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1. 发明申请

US20160178648A1 MARKER FOR DETECTING PROLIFERATION AND TREATMENT CAPACITIES OF ADIPOSE-DERIVED STEM CELL CULTURED IN MEDIUM CONTAINING EGF OR BFGF, AND USE THEREOF 有权
标题翻译：检测在含有EGF或BFGF的培养基中培养的ADIPOSE衍生的干细胞的增殖和治疗能力的标记及其用途
公开(公告)号：US20160178648A1
公开(公告)日：2016-06-23
申请号：US14758710
申请日：2014-06-11
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , ANTEROGEN CO., LTD.
发明人： Kyung Sook CHUNG , Mi Hyung KIM
IPC分类号： G01N33/74 , C12Q1/68
CPC分类号： G01N33/74 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , G01N2333/726 , G01N2500/10
摘要： The present invention relates to: a composition for detecting a marker for detecting the proliferation capacity or treatment capacity of adipose-derived stem cells cultured in a medium containing epidermal growth factor (EGF) or basic fibroblast growth factor (bFGF); and a detection method.
摘要翻译：本发明涉及：用于检测在含有表皮生长因子（EGF）或碱性成纤维细胞生长因子（bFGF）的培养基中培养的脂肪来源的干细胞的增殖能力或治疗能力的标记物的检测用组合物。和检测方法。

2. 发明授权

US09874574B2 Marker for detecting proliferation and treatment capacities of adipose-derived stem cell cultured in medium containing EGF or BFGF, and use thereof 有权
公开(公告)号：US09874574B2
公开(公告)日：2018-01-23
申请号：US14758710
申请日：2014-06-11
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , ANTEROGEN CO. LTD.
发明人： Kyung Sook Chung , Mi Hyung Kim
IPC分类号： C12Q1/68 , G01N33/74
CPC分类号： G01N33/74 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , G01N2333/726 , G01N2500/10
摘要： The present invention relates to: a composition for detecting a marker for detecting the proliferation capacity or treatment capacity of adipose-derived stem cells cultured in a medium containing epidermal growth factor (EGF) or basic fibroblast growth factor (bFGF); and a detection method.

3. 发明申请

US20150376573A1 AUTOLOGOUS AND ALLOGENIC ADIPOSE-DERIVED STROMAL STEM CELL COMPOSITION FOR TREATING FISTULAS 审中-公开
标题翻译：自动和同种异体衍生的结构干细胞组合物
公开(公告)号：US20150376573A1
公开(公告)日：2015-12-31
申请号：US14850679
申请日：2015-09-10
申请人： ANTEROGEN CO., LTD.
发明人： Sung-Koo LEE , Mi-Hyung KIM
IPC分类号： C12N5/0775 , A61K35/28
CPC分类号： C12N5/0667 , A61K35/12 , A61K35/28 , C12N2501/115
摘要： The present invention relates to a method for producing clinically effective quantities of human adipose tissue-derived stromal cells for treating fistulas and a composition made with the same. The method of the present invention can efficiently produce clinically effective number of adipose tissue-derived stromal cells within a short period by improving conventional standard culturing methods. The adipose stem cells composition containing the adipose tissue-derived stromal cells obtained by the method of the present invention exhibit superior multipotency and immunomodulatory activity over those of a cell composition produced by conventional methods, and thus is more suitable for treating fistulas. The cell composition of the present invention has excellent clinical usages especially since immune response is suppressed in allogenic adipose-derived stem cells.
摘要翻译：本发明涉及一种临床有效量的用于治疗瘘的人体脂肪组织来源的基质细胞的方法及其制备的组合物。本发明的方法可以通过改进常规的标准培养方法在短时间内有效地产生临床有效数量的脂肪组织来源的基质细胞。含有通过本发明方法获得的脂肪组织来源的基质细胞的脂肪干细胞组合物与通过常规方法制备的细胞组合物相比具有优异的多能性和免疫调节活性，因此更适合于治疗瘘。本发明的细胞组合物具有优异的临床用途，特别是因为在同种异体脂肪干细胞中免疫应答被抑制。

