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1. 发明授权

US08138377B2 Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use 有权
标题翻译：芳基二环[3.1.0]己胺及其制备和使用的方法和组合物
公开(公告)号：US08138377B2
公开(公告)日：2012-03-20
申请号：US11936016
申请日：2007-11-06
申请人： Phil Skolnick , Zhengming Chen , Ji Yang
发明人： Phil Skolnick , Zhengming Chen , Ji Yang
IPC分类号： C07C211/00
CPC分类号： C07C211/41 , C07C2602/18
摘要： The invention provides novel arylbicyclo[3.1.0]hexylamines, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including but not limited to depression and anxiety.
摘要翻译：本发明提供新的芳基双环[3.1.0]己胺，以及用于制备这些化合物的相关方法和中间体，以及使用这些化合物治疗和/或预防中枢神经系统（CNS）障碍的组合物和方法，包括但不限于局限于抑郁和焦虑。

2. 发明授权

US07756819B2 Integrated authoring system for electronic technical manual and paper technical manual using logistics support analysis data and authoring method therefor 有权
标题翻译：电子技术手册和纸张技术手册综合制作系统采用物流支持分析数据及其制作方法
公开(公告)号：US07756819B2
公开(公告)日：2010-07-13
申请号：US11207061
申请日：2005-08-17
申请人： Myung-Jin Jang , Byung-Jik Yoo , Kwang-Taek Lee , Hyun-Jun Ju
发明人： Myung-Jin Jang , Byung-Jik Yoo , Kwang-Taek Lee , Hyun-Jun Ju
IPC分类号： G06F17/00 , G06F7/00
CPC分类号： G06F17/30011 , G06F17/2229 , G06F17/2247 , G06F17/2288 , G06F17/24 , Y10S707/99948
摘要： Disclosed are an integrated authoring system for an electronic technical manual and a paper technical manual using logistics support analysis data, which is capable of authoring an interactive electronic technical manual (IETM) of Class IV level and a paper technical manual at the same time. The integrated authoring system for an electronic technical manual and a paper technical manual using logistics support analysis data comprises: an iCAST-LSA (intelligent computer based acquisition support tool-logistics support analysis) module; a TMM (Technical Manual Management) module for performing a technical manual management function by importing from the DB of the iCAST-LSA module or exporting to the DB of the iCAST-LSA module; an illustrated drawing manager module; and a TMA (Technical Manual Author) module for performing a manual author manager function for sending and receiving illustrated drawings (ID) or CGM data to and from the illustrated drawing manager module.
摘要翻译：披露了一个电子技术手册和纸质技术手册的综合制作系统，使用物流支持分析数据，能够同时制作IV级交互式电子技术手册（IETM）和纸质技术手册。使用物流支持分析数据的电子技术手册和纸张技术手册的综合制作系统包括：iCAST-LSA（基于智能计算机的采购支持工具 - 物流支持分析）模块; 用于通过从iCAST-LSA模块的DB导入或导出到iCAST-LSA模块的DB来执行技术手册管理功能的TMM（技术手册管理）模块; 图示管理模块; 以及用于执行手动作者管理器功能的TMA（技术手册作者）模块，用于向图示的绘图管理器模块发送和接收图示的图（ID）或CGM数据。

3. 发明授权

US09486472B2 Methods for modulating neuronal responses 有权
标题翻译：调节神经元反应的方法
公开(公告)号：US09486472B2
公开(公告)日：2016-11-08
申请号：US13066700
申请日：2011-04-22
申请人： Yu Tian Wang , Yushan Wang , Anthony Phillips , Lidong Liu , Yitao Liu
发明人： Yu Tian Wang , Yushan Wang , Anthony Phillips , Lidong Liu , Yitao Liu
IPC分类号： A61K38/00 , A61K38/08 , A61K38/10 , C07K7/06 , A61K31/7088 , C07K14/705 , C12N9/12
CPC分类号： A61K31/7088 , A61K38/00 , C07K7/06 , C07K14/705 , C12N9/1205 , G01N2333/705 , G01N2500/02 , G01N2500/04
摘要： Methods and compositions for treating neurological damage or dysfunction are described, including methods implemented by administration of peptide inhibitors of AMPA receptor endocytosis.
摘要翻译：描述了用于治疗神经损伤或功能障碍的方法和组合物，包括通过施用AMPA受体内吞作用的肽抑制剂实施的方法。

