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1. 发明授权

US08354270B2 Method and apparatus for performing a lateral flow assay 有权
标题翻译：用于进行侧流测定的方法和装置
公开(公告)号：US08354270B2
公开(公告)日：2013-01-15
申请号：US11868923
申请日：2007-10-08
申请人： Alan J. Polito , Richard M. Thayer , Robert K. Dinello , George H. Sierra , Dennis Nixon , Alan Phillips , Stuart Neubarth
发明人： Alan J. Polito , Richard M. Thayer , Robert K. Dinello , George H. Sierra , Dennis Nixon , Alan Phillips , Stuart Neubarth
IPC分类号： C12M1/00 , C12M1/36 , C12M1/38 , C12M1/42 , C12M3/00
CPC分类号： G01N27/227 , B01L3/5023 , G01N33/4875 , G01N33/54386 , G01N33/54393 , G01N33/558 , Y10S436/806 , Y10S436/807 , Y10T436/114998
摘要： An embodiment of the present invention provides a-method for performing a lateral flow assay. The method includes depositing a sample on a test strip at an application region, detecting a first detection signal arising from the test strip in the first detection zone, and generating a baseline for the first measurement zone by interpolating between values of the detection signal outside of the first measurement zone and inside of the first detection zone. The method may include locating a beginning boundary and an ending boundary for the first measurement zone on the test strip. Additional detection zones having measurement zones may also be incorporated with the embodiment.
摘要翻译：本发明的一个实施方案提供了一种用于进行侧流测定的方法。该方法包括将样品沉积在应用区域的测试条上，检测在第一检测区域中由测试条产生的第一检测信号，以及通过在第一检测区域之外的检测信号的值之间进行内插来生成第一测量区域的基线第一测量区域和第一检测区域内部。该方法可以包括在测试条上定位用于第一测量区域的开始边界和结束边界。具有测量区域的附加检测区域也可以结合实施例。

2. 发明授权

US07955791B2 Prewetting lateral flow test strip 有权
标题翻译：预湿侧流测试条
公开(公告)号：US07955791B2
公开(公告)日：2011-06-07
申请号：US12426777
申请日：2009-04-20
申请人： Robert K. Dinello , Alan J. Polito , Stella Quan
发明人： Robert K. Dinello , Alan J. Polito , Stella Quan
IPC分类号： G01N33/53
CPC分类号： G01N33/558 , B01L3/5023 , B01L3/5055 , B01L2300/0867 , G01N33/54386 , Y10S435/81 , Y10S435/97 , Y10S435/974 , Y10S435/975 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/81 , Y10S436/811 , Y10S436/817 , Y10T156/1089
摘要： A test strip and method for detecting an analyte present in a sample. The test strip comprising: a buffer addition zone to which a buffer may be added; an absorbent zone proximal to the buffer addition zone; one or more test zones distal to the buffer addition zone, at least one of the test zones including a first analyte binding agent immobilized therein which is capable of binding to the analyte to be detected; a terminal buffer flow zone distal to the one or more test zones, the absorbent zone being positioned relative to the buffer addition zone and having an absorption capacity relative to the other zones of the test strip such that when a volume of buffer within a predetermined buffer volume range for the test strip is added to the buffer addition zone, a distal diffusion front of the buffer diffuses from the buffer addition zone to a distal diffusion point within the terminal buffer flow zone and then diffuses proximal relative to the one or more test zones; and a sample addition zone distal to the terminal buffer flow zone to which a sample may be added.
摘要翻译：用于检测样品中存在的分析物的测试条和方法。所述测试条包括：可以添加缓冲液的缓冲添加区; 靠近缓冲添加区的吸收区; 至少一个测试区域包括固定在其中的能够结合待检测分析物的第一分析物结合剂; 位于所述一个或多个测试区域的末端缓冲液流动区域，所述吸收区域相对于所述缓冲添加区域定位，并且具有相对于所述测试条带的其它区域的吸收能力，使得当预定缓冲液测试条的体积范围被添加到缓冲添加区域中，缓冲区的远端扩散前沿从缓冲添加区扩散到末端缓冲液流动区域内的远端扩散点，然后相对于一个或多个测试区域扩散 ; 以及可以添加样品的末端缓冲液流动区域的远端的样品添加区域。

