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1. 发明申请

US20180221392A1 PAIN-KILLING COMPOSITION COMPRISING A SALICYLIC ACID DERIVATIVE 审中-公开
公开(公告)号：US20180221392A1
公开(公告)日：2018-08-09
申请号：US15749348
申请日：2016-08-09
申请人： AB7 INNOVATION S.A.S.U
发明人： Rene CHELLE
IPC分类号： A61K31/618 , A61K9/00 , A61K47/32 , A61K36/45 , A61P29/00 , A61P19/02 , A61K36/53 , A61K31/35 , A61K47/34
CPC分类号： A61K31/618 , A01K13/003 , A61K9/0017 , A61K31/35 , A61K31/352 , A61K36/23 , A61K36/45 , A61K36/53 , A61K36/534 , A61K36/899 , A61K47/32 , A61K47/34 , A61P19/02 , A61P29/00 , A61K2300/00
摘要： The subject-matter of the present invention is the use of a therapeutic composition comprising, in an applying carrier, at least one essential oil for relieving muscle and/or joint pain in an animal subject, wherein said composition topically treats an area of the skin of said subject, characterized in that said composition comprises methyl salicylate, which constitutes, with at least one essential oil of the composition containing same in only a small amount or not at all, an active agent within which the rate of transport of the methyl salicylate through the skin is increased by virtue of the oil, which is an essential oil.

2. 发明授权

US09669100B2 Polymer support for the distribution of a naturally crystalline substance and production method 有权
公开(公告)号：US09669100B2
公开(公告)日：2017-06-06
申请号：US14767707
申请日：2014-02-10
申请人： AB7 INNOVATION S.A.S.U.
发明人： Rene Chelle , Arnaud Vilbert
IPC分类号： A61K47/34 , A61K31/522 , A01N25/10 , A01N25/34 , A01N53/00 , A01K27/00 , C08J3/205
CPC分类号： A61K47/34 , A01K27/007 , A01N25/10 , A01N25/34 , A01N53/00 , A61K31/522 , C08J3/2053 , C08J2375/08 , C08J2377/00 , A01N25/02
摘要： The invention relates to the implementation of a method for loading, without a vehicle, a naturally crystalline substance solubilized by a solvent mixture in a lipophilic medium in a mixture of granulated polymers, for forming, without a plasticizer, a polymer support for the long-term controlled distribution of the naturally crystalline substance in the stable solubilized state, without permanent crystallization on the surface of said support. Said substance according to the invention can be insecticides and pesticides of the group of pyrethroids (e.g. deltamethrin), formamidines (e.g. amitraz) and carbamates (e.g. propoxur), or the mixture thereof, or cosmetics of the group of alkaloids (e.g. caffeine), or medicaments (e.g. ibuprofen). The permanent non-crystallization state on the surface of the polymer support is only ensured when said substance is solubilized in the solvent mixture consisting of an oxygenated solvent of dibasic esters of methylenic fatty acids and an oxygenated methylenic cosolvent in an active lipophilic solution incorporated into a polymer mixture consisting of a polyether block amide (PEBA) and a thermoplastic polyurethane elastomer (TPU). Said support can be shaped as a collar, as an ear tag for animals, a band, a patch, a tag, a polymer block or any other device for the distribution of the active substances. It is shaped by any one of the plastic processing techniques known by a person skilled in the art. It is advantageous in that it is loaded with a quantity of active substance of between 30% and 50% less than the previous devices for at least the same active efficiency.

3. 发明授权

US11382313B2 Collar tightening structure 有权
公开(公告)号：US11382313B2
公开(公告)日：2022-07-12
申请号：US16759558
申请日：2018-10-22
申请人： AB7 Innovation S.A.S.U.
发明人： René Chelle , Arnaud Vilbert , Giovanni Chabot
IPC分类号： A01K27/00 , A44B11/22
摘要： The present invention relates to a collar (1) for pets, the collar (1) comprising a tightening structure consisting of a buckle (2) having a first projecting structure (21) formed longitudinally on the top (23a) and a second projecting structure 22a formed transversely to the center of the bottom (23b) of the buckle (2), the first and second projecting structures (21, 22a) facing one another without touching.

