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1. 发明授权

US07956083B2 Compounds 失效
标题翻译：化合物
公开(公告)号：US07956083B2
公开(公告)日：2011-06-07
申请号：US12864933
申请日：2009-02-17
申请人： Christopher Norbert Johnson , David G. Jones , Xi Liang , David Timothy MacPherson , Aaron B Miller , Steven James Stanway , Andrew Kenneth Takle , Giancarlo Trani , Antoinette Wilson
发明人： Christopher Norbert Johnson , David G. Jones , Xi Liang , David Timothy MacPherson , Aaron B Miller , Steven James Stanway , Andrew Kenneth Takle , Giancarlo Trani , Antoinette Wilson
IPC分类号： A01N43/38 , C07D209/04
CPC分类号： C07D209/08
摘要： The present invention relates to novel indole derivatives having pharmacological activity, processes for their preparation, compositions containing them and the use of these compounds in the treatment of estrogen receptor beta mediated diseases.
摘要翻译：本发明涉及具有药理活性的新型吲哚衍生物，其制备方法，含有它们的组合物以及这些化合物在治疗雌激素受体β介导的疾病中的用途。

2. 发明申请

US20100087502A1 Indazoles Used To Treat Estrogen Receptor Beta Mediated Disorders 失效
标题翻译：用于治疗雌激素受体β介导性疾病的吲唑
公开(公告)号：US20100087502A1
公开(公告)日：2010-04-08
申请号：US12529561
申请日：2008-03-05
申请人： Christopher Norbert Johnson , David G. Jones , Xi Liang , David Timothy Macpherson , Aaron B. Miller , Antoinette Naylor , Steven James Stanway , Andrew Kenneth Takle , Giancarlo Trani
发明人： Christopher Norbert Johnson , David G. Jones , Xi Liang , David Timothy Macpherson , Aaron B. Miller , Antoinette Naylor , Steven James Stanway , Andrew Kenneth Takle , Giancarlo Trani
IPC分类号： A61K31/416 , C07D231/56 , A61P9/00 , A61P25/00 , A61P29/00 , A61P37/00 , A61P3/00
CPC分类号： C07D231/56
摘要： The present invention relates to novel indazole derivatives having pharmacological activity, processes for their preparation, compositions containing them and uses of these compounds in the treatment of estrogen receptor beta mediated diseases.
摘要翻译：本发明涉及具有药理学活性的新的吲唑衍生物，其制备方法，含有它们的组合物以及这些化合物在治疗雌激素受体β介导的疾病中的用途。

3. 发明授权

US5622948A Pyrrole pyridazine and pyridazinone anti-inflammatory agents 失效
标题翻译：吡咯哒嗪和哒嗪酮抗炎药
公开(公告)号：US5622948A
公开(公告)日：1997-04-22
申请号：US347915
申请日：1994-12-01
申请人： James P. Dunn , Chakk S. Ramesha , Jim W. Barnett , Denis J. Kertesz , Aaron B. Miller , David Morgans, Jr. , C. Elliott Sigal , Eric B. Sjogren , David B. Smith , Francisco X. Talamas
发明人： James P. Dunn , Chakk S. Ramesha , Jim W. Barnett , Denis J. Kertesz , Aaron B. Miller , David Morgans, Jr. , C. Elliott Sigal , Eric B. Sjogren , David B. Smith , Francisco X. Talamas
IPC分类号： C07D401/06 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/495 , A61K31/50 , A61P25/04 , A61P29/00 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14
CPC分类号： C07D403/06
摘要： Pyrrole pyridazine and pyridazinone compounds are described. These compounds are useful as anti-inflammatory agents in the treatment of inflammation and pain. The preparation of these compounds, their pharmaceutically acceptable salts, and pharmaceutical compositions containing these compounds, is also described.
摘要翻译：描述了吡咯哒嗪和哒嗪酮化合物。这些化合物可用作治疗炎症和疼痛的抗炎剂。还描述了这些化合物的制备，其药学上可接受的盐和含有这些化合物的药物组合物。