3. 发明授权

US07309611B2 Prewetting stop flow test strip 有权
标题翻译：预湿停止流动试纸
公开(公告)号：US07309611B2
公开(公告)日：2007-12-18
申请号：US10867420
申请日：2004-06-14
申请人： Robert K. DiNello , Alan J. Polito , Stella S. Quan
发明人： Robert K. DiNello , Alan J. Polito , Stella S. Quan
IPC分类号： G01N33/53
CPC分类号： G01N33/558 , B01L3/5023 , B01L3/5055 , B01L2300/0867 , G01N33/54386 , Y10S435/81 , Y10S435/97 , Y10S435/974 , Y10S435/975 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/81 , Y10S436/811 , Y10S436/817 , Y10T156/1089
摘要： A test strip and method for detecting an analyte present in a sample. The test strip comprising: a buffer addition zone to which a buffer may be added; an absorbent zone proximal to the buffer addition zone; one or more test zones distal to the buffer addition zone, at least one of the test zones including a first analyte binding agent immobilized therein which is capable of binding to the analyte to be detected; a terminal buffer flow zone distal to the one or more test zones, the absorbent zone being positioned relative to the buffer addition zone and having an absorption capacity relative to the other zones of the test strip such that when a volume of buffer within a predetermined buffer volume range for the test strip is added to the buffer addition zone, a distal diffusion front of the buffer diffuses from the buffer addition zone to a distal diffusion point within the terminal buffer flow zone and then diffuses proximal relative to the one or more test zones; and a sample addition zone distal to the terminal buffer flow zone to which a sample may be added.
摘要翻译：用于检测样品中存在的分析物的测试条和方法。所述测试条包括：可以添加缓冲液的缓冲添加区; 靠近缓冲添加区的吸收区; 至少一个测试区域包括固定在其中的能够结合待检测分析物的第一分析物结合剂; 位于所述一个或多个测试区域的末端缓冲液流动区域，所述吸收区域相对于所述缓冲添加区域定位，并且具有相对于所述测试条带的其它区域的吸收能力，使得当预定缓冲液测试条的体积范围被添加到缓冲添加区域中，缓冲区的远端扩散前沿从缓冲添加区扩散到末端缓冲液流动区域内的远端扩散点，然后相对于一个或多个测试区域扩散 ; 以及可以添加样品的末端缓冲液流动区域的远端的样品添加区域。

4. 发明授权

US07297529B2 Method and apparatus for performing a lateral flow assay 有权
标题翻译：用于进行侧流测定的方法和装置
公开(公告)号：US07297529B2
公开(公告)日：2007-11-20
申请号：US10634331
申请日：2003-08-04
申请人： Alan J. Polito , Richard M. Thayer , Robert K. DiNello , George H. Sierra , Dennis Nixon , Alan Phillips , Stuart Neubarth
发明人： Alan J. Polito , Richard M. Thayer , Robert K. DiNello , George H. Sierra , Dennis Nixon , Alan Phillips , Stuart Neubarth
IPC分类号： C12M1/00 , C12M1/42 , C12M1/36 , C12M3/00 , C12M1/34
CPC分类号： G01N27/227 , B01L3/5023 , G01N33/4875 , G01N33/54386 , G01N33/54393 , G01N33/558 , Y10S436/806 , Y10S436/807 , Y10T436/114998
摘要： An embodiment of the present invention provides a method for performing a lateral flow assay. The method includes depositing a sample on a test strip at an application region, detecting a first detection signal arising from the test strip in the first detection zone, and generating a baseline for the first measurement zone by interpolating between values of the detection signal outside of the first measurement zone and inside of the first detection zone. The method may include locating a beginning boundary and an ending boundary for the first measurement zone on the test strip. Additional detection zones having measurement zones may also be incorporated with the embodiment.
摘要翻译：本发明的一个实施方案提供了一种用于进行侧流测定的方法。该方法包括将样品沉积在应用区域的测试条上，检测由第一检测区域中的测试条产生的第一检测信号，以及通过在第一测量区域之外的检测信号的值之间进行内插来生成第一测量区域的基线第一测量区域和第一检测区域内部。该方法可以包括在测试条上定位用于第一测量区域的开始边界和结束边界。具有测量区域的附加检测区域也可以结合实施例。