4. 发明申请

US20200206994A1 MULTIPLE-MATRIX MONOLITHIC MOULDED PART FOR THE DIFFUSION OF ACTIVE INGREDIENTS AND METHOD FOR OBTAINING SAME 审中-公开
公开(公告)号：US20200206994A1
公开(公告)日：2020-07-02
申请号：US16643278
申请日：2018-08-24
申请人： AB7 Innovation S.A.S.U
发明人： René CHELLE , Arnaud VILBERT , Sophie LECLERC
IPC分类号： B29C45/16 , A01N25/34 , A01N25/10 , A01N25/24 , A61L9/04 , A61L9/12
摘要： This invention relates to a monolithic molded part comprising multiple cohesive matrices for the simultaneous diffusion of volatile active ingredients, in contact or separately, wherein said multiple matrix is formed by the combination of several simple matrices, characterized in that each of said simple matrices is capable of containing one or more active ingredient(s), each active ingredient having its own release kinetics.

5. 发明申请

US20170224631A1 MONOPOLYMER MULTIFUNCTIONAL SEQUENCED CAST POLYURETHANE MATRIX AND PRODUCTION THEREOF 审中-公开
公开(公告)号：US20170224631A1
公开(公告)日：2017-08-10
申请号：US15497871
申请日：2017-04-26
申请人： AB7 INNOVATION S.A.S.U.
发明人： Aurelie ALBA , Arnaud VILBERT , Rene CHELLE
IPC分类号： A61K9/70 , A61M37/00 , C11B9/00 , A43B1/00 , A01N25/24 , A01N25/10
CPC分类号： A61K9/7092 , A01N25/10 , A01N25/24 , A43B1/0045 , A43B7/1455 , A61K9/7069 , A61K9/7084 , A61M37/00 , B29C39/003 , B29K2029/04 , B29K2075/00 , B29L2009/00 , C08G18/4829 , C08G18/7671 , C09J175/04 , C09J2475/00 , C11B9/00
摘要： The invention relates to a monopolymer multifunctional sequenced cast polyurethane matrix produced simply and efficiently, by sequentially pouring various isocyanate/polyol complex phase solutions successively into a mould with alternating solidification of said phase solutions according to a defined order and respecting the polymerisation stage (after the pot life and before the demolding time) of the sequence preceding the one being cast, so as to end with the casting of the last phase solution that will go up to the demolding time thereof and thereby finish the polymerisation of the whole of the matrix. It is loaded, in its “reservoir” sequences, with naturally originating or synthesised transdermally penetrating or volatile active substances. They are medicating and therapeutic, cosmetic, phytosanitary or wellness substances, repellents, attractants, pheromones, biocides, perfumes or deodorants. At least two active substances can be loaded into the same matrix in order to act unidirectionally or in opposite directions. Said matrix is used to form different devices that adhere to the skin or any other surface, in order to deliver at least one substance in a controlled manner. Said devices are patches, patches with a plurality of active substances, replaceable plasters stuck to a textile support, active heel pads and ball pads for shoes, pheromone cards for controlling insects, self-adhesive insecticide attractant cards, or other devices equivalent in terms of structure and function.

