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1. 发明授权

US09561167B2 Skin and hair color-controlling factor 有权
标题翻译：皮肤和头发颜色控制因素
公开(公告)号：US09561167B2
公开(公告)日：2017-02-07
申请号：US13882669
申请日：2011-10-31
申请人： Daiki Murase , Akira Hachiya
发明人： Daiki Murase , Akira Hachiya
IPC分类号： C12Q1/68 , A61K8/60 , C07K14/47 , A61Q5/06 , A61Q19/00 , G01N33/50 , A61K48/00
CPC分类号： C12N15/113 , A61K8/606 , A61K48/005 , A61Q5/065 , A61Q19/00 , C07K14/4702 , C12N2310/14 , C12Q1/6876 , C12Q2600/136 , C12Q2600/148 , C12Q2600/158 , G01N33/5023 , G01N33/5044
摘要： Provided are a gene involved in the regulation of the amount of melanin in keratinocytes, and the control of the color of skin or hair, the gene being selected from the group consisting of ATG7 gene, RAB11A gene, CLIP-170 gene, Rubicon gene and RAB7B gene, and a molecule encoded by the gene.
摘要翻译：提供了参与角质形成细胞中黑色素量的调节和控制皮肤或毛发颜色的基因，该基因选自ATG7基因，RAB11A基因，CLIP-170基因，Rubicon基因和 RAB7B基因和由该基因编码的分子。

2. 发明申请

US20130243713A1 Skin and Hair Color-Controlling Factor 有权
标题翻译：皮肤和头发颜色控制因子
公开(公告)号：US20130243713A1
公开(公告)日：2013-09-19
申请号：US13882669
申请日：2011-10-31
申请人： Daiki Murase , Akira Hachiya
发明人： Daiki Murase , Akira Hachiya
IPC分类号： A61K8/60 , A61Q5/06 , A61Q19/00 , C12Q1/68
CPC分类号： C12N15/113 , A61K8/606 , A61K48/005 , A61Q5/065 , A61Q19/00 , C07K14/4702 , C12N2310/14 , C12Q1/6876 , C12Q2600/136 , C12Q2600/148 , C12Q2600/158 , G01N33/5023 , G01N33/5044
摘要： Provided are a gene involved in the regulation of the amount of melanin in keratinocytes, and the control of the color of skin or hair, the gene being selected from the group consisting of ATG7 gene, RAB11A gene, CLIP-170 gene, Rubicon gene and RAB7B gene, and a molecule encoded by the gene.
摘要翻译：提供了参与角质形成细胞中黑色素量的调节和控制皮肤或毛发颜色的基因，该基因选自ATG7基因，RAB11A基因，CLIP-170基因，Rubicon基因和 RAB7B基因和由该基因编码的分子。

3. 发明授权

US07736894B2 Method for constructing reconstructed skin 有权
标题翻译：构造重建皮肤的方法
公开(公告)号：US07736894B2
公开(公告)日：2010-06-15
申请号：US10847380
申请日：2004-05-18
申请人： Akira Hachiya , Eiko Kaiho
发明人： Akira Hachiya , Eiko Kaiho
IPC分类号： C12N5/00
CPC分类号： A61F2/105
摘要： The present invention relates to a method for constructing human skin tissue, in which human skin tissue is reconstructed on a body surface of an immunodeficient non-human animal.
摘要翻译：本发明涉及一种构建人体皮肤组织的方法，其中人体皮肤组织在免疫缺陷型非人动物的身体表面上被重建。