5. 发明授权

US4158703A T.sub.3 uptake test employing covalently bound bovine serum albumin 失效
标题翻译：使用共价结合的牛血清白蛋白的T {HD 3 {B摄取试验
公开(公告)号：US4158703A
公开(公告)日：1979-06-19
申请号：US877043
申请日：1978-02-13
申请人： Alan J. Polito
发明人： Alan J. Polito
IPC分类号： G01N33/541 , G01N33/16 , A61K43/00
CPC分类号： G01N33/541 , Y10S436/804 , Y10S436/825 , Y10S436/826 , Y10S530/813 , Y10S530/814 , Y10S530/816
摘要： An improved T.sub.3 uptake test procedure characterized in that the separating agent employed therein comprises bovine serum albumin covalently coupled to a derivatized polysaccharide matrix by a bifunctional coupling agent selected from a group consisting of ##STR1## WHEREIN N IS AN INTEGER FROM 1 TO 6 AND WHEREIN E IS AN INTEGER FROM 1 TO 2.A separating agent comprising bovine serum albumin covalently coupled to a derivatived polysaccharide matrix by a bifunctional coupling agent selected from a group consisting of ##STR2## WHEREIN N IS AN INTEGER FROM 1 TO 6 AND WHEREIN E IS AN INTEGER FROM 1 TO 2.
摘要翻译：一种改进的T3摄取试验方法，其特征在于其中使用的分离剂包含牛血清白蛋白，其通过双功能偶联剂共价偶联到衍生化的多糖基质上，所述双官能偶联剂选自由以下组成的组：其中N为1至6的整数， E是从1到2的整数。

6. 发明授权

US4081245A Immunoassay procedure employing novel immunochemical composites 失效
标题翻译：采用新型免疫化学复合材料的免疫测定方法
公开(公告)号：US4081245A
公开(公告)日：1978-03-28
申请号：US682808
申请日：1976-05-03
申请人： Alan J. Polito
发明人： Alan J. Polito
IPC分类号： G01N33/541 , G01N31/06 , G01N33/16
CPC分类号： G01N33/541 , Y10S436/804 , Y10S436/825 , Y10S436/826 , Y10S530/813 , Y10S530/814 , Y10S530/816
摘要： A method of separating free from bound fractions in an immunoassay procedure of the type wherein a solution is contacted with a composite comprising a derivatized polysaccharide matrix covalently coupled to an antibody by a bifunctional coupling agent, wherein the improvement comprises selecting said bifunctional coupling agent from a group comprising ##STR1## WHEREIN N IS AN INTEGER FROM 1 TO 6 AND WHEREIN E IS AN INTEGER FROM 1 TO 2.
摘要翻译：一种在免疫测定方法中分离游离结合部分的方法，其中将溶液与包含通过双功能偶联剂共价偶联于抗体的衍生化多糖基质的复合物接触，其中所述改进包括从以下物质中选择所述双官能偶联剂：包括，其中N是从1到6的整数，并且从1到2是整数。