6. 发明申请

US20150374829A1 POLYMER SUPPORT FOR THE DISTRIBUTION OF A NATURALLY CRYSTALLINE SUBSTANCE AND PRODUCTION METHOD 有权
标题翻译：用于分配自然晶体物质和生产方法的聚合物支持
公开(公告)号：US20150374829A1
公开(公告)日：2015-12-31
申请号：US14767707
申请日：2014-02-10
申请人： AB7 INNOVATION S.A.S.U
发明人： Rene CHELLE , Arnaud VILBERT
IPC分类号： A61K47/34 , A61K31/522 , A01N25/10 , A01N53/00
CPC分类号： A61K47/34 , A01K27/007 , A01N25/10 , A01N25/34 , A01N53/00 , A61K31/522 , C08J3/2053 , C08J2375/08 , C08J2377/00 , A01N25/02
摘要： The invention relates to the implementation of a method for loading, without a vehicle, a naturally crystalline substance solubilised by a solvent mixture in a lipophilic medium in a mixture of granulated polymers, for forming, without a plasticiser, a polymer support for the long-term controlled distribution of the naturally crystalline substance in the stable solubilised state, without permanent crystallisation on the surface of said support. Said substance according to the invention can be insecticides and pesticides of the group of pyrethroids (e.g. deltamethrin), formamidines (e.g. amitraz) and carbamates (e.g. propoxur), or the mixture thereof, or cosmetics of the group of alkaloids (e.g. caffeine), or medicaments (e.g. ibuprofen). The permanent non-crystallisation state on the surface of the polymer support is only ensured when said substance is solubilised in the solvent mixture consisting of an oxygenated solvent of dibasic esters of methylenic fatty acids and an oxygenated methylenic cosolvent in an active lipophilic solution incorporated into a polymer mixture consisting of a polyether block amide (PEBA) and a thermoplastic polyurethane elastomer (TPU). Said support can be shaped as a collar, as an ear tag for animals, a band, a patch, a tag, a polymer block or any other device for the distribution of the active substances. It is shaped by any one of the plastic processing techniques known by a person skilled in the art. It is advantageous in that it is loaded with a quantity of active substance of between 30% and 50% less than the previous devices for at least the same active efficiency.
摘要翻译：本发明涉及一种用于在没有载体的情况下将在溶剂混合物中溶解的颗粒状聚合物的混合物中的亲脂性介质中加载的天然结晶物质的方法的实施，用于在没有增塑剂的情况下形成长链聚合物的聚合物载体，天然结晶物质在稳定的溶解状态下的长期受控分布，而不会在所述载体的表面上持续结晶。根据本发明的所述物质可以是拟除虫菊酯类（例如溴氰菊酯），甲酰胺（例如氨基甲酰胺）和氨基甲酸酯（例如丙氧基）或其混合物的组合物的杀虫剂和农药，或生物碱（例如咖啡因）组的化妆品，或药物（如布洛芬）。只有当所述物质溶解在由亚甲基脂肪酸的二元酯的含氧溶剂和含氧的亚甲基共溶剂组成的溶剂混合物中时，才能确保聚合物载体表面上的永久非结晶状态，由聚醚嵌段酰胺（PEBA）和热塑性聚氨酯弹性体（TPU）组成的聚合物混合物。所述支撑体可以形成为颈圈，作为用于动物的耳标，带，贴片，标签，聚合物块或用于分配活性物质的任何其它装置。它由本领域技术人员已知的任何一种塑料加工技术成形。有利的是，为了至少相同的活性效率，其装载的活性物质的量比先前的装置小30％至50％。

7. 发明授权

US11045483B2 Pain-killing composition comprising a salicylic acid derivative 有权
公开(公告)号：US11045483B2
公开(公告)日：2021-06-29
申请号：US15749348
申请日：2016-08-09
申请人： AB7 INNOVATION S.A.S.U
发明人： Rene Chelle
IPC分类号： A61K31/618 , A61K36/45 , A61K36/53 , A61K47/32 , A61K47/34 , A61K9/00 , A61K31/352 , A01K13/00 , A61K36/534 , A61K36/899 , A61K36/23 , A61P19/02 , A61P29/00 , A61K31/35
摘要： The subject-matter of the present invention is the use of a therapeutic composition comprising, in an applying carrier, at least one essential oil for relieving muscle and/or joint pain in an animal subject, wherein said composition topically treats an area of the skin of said subject, characterized in that said composition comprises methyl salicylate, which constitutes, with at least one essential oil of the composition containing same in only a small amount or not at all, an active agent within which the rate of transport of the methyl salicylate through the skin is increased by virtue of the oil, which is an essential oil.

