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1. 发明授权

US06858440B1 Tapered tubular optical waveguide probe for magnetic focusing immunosensors 失效
标题翻译：用于磁聚焦免疫传感器的锥形管状光波导探针
公开(公告)号：US06858440B1
公开(公告)日：2005-02-22
申请号：US10285954
申请日：2002-11-01
申请人： Stephen Letcher , He Cao , Hazem Baqaen , A. Garth Rand
发明人： Stephen Letcher , He Cao , Hazem Baqaen , A. Garth Rand
IPC分类号： G01N21/64 , G01N33/553
CPC分类号： G01N21/645 , G01N21/6428 , G01N2021/6417 , G01N2021/6484
摘要： A waveguide probe for the detection of pathogens in a sample which comprises a laser, a first and a second tubes that converge at a point to form a proximal end. A magnet is positioned in the end to configure to focus paramagnetic microspheres attached to antigen/antibody/optically labeled antibody complexes in the field of view. The proximal end is polished to form an aperture.
摘要翻译：一种用于检测样品中的病原体的波导探针，其包括激光，在一点收敛以形成近端的第一和第二管。将磁体定位在末端以配置为在视野中聚焦附着于抗原/抗体/光学标记的抗体复合物的顺磁性微球。近端被抛光以形成孔。

2. 发明授权

US06645777B1 Tapered tubular optical waveguide probe for magnetic focusing immunosensors 失效
标题翻译：用于磁聚焦免疫传感器的锥形管状光波导探针
公开(公告)号：US06645777B1
公开(公告)日：2003-11-11
申请号：US09859685
申请日：2001-05-17
申请人： Stephen Letcher , He Cao , Hazem Baqaen , A. Garth Rand
发明人： Stephen Letcher , He Cao , Hazem Baqaen , A. Garth Rand
IPC分类号： G01N33553
CPC分类号： G01N21/645 , G01N21/6428 , G01N2021/6417 , G01N2021/6484
摘要： A waveguide probe for the detection of pathogens in a sample which comprises a laser, a first and a second tubes that converge at a point to form a proximal end. A magnet is positioned in the end to configure to focus paramagnetic microspheres attached to antigen/antibody/optically labeled antibody complexes in the field of view. The proximal end is polished to form an aperture.
摘要翻译：一种用于检测样品中的病原体的波导探针，其包括激光，在一点收敛以形成近端的第一和第二管。将磁体定位在末端以配置为在视野中聚焦附着于抗原/抗体/光学标记的抗体复合物的顺磁性微球。近端被抛光以形成孔。

3. 发明授权

US06326213B1 Acoustic standing-wave enhancement of a fiber-optic Salmonella biosensor 失效
标题翻译：光学沙门菌生物传感器的声波驻波增强
公开(公告)号：US06326213B1
公开(公告)日：2001-12-04
申请号：US09020434
申请日：1998-02-09
申请人： Stephen V. Letcher , A. Garth Rand , Chonghua Zhou
发明人： Stephen V. Letcher , A. Garth Rand , Chonghua Zhou
IPC分类号： G01N33543
CPC分类号： G01N33/54373 , G01N33/56916 , G01N2333/255 , Y10S435/808 , Y10S436/805
摘要： A fluorescent fiber-optic biosensor system using ultrasonic concentration of particles and cells for the detection of Salmonella typhimurium. A biosensor test chamber serves as an ultrasonic standing-wave cell that allows microspheres or cells to be concentrated in parallel layers or in a column along the axis of the cell. A fiber probe along the axis delivers laser excitation to fluorescent-labeled antibodies of Salmonella and collects the fluorescent signal. The Salmonella-antibody complexes are moved acoustically to the axis of the cell, increasing the fluorescent signal. Alternatively, the Salmonella-labelled antibody complexes attach to unlabeled antibodies that have been immobilized on the surface of polystyrene microspheres. This entire structure can be manipulated acoustically and the increase in the fluorescent signal, which can be an order of magnitude, indicates the presence of Salmonella.
摘要翻译：一种荧光光纤生物传感器系统，使用超声浓度的颗粒和细胞来检测鼠伤寒沙门氏菌。生物传感器测试室用作超声波驻波电池，其允许微球或细胞沿着电池的轴线平行地集中在一列中。沿着轴的光纤探针将激光激发发射到沙门氏菌的荧光标记抗体并收集荧光信号。沙门氏菌 - 抗体复合物在声学上移动到细胞的轴上，增加荧光信号。或者，沙门氏菌标记的抗体复合物附着到已经固定在聚苯乙烯微球表面上的未标记的抗体上。该整个结构可以在声学上被操纵，并且荧光信号的增加（其可以是一个数量级）表示沙门氏菌的存在。

