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1. 发明授权

US10633481B2 Polyurea systems, processes for preparing the same and use thereof for postoperative adhesion barriers 有权
公开(公告)号：US10633481B2
公开(公告)日：2020-04-28
申请号：US14635472
申请日：2015-03-02
申请人： Adhesys Medical GmbH
发明人： Heike Heckroth , Hartmut Nefzger , Christian Wamprecht
IPC分类号： C08G18/38 , A61L31/06 , C08G18/10 , C08G18/42 , C08G18/48 , C08G18/73 , C08G18/76 , C08G18/32 , A61L15/26 , A61L31/14
CPC分类号： C08G18/3821 , A61L15/26 , A61L31/06 , A61L31/148 , C08G18/10 , C08G18/3262 , C08G18/4252 , C08G18/485 , C08G18/4841 , C08G18/73 , C08G18/7621 , A61L2430/00 , Y10T428/31551 , Y10T428/31594 , A61L15/26 , C08L75/02 , A61L31/06 , C08L75/02 , C08G18/10 , C08G18/3821
摘要： Polyurea systems comprising: (a) an amino-functional aspartic ester of the general formula (I)

wherein X represents an n-valent organic radical derived from a corresponding n-functional primary amine X(NH2)n, R1 and R2 each independently represent an organic radical having no Zerevitinov active hydrogens and n represents an integer of at least 2; and (b) an isocyanate functional prepolymer having a residual monomer content of less than 1% by weight, the prepolymer prepared by reacting: (b1) an aliphatic isocyante; and (b2) a polyol component having a number average molecular weight of ≥400 g/mol and an average OH functionality of 2 to 6, wherein the polyol component comprises one or more constituents selected from the group consisting of polyester polyols, polyester-polyether polyols and mixtures thereof; processes for making the same; postoperative adhesions barriers prepared therewith and dispensing systems for such polyurea systems.

2. 发明授权

US09757492B2 Hydroxy amino polymer and use thereof in polyurea/polyurethane tissue adhesives 有权
公开(公告)号：US09757492B2
公开(公告)日：2017-09-12
申请号：US15402702
申请日：2017-01-10
申请人： Adhesys Medical GmbH
发明人： Heike Heckroth , Christoph Eggert , Jörg Hofmann , Klaus Lorenz , Edward Browne , Hartmut Nefzger
IPC分类号： C08G18/46 , A61L24/00 , A61L24/04 , C08G63/91 , C08G18/73 , C08G18/10 , C08G18/48 , C08G18/38
CPC分类号： A61L24/046 , A61L24/0042 , C08G18/10 , C08G18/3821 , C08G18/4252 , C08G18/4615 , C08G18/4837 , C08G18/485 , C08G18/4866 , C08G18/4887 , C08G18/73 , C08G63/91 , C08G2230/00 , C09J175/04 , C08G18/42 , C08L75/04
摘要： The present invention relates to a process for producing a hydroxy amino polymer comprising the steps: a) Reaction of an H functional starter compound bearing at least one Zerewitinoff active H atom with an unsaturated, cyclical carboxylic acid anhydride and at least one alkylene oxide compound for obtaining a prepolymer bearing hydroxyl groups, b) Addition of a primary amine and/or of ammonia to the double bond(s) of the prepolymer bearing hydroxyl groups obtained according to step a) for obtaining the hydroxy amino polymer, wherein the ratio of added amino groups to hydroxyl groups in a hydroxy amino polymer is at least 0.6. Furthermore, the invention relates to a hydroxy amino polymer, which can be achieved according to this process as well as a polyurea/polyurethane system, which contains such a hydroxy amino polymer.

3. 发明授权

US10722609B2 Medical adhesives for stopping heavy bleeding and sealing leakages 有权
公开(公告)号：US10722609B2
公开(公告)日：2020-07-28
申请号：US16451283
申请日：2019-06-25
申请人： Adhesys Medical GmbH
发明人： Heike Heckroth , Burkhard Köhler , Sebastian Dörr
IPC分类号： A61L24/00 , A61L24/04 , C08G18/08 , C08G18/10 , C08G18/48 , C09J175/12 , C08L75/04
摘要： The present invention relates to a method that includes providing a formulation having an isocyanate-functional prepolymer and a curing component comprising an amino-functional aspartic ester of the general formula (I) applying the formulation to a cell tissue; and curing the formulation such that the loss of blood (haemostatic) or tissue fluids is staunched or leaks in cell tissues are sealed.