8. 发明申请

US20190194456A1 POLYAMIDE HOT-MELT RESIN GRANULES LOADED WITH ACTIVE INGREDIENTS 审中-公开
公开(公告)号：US20190194456A1
公开(公告)日：2019-06-27
申请号：US16221053
申请日：2018-12-14
申请人： AB7 INNOVATION S.A.S.U.
发明人： René Chelle , David Nguyen , Arnaud Vilbert
IPC分类号： C08L77/06 , C08K5/092 , C08K5/20 , C08K5/00 , C08K5/02 , C08K5/3432 , C08K5/49 , C08G69/34 , C09J177/08
CPC分类号： C08L77/06 , A01N25/10 , C08G69/34 , C08K5/0058 , C08K5/02 , C08K5/092 , C08K5/20 , C08K5/3432 , C08K5/49 , C09J177/08
摘要： The present document describes a polyamide hot-melt resin having a chemical structure consisting of dimerized fatty acids and diamines, loaded with an active ingredient. The dimerized fatty acids may have 12 to 24 carbons and the diamines may have 2 to 14 carbons. The amine residual functional groups and acid residual functional groups within the polyamide hot-melt resin may have a [NH2]/[COOH] molar ratio below 5, and the active ingredient may be incorporated in quantities of between about 0.01 and about 55% by weight of weight of the resin. The present document also describes items molded from the polyamide hot-melt resins, and processes of preparing the polyamide hot-melt resins.

9. 发明申请

US20180132470A1 CONTROLLED STAND-ALONE MATRIX SYSTEM FOR THE CONTROLLED DISTRIBUTION OF ACTIVE SUBSTANCES 审中-公开
公开(公告)号：US20180132470A1
公开(公告)日：2018-05-17
申请号：US15564380
申请日：2016-04-08
申请人： AB7 Innovation S.A.S.U.
发明人： René CHELLE , David NGUYEN , Arnaud VILBERT , Sylvain AUGIER
IPC分类号： A01M1/20 , A61L9/03 , A01N25/10 , A01N25/18
CPC分类号： A01M1/2077 , A01N25/10 , A01N25/18 , A61L9/03 , A01N31/06 , A01N37/46 , A01N51/00 , A01N53/00 , A01N65/00 , A01N65/22 , A01N65/40
摘要： The invention relates to a controlled stand-alone matrix system (1) for the controlled and variable distribution of at least one active substance solely at precise appropriate moments, characterised in that it comprises a polymer matrix (2) loaded with the active substance, at least one heating element (4) embedded in the loaded matrix (2), and an electricity generator (5) connected to an electronic control card in turn connected to the heating element (4), the electricity supplied to same by the generator (5) being controlled by the card which is housed in an electronic box (3).

10. 发明授权

US11084926B2 Polyamide hot-melt resin granules loaded with active ingredients 有权
公开(公告)号：US11084926B2
公开(公告)日：2021-08-10
申请号：US16221053
申请日：2018-12-14
申请人： AB7 INNOVATION S.A.S.U.
发明人： René Chelle , David Nguyen , Arnaud Vilbert
IPC分类号： C08L77/06 , C08K5/092 , C08K5/20 , C08K5/00 , A01N25/10 , C08K5/3432 , C08K5/49 , C08G69/34 , C09J177/08 , C08K5/02 , C08L77/08 , C08K11/00
摘要： The present document describes a polyamide hot-melt resin having a chemical structure consisting of dimerized fatty acids and diamines, loaded with an active ingredient. The dimerized fatty acids may have 12 to 24 carbons and the diamines may have 2 to 14 carbons. The amine residual functional groups and acid residual functional groups within the polyamide hot-melt resin may have a [NH2]/[COOH] molar ratio below 5, and the active ingredient may be incorporated in quantities of between about 0.01 and about 55% by weight of weight of the resin. The present document also describes items molded from the polyamide hot-melt resins, and processes of preparing the polyamide hot-melt resins.

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