7. 发明申请

US20120064637A1 PREWETTING LATERAL FLOW TEST STRIP 审中-公开
标题翻译：预测横向流量测试条
公开(公告)号：US20120064637A1
公开(公告)日：2012-03-15
申请号：US13153034
申请日：2011-06-03
申请人： Robert K. Dinello , Alan J. Polito , Stella Quan
发明人： Robert K. Dinello , Alan J. Polito , Stella Quan
IPC分类号： G01N21/55
CPC分类号： G01N33/558 , B01L3/5023 , B01L3/5055 , B01L2300/0867 , G01N33/54386 , Y10S435/81 , Y10S435/97 , Y10S435/974 , Y10S435/975 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/81 , Y10S436/811 , Y10S436/817 , Y10T156/1089
摘要： A test strip and method for detecting an analyte present in a sample. The test strip comprising: a buffer addition zone to which a buffer may be added; an absorbent zone proximal to the buffer addition zone; one or more test zones distal to the buffer addition zone, at least one of the test zones including a first analyte binding agent immobilized therein which is capable of binding to the analyte to be detected; a terminal buffer flow zone distal to the one or more test zones, the absorbent zone being positioned relative to the buffer addition zone and having an absorption capacity relative to the other zones of the test strip such that when a volume of buffer within a predetermined buffer volume range for the test strip is added to the buffer addition zone, a distal diffusion front of the buffer diffuses from the buffer addition zone to a distal diffusion point within the terminal buffer flow zone and then diffuses proximal relative to the one or more test zones; and a sample addition zone distal to the terminal buffer flow zone to which a sample may be added.
摘要翻译：用于检测样品中存在的分析物的测试条和方法。所述测试条包括：可以添加缓冲液的缓冲添加区; 靠近缓冲添加区的吸收区; 至少一个测试区域包括固定在其中的能够结合待检测分析物的第一分析物结合剂; 位于所述一个或多个测试区域的末端缓冲液流动区域，所述吸收区域相对于所述缓冲添加区域定位，并且具有相对于所述测试条带的其它区域的吸收能力，使得当预定缓冲液测试条的体积范围被添加到缓冲添加区域中，缓冲区的远端扩散前沿从缓冲添加区扩散到末端缓冲液流动区域内的远端扩散点，然后相对于一个或多个测试区域扩散 ; 以及可以添加样品的末端缓冲液流动区域的远端的样品添加区域。

8. 发明授权

US07521196B2 Prewetting lateral flow test strip 有权
标题翻译：预湿侧流测试条
公开(公告)号：US07521196B2
公开(公告)日：2009-04-21
申请号：US11759874
申请日：2007-06-07
申请人： Robert K. Dinello , Alan J. Polito , Stella Quan
发明人： Robert K. Dinello , Alan J. Polito , Stella Quan
IPC分类号： G01N33/543
CPC分类号： G01N33/558 , B01L3/5023 , B01L3/5055 , B01L2300/0867 , G01N33/54386 , Y10S435/81 , Y10S435/97 , Y10S435/974 , Y10S435/975 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/81 , Y10S436/811 , Y10S436/817 , Y10T156/1089
摘要： A test strip and method for detecting an analyte present in a sample. The test strip comprising: a buffer addition zone to which a buffer may be added; an absorbent zone proximal to the buffer addition zone; one or more test zones distal to the buffer addition zone, at least one of the test zones including a first analyte binding agent immobilized therein which is capable of binding to the analyte to be detected; a terminal buffer flow zone distal to the one or more test zones, the absorbent zone being positioned relative to the buffer addition zone and having an absorption capacity relative to the other zones of the test strip such that when a volume of buffer within a predetermined buffer volume range for the test strip is added to the buffer addition zone, a distal diffusion front of the buffer diffuses from the buffer addition zone to a distal diffusion point within the terminal buffer flow zone and then diffuses proximal relative to the one or more test zones; and a sample addition zone distal to the terminal buffer flow zone to which a sample may be added.
摘要翻译：用于检测样品中存在的分析物的测试条和方法。所述测试条包括：可以添加缓冲液的缓冲添加区; 靠近缓冲添加区的吸收区; 至少一个测试区域包括固定在其中的能够结合待检测分析物的第一分析物结合剂; 位于所述一个或多个测试区域的末端缓冲液流动区域，所述吸收区域相对于所述缓冲添加区域定位，并且具有相对于所述测试条带的其它区域的吸收能力，使得当预定缓冲液测试条的体积范围被添加到缓冲添加区域中，缓冲区的远端扩散前沿从缓冲添加区扩散到末端缓冲液流动区域内的远端扩散点，然后相对于一个或多个测试区域扩散 ; 以及可以添加样品的末端缓冲液流动区域的远端的样品添加区域。