4. 发明授权

US07642402B2 Human photoaged skin model 有权
标题翻译：人类皮肤皮肤模型
公开(公告)号：US07642402B2
公开(公告)日：2010-01-05
申请号：US11311239
申请日：2005-12-20
申请人： Akira Hachiya , Tsutomu Fujimura
发明人： Akira Hachiya , Tsutomu Fujimura
IPC分类号： C12N15/00 , A01K67/00 , A01K67/033 , A01K67/027
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/035
摘要： The invention provides a human photoaged skin model and an animal model which are useful for evaluating cosmetics and similar products in terms of their anti-aging or rejuvenating effect, as well as a method for producing such a skin model and such an animal model. The method of producing the human photoaged skin model is characterized in that a transplanted skin area of an immunodeficient non-human animal which has undergone transplantation of human skin is irradiated with UV-B light of 80-100 mJ/cm2 for consecutive 4 to 8 weeks, and the irradiated area is left to take its own course for at least 3 weeks. A human photoaged skin model and an animal model produced through this method are also disclosed.
摘要翻译：本发明提供一种用于评价化妆品和类似产品的抗衰老或复原效果的人类皮肤模型和动物模型，以及生产这种皮肤模型和动物模型的方法。生产人类皮肤皮肤模型的方法的特征在于用80-100mJ / cm 2的UV-B光照射已经经历人皮肤移植的免疫缺陷型非人动物的移植皮肤区域，连续4至8次星期，照射区域自行进行至少3周。还公开了通过该方法生产的人类皮肤皮肤模型和动物模型。

5. 发明申请

US20050112079A1 Depilatories and agents for external use 失效
标题翻译：脱毛剂和外用药剂
公开(公告)号：US20050112079A1
公开(公告)日：2005-05-26
申请号：US11026090
申请日：2005-01-03
申请人： Atsushi Ohuchi , Akemi Kobayashi , Akira Hachiya
发明人： Atsushi Ohuchi , Akemi Kobayashi , Akira Hachiya
IPC分类号： A45D26/00 , A61K8/00 , A61K8/04 , A61K8/64 , A61K38/00 , A61K38/19 , A61K38/22 , A61K45/00 , A61P17/00 , A61Q7/02 , A61Q9/04 , A61K7/06 , A61K7/11 , A61K7/15
CPC分类号： A61Q9/04 , A61K8/046 , A61K8/64 , A61K38/1703 , A61K38/2285 , A61Q7/02
摘要： This invention relates to depilatories and external preparations, each of which contains endothelin or its agonist, and also to a depilating method characterized by administering endothelin or its agonist. As the depilatories and external preparations according to the present invention inhibit growth of hair in mammalian skin, their application to the human body as drugs or cosmetics permits safe and effective removal of hair from the body. These depilatories and external preparations are also usable as wool harvesting preparations.
摘要翻译：本发明涉及脱毛剂和外用制剂，其各自含有内皮缩血管肽或其激动剂，还涉及以给药内皮素或其激动剂为特征的脱毛方法。由于根据本发明的脱毛剂和外用制剂抑制哺乳动物皮肤中的毛发生长，因此将其作为药物或化妆品施用于人体允许从身体安全有效地去除毛发。这些脱毛剂和外用制剂也可用作羊毛收获制剂。

6. 发明授权

US08771647B2 Human photoaged skin model 有权
标题翻译：人类皮肤皮肤模型
公开(公告)号：US08771647B2
公开(公告)日：2014-07-08
申请号：US11766522
申请日：2007-06-21
申请人： Akira Hachiya , Tsutomu Fujimura
发明人： Akira Hachiya , Tsutomu Fujimura
IPC分类号： A01K67/027
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/035
摘要： The present invention provides a human photoaged skin model and an animal model, and a method of making the same, for evaluating cosmetics and similar products in terms of their anti-aging or rejuvenating effect.
摘要翻译：本发明提供一种人类皮肤皮肤模型和动物模型及其制备方法，用于评估化妆品和类似产品的抗老化或恢复活力。