4. 发明申请

US20200223973A1 POLYUREA SYSTEMS, PROCESSES FOR PREPARING THE SAME AND USE THEREOF FOR POSTOPERATIVE ADHESION BARRIERS 审中-公开
公开(公告)号：US20200223973A1
公开(公告)日：2020-07-16
申请号：US16829104
申请日：2020-03-25
申请人： Adhesys Medical GmbH
发明人： Heike HECKROTH , Hartmut NEFZGER , Christian WAMPRECHT
IPC分类号： C08G18/38 , A61L31/06 , C08G18/10 , C08G18/42 , C08G18/48 , C08G18/73 , C08G18/76 , C08G18/32 , A61L15/26 , A61L31/14
摘要： Polyurea systems comprising: (a) an amino-functional aspartic ester of the general formula (I) wherein X represents an n-valent organic radical derived from a corresponding n-functional primary amine X(NH2)n, R1 and R2 each independently represent an organic radical having no Zerevitinov active hydrogens and n represents an integer of at least 2; and (b) an isocyanate functional prepolymer having a residual monomer content of less than 1% by weight, the prepolymer prepared by reacting: (b1) an aliphatic isocyante; and (b2) a polyol component having a number average molecular weight of ≥400 g/mol and an average OH functionality of 2 to 6, wherein the polyol component comprises one or more constituents selected from the group consisting of polyester polyols, polyester-polyether polyols and mixtures thereof; processes for making the same; postoperative adhesions barriers prepared therewith and dispensing systems for such polyurea systems.

5. 发明申请

US20170326268A1 MEDICAL ADHESIVES FOR STOPPING HEAVY BLEEDING AND SEALING LEAKAGES 审中-公开
公开(公告)号：US20170326268A1
公开(公告)日：2017-11-16
申请号：US15667744
申请日：2017-08-03
申请人： Adhesys Medical GmbH
发明人： Heike Heckroth , Burkhard KOHLER , Sebastian DORR
IPC分类号： A61L24/00 , C08L75/04 , C08G18/10 , A61L24/04 , C08G18/08 , C09J175/12 , C08G18/48
CPC分类号： A61L24/0094 , A61L24/046 , A61L2400/04 , C08G18/089 , C08G18/10 , C08G18/4837 , C08L75/04 , C09J175/12 , C08G18/48 , C08G18/3821
摘要： The present invention relates to a method that includes providing a formulation having an isocyanate-functional prepolymer and a curing component comprising an amino-functional aspartic ester of the general formula (I) applying the formulation to a cell tissue; and curing the formulation such that the loss of blood (haemostatic) or tissue fluids is staunched or leaks in cell tissues are sealed.

6. 发明申请

US20220142630A1 APPLICATOR FOR A TWO-COMPONENT FABRIC ADHESIVE 有权
公开(公告)号：US20220142630A1
公开(公告)日：2022-05-12
申请号：US17431949
申请日：2020-02-17
申请人： ADHESYS MEDICAL GMBH
发明人： Hayley A. LOUGH , Matthew BAYES , Ralf DORSCHEID
IPC分类号： A61B17/00 , A61L24/04
摘要： The present invention relates to a dispensing system (1) having at least two chambers (2,3) for a tissue adhesive system comprising at least two components, wherein first chamber (2) is designed as a hollow cylinder (H), which has a closed design on an end face (2a) and an open design on its opposite end face (2b) and second chamber (3) in a solid cylinder (V) is designed as an annular gap (4) and annular gap (4) extends from an end face (3a) facing hollow cylinder (H) to a mixing chamber (5) arranged on opposite end (3b) of solid cylinder (V) and hollow cylinder (H) is arranged on the side of its open end face (2b) in annular gap (4) of solid cylinder (V) so it can move in longitudinal direction (L), wherein at least one feed duct (6) is designed in solid cylinder (V), which extends on the inside of annular gap (4) from end face (3a) of solid cylinder (V) facing hollow cylinder (H) to mixing chamber (5), wherein a mixing tube (7) is provisioned in mixing chamber (5), which projects laterally from solid cylinder (V) and is arranged so it can move essentially transversely to the longitudinal expansion of solid cylinder (V) and closes the inside of mixing tube (7) off from feed duct (6) and annular gap (4) in a first position and unblocks it in a second position. The invention also relates to a kit consisting of a dispensing system, which is filled with tissue adhesive system comprising at least two components as well as a method for closing a wound using said kit.