4. 发明授权

US07960563B2 Indazoles used to treat estrogen receptor beta mediated disorders 失效
标题翻译：吲唑用于治疗雌激素受体β介导的疾病
公开(公告)号：US07960563B2
公开(公告)日：2011-06-14
申请号：US12529561
申请日：2008-03-05
申请人： Christopher Norbert Johnson , David G Jones , Xi Liang , David Timothy MacPherson , Aaron B Miller , Antoinette Naylor , Steven James Stanway , Andrew Kenneth Takle , Giancarlo Trani
发明人： Christopher Norbert Johnson , David G Jones , Xi Liang , David Timothy MacPherson , Aaron B Miller , Antoinette Naylor , Steven James Stanway , Andrew Kenneth Takle , Giancarlo Trani
IPC分类号： C07D231/56 , A61K31/416
CPC分类号： C07D231/56
摘要： The present invention relates to novel indazole derivatives having pharmacological activity, processes for their preparation, compositions containing them and uses of these compounds in the treatment of estrogen receptor beta mediated diseases.
摘要翻译：本发明涉及具有药理学活性的新的吲唑衍生物，其制备方法，含有它们的组合物以及这些化合物在治疗雌激素受体β介导的疾病中的用途。

5. 发明申请

US20100324106A1 COMPOUNDS 失效
标题翻译：化合物
公开(公告)号：US20100324106A1
公开(公告)日：2010-12-23
申请号：US12864933
申请日：2009-02-17
申请人： Christopher Norbert Johnson , David G. Jones , Xi Liang , David Timothy Macpherson , Aaron B. Miller , Steven James Stanway , Andrew Kenneth Takle , Giancarlo Trani , Antoinette Wilson
发明人： Christopher Norbert Johnson , David G. Jones , Xi Liang , David Timothy Macpherson , Aaron B. Miller , Steven James Stanway , Andrew Kenneth Takle , Giancarlo Trani , Antoinette Wilson
IPC分类号： A61K31/404 , C07D209/12 , A61P9/00 , A61P29/00 , A61P35/00 , A61P25/00 , A61P3/00 , A61P3/04
CPC分类号： C07D209/08
摘要： The present invention relates to novel indole derivatives having pharmacological activity, processes for their preparation, compositions containing them and the use of these compounds in the treatment of estrogen receptor beta mediated diseases.
摘要翻译：本发明涉及具有药理活性的新型吲哚衍生物，其制备方法，含有它们的组合物以及这些化合物在治疗雌激素受体β介导的疾病中的用途。

6. 发明授权

US4544307A Drilling jig for flathead screw pilot holes 失效
标题翻译：平头螺钉导向孔钻孔夹具
公开(公告)号：US4544307A
公开(公告)日：1985-10-01
申请号：US499435
申请日：1983-05-31
申请人： Aaron B. Miller
发明人： Aaron B. Miller
IPC分类号： B23B47/28 , B23B49/02
CPC分类号： B23B47/28 , Y10T408/55 , Y10T408/56245 , Y10T408/568 , Y10T408/569
摘要： In its preferred embodiment this jig is a rigid foam plastic casting specific to a particular type of workpiece. It enables accurate fastening of workpiece to external structure with flathead screws. Each such workpiece has a plurality of countersunk orifices of identical size and distribution pattern. Jig and workpiece are of general rectangular plan, the jig thick enough to allow for integral functional guide holes. Jig is fitted to workpiece and the associated two held against an external structure while pilot holes are drilled into the structure through the jig guide holes centered with respect to the workpiece orifices. Proper orientation of jig to workpiece is obtained and maintained by a plurality of truncated conical protuberances on the jig extending from one of its two major parallel surfaces. These protuberances are complementary in shape and distribution pattern to the countersunk orifices of the workpiece. When protuberances are severally and simultaneously fitted into orifices, that surface of the jig from which the protuberances extend will be juxtaposed and common to that surface of the workpiece exhibiting contersunk recesses. This insures proper orientation and inherent stability during drilling of pilot holes. Where the jig substance permits, grooves are provided to allow breaking cleanly into several parts, if desired, each part constituting one jig with one protuberance.
摘要翻译：在其优选实施例中，该夹具是特定于特定类型的工件的刚性泡沫塑料铸件。它可以使用平头螺钉将工件精确地紧固到外部结构。每个这样的工件具有多个相同尺寸和分布图案的沉头孔。夹具和工件具有一般矩形平面图，夹具厚度足以允许整体功能导向孔。夹具安装在工件上，相关的两个固定在一个外部结构上，而导向孔通过相对于工件孔中心的夹具导向孔钻进结构中。通过夹具从其两个主平行表面之一延伸的夹具上的多个截锥形突起获得并维持夹具对工件的正确取向。这些突起在形状和分布方式上与工件的沉孔相互补充。当突起分别同时装配到孔中时，突起延伸的夹具的表面将并列并且表现为表现出锥形凹槽的工件的表面。这样可确保钻孔过程中导向孔的正确定位和固有的稳定性。在夹具物质允许的情况下，设置槽以允许破碎成几个部分，如果需要，每个部件构成一个具有一个突起的夹具。

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