4. 发明授权

US11945833B2 Prodrugs of L-BHDU and methods of treating viral infections 有权
公开(公告)号：US11945833B2
公开(公告)日：2024-04-02
申请号：US17976407
申请日：2022-10-28
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , Anterogen Co., Ltd
发明人： Uma Sharan Singh , Chung Chu
IPC分类号： C07F9/6558 , A61K31/675 , A61K45/06 , A61P31/22
CPC分类号： C07F9/65586 , A61K31/675 , A61K45/06 , A61P31/22
摘要： In an embodiment, the invention is directed to prodrug compounds of L-BHDU according to the chemical structure I:

Where R1 is a —(CH2)n—O—R1a group or a —(CH2)j—O—C(O)Ok—R2a group;
R2 is H, a —(CH2)n—O—R1a group or a —(CH2)j—O—C(O)Ok—R2a group;
R1a is independently a C6-C30 alkyl group, often a C12-C22 alkyl group, often a C14-C20 alkyl group or a C16-C18 alkyl group, often a C16 or C18 alkyl group;
R2a is independently a C1-C12 alkyl group, often a C2-C6 alkyl group, a C3-C4 alkyl group, an isopropyl, t-butyl or sec-butyl group, or an isopropyl or t-butyl group;
Each j is independently 1-6, 1-3, often 1 or 2;
Each k is 0 or 1;
Each n is independently 1-6, 1-4, 2-4 or 2 or 3; or
A pharmaceutically acceptable salt, solute or polymorph thereof. Additional embodiments are directed to pharmaceutical compositions based upon the disclosed chemical compounds and methods of treating or reducing the likelihood of VZV, HSV-1 or HSV-2 infections. Methods of synthesizing compounds according to the present invention represent further embodiments of the invention.

5. 发明公开

US20230405180A1 MESENCHYMAL STEM CELL-HYDROGEL-BIODEGRADABLE OR MESENCHYMAL STEM CELL-HYDROGEL-UNDEGRADABLE SUPPORT COMPOSITION FOR SKIN REGENERATION OR WOUND HEALING 审中-公开
公开(公告)号：US20230405180A1
公开(公告)日：2023-12-21
申请号：US18158215
申请日：2023-01-23
申请人： ANTEROGEN CO., LTD.
发明人： Sung-Koo LEE , Mihyung KIM , Inok KIM
IPC分类号： A61L26/00 , A61L15/40 , A61L27/52 , A61L27/38 , A61L27/60 , A61K35/28 , C12N5/0775
CPC分类号： A61L26/008 , C12N2533/56 , A61L27/52 , A61L27/3834 , A61L27/60 , A61K35/28 , A61L26/0052 , A61L26/0057 , C12N5/0667 , C12N2533/54 , C12N2533/78 , C12N2533/80 , A61L2300/412 , A61L2300/64 , C12N2533/30 , A61L15/40
摘要： The present invention relates to a composition comprising mesenchymal stem cell-hydrogel-biodegradable support or mesenchymal stem cell-hydrogel-undegradable support, a sheet comprising the composition and a method for the preparation thereof. By using the sheet comprising the adipose-derived mesenchymal stem cell-hydrogel biodegradable or undegradable support, stem cells of high activity may be applied directly to the wound without isolation process using protease. The sheet has extracellular matrices such as collagen, laminin, fibronectin and elastin secreted by stem cells in the culture stage and included completely in the hydrogel, and therefore it has superior skin regeneration and wound healing effects compared with conventional pharmaceutical preparations and shortens therapeutic period.

