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1. 发明授权

US5173189A Membrane for separating an organic solvent from a water-organic solvent mixture 失效
标题翻译：从有机溶剂混合物分离有机溶剂的膜
公开(公告)号：US5173189A
公开(公告)日：1992-12-22
申请号：US714036
申请日：1991-06-12
申请人： Masaru Hoshi , Tsutomu Nakagawa , Akon Higuchi , Toshio Sugizaki
发明人： Masaru Hoshi , Tsutomu Nakagawa , Akon Higuchi , Toshio Sugizaki
IPC分类号： B01D69/12 , B01D71/40
CPC分类号： B01D69/12 , B01D71/40 , B01D71/76
摘要： A membrane for the separation of an organic solvent from a water-organic solvent mixture has a polymeric membrane of a copolymer consisting essentially of an .alpha., .beta.-unsaturated carbonyl compound as a main monomer. The .alpha., .beta.-unsaturated carbonyl compound includes an acrylic acid ester or a methacrylic acid ester. The polymeric membrane has a crosslinked structure. The polymeric membrane is carried on a support member in the form of a flat membrane, a pipe or a hollow fiber. The polymeric member includes particles therein. The polymeric membrane is sandwiched by the support members to form a composite-type separation membrane. The composite-type separation membrane is modulated.

2. 发明授权

US4948508A Surface-hydrophilic, highly selective semipermeable membrane 失效
标题翻译：表面亲水，高选择性半透膜
公开(公告)号：US4948508A
公开(公告)日：1990-08-14
申请号：US341217
申请日：1989-04-21
申请人： Tsutomu Nakagawa , Akon Higuchi
发明人： Tsutomu Nakagawa , Akon Higuchi
IPC分类号： C08J9/36 , B01D65/10 , B01D67/00 , C08J7/12 , D01F6/74 , D01F6/76
CPC分类号： B01D67/0093 , C08J7/12
摘要： A surface-hydrophilic, highly selective semipermeable membrane comprising a semipermeable membrane of a hydrophobic polymer and a hydrophilic segment having at least one end directly bonded to at least one surface of the semipermeable membrane is disclosed. The hydrophilic segment comprises at least one methylene group or substituted methylene group which is positioned at least at one end of the segment and at least one neutral hydroxyl group. The surface-hydrophilic, highly selective semipermeable membrane not only has excellent resistance to heat and organic solvents, but also non-adsorptivity for organic substances including even ionic organic substances. Therefore, the surface-hydrophilic, highly selective semipermeable membrane of the present invention can advantageously be used for microfiltration, ultrafiltration, reverse osmosis and dialysis.
摘要翻译：公开了一种表面亲水性，高度选择性的半透膜，其包含疏水性聚合物的半透膜和亲水性链段，其至少一端直接结合至半透膜的至少一个表面。亲水性片段包含至少一个位于片段的至少一个末端和至少一个中性羟基的亚甲基或取代的亚甲基。表面亲水，高选择性的半透膜不仅具有优异的耐热性和有机溶剂性，而且对有机物质（包括均匀的离子有机物质）也具有非吸附性。因此，本发明的表面亲水性高选择性半透膜可以有利地用于微滤，超滤，反渗透和透析。

3. 发明授权

US08062751B2 Low biofouling filtration membranes and their forming method 有权
标题翻译：低生物污垢过滤膜及其成型方法
公开(公告)号：US08062751B2
公开(公告)日：2011-11-22
申请号：US11963406
申请日：2007-12-21
申请人： Yung Chang , Ruoh-Chyu Ruaan , Wen-Yih Chen , Akon Higuchi , Yan-Che Chiang , Juin-Yih Lai
发明人： Yung Chang , Ruoh-Chyu Ruaan , Wen-Yih Chen , Akon Higuchi , Yan-Che Chiang , Juin-Yih Lai
IPC分类号： B32B27/08 , B32B27/16 , B32B27/30
CPC分类号： B01D67/0023 , B01D61/145 , B01D69/02 , B01D71/34 , B01D2323/38 , B01D2325/18 , B01D2325/28 , Y10T428/31504 , Y10T428/31536 , Y10T428/3154 , Y10T428/31544 , Y10T428/31935
摘要： The present invention discloses a method for forming a low biofouling filtration membrane. First, an ozone treatment is performed to a fluorine-based porous membrane to introduce peroxides on surface. Afterwards, a first grafting polymerization is initiated from the peroxides, and functional monomers are polymerized to introduce halide groups on surface. Finally, a second grafting polymerization is initiated from the halide groups, and macro-monomers are polymerized to introduce zwitterionic group on surface, so as to form the low biofouling filtration membrane.
摘要翻译：本发明公开了一种形成低生物污垢过滤膜的方法。首先，对氟系多孔膜进行臭氧处理以在表面引入过氧化物。之后，从过氧化物引发第一次接枝聚合，并将官能单体聚合以在表面上引入卤化物基团。最后，从卤化物基团引发第二次接枝聚合，聚合大分子单体以在表面引入两性离子基团，形成低生物污垢过滤膜。

