专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090291437A1 METHODS FOR TARGETING QUADRUPLEX SEQUENCES 审中-公开
标题翻译：用于指导四边形序列的方法
公开(公告)号：US20090291437A1
公开(公告)日：2009-11-26
申请号：US12092557
申请日：2006-11-02
申请人： Sean O'Brien , Adam Siddiqui-Jain
发明人： Sean O'Brien , Adam Siddiqui-Jain
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876
摘要： Provided are quadruplex nucleotide sequences and methods for identifying interacting molecules.
摘要翻译：提供四核苷酸序列和鉴定相互作用分子的方法。

2. 发明授权

US07405041B2 Methods for regulating transcription by targeting quadruplex DNA 失效
标题翻译：通过靶向四联体DNA调节转录的方法
公开(公告)号：US07405041B2
公开(公告)日：2008-07-29
申请号：US10645471
申请日：2003-08-20
申请人： Scot W. Ebbinghaus , Laurence H. Hurley , Adam Siddiqui-Jain , Regan Memmott
发明人： Scot W. Ebbinghaus , Laurence H. Hurley , Adam Siddiqui-Jain , Regan Memmott
IPC分类号： C12Q1/68
CPC分类号： C07D513/22 , Y10S977/924
摘要： Among the different intrastrand quadruplex structures that can arise from duplex DNA, it has been discovered that the nucleotide sequences (GGA)4 (SEQ ID NO: 1) and (GGA)3GG (SEQ ID NO: 2) form biologically significant quadruplex structures. Thus, provided herein are methods for identifying molecules that modulate the biological activity of quadruplex DNA comprising the nucleotide sequence (GGA)4 (SEQ ID NO: 1) or the nucleotide sequence (GGA)3GG (SEQ ID NO: 2), and specifically, methods for identifying molecules that bind such quadruplexes. Also provided herein are methods for modulating the biological activity of a biologically significant native quadruplex DNA with a molecule identified by the methods described herein.
摘要翻译：在双链DNA可能产生的不同的intrastrand四链体结构中，已经发现核苷酸序列（GGA）4（SEQ ID NO：1）和（GGA）3

3. 发明授权

US07326702B2 Substituted quinobenzoxazine analogs 有权
公开(公告)号：US07326702B2
公开(公告)日：2008-02-05
申请号：US11390810
申请日：2006-03-28
申请人： Jeffrey P. Whitten , Michael Schwaebe , Adam Siddiqui-Jain , Terence Moran
发明人： Jeffrey P. Whitten , Michael Schwaebe , Adam Siddiqui-Jain , Terence Moran
IPC分类号： C07D498/06 , C07D498/16 , A61K31/5365
CPC分类号： C07D471/06 , C07D513/04
摘要： The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, V, W, X and Z are substituents. The present invention also relates to methods for using such compounds.

4. 发明申请

US20060286575A1 MCL-1 quadruplex nucleic acids and uses thereof 审中-公开
标题翻译： MCL-1四核苷酸及其用途
公开(公告)号：US20060286575A1
公开(公告)日：2006-12-21
申请号：US11404552
申请日：2006-04-14
申请人： Thomas Farrell , Adam Siddiqui-Jain
发明人： Thomas Farrell , Adam Siddiqui-Jain
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： A biologically significant quadruplex structure in the MCL-1 regulatory region has been discovered. Certain mutations in quadruplex forming nucleotide sequences alter quadruplex structure and are associated with cancer and perhaps other diseases. Thus, provided herein are MCL-1 quadruplex nucleic acid acids, cancer diagnostics and prognostics, methods for using the cancer diagnostics and prognostics to prevent and/or treat cancer, nucleic acid therapeutics that target altered MCL-1 nucleotide sequences and related methods, methods for identifying compounds that modulate the biological activity of a native MCL-1 quadruplex DNA, and methods for modulating the biological activity of a native MCL-1 quadruplex DNA with a compound identified by the methods described herein. Also provided are methods of selecting a subject for treatment of a cell-proliferative disorder with a quadruplex-interacting molecule.
摘要翻译：已经发现了MCL-1调节区的生物学显着的四重结构。四连体形成核苷酸序列中的某些突变改变了四重结构，并与癌症和其他疾病有关。因此，本文提供了MCL-1四核苷酸，癌症诊断和预后，使用癌症诊断和预后来预防和/或治疗癌症的方法，靶向改变的MCL-1核苷酸序列的核酸治疗剂和相关方法，方法用于鉴定调节天然MCL-1四链体DNA的生物活性的化合物，以及通过本文所述方法鉴定的化合物调节天然MCL-1四链体DNA的生物学活性的方法。还提供了用四联体相互作用分子选择受试者治疗细胞增殖性病症的方法。

5. 发明授权

US07141565B1 Substituted quinobenzoxazine analogs 有权
公开(公告)号：US07141565B1
公开(公告)日：2006-11-28
申请号：US10821243
申请日：2004-04-07
申请人： Jeffrey P. Whitten , Michael Schwaebe , Adam Siddiqui-Jain , Terrance Moran
发明人： Jeffrey P. Whitten , Michael Schwaebe , Adam Siddiqui-Jain , Terrance Moran
IPC分类号： C07D498/06 , C07D498/16 , A61K31/5365
CPC分类号： C07D471/06 , C07D513/04
摘要： The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, V, W, X and Z are substituents. The present invention also relates to methods for using such compounds.

