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1. 发明授权

US5218139A Method for inhibiting IgE production 失效
标题翻译：抑制IgE产生的方法
公开(公告)号：US5218139A
公开(公告)日：1993-06-08
申请号：US892870
申请日：1992-06-03
申请人： Alan D. Levine , Paul W. Collins
发明人： Alan D. Levine , Paul W. Collins
IPC分类号： A61K31/557
CPC分类号： A61K31/557
摘要： A method is described for inhibiting IgE production which comprises administering, in an amount effective to inhibit IgE production, a prostaglandin of the formula: ##STR1## or a pharmaceutically acceptable non-toxic salt thereof, in which R is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.8 cycloalkyl, phenyl, or mono, di- or tri-substituted phenyl in which the substituents are selected form the group consisting of bromo, chloro, fluoro, iodo, C.sub.1 -C.sub.5 alkyl, hydroxy, nitro, acetyl, alkoxy, carboxy, acetoxy, amino, mono- or di- alkyl amino, amido and acetamido; R.sub.1 and R.sub.2 independently are hydrogen or C.sub.1 -C.sub.5 alkyl, n.sub.3, n.sub.4, n.sub.5, n.sub.6, n.sub.7, and n.sub.8 independently are zero or one; when n's are zeros, R.sub.3 and R.sub.4 together, R.sub.4 and R.sub.5 together, R.sub.5 and R.sub.6 together, and R.sub.7 and R.sub.8 together are double bonds; when n's are ones, R.sub.3, R.sub.5, R.sub.6 R.sub.7 and R.sub.8 independently are hydrogen, R.sub.4 is hydrogen or methyl, or R.sub.3 and R.sub.4 together, R.sub.4 and R.sub.5 together, or R.sub.5 and R.sub.6 together are methylene.
摘要翻译：描述了一种用于抑制IgE产生的方法，其包括以有效抑制IgE产生的量施用下式的前列腺素：其中R是氢，其中R是氢，C 1 -C 5烷基，其中取代基选自溴，氯，氟，碘，C 1 -C 5烷基，羟基，硝基，乙酰基，烷氧基，C 1 -C 5烷基，羧基，乙酰氧基，氨基，单或二烷基氨基，酰氨基和乙酰氨基; R 1和R 2独立地为氢或C 1 -C 5烷基，n 3，n 4，n 5，n 6，n 7和n 8独立地为0或1; 当n为零时，R 3和R 4一起，R 4和R 5一起，R 5和R 6一起，并且R 7和R 8一起是双键; 当n为1时，R 3，R 5，R 6 + L，R 7和R 8分别是氢，R 4是氢或甲基，或者R 3和R 4一起，R 4和R 5一起，或者R 5和R 6一起是亚甲基。

2. 发明授权

US5157052A Method for inhibiting IgE production 失效
标题翻译：阻止生产的方法
公开(公告)号：US5157052A
公开(公告)日：1992-10-20
申请号：US635000
申请日：1990-12-27
申请人： Alan D. Levine , Paul W. Collins
发明人： Alan D. Levine , Paul W. Collins
IPC分类号： A61K31/557 , A61K31/5575 , A61P37/00 , A61P37/08 , C07C405/00
CPC分类号： A61K31/557
摘要： A method is described for inhibiting IgE production which comprises administering, in an amount effective to inhibit IgE production, a prostaglandin of the formula: ##STR1## or a pharmaceutically acceptable non-toxic salt thereof, in which R is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.8 cycloalkyl, phenyl, or mono, di- or tri-substituted phenyl in which the substituents, are selected from the group consisting of bromo, chloro, fluoro, iodo, C.sub.1 -C.sub.5 alkyl, hydroxy, nitro, acetyl, alkoxy, carboxy, acetoxy, amino, mono- or di- alkyl amino, amido and acetamido; R.sub.1 and R.sub.2 independently are hydrogen or C.sub.1 -C.sub.5 alkyl, n.sub.3, n.sub.4, n.sub.5, n.sub.6, n.sub.7, and n.sub.8 independently are zero or one; when n's are zeros, R.sub.3 and R.sub.4 together, R.sub.4 and R.sub.5 together, R.sub.5 and R.sub.6 together, and R.sub.7 and R.sub.8 together are double bonds; when n's are ones, R.sub.3, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 independently are hydrogen, R.sub.4 is hydrogen or methyl, or R.sub.3 and R.sub.4 together, R.sub.4 and R.sub.5 together, or R.sub.5 and R.sub.6 together are methylene.

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