4. 发明授权

US06630355B1 Magnetic focusing immunosensor for the detection of pathogens 有权
标题翻译：用于检测病原体的磁聚焦免疫传感器
公开(公告)号：US06630355B1
公开(公告)日：2003-10-07
申请号：US09753201
申请日：2001-01-02
申请人： Philip Pivarnik , He Cao , Stephen V. Letcher , A. Garth Rand
发明人： Philip Pivarnik , He Cao , Stephen V. Letcher , A. Garth Rand
IPC分类号： G01N2100
CPC分类号： G01N21/645 , G01N21/6428 , G01N2021/6417 , G01N2021/6484 , Y10S435/808 , Y10S436/80 , Y10S436/805 , Y10S436/806
摘要： A magnetic focusing immunosensor for the detection of pathogens comprising a laser, an exciting fiber and a collecting fiber, a fiber optic magnetic probe in communication with the collecting and exciting fibers and means for detecting, collecting and measuring fluorescent signals in communication with the collecting fiber. The probe and the collecting and exciting fibers are configured to focus paramagnetic microspheres attached to antigen/antibody/optically labeled complexes in a predetermined pattern in the field of view of the collecting fiber while blocking background interference.
摘要翻译：一种用于检测包括激光，激发光纤和收集光纤的病原体的磁聚焦免疫传感器，与收集和激发光纤连通的光纤磁探头和用于检测，收集和测量与收集光纤通信的荧光信号的装置。探针和收集和激发纤维被配置成在附着在抗原/抗体/光学标记的复合物上的顺磁性微球以收集纤维的视野中的预定图案聚焦，同时阻止背景干扰。

5. 发明授权

US06391653B1 Acoustic standing-wave enhancement of a fiber-optic salmonella biosensor 失效
标题翻译：光纤沙门氏杆菌生物传感器的声波驻波增强
公开(公告)号：US06391653B1
公开(公告)日：2002-05-21
申请号：US09619230
申请日：2000-07-19
申请人： Stephen V. Letcher , A. Garth Rand , Chonghua Zhou
发明人： Stephen V. Letcher , A. Garth Rand , Chonghua Zhou
IPC分类号： G01N33543
CPC分类号： G01N33/54373 , G01N33/56916 , G01N2333/255 , Y10S435/808 , Y10S436/805
摘要： A fluorescent fiber-optic biosensor system using ultrasonic concentration of particles and cells for the detection of Salmonella typhimurium. A biosensor test chamber serves as an ultrasonic standing-wave cell that allows microspheres or cells to be concentrated in parallel layers or in a column along the axis of the cell. A fiber probe along the axis delivers laser excitation to fluorescent-labeled antibodies of Salmonella and collects the fluorescent signal. The Salmonella-antibody complexes are moved acoustically to the axis of the cell, increasing the fluorescent signal. Alternatively, the Salmonella-labelled antibody complexes attach to unlabeled antibodies that have been immobilized on the surface of polystyrene microspheres. This entire structure can be manipulated acoustically and the increase in the fluorescent signal, which can be an order of magnitude, indicates the presence of Salmonella.
摘要翻译：一种荧光光纤生物传感器系统，使用超声浓度的颗粒和细胞来检测鼠伤寒沙门氏菌。生物传感器测试室用作超声波驻波电池，其允许微球或细胞沿着电池的轴线平行地集中在一列中。沿着轴的光纤探针将激光激发发射到沙门氏菌的荧光标记抗体并收集荧光信号。沙门氏菌 - 抗体复合物在声学上移动到细胞的轴上，增加荧光信号。或者，沙门氏菌标记的抗体复合物附着到已经固定在聚苯乙烯微球表面上的未标记的抗体上。该整个结构可以在声学上被操纵，并且荧光信号的增加（其可以是一个数量级）表示沙门氏菌的存在。

6. 发明授权

US06254830B1 Magnetic focusing immunosensor for the detection of pathogens 有权
标题翻译：用于检测病原体的磁聚焦免疫传感器
公开(公告)号：US06254830B1
公开(公告)日：2001-07-03
申请号：US09435081
申请日：1999-11-05
申请人： Philip Pivarnik , He Cao , Stephen V. Letcher , A. Garth Rand
发明人： Philip Pivarnik , He Cao , Stephen V. Letcher , A. Garth Rand
IPC分类号： G01N2164
CPC分类号： G01N21/645 , G01N21/6428 , G01N2021/6417 , G01N2021/6484 , Y10S435/808 , Y10S436/80 , Y10S436/805 , Y10S436/806
摘要： A magnetic focusing immunosensor for the detection of pathogens comprising a laser, an exciting fiber and a collecting fiber, a fiber optic magnetic probe in communication with the collecting and exciting fibers and means for detecting, collecting and measuring fluorescent signals in communication with the collecting fiber. The probe and the collecting and exciting fibers are configured to focus paramagnetic microspheres attached to antigen/antibody/optically labeled complexes in a predetermined pattern in the field of view of the collecting fiber while blocking background interference.
摘要翻译：一种用于检测包括激光，激发光纤和收集光纤的病原体的磁聚焦免疫传感器，与收集和激发光纤连通的光纤磁探头和用于检测，收集和测量与收集光纤通信的荧光信号的装置。探针和收集和激发纤维被配置成在附着在抗原/抗体/光学标记的复合物上的顺磁性微球以收集纤维的视野中的预定图案聚焦，同时阻止背景干扰。

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