7. 发明申请

US20200046875A1 MEDICAL ADHESIVES FOR STOPPING HEAVY BLEEDING AND SEALING LEAKAGES 审中-公开
公开(公告)号：US20200046875A1
公开(公告)日：2020-02-13
申请号：US16451283
申请日：2019-06-25
申请人： Adhesys Medical GmbH
发明人： Heike Heckroth , Burkhard KÖHLER , Sebastian DÖRR
IPC分类号： A61L24/00 , C09J175/12 , C08G18/48 , C08G18/10 , C08L75/04 , C08G18/08 , A61L24/04
摘要： The present invention relates to a method that includes providing a formulation having an isocyanate-functional prepolymer and a curing component comprising an amino-functional aspartic ester of the general formula (I) applying the formulation to a cell tissue; and curing the formulation such that the loss of blood (haemostatic) or tissue fluids is staunched or leaks in cell tissues are sealed.

8. 发明申请

US20190030206A1 MEDICAL ADHESIVES FOR STOPPING HEAVY BLEEDING AND SEALING LEAKAGES 审中-公开
公开(公告)号：US20190030206A1
公开(公告)日：2019-01-31
申请号：US16148272
申请日：2018-10-01
申请人： Adhesys Medical GmbH
发明人： Heike HECKROTH , Burkhard KÖHLER , Sebastian DÖRR
IPC分类号： A61L24/00 , C08L75/04 , A61L24/04 , C08G18/08 , C09J175/12 , C08G18/48 , C08G18/10 , C08G18/38
CPC分类号： A61L24/0094 , A61L24/046 , A61L2400/04 , C08G18/089 , C08G18/10 , C08G18/4837 , C08L75/04 , C09J175/12 , C08G18/48 , C08G18/3821
摘要： The present invention relates to a method that includes providing a formulation having an isocyanate-functional prepolymer and a curing component comprising an amino-functional aspartic ester of the general formula (I) applying the formulation to a cell tissue; and curing the formulation such that the loss of blood (haemostatic) or tissue fluids is staunched or leaks in cell tissues are sealed.

9. 发明申请

US20170119921A1 HYDROXY AMINO POLYMER AND USE THEREOF IN POLYUREA/POLYURETHANE TISSUE ADHESIVES 有权
公开(公告)号：US20170119921A1
公开(公告)日：2017-05-04
申请号：US15402702
申请日：2017-01-10
申请人： Adhesys Medical GmbH
发明人： Heike HECKROTH , Christoph EGGERT , Jörg HOFMANN , Klaus LORENZ , Edward BROWNE , Hartmut NEFZGER
IPC分类号： A61L24/04 , C08G18/38 , C08G18/73 , C08G18/48 , A61L24/00 , C08G18/10
CPC分类号： A61L24/046 , A61L24/0042 , C08G18/10 , C08G18/3821 , C08G18/4252 , C08G18/4615 , C08G18/4837 , C08G18/485 , C08G18/4866 , C08G18/4887 , C08G18/73 , C08G63/91 , C08G2230/00 , C09J175/04 , C08G18/42 , C08L75/04
摘要： The present invention relates to a process for producing a hydroxy amino polymer comprising the steps: a) Reaction of an H functional starter compound bearing at least one Zerewitinoff active H atom with an unsaturated, cyclical carboxylic acid anhydride and at least one alkylene oxide compound for obtaining a prepolymer bearing hydroxyl groups, b) Addition of a primary amine and/or of ammonia to the double bond(s) of the prepolymer bearing hydroxyl groups obtained according to step a) for obtaining the hydroxy amino polymer, wherein the ratio of added amino groups to hydroxyl groups in a hydroxy amino polymer is at least 0.6. Furthermore, the invention relates to a hydroxy amino polymer, which can be achieved according to this process as well as a polyurea/polyurethane system, which contains such a hydroxy amino polymer.

10. 发明授权

US10391198B2 Medical adhesives for stopping heavy bleeding and sealing leakages 有权
公开(公告)号：US10391198B2
公开(公告)日：2019-08-27
申请号：US16148272
申请日：2018-10-01
申请人： Adhesys Medical GmbH
发明人： Heike Heckroth , Burkhard Köhler , Sebastian Dörr
IPC分类号： A61L24/00 , A61L24/04 , C08G18/08 , C08G18/10 , C08G18/38 , C09J175/12 , C08L75/04 , C08G18/48
摘要： The present invention relates to a method that includes providing a formulation having an isocyanate-functional prepolymer and a curing component comprising an amino-functional aspartic ester of the general formula (I) applying the formulation to a cell tissue; and curing the formulation such that the loss of blood (haemostatic) or tissue fluids is staunched or leaks in cell tissues are sealed.

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