4. 发明授权

US09290751B2 LPL variant therapeutics 有权
标题翻译： LPL变体治疗
公开(公告)号：US09290751B2
公开(公告)日：2016-03-22
申请号：US14324151
申请日：2014-07-04
申请人： Michael R. Hayden , John P. Kastelein
发明人： Michael R. Hayden , John P. Kastelein
IPC分类号： C12N9/20 , A61K48/00
CPC分类号： C12N9/20 , A61K48/00 , A61K48/005 , C12N2710/10343 , C12N2710/10371 , C12Y301/01034
摘要： The invention provides for the use of a therapeutic derived from a truncated lipoprotein lipase protein (LPL S447X), including nucleic acids encoding such proteins, for the treatment of conditions including LPL responsive conditions, such as cardiovascular disease, hypertension, LPL deficiency, high triglyceride levels, low HDL-cholesterol levels or atherosclerosis.
摘要翻译：本发明提供了使用衍生自截短脂蛋白脂肪酶蛋白（LPL S447X）的治疗剂，包括编码这种蛋白质的核酸，用于治疗包括LPL反应性病症如心血管疾病，高血压，LPL缺乏，高甘油三酸酯水平，低HDL胆固醇水平或动脉粥样硬化。

5. 发明授权

US08461196B2 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders 有权
公开(公告)号：US08461196B2
公开(公告)日：2013-06-11
申请号：US13366219
申请日：2012-02-03
申请人： Phil Skolnick , Anthony Basile , Zhengming Chen , Joseph W. Epstein
发明人： Phil Skolnick , Anthony Basile , Zhengming Chen , Joseph W. Epstein
IPC分类号： A61K31/403 , C07D209/02
CPC分类号： A61K31/403 , C07D209/52
摘要： The invention provides novel, multiply-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including depression and anxiety.

6. 发明授权

US08273384B2 Process for the preparation of a non-corrosive base solution and methods of using same 有权
标题翻译：非腐蚀性碱溶液的制备方法及其使用方法
公开(公告)号：US08273384B2
公开(公告)日：2012-09-25
申请号：US12167123
申请日：2008-07-02
申请人： Stephen Ray Wurzberger
发明人： Stephen Ray Wurzberger
IPC分类号： A61K33/08 , A61K33/04 , A01N59/02 , A01N59/06
CPC分类号： A61K33/08 , A61K45/06 , C09K15/02
摘要： The present invention provides novel methods of making a non-corrosive base solution for use as an alkalinity increasing agent and/or antioxidant. The present invention further provides novel compositions and methods which can be used to provide relief from disorders related to or complicated by acidosis or excessive free radical or other reactive oxygen species production including, but not limited to, gout, Lesch-Nyhan syndrome, hemochromatosis, Alzheimer's, amyotropic lateral sclerosis, arthritis, atherosclerosis, cancer, cataracts, chronic obstructive pulmonary disease, diabetes, cellulitis, coronary artery disease, heart failure, hypertension, inflammatory bowel disease, macular degeneration, multiple sclerosis, Parkinson's, Reynaud's phenomenon, reperfusion injury, pancreatic impairment, skin infections, Hepatitis C, methicillin-resistant Staphylococcus aureus and infection. The compositions and methods of the present invention additionally supply relief from microbial infections including fungal infections as well as prevent secondary infections. Additional compositions and methods are provided which employ a non-corrosive base solution in combination with a second alkalinity increasing agent and/or antioxidant, or other therapeutic agent to yield a more effective treatment tool against acidosis and/or excessive ROS production including free radical production useful to prevent or reduce acidosis and/or excessive ROS production or related symptoms or conditions associated with acidosis and/or excessive free radical production in mammalian subjects.
摘要翻译：本发明提供了制备用作碱性增加剂和/或抗氧化剂的非腐蚀性碱溶液的新方法。本发明还提供了新的组合物和方法，其可用于缓解与酸中毒或过量自由基或其他活性氧物质产生相关或复杂的紊乱，包括但不限于痛风，Lesch-Nyhan综合征，血色素沉着症，阿尔茨海默氏症，肌萎缩性侧索硬化，关节炎，动脉粥样硬化，癌症，白内障，慢性阻塞性肺病，糖尿病，蜂窝织炎，冠状动脉疾病，心力衰竭，高血压，炎性肠病，黄斑变性，多发性硬化，帕金森病，雷诺氏现象，再灌注损伤，胰腺损伤，皮肤感染，丙型肝炎，耐甲氧西林金黄色葡萄球菌和感染。本发明的组合物和方法另外还提供了微生物感染的缓解，包括真菌感染以及预防继发性感染。提供了另外的组合物和方法，其采用非腐蚀性碱溶液与第二碱性增加剂和/或抗氧化剂或其它治疗剂组合以产生更有效的治疗工具来防止酸中毒和/或过量的ROS产生，包括自由基生成可用于预防或减少酸中毒和/或过量的ROS产生或与哺乳动物受试者的酸中毒和/或过量自由基产生相关的相关症状或症状。