6. 发明申请

US20060029950A1 Substituted quinobenzoxazine analogs and methods of using thereof 失效
标题翻译：取代的喹苯恶嗪类似物及其使用方法
公开(公告)号：US20060029950A1
公开(公告)日：2006-02-09
申请号：US11106909
申请日：2005-04-15
申请人： Jeffrey Whitten , Michael Schwaebe , Adam Siddiqui-Jain , Terence Moran
发明人： Jeffrey Whitten , Michael Schwaebe , Adam Siddiqui-Jain , Terence Moran
IPC分类号： C12Q1/68
CPC分类号： C07D498/06 , A61K31/5383
摘要： The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein V, A, X, Z, W, U and R5 are substituents. The present invention also relates to methods for using such compounds, such as in screening and for inducing apoptosis.
摘要翻译：本发明涉及具有以下通式的醌苯并恶嗪类似物及其药学上可接受的盐，酯和前药; 其中V，A，X，Z，W，U和R 5是取代基。本发明还涉及使用这些化合物的方法，例如在筛选和诱导凋亡中。

7. 发明申请

US20120122804A1 SUBSTITUTED QUINOBENZOXAZINE ANALOGS 审中-公开
标题翻译：取代喹诺酮类似物
公开(公告)号：US20120122804A1
公开(公告)日：2012-05-17
申请号：US11694682
申请日：2007-03-30
申请人： Jeffrey P. Whitten , Michael Schwaebe , Adam Siddiqui-Jain , Terrance Moran
发明人： Jeffrey P. Whitten , Michael Schwaebe , Adam Siddiqui-Jain , Terrance Moran
IPC分类号： A61K31/5383 , C07D471/06 , A61K31/4985 , C07D513/06 , A61K31/542 , A61K31/551 , C07D498/16 , C07D519/00 , C07H5/06 , A61K31/706 , A61K31/55 , A61P31/04 , A61P31/12 , A61P35/00 , C12N5/02 , C07D498/06
CPC分类号： C07D471/06 , C07D513/04
摘要： The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, V, W, X and Z are substituents.The present invention also relates to methods for using such compounds.
摘要翻译：本发明涉及具有以下通式的醌苯并恶嗪类似物及其药学上可接受的盐，酯和前药; 其中A，U，V，W，X和Z是取代基。本发明还涉及使用这些化合物的方法。

8. 发明申请

US20090181377A1 HUMAN RIBOSOMAL DNA (rDNA) AND RIBOSOMAL RNA (rRNA) NUCLEIC ACIDS AND USES THEREOF 审中-公开
标题翻译：人类RIBOSOMAL DNA（rDNA）和RIBOSOMAL RNA（rRNA）核酸及其用途
公开(公告)号：US20090181377A1
公开(公告)日：2009-07-16
申请号：US12025705
申请日：2008-02-04
申请人： Denis Drygin , Emil Michelotti , Sean O'Brien , William G. Rice , Adam Siddiqui-Jain , Jeffrey P. Whitten
发明人： Denis Drygin , Emil Michelotti , Sean O'Brien , William G. Rice , Adam Siddiqui-Jain , Jeffrey P. Whitten
IPC分类号： C12Q1/68 , C07H21/02
CPC分类号： C12N15/113 , C12N2310/3511
摘要： Provided herein are isolated nucleic acids that comprise a human rRNA or rDNA subsequence and related compositions and methods of use.
摘要翻译：本文提供了分离的核酸，其包含人rRNA或rDNA亚序列以及相关组合物和使用方法。

9. 发明申请

US20070117770A1 Human ribosomal DNA (rDNA) and ribosomal RNA (rRNA) nucleic acids and uses thereof 审中-公开
标题翻译：人核糖体DNA（rDNA）和核糖体RNA（rRNA）核酸及其用途
公开(公告)号：US20070117770A1
公开(公告)日：2007-05-24
申请号：US11506588
申请日：2006-08-18
申请人： Denis Drygin , Emil Michelotti , Sean O'Brien , William Rice , Adam Siddiqui-Jain , Jeffrey Whitten
发明人： Denis Drygin , Emil Michelotti , Sean O'Brien , William Rice , Adam Siddiqui-Jain , Jeffrey Whitten
IPC分类号： A61K48/00 , A61K31/496 , A61K31/4709 , C07H21/04
CPC分类号： C12N15/113 , C12N2310/3511
摘要： Provided herein are isolated nucleic acids that comprise a human rRNA or rDNA subsequence and related compositions and methods of use.
摘要翻译：本文提供了分离的核酸，其包含人rRNA或rDNA亚序列以及相关组合物和使用方法。

10. 发明申请

US20060229303A1 Substituted quinobenzoxazine analogs 有权
公开(公告)号：US20060229303A1
公开(公告)日：2006-10-12
申请号：US11390810
申请日：2006-03-28
申请人： Jeffrey Whitten , Michael Schwaebe , Adam Siddiqui-Jain , Terrance Moran
发明人： Jeffrey Whitten , Michael Schwaebe , Adam Siddiqui-Jain , Terrance Moran
IPC分类号： A61K31/5415 , A61K31/538 , C07D498/14 , C07D491/14
CPC分类号： C07D471/06 , C07D513/04
摘要： The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, V, W, X and Z are substituents. The present invention also relates to methods for using such compounds.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式