6. 发明公开

US20230167143A1 PRODRUGS OF L-BHDU AND METHODS OF TREATING VIRAL INFECTIONS 审中-公开
公开(公告)号：US20230167143A1
公开(公告)日：2023-06-01
申请号：US17976407
申请日：2022-10-28
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , Anterogen Co., Ltd
发明人： Uma Sharan Singh , Chung Chu
IPC分类号： C07F9/6558 , A61K31/675 , A61K45/06 , A61P31/22
CPC分类号： C07F9/65586 , A61K31/675 , A61K45/06 , A61P31/22
摘要： In an embodiment, the invention is directed to prodrug compounds of L-BHDU according to the chemical structure I:

Where R1 is a —(CH2)n—O—R1a group or a —(CH2)j—O—C(O)Ok—R2a group;

R2 is H, a —(CH2)n—O—R1a group or a —(CH2)j—O—C(O)Ok—R2a group;

R1a is independently a C6-C30 alkyl group, often a C12-C22 alkyl group, often a C14-C20 alkyl group or a C16-C18 alkyl group, often a C16 or C18 alkyl group;

R2a is independently a C1-C12 alkyl group, often a C2-C6 alkyl group, a C3-C4 alkyl group, an isopropyl, t-butyl or sec-butyl group, or an isopropyl or t-butyl group;

Each j is independently 1-6, 1-3, often 1 or 2;

Each k is 0 or 1;

Each n is independently 1-6, 1-4, 2-4 or 2 or 3; or

A pharmaceutically acceptable salt, solute or polymorph thereof. Additional embodiments are directed to pharmaceutical compositions based upon the disclosed chemical compounds and methods of treating or reducing the likelihood of VZV, HSV-1 or HSV-2 infections. Methods of synthesizing compounds according to the present invention represent further embodiments of the invention.

7. 发明申请

US20220175666A1 INJECTION FORMULATION COMPOSITION CONTAINING MESENCHYMAL STEM CELL-HYDROGEL AND METHOD FOR PREPARING, FREEZING AND DEFROSTING SAME 有权
公开(公告)号：US20220175666A1
公开(公告)日：2022-06-09
申请号：US17437306
申请日：2020-03-20
申请人： ANTEROGEN CO., LTD.
发明人： Sung-Koo LEE , Mi-Hyung KIM
IPC分类号： A61K9/00 , A61K35/28 , A61K9/16 , A61P19/02 , A61P29/00 , C12N11/04
摘要： The present invention relates to a composition containing injectable mesenchymal stem cell-hydrogel and a method of preparing the same. Specifically, in a mesenchymal stem cell-hydrogel composition for injection prepared by a method of the present invention, since stem cells are attached to scaffolds in hydrogel beads, the stem cells are not easily lost or killed after the injection, and thus there is an advantage that an engraftment rate increases since the paracrine effect of the stem cells is continuously exhibited, and the stem cells are gradually released as hydrogel is degraded. In addition, the present invention has an advantage that healthy cells can be used without damages in cell membranes since injection formulation can be prepared without a treatment with proteolytic enzymes, and also a cryopreservation solution is easily removed from the mesenchymal stem cell-hydrogel beads even after freezing and thawing.

8. 发明公开

US20240199662A1 PRODRUGS OF L-BHDU AND METHODS OF TREATING VIRAL INFECTIONS 审中-公开
公开(公告)号：US20240199662A1
公开(公告)日：2024-06-20
申请号：US18435109
申请日：2024-02-07
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , Anterogen Co., Ltd.
发明人： Uma Sharan Singh , Chung Chu
IPC分类号： C07F9/6558 , A61K31/675 , A61K45/06 , A61P31/22
CPC分类号： C07F9/65586 , A61K31/675 , A61K45/06 , A61P31/22
摘要： In an embodiment, the invention is directed to prodrug compounds of L-BHDU according to the chemical structure I:

Where R1 is a —(CH2)n—O—R1a group or a —(CH2)j—O—C(O)Ok—R2a group;
R2 is H, a —(CH2)n—O—R1a group or a —(CH2)j—O—C(O)Ok— R2a group;
R1a is independently a C6-C30alkyl group, often a C12-C22 alkyl group, often a C14-C20 alkyl group or a C16-C18 alkyl group, often a C16 or C18 alkyl group;
R2a is independently a C1-C12 alkyl group, often a C2-C6 alkyl group, a C3-C4 alkyl group, an isopropyl, t-butyl or sec-butyl group, or an isopropyl or t-butyl group;
Each j is independently 1-6, 1-3, often 1 or 2;
Each k is 0 or 1;
Each n is independently 1-6, 1-4, 2-4 or 2 or 3; or
A pharmaceutically acceptable salt, solute or polymorph thereof. Additional embodiments are directed to pharmaceutical compositions based upon the disclosed chemical compounds and methods of treating or reducing the likelihood of VZV, HSV-1 or HSV-2 infections. Methods of synthesizing compounds according to the present invention represent further embodiments of the invention.

