted pathogens.
摘要翻译：逆转录肽是针对细菌和病毒的有效活性的小抗微生物剂。肽是非溶血性的，并且表现出最小的体外细胞毒性。包含逆转录酶作为活性剂的药物组合物治疗性地给予患有细菌和/或病毒感染的患者或面临暴露于细菌和/或病毒感染的个体，特别是由HIV-1逆转录病毒或其他性传播病原体。

5. 发明授权

US06660833B1 Respiratory distress syndrome therapy with peptide analogs of human SP-B 有权
标题翻译：呼吸窘迫综合征治疗与人类SP-B的肽类似物
公开(公告)号：US06660833B1
公开(公告)日：2003-12-09
申请号：US09515356
申请日：2000-02-29
申请人： Frans J. Walther , Alan J. Waring , Larry M. Gordon , Joseph A. Zasadzinski
发明人： Frans J. Walther , Alan J. Waring , Larry M. Gordon , Joseph A. Zasadzinski
IPC分类号： A61K3800
CPC分类号： A61K38/1709 , C07K14/785
摘要： A therapeutic pharmaceutical composition for the treatment of respiratory disease is disclosed, including particularly Respiratory Distress Syndrome (RDS). The composition is comprised of a synthetic dimer of an N-terminal fragment of Surfactant Protein B (SP-B) that advantageously mimics the functional activity of native human Surfactant Protein B, and to therapeutic methods of administration of such pharmaceutical compositions.
摘要翻译：公开了用于治疗呼吸系统疾病的治疗药物组合物，包括特别是呼吸窘迫综合征（RDS）。该组合物由有利地模拟天然人表面活性蛋白B的功能活性的表面活性蛋白B（SP-B）的N-末端片段的合成二聚体以及这种药物组合物的施用的治疗方法组成。

6. 发明授权

US06372720B1 Liposome fusion and delivery vehicle 失效
标题翻译：脂质体融合和递送载体
公开(公告)号：US06372720B1
公开(公告)日：2002-04-16
申请号：US09019346
申请日：1998-02-05
申请人： Kenneth J. Longmuir , Alan J. Waring , Sherry M. Haynes
发明人： Kenneth J. Longmuir , Alan J. Waring , Sherry M. Haynes
IPC分类号： A61K4800
CPC分类号： C07K14/005 , A61K9/1271 , A61K48/00 , C07K14/785 , C12N15/88 , C12N2740/16222
摘要： Described herein are liposome complexes and the individual components thereof for intracellular and/or intranuclear delivery of substances. Methods of use of the provided liposome complexes and components are also described. Generally, the liposome complexes described herein include a non-cationic lipid, a fusogenic peptide and a substance to be delivered to the cell and/or nucleus. In some of the liposome complexes described herein, the fusogenic peptide does not contain multiple positive charges at neutral pH and above. In these liposome complexes, two additional components are used in assembling the liposome complex with DNA.
摘要翻译：本文描述的是用于细胞内和/或核内递送物质的脂质体复合物及其各自的成分。还描述了所提供的脂质体复合物和组分的使用方法。通常，本文所述的脂质体复合物包括非阳离子脂质，融合肽和待递送至细胞和/或细胞核的物质。在本文所述的一些脂质体复合物中，融合肽在中性pH及以上不含多重正电荷。在这些脂质体复合物中，另外两种组分用于与DNA组装脂质体复合物。

7. 发明授权

US08563683B2 Synthetic lung surfactant and use thereof 有权
标题翻译：合成肺表面活性剂及其用途
公开(公告)号：US08563683B2
公开(公告)日：2013-10-22
申请号：US12374458
申请日：2007-07-20
申请人： Robert H. Notter , Zhengdong Wang , Adrian L. Schwan , Zhongyi Wang , Jason A. Davy , Alan J. Waring , Frans J. Walther , Larry M. Gordon
发明人： Robert H. Notter , Zhengdong Wang , Adrian L. Schwan , Zhongyi Wang , Jason A. Davy , Alan J. Waring , Frans J. Walther , Larry M. Gordon
IPC分类号： A61K38/00
CPC分类号： C07F9/091 , A61K9/0082 , C07F9/4006 , C07F9/4075 , C07K14/001 , C07K14/785
摘要： The present invention relates to synthetic lung surfactant compositions that contain one or more of phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active proteins or peptides, more preferably a combination of at least two or all three of these materials. Novel phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active peptides are also disclosed herein. Uses of the surfactant compositions of the present invention to treat endogenous surfactant dysfunctional or deficient lung tissue, to prepare synthetic peptides for use in the surfactant compositions, and to deliver therapeutic agents are also disclosed.
摘要翻译：本发明涉及含有一种或多种磷脂酶抗性磷酸甘油衍生物，磷脂酶抗性磷酸胆碱衍生物和表面活性蛋白质或肽的合成肺表面活性剂组合物，更优选至少两种或全部三种这些材料。本文还公开了新型磷脂酶抗性磷酸甘油衍生物，磷脂酶抗性磷酸胆碱衍生物和表面活性肽。还公开了本发明的表面活性剂组合物用于治疗内源性表面活性物质功能障碍或缺乏肺组织，制备用于表面活性剂组合物的合成肽和递送治疗剂的用途。