7. 发明授权

US08088570B2 Method for screening an agent for preventing or ameliorating wrinkles 有权
标题翻译：用于筛选用于预防或改善皱纹的药剂的方法
公开(公告)号：US08088570B2
公开(公告)日：2012-01-03
申请号：US11405471
申请日：2006-04-18
申请人： Tsutomu Fujimura , Takuji Kume , Akira Hachiya
发明人： Tsutomu Fujimura , Takuji Kume , Akira Hachiya
IPC分类号： C12Q1/00
CPC分类号： G01N33/5044 , G01N33/5082 , G01N2333/4742
摘要： There is provided a screening method which can select a photoaging-preventing or improving agent or a wrinkle-preventing or improving agent with efficiency and reliability. The screening method for a photoaging- or wrinkle-preventing or improving agent selects, as a candidate, a substance inhibiting the expression of keratin 6 and/or keratin 16 genes or keratin 6 and/or keratin 16 proteins in a skin tissue or cell.
摘要翻译：提供了一种筛选方法，其可以有效地和可靠地选择光老化防止或改善剂或防皱或改善剂。光老化或防皱或改善剂的筛选方法选择抑制角蛋白6和/或角蛋白16基因或角蛋白6和/或角蛋白16蛋白在皮肤组织或细胞中表达的物质作为候选物质。

8. 发明授权

US07973211B2 Animal model for hyperpigmentation 有权
标题翻译：用于色素沉着过度的动物模型
公开(公告)号：US07973211B2
公开(公告)日：2011-07-05
申请号：US12073869
申请日：2008-03-11
申请人： Akira Hachiya , Penkanok Sriwiriyanont , Shinya Kasamatsu
发明人： Akira Hachiya , Penkanok Sriwiriyanont , Shinya Kasamatsu
IPC分类号： A01K67/00
CPC分类号： A01K67/0271 , A01K2267/03
摘要： An animal model for hyperpigmentations in which the formation of hyperpigmentations in human skin is faithfully simulated is provided. An animal model for hyperpigmentations, wherein a black person's skin is grafted onto a non-human animal, is provided.
摘要翻译：提供了一种用于色素沉着过度的动物模型，其中人皮肤中色素沉着过度的形成被真实地模拟。提供了一种用于色素沉着的动物模型，其中将黑人的皮肤移植到非人动物上。

9. 发明申请

US20080263686A1 ANIMAL MODEL FOR PIGMENT SPOTS 有权
标题翻译：动物模型用于颜色搭配
公开(公告)号：US20080263686A1
公开(公告)日：2008-10-23
申请号：US11785549
申请日：2007-04-18
申请人： Akira Hachiya , Penkanok Sriwiriyanont
发明人： Akira Hachiya , Penkanok Sriwiriyanont
IPC分类号： A01K67/00 , A61K49/00 , C12N5/06
CPC分类号： A61K49/0006 , A01K67/0271 , A61K49/0008
摘要： An animal model for pigment spots in which the formation of pigment spots in human skin is faithfully simulated is provided. An animal model for pigment spots, wherein a black person's skin is grafted onto a non-human animal, is provided.
摘要翻译：提供了一种用于颜色斑点的动物模型，其中人类皮肤中颜料斑点的形成被真实地模拟。提供了将黑人皮肤移植到非人动物上的颜料斑点的动物模型。

10. 发明申请

US20070243520A1 Method for screening an agent for preventing or ameliorating wrinkles 有权
标题翻译：用于筛选用于预防或改善皱纹的药剂的方法
公开(公告)号：US20070243520A1
公开(公告)日：2007-10-18
申请号：US11405471
申请日：2006-04-18
申请人： Tsutomu Fujimura , Takuji Kume , Akira Hachiya
发明人： Tsutomu Fujimura , Takuji Kume , Akira Hachiya
IPC分类号： C12Q1/00
CPC分类号： G01N33/5044 , G01N33/5082 , G01N2333/4742
摘要： There is provided a screening method which can select a photoaging-preventing or improving agent or a wrinkle-preventing or improving agent with efficiency and reliability. The screening method for a photoaging- or wrinkle-preventing or improving agent selects, as a candidate, a substance inhibiting the expression of keratin 6 and/or keratin 16 genes or keratin 6 and/or keratin 16 proteins in a skin tissue or cell.
摘要翻译：提供了一种筛选方法，其可以有效地和可靠地选择光老化防止或改善剂或防皱或改善剂。光老化或防皱或改善剂的筛选方法选择抑制角蛋白6和/或角蛋白16基因或角蛋白6和/或角蛋白16蛋白在皮肤组织或细胞中表达的物质作为候选物质。

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