9. 发明授权

US07229839B2 Bidirectional lateral flow test strip and method 有权
标题翻译：双向横向流动试纸和方法
公开(公告)号：US07229839B2
公开(公告)日：2007-06-12
申请号：US10346683
申请日：2003-01-17
申请人： Richard M. Thayer , Alan J. Polito , Robert K. Dinello , George H. Sierra , Henry J. Wieck
发明人： Richard M. Thayer , Alan J. Polito , Robert K. Dinello , George H. Sierra , Henry J. Wieck
IPC分类号： G01N33/53
CPC分类号： G01N33/558 , G01N33/54386 , Y10S435/81 , Y10S435/97 , Y10S435/974 , Y10S435/975 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/81 , Y10S436/811 , Y10S436/817
摘要： A test strip adapted to receive a sample and detect an analyte therein is provided. The test strip comprises a sample addition zone to which a sample may be added; an absorbent zone proximal to the sample addition zone; one or more test zones distal to the sample addition zone, at least one of the test zones including a first analyte binding agent immobilized therein which is capable of binding to the analyte to be detected; and a terminal sample flow zone distal to the one or more test zones, the absorbent zone being positioned relative to the sample addition zone and having an absorption capacity relative to the other zones of the test strip such that a distal diffusion front of a sample added to the sample addition zone diffuses from the sample addition zone to a distal diffusion point within the terminal sample flow zone and then reverses direction and diffuses proximal relative to the one or more test zones.
摘要翻译：提供了适于接收样品并检测其中的分析物的测试条。测试条包括可以加入样品的样品添加区域; 靠近样品添加区的吸收区; 至少一个测试区域包括固定在其中的能够结合待检测分析物的第一分析物结合剂; 以及远离所述一个或多个测试区域的终端样品流动区域，所述吸收区域相对于所述样品添加区域定位，并且相对于所述测试条带的其它区域具有吸收能力，使得样品的远端扩散前沿到样品添加区域从样品添加区域扩散到终端样品流动区域内的远端扩散点，然后反转方向并相对于一个或多个测试区域扩散近端。

10. 发明授权

US4069305A I.sup.125 Imidazole steroid derivatives 失效
标题翻译： I {HU 125 {B咪唑类固醇衍生物
公开(公告)号：US4069305A
公开(公告)日：1978-01-17
申请号：US684688
申请日：1976-05-10
申请人： Alan J. Polito , William S. Knight
发明人： Alan J. Polito , William S. Knight
IPC分类号： C07J19/00 , C07J43/00 , G01N33/60 , A61K43/00 , C07J17/00
CPC分类号： C07J19/005 , C07J43/003 , G01N33/60 , Y10S436/817
摘要： Derivatives of steroids containing an imidazole group specifically bind to the desired antibody without nonspecifically binding to other substances (e.g., proteins in a patient's plasma or serum and the surfaces of reaction vessels).
摘要翻译：含有咪唑基的类固醇的衍生物特异性结合所需抗体，而不与其他物质（例如患者的血浆或血清中的蛋白质和反应容器的表面）非特异性地结合。

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