8. 发明授权

US07718610B2 Retrocyclins: antiviral and antimicrobial peptides 有权
标题翻译：逆转录酶：抗病毒和抗菌肽
公开(公告)号：US07718610B2
公开(公告)日：2010-05-18
申请号：US11968178
申请日：2008-01-01
申请人： Robert I. Lehrer , Alan J. Waring , Alexander M. Cole , Teresa B. Hong
发明人： Robert I. Lehrer , Alan J. Waring , Alexander M. Cole , Teresa B. Hong
IPC分类号： A61K38/00 , A61K38/12 , C07K7/00
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K7/64
摘要： Retrocyclin peptides are small antimicrobial agents with potent activity against bacteria and viruses. The peptides are nonhemolytic, and exhibit minimal in vitro cytotoxicity. A pharmaceutical composition comprising retrocyclin as an active agent is administered therapeutically to a patient suffering from a bacterial and/or viral infection, or to an individual facing exposure to a bacterial and/or viral infection, especially one caused by the HIV-1 retrovirus or other sexually-transmitted pathogens.
摘要翻译：逆转录肽是针对细菌和病毒的有效活性的小抗微生物剂。肽是非溶血性的，并且表现出最小的体外细胞毒性。包含逆转录酶作为活性剂的药物组合物治疗性地给予患有细菌和/或病毒感染的患者或面临暴露于细菌和/或病毒感染的个体，特别是由HIV-1逆转录病毒或其他性传播病原体。

9. 发明申请

US20090264344A1 RETROCYCLINS: ANTIVIRAL AND ANTIMICROBIAL PEPTIDES 有权
标题翻译： RETROCYCLINS：抗病毒和抗微生物肽
公开(公告)号：US20090264344A1
公开(公告)日：2009-10-22
申请号：US11968178
申请日：2008-01-01
申请人： ROBERT I. LEHRER , ALAN J. WARING , ALEXANDER M. COLE , TERESA B. HONG
发明人： ROBERT I. LEHRER , ALAN J. WARING , ALEXANDER M. COLE , TERESA B. HONG
IPC分类号： A61K38/12 , C07K7/08 , C07K7/64 , C07H21/00 , C12N5/06 , A01N37/18
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K7/64
摘要： Retrocyclin peptides are small antimicrobial agents with potent activity against bacteria and viruses. The peptides are nonhemolytic, and exhibit minimal in vitro cytotoxicity. A pharmaceutical composition comprising retrocyclin as an active agent is administered therapeutically to a patient suffering from a bacterial and/or viral infection, or to an individual facing exposure to a bacterial and/or viral infection, especially one caused by the HIV-1 retrovirus or other sexually-transmitted pathogens.
摘要翻译：逆转录肽是针对细菌和病毒的有效活性的小抗微生物剂。肽是非溶血性的，并且表现出最小的体外细胞毒性。包含逆转录酶作为活性剂的药物组合物治疗性地给予患有细菌和/或病毒感染的患者或面临暴露于细菌和/或病毒感染的个体，特别是由HIV-1逆转录病毒或其他性传播病原体。

10. 发明授权

US07538090B1 Exogenous surfactant protein B mimic 有权
标题翻译：外源性表面活性蛋白B模拟
公开(公告)号：US07538090B1
公开(公告)日：2009-05-26
申请号：US11133812
申请日：2005-05-19
申请人： Alan J. Waring , Frans J. Walther , Larry M. Gordon , Joseph A. Zasadzinski
发明人： Alan J. Waring , Frans J. Walther , Larry M. Gordon , Joseph A. Zasadzinski
IPC分类号： A61K38/16 , A61K35/42 , C12P13/16
CPC分类号： C07K14/785 , A61K38/00 , A61K45/06
摘要： A composition including a C terminal region having residues corresponding to a peptide identified by PDB ID: 1RG3; an N terminal region having residues corresponding to a peptide identified by PDB ID: 1RG4; and a disulfide linkage between the residues near the C terminal region and the N terminal region. A composition including an exogenous peptide comprising amino acid residues comprising a C terminal region; amino acid residues comprising an N terminal region; a helix-loop-helix conformation between the residues comprising the C terminal region and the residues including the N terminal region; and at least one disulfide linkage between the residues comprising the C terminal region and the residues including N terminal region, wherein the residues including the C terminal region and the residues comprising the N terminal region have an amphiphatic property, and wherein the peptide has an a biological activity comparable to native surfactant protein SP-B. A method including delivering to a body a composition comprising an exogenous peptide having a biological activity comparable to native surfactant protein SP-B. A kit including an exogenous peptide having a biological activity comparable to native surfactant protein SP-B; and a treatment agent different from the peptide.
摘要翻译：包含具有对应于由PDB ID：1RG3鉴定的肽的残基的C末端区域的组合物; 具有对应于由PDB ID：1RG4鉴定的肽的残基的N末端区域; 以及在C末端区域和N末端区域附近的残基之间的二硫键。包含外源肽的组合物，其包含C末端区域的氨基酸残基; 包含N末端区域的氨基酸残基; 在包含C末端区域的残基和包括N末端区域的残基之间的螺旋 - 环 - 螺旋构象; 和包含C末端区域的残基和包括N末端区域的残基之间的至少一个二硫键，其中包括C末端区域的残基和包含N末端区域的残基具有两亲性性质，并且其中肽具有与天然表面活性蛋白SP-B相当的生物活性。一种方法，包括向身体递送包含具有与天然表面活性蛋白SP-B相当的生物活性的外源肽的组合物。一种试剂盒，其包括具有与天然表面活性蛋白SP-B相当的生物活性的外源肽; 和与肽不同的处理剂。

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