7. 发明授权

US08138356B2 Chemical inhibitors of inhibitors of differentiation 有权
标题翻译：分化抑制剂的化学抑制剂
公开(公告)号：US08138356B2
公开(公告)日：2012-03-20
申请号：US12253009
申请日：2008-10-16
申请人： Jaideep Chaudhary , William A. Garland
发明人： Jaideep Chaudhary , William A. Garland
IPC分类号： C07D409/02 , A61K31/33
CPC分类号： A01K67/0271 , A01K2207/20 , A01K2227/105 , A01K2267/0331 , A61K31/165 , A61K31/38 , A61K45/06 , A61K2300/00
摘要： The present invention provides identification of inhibitors of inhibitors of differentiation (Id) for use in the treatment and prevention of diseases in mammals. The inhibitors of Id are effective alone in the treatment of a variety of cellular proliferative disorders including, but not limited to, diseases such as cancer, arthritis, age-related macular degeneration, psoriasis, neoplasms, angiomas, endometriosis, obesity, age-related macular degeneration, retinopathies, restenosis, scaring, fibrogenesis, fibrosis, cardiac remodeling, pulmonary fibrosis, scleroderma, failure associated with myocardial infarction, keloids, fibroid tumors and stenting. Additionally, these compounds are effective in blocking angiogenesis in tumor development, inducing apoptosis in malignant cells, inhibiting proliferation of cancer cells, increasing the effectiveness of chemotherapeutic agents, regulating transcriptional activity, reducing inflammation, increasing cellular differentiation, modulating ETS domain transcription factors, modulating PAX transcription factors, modulating TCF-ETS domain transcription factors, down regulating RAF-1/MAPK, upregulating JNK signaling pathways, and modulating cellular transformation.
摘要翻译：本发明提供用于治疗和预防哺乳动物疾病的分化抑制剂抑制剂（Id）的鉴定。 Id的抑制剂单独用于治疗各种细胞增殖性疾病，包括但不限于疾病如癌症，关节炎，年龄相关性黄斑变性，牛皮癣，肿瘤，血管瘤，子宫内膜异位症，肥胖症，年龄相关黄斑变性，视网膜病变，再狭窄，惊厥，纤维发生，纤维化，心脏重塑，肺纤维化，硬皮病，与心肌梗塞相关的衰竭，瘢痕疙瘩，纤维瘤和支架置入术。此外，这些化合物有效阻断肿瘤发展中的血管生成，诱导恶性细胞凋亡，抑制癌细胞增殖，增加化疗药物的有效性，调节转录活性，减少炎症，增加细胞分化，调节ETS结构域转录因子，调节 PAX转录因子，调节TCF-ETS结构域转录因子，调控RAF-1 / MAPK，上调JNK信号通路，调节细胞转化。

8. 发明授权

US07880023B2 2-Nitratoethyl oxirane, poly (2-nitratoethyl oxirane) and preparation method thereof 有权
标题翻译： 2-硝基乙基环氧乙烷，聚（2-硝基乙基环氧乙烷）及其制备方法
公开(公告)号：US07880023B2
公开(公告)日：2011-02-01
申请号：US12431754
申请日：2009-04-28
申请人： Jin Seuk Kim , Jin Rai Cho , Keun Deuk Lee , Jeong-Kook Kim
发明人： Jin Seuk Kim , Jin Rai Cho , Keun Deuk Lee , Jeong-Kook Kim
IPC分类号： C07D303/08
CPC分类号： C07D303/08 , C08G65/22 , C08G65/2609
摘要： A synthesis of an energetic prepolymer used as a high-energy binder for an insensitive and high performance explosive is disclosed. More specifically, provided are a novel compound 2-nitratoethyl oxirane expressed by formula III, a novel compound poly(2-nitratoethyl oxirane) expressed by formula IV, obtained by polymerization of 2-nitratoethyl oxirane used as a monomer and a preparation method thereof. The compound, used as an energetic prepolymer and a monomer for preparation thereof can substitute for existing poly(glycidyl nitrate) (PGN) which has been known to be a promising one having the best performance among existing energetic prepolymers, but which has a problem to be self-decomposed after synthesis of polyurethane elastomer, to solve this problem.
摘要翻译：公开了用作不敏感和高性能炸药的高能粘合剂的能量预聚物的合成。更具体地说，提供了由式III表示的新型化合物2-硝基乙基环氧乙烷，通过用作单体的2-硝基乙基环氧乙烷的聚合获得的式IV表示的新型化合物聚（2-硝基乙基环氧乙烷）及其制备方法。用作能量预聚物的化合物和用于制备其的单体可以代替已知在现有能量预聚物中具有最佳性能的有前途的聚（缩水甘油基硝酸酯）（PGN），但是具有问题在聚氨酯弹性体合成后自行分解，解决这个问题。

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