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1. 发明授权

US12091408B2 Store overload-induced calcium release inhibitors and methods for producing and using the same 有权
公开(公告)号：US12091408B2
公开(公告)日：2024-09-17
申请号：US14915368
申请日：2014-09-27
申请人： Tom Back , Wayne Chen , Chris Smith , Dawei Jiang , UTI Limited Partnership
发明人： Tom Back , Wayne Chen , Chris Smith , Dawei Jiang
IPC分类号： C07D419/12 , C07C217/28 , C07C217/32 , C07C217/34 , C07C217/38 , C07C217/54 , C07C217/92 , C07C233/20 , C07D209/08 , C07D209/88 , C07D215/227 , C07D231/56 , C07D235/06 , C07D235/08 , C07D265/36 , C07D279/16 , C07D279/20 , C07D279/34 , C07D281/10 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/06
CPC分类号： C07D419/12 , C07C217/28 , C07C217/32 , C07C217/34 , C07C217/38 , C07C217/54 , C07C217/92 , C07C233/20 , C07D209/08 , C07D209/88 , C07D215/227 , C07D231/56 , C07D235/06 , C07D235/08 , C07D265/36 , C07D279/16 , C07D279/20 , C07D279/34 , C07D281/10 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/06 , C07C2603/18 , C07C2603/74
摘要： The present invention provides compounds having store overload-induced Ca2+ release (SOICR) inhibitory activity and methods for producing and using the same. In particular, compounds of the invention is of the formula: R1—X1-L-X2—R2, wherein R1, X1, L, X2, and R2 are those defined herein.

2. 发明授权

US12048526B2 Devices and methods of calculating and displaying continuously monitored tidal breathing flow-volume loops (TBFVL) obtained by non-invasive impedance-based respiratory volume monitoring 有权
公开(公告)号：US12048526B2
公开(公告)日：2024-07-30
申请号：US16222783
申请日：2018-12-17
申请人： Respiratory Motion, Inc.
发明人： Jordan Brayanov , Jenny Freeman , Brian Harvey , Chunyuan Qiu , Man Ching Cheung , Jasmin Imsirovic
IPC分类号： A61B5/08 , A61B5/00 , A61B5/085 , G16H40/63 , G16H50/20 , G16H50/30 , A61B5/091
CPC分类号： A61B5/0809 , A61B5/0803 , A61B5/085 , A61B5/742 , G16H40/63 , G16H50/20 , G16H50/30 , A61B5/0826 , A61B5/091
摘要： Methods and systems of displaying flow-volume loops of a patient and variability of the flow-volume loops across measured breaths are disclosed. The methods comprise obtaining a physiological dataset of the patient on a data acquisition device, applying a smoothing and curve fitting algorithm to the physiological dataset on a processing device to obtain real-time volume and flow data at a plurality of time instances, applying a visualization algorithm on the processing device to the volume and flow data to create a series of flow-volume loops based on the volume and flow data, and outputting a plot of the flow-volume loops on a display device to aid evaluation or diagnosis of the patient.

3. 发明授权

US12012415B2 Compositions and methods for the diagnosis, treatment and prevention of neoplastic and neurological disorders 有权
公开(公告)号：US12012415B2
公开(公告)日：2024-06-18
申请号：US16973119
申请日：2019-06-27
申请人： AscentGene, Inc.
发明人： Hui Ge
IPC分类号： C07D487/22 , A61K9/00 , A61K9/19 , A61K31/409 , A61K39/39 , A61P25/28 , A61P35/00
CPC分类号： C07D487/22 , A61K9/0019 , A61K9/19 , A61K39/39 , A61P25/28 , A61P35/00
摘要： The invention is directed to composition and methods for the diagnosis, treatment and prevention of various disorders including but not limited to cancer and neurological disorders. In particular, the invention is directed to compositions and methods for the inhibition of PC4.

4. 外观设计

USD1010090S1 Air filtration device 有权
公开(公告)号：USD1010090S1
公开(公告)日：2024-01-02
申请号：US29856710
申请日：2022-10-17
申请人： DSS PureAir, Inc.
设计人： Neil J. Campbell , Iyam Lynch , Michelle Campbell
摘要： FIG. 1 is a perspective view of a first embodiment of an air filtration device;
FIG. 2 is a front view thereof;
FIG. 3 is a rear view thereof;
FIG. 4 is a right side view thereof;
FIG. 5 is a left side view thereof;
FIG. 6 is a top view thereof; and,
FIG. 7 is a bottom view thereof.
The broken lines shown represent unclaimed portions of the air filtration device and form no part of the claimed design.

5. 外观设计

USD1010088S1 Air filtration stand 有权
公开(公告)号：USD1010088S1
公开(公告)日：2024-01-02
申请号：US29855882
申请日：2022-10-07
申请人： DSS PureAir, Inc.
设计人： Neil J. Campbell , Iyam Lynch , Michelle Campbell
摘要： FIG. 1 is a perspective view of a first embodiment of an air filtration stand;
FIG. 2 is a front view thereof;
FIG. 3 is a rear view thereof;
FIG. 4 is a right side view thereof;
FIG. 5 is a left side view thereof;
FIG. 6 is a top view thereof; and,
FIG. 7 is a bottom view thereof.
The broken lines shown represent unclaimed portions of the air filtration stand and form no part of the claimed design.