9. 发明申请

US20220378982A1 MESENCHYMAL STEM CELLS-HYDROGEL-BIODEGRADABLE OR MESENCHYMAL STEM CELLS-HYDROGEL-NONDEGRADABLE SUPPORT COMPOSITION FOR ALLEVIATING OR IMPROVING EPIDERMOLYSIS BULLOSA 有权
公开(公告)号：US20220378982A1
公开(公告)日：2022-12-01
申请号：US17819220
申请日：2022-08-11
申请人： ANTEROGEN CO., LTD.
发明人： Sung-Koo LEE , Mihyung KIM
IPC分类号： A61L27/38 , A61K9/70 , A61K9/00 , A61P17/00 , A61K38/39 , A61K47/30 , A61L27/52 , A61L27/54 , C12N5/00 , C12N5/071 , C12N5/0775
摘要： Provided are a composition and a sheet, including a mesenchymal stem cells-hydrogel-biodegradable support or a mesenchymal stem cells-hydrogel-nondegradable support and a preparing method thereof. More specifically, in the sheet including a mesenchymal stem cells-hydrogel-biodegradable support or a mesenchymal stem cells-hydrogel-nondegradable support according to the present invention, the high-active mesenchymal stem cells may be applied to a wounded part of a patient with epidermolysis bullosa as it is without isolation using proteases, and in the culturing, an extracellular matrix such as collagen, laminin, fibronectin, and elastin secreted from the mesenchymal stem cells is wholly present on the hydrogel to have an advantageous effect that skin reproduction and re-epithelization abilities are significantly excellent as compared with conventional dressing agents used for epidermolysis bullosa.

10. 发明申请

US20180117217A1 MESENCHYMAL STEM CELLS-HYDROGEL-BIODEGRADABLE OR MESENCHYMAL STEM CELLS-HYDROGEL-NONDEGRADABLE SUPPORT COMPOSITION FOR ALLEVIATING OR IMPROVING EPIDERMOLYSIS BULLOSA 审中-公开
公开(公告)号：US20180117217A1
公开(公告)日：2018-05-03
申请号：US15803132
申请日：2017-11-03
申请人： ANTEROGEN CO., LTD
发明人： Sung-Koo LEE , Mihyung KIM
IPC分类号： A61L27/38 , C12N5/0775 , A61K38/39 , A61K47/30 , A61L27/52 , C12N5/071 , C12N5/00 , A61P17/00 , A61L27/54
CPC分类号： A61L27/3813 , A61K9/0014 , A61K9/70 , A61K38/39 , A61K47/30 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L2300/20 , A61L2300/64 , A61P17/00 , C12N5/0062 , C12N5/0068 , C12N5/0625 , C12N5/0665
摘要： Provided are a composition and a sheet, including a mesenchymal stem cells-hydrogel-biodegradable support or a mesenchymal stem cells-hydrogel-nondegradable support and a preparing method thereof. More specifically, in the sheet including a mesenchymal stem cells-hydrogel-biodegradable support or a mesenchymal stem cells-hydrogel-nondegradable support according to the present invention, the high-active mesenchymal stem cells may be applied to a wounded part of a patient with epidermolysis bullosa as it is without isolation using proteases, and in the culturing, an extracellular matrix such as collagen, laminin, fibronectin, and elastin secreted from the mesenchymal stem cells is wholly present on the hydrogel to have an advantageous effect that skin reproduction and re-epithelization abilities are significantly excellent as compared with conventional dressing agents used for epidermolysis bullosa.

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