专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 外观设计

USD678982S1 Dual flush toilet mechanism 有权
标题翻译：双抽水马桶机构
公开(公告)号：USD678982S1
公开(公告)日：2013-03-26
申请号：US29407955
申请日：2011-12-05
申请人： Adam Sampson , Tuan Le , Tom Stout , John Whaley , David Peschel , Zaafir Kherani , Matt Vargas
设计人： Adam Sampson , Tuan Le , Tom Stout , John Whaley , David Peschel , Zaafir Kherani , Matt Vargas

2. 发明授权

US06296845B1 Selective killing and diagnosis of p53+ neoplastic cells 失效
标题翻译：选择性杀伤和诊断p53 +肿瘤细胞
公开(公告)号：US06296845B1
公开(公告)日：2001-10-02
申请号：US09190930
申请日：1998-11-12
申请人： Adam Sampson-Johannes , David Kirn
发明人： Adam Sampson-Johannes , David Kirn
IPC分类号： A61K4800
CPC分类号： G01N33/57484 , A61K35/761 , C12N2710/10332 , C12N2710/10362
摘要： Methods and compositions for treating and diagnosing neoplastic disease using viruses are provided. Preferably, mutant adenovirus lacking viral proteins which bind and/or inactivate p53 are administered to a patient having a neoplasm which comprises cells exhibiting p53 and lacking, or substantially devoid of mismatch repair activity. The mutant virus is able to substantially produce a replication phenotype in such neoplastic cells but is substantially unable to produce a replication phenotype in non-replicating, non-neoplastic cells having essentially normal p53 function. The preferential generation of a replication phenotype in neoplastic cells results in a preferential killing of the neoplastic cells, either directly or by expression of a cytotoxic gene in cells expressing a viral replication phenotype.
摘要翻译：提供了使用病毒治疗和诊断肿瘤疾病的方法和组合物。优选地，将具有结合和/或失活p53的病毒蛋白质的突变型腺病毒施用于具有肿瘤的患者，所述肿瘤包含表现出p53并且缺乏或基本上没有错配修复活性的细胞。突变型病毒能够在这种肿瘤细胞中基本上产生复制表型，但是在具有基本正常p53功能的非复制型非肿瘤细胞中基本上不能产生复制表型。在肿瘤细胞中优先产生复制表型导致直接或通过在表达病毒复制表型的细胞中表达细胞毒性基因来赘瘤细胞的优先杀伤。

3. 发明申请

US20140109996A1 Constant Flow Rate Pressure Regulator 有权
标题翻译：恒流量压力调节器
公开(公告)号：US20140109996A1
公开(公告)日：2014-04-24
申请号：US13655180
申请日：2012-10-18
申请人： Tuan LE , Jaime Berndt , Adam Sampson
发明人： Tuan LE , Jaime Berndt , Adam Sampson
IPC分类号： G05D16/04
CPC分类号： G05D16/04 , G05D7/012 , Y10T137/7793
摘要： A flow valve that maintains a constant flow valve despite varying pressures at its inlet, comprising: (a) an elongated cage with alternating axially-extending pockets and ridges on its inner surface; and (b) an elongated generally conical shaped elastomeric sleeve received within the elongated cage; wherein the sleeve flexes outwardly at higher pressures, thereby decreasing the size of the flow channel between the sleeve and cage, thereby restricting flow to maintain constant flow valve despite varying inlet pressures.
摘要翻译：尽管在其入口处具有变化的压力，仍保持恒定流量阀的流量阀包括：（a）在其内表面上具有交替轴向延伸的凹穴和凸脊的细长保持架; 和（b）细长的笼形体中的细长的大致圆锥形的弹性体套筒; 其中套筒在较高压力下向外弯曲，从而减小套筒和保持架之间的流动通道的尺寸，从而限制流量以保持恒定的流量阀，尽管变化的入口压力。

4. 发明授权

US06302919B1 Reverse-flow centrifugal filtration method 有权
标题翻译：反流离心过滤法
公开(公告)号：US06302919B1
公开(公告)日：2001-10-16
申请号：US09358130
申请日：1999-07-20
申请人： Brian Chambers , Adam Sampson , Matt McDermott , Byron Knight , Gunars E. Valkirs , Howard J. Kirchick
发明人： Brian Chambers , Adam Sampson , Matt McDermott , Byron Knight , Gunars E. Valkirs , Howard J. Kirchick
IPC分类号： B01D2126
CPC分类号： G01N1/4077 , B01L3/5021
摘要： A filtration device, apparatus, and method of filtration useful for filtering liquid samples are disclosed wherein filtration occurs opposite the direction of centrifugal force. The filtration device is placed within a container that contains the liquid sample to be filtered. Together, the filtration device and the container comprise the filtration apparatus. Centrifugation forces the liquid sample present in the container to enter the filtration device, thereby effecting filtration. The vertical position of the filtration device is fixed within this container during filtration.
摘要翻译：公开了用于过滤液体样品的过滤装置，装置和过滤方法，其中过滤与离心力方向相反。将过滤装置放置在容纳要过滤的液体样品的容器内。过滤装置和容器一起包括过滤装置。离心迫使存在于容器中的液体样品进入过滤装置，从而进行过滤。在过滤期间，过滤装置的垂直位置固定在该容器内。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式