6. 发明授权

US11542213B2 Reactive inorganic coatings for agricultural fertilizers 有权
公开(公告)号：US11542213B2
公开(公告)日：2023-01-03
申请号：US17126461
申请日：2020-12-18
申请人： Anuvia Plant Nutrients Corporation
发明人： Sanford A. Siegel , Jeffrey C. Burnham
IPC分类号： C05G5/30 , C05F3/00 , C05F5/00 , C05D9/02 , C05G5/12
摘要： The invention relates to a coated granular fertilizer, preferably wherein granules are sulfate-based or phosphate-based. When sulfate-based granules, as in ammonium sulfate, the coating substance is an inorganic salt of alkaline earth elements, preferably calcium, such that when applied to the surface of fertilizers, forms calcium sulfate, preferably a calcium sulfate-dihydrate, as a protective coating. For a reactive coating of a thiosulfate, free sulfuric acid present on the granule reacts to provide an elemental sulfur coating. For ammonium phosphate-based granules, coatings may comprise compounds of Ca++, Al+++ and/or Fe+++ salts thereby forming a calcium, an aluminum, an iron, or mixed cation phosphate protective coating. Thiosulfate is also effective with phosphate-based granules which are manufactured with sulfuric acid. Granules coated according to the disclosure have advantageous properties as the coating can be applied in a specified and sparing manner due to its tendency to adhere to surfaces during the reaction. Coated fertilizer granules of the disclosure are also advantageous in that, with regard to the applied amount of coating, they provide increased resistance to dusting in long term warehouse storage, to moisture uptake and to oxidative heating. Coating components also add nutrients to plants that can provide nutrients over a longer period of time such as a slow-release characteristic.

7. 发明授权

US11299703B2 Portable disposable re-usable culture device for rapid diagnosis of infectious agents 有权
公开(公告)号：US11299703B2
公开(公告)日：2022-04-12
申请号：US15131338
申请日：2016-04-18
申请人： Vax-Immune, LLC
发明人： Bhairavi Parikh
IPC分类号： C12M1/34 , C12M1/36 , C12M1/00 , C12M1/26 , C12M3/06 , C12Q1/04 , C12M1/30
摘要： The present invention is directed to compositions, tools, methods and devices to culture microorganisms and, in particular, to compositions, tools, methods and devices for the detection of microorganisms in biological samples.

8. 发明授权

US11299702B2 Portable disposable re-usable culture device for rapid diagnosis of infectious agents 有权
公开(公告)号：US11299702B2
公开(公告)日：2022-04-12
申请号：US16004590
申请日：2018-06-11
申请人： Vax-Immune, LLC
发明人： Bhairavi Parikh , James Stone
IPC分类号： C12M1/34 , C12M1/00 , C12M3/00 , C12M1/02 , C12M1/30
摘要： The present invention is directed to compositions, tools, methods and devices to culture microorganisms and, in particular, to compositions, tools, methods and devices for the detection of microorganisms in biological samples.

9. 发明授权

US11272814B2 Toilet/shower combination fixture 有权
公开(公告)号：US11272814B2
公开(公告)日：2022-03-15
申请号：US17101112
申请日：2020-11-23
申请人： Wilco Partnership, LLC
发明人： Gregg Williams
IPC分类号： A47K4/00 , A47K3/28 , A47K3/34 , A47K3/32
摘要： A combination shower and toilet is disclosed. The device comprises a base, a toilet bowl extending from the base, a shower head coupled to the base, a pivoting curtain rod coupled to the base, and a shower curtain coupled to the curtain rod.

10. 发明授权

US11260422B2 System of applying a coating to a vehicle 有权
公开(公告)号：US11260422B2
公开(公告)日：2022-03-01
申请号：US16006293
申请日：2018-06-12
申请人： Ground Effects, Ltd.
发明人： Benjamin William Dollar , Michael Scott Boyko , Robert William Scott , Bradley John Pattison
IPC分类号： B05D7/14 , B05D1/06 , B32B15/04 , B05B12/20 , B25J11/00 , B05B12/00 , B05B13/00 , B25J9/00
摘要： A system of applying a coating to a vehicle in sequence with vehicle manufacture is disclosed. The vehicle may be inspected and/or logged into inventory. The vehicle may be electronically recorded into inventory using a computerized data acquisition and/or process control system. The vehicle may be prepared by an operator. The vehicle preparation may include applying masking materials to at least a portion of the vehicle. The vehicle preparation may include application of a pre-treatment to at least a portion of the vehicle. A coating may be applied to at least a portion of the vehicle. The coating may include one or more layers. The masking materials may be removed from the vehicle after the completion of the coating application. The vehicle may be electronically recorded into inventory using a data acquisition and/or process control system. The vehicle may be delivered and/or returned to the vehicle manufacturer.

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