4. 发明申请

US20100291534A1 Methods and Systems for Isolating, Ex Vivo Expanding and Harvesting Hematopoietic Stem Cells 审中-公开
标题翻译：用于隔离，体外扩增和收获造血干细胞的方法和系统
公开(公告)号：US20100291534A1
公开(公告)日：2010-11-18
申请号：US12464210
申请日：2009-05-12
申请人： Akon Higuchi , Siou-Ting Yang , Pei-Tsz Li
发明人： Akon Higuchi , Siou-Ting Yang , Pei-Tsz Li
IPC分类号： A01N1/02 , C12M1/00 , C12N5/06
CPC分类号： C12M33/14 , C12M45/00 , C12M47/04
摘要： Disclosed herein are methods and systems for isolating, ex vivo expanding and harvesting hematopoietic stem cells. Methods and systems described herein are easy to use, time-efficient, and allow isolation, ex vivo expansion and harvest of hematopoietic stem cells either batchly or continuously.
摘要翻译：本文公开了用于分离，离体扩增和收获造血干细胞的方法和系统。本文描述的方法和系统易于使用，时间有效，并且允许分批或连续地分离，离体扩增和收获造血干细胞。

5. 发明申请

US20090148958A1 NUCLEOTIDE-TRANSITION METAL COMPLEX CATALYST 审中-公开
标题翻译：核转移金属络合催化剂
公开(公告)号：US20090148958A1
公开(公告)日：2009-06-11
申请号：US12298732
申请日：2007-04-27
申请人： Akon Higuchi
发明人： Akon Higuchi
IPC分类号： G01N33/566 , C07H21/02 , C07F15/00
CPC分类号： B01J31/003 , B01J31/28
摘要： This invention is to provide a catalyst (an artificial enzyme) which can be used as an alternative to a protein enzyme in the field relating to medicine, pharmaceuticals, biochemistry or chemical engineering. Such a catalyst comprises a complex of a transition metal and a monomeric or polymeric nucleotide or an analogue thereof.
摘要翻译：本发明提供一种催化剂（人造酶），其可以用作与药物，药物，生物化学或化学工程有关的领域中的蛋白酶的替代物。这种催化剂包括过渡金属和单体或聚合核苷酸或其类似物的复合物。

6. 发明申请

US20090162662A1 Low BIOFOULING FILTRATION MEMBRANES AND THEIR FORMING METHOD 有权
标题翻译：低生物滤膜及其形成方法
公开(公告)号：US20090162662A1
公开(公告)日：2009-06-25
申请号：US11963406
申请日：2007-12-21
申请人： Yung Chang , Ruoh-Chyu Ruaan , Wen-Yih Chen , Akon Higuchi , Yan-Che Chiang , Juin-Yih Lai
发明人： Yung Chang , Ruoh-Chyu Ruaan , Wen-Yih Chen , Akon Higuchi , Yan-Che Chiang , Juin-Yih Lai
IPC分类号： B32B27/06 , C08F2/00
CPC分类号： B01D67/0023 , B01D61/145 , B01D69/02 , B01D71/34 , B01D2323/38 , B01D2325/18 , B01D2325/28 , Y10T428/31504 , Y10T428/31536 , Y10T428/3154 , Y10T428/31544 , Y10T428/31935
摘要： The present invention discloses a method for forming a low biofouling filtration membrane. First, an ozone treatment is performed to a fluorine-based porous membrane to introduce peroxides on surface. Afterwards, a first grafting polymerization is initiated from the peroxides, and functional monomers are polymerized to introduce halide groups on surface. Finally, a second grafting polymerization is initiated from the halide groups, and macro-monomers are polymerized to introduce zwitterionic group on surface, so as to form the low biofouling filtration membrane.
摘要翻译：本发明公开了一种形成低生物污垢过滤膜的方法。首先，对氟系多孔膜进行臭氧处理以在表面引入过氧化物。之后，从过氧化物引发第一次接枝聚合，并将官能单体聚合以在表面上引入卤化物基团。最后，从卤化物基团引发第二次接枝聚合，聚合大分子单体以在表面引入两性离子基团，形成低生物污垢过滤膜。

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