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1. 再颁专利

USRE40697E1 Method for making an aromatic polycarbonate 有权
标题翻译：制备芳族聚碳酸酯的方法
公开(公告)号：USRE40697E1
公开(公告)日：2009-04-07
申请号：US11345691
申请日：2006-01-31
申请人： Norberto Silvi , Mark Howard Giammattei , Patrick Joseph McCloskey , Alberto Nisoli , James Day , Narayan Ramesh , Paul Michael Smigelski, Jr. , Paul Russell Wilson
发明人： Norberto Silvi , Mark Howard Giammattei , Patrick Joseph McCloskey , Alberto Nisoli , James Day , Narayan Ramesh , Paul Michael Smigelski, Jr. , Paul Russell Wilson
IPC分类号： C08G64/00
CPC分类号： B29C47/0004 , B29C47/0009 , B29C47/60 , B29C47/76 , B29C47/767 , B29C67/246 , B29K2069/00 , C08G64/081 , C08G64/14 , C08G64/205 , C08G64/307
摘要： This invention relates to an extrusion method preparing polycarbonates from a solution of an oligomeric polycarbonate. A mixture of bis(methyl salicyl)carbonate (BMSC), BPA and a transesterification catalyst are first equilibrated at moderate temperatures to provide a solution of polycarbonate oligomer in methyl salicylate. The solution is then fed to a devolatilizing extruder, where the polymerization reaction is completed and the methyl salicylate solvent is removed. The solution comprising the oligomeric polycarbonate can also be pre-heated under pressure to a temperature above the boiling point of methyl salicylate and subsequently fed to a devolatilizing extruder equipped for rapid flashing off the solvent. The method provides polycarbonate with greater efficiency than the corresponding process in which unreacted monomers are fed to the extruder. Additionally, the method of the invention does not require the isolation of a precursor polycarbonate comprising ester-substituted phenoxy terminal groups.
摘要翻译：本发明涉及从低聚聚碳酸酯溶液制备聚碳酸酯的挤压方法。首先在中等温度下平衡双（甲基水杨酸）碳酸酯（BMSC），BPA和酯交换催化剂的混合物，以提供聚碳酸酯低聚物在水杨酸甲酯中的溶液。然后将溶液进料到脱挥发分挤出机中，其中聚合反应完成并除去水杨酸甲酯溶剂。包含低聚物聚碳酸酯的溶液也可以在压力下预加热到高于水杨酸甲酯沸点的温度，随后进料到脱挥发分的挤出机中，以便迅速地从溶剂中闪蒸。该方法提供聚碳酸酯比未反应的单体进料到挤出机的相应方法具有更高的效率。另外，本发明的方法不需要分离包含酯取代的苯氧基末端基团的前体聚碳酸酯。

2. 发明授权

US07485695B2 Polycarbonates containing low levels of methyl salicylate prepared by a melt polymerization in a reactive extruder 有权
标题翻译：含有低水平的水杨酸甲酯的聚碳酸酯通过在反应性挤出机中的熔融聚合制备
公开(公告)号：US07485695B2
公开(公告)日：2009-02-03
申请号：US11470333
申请日：2006-09-06
申请人： Peter Davis , Hans Looij
发明人： Peter Davis , Hans Looij
IPC分类号： C08G64/00 , C08G63/02
CPC分类号： C08G64/205 , B29C47/0004 , B29C47/0009 , B29C47/0021 , B29C47/0871 , B29C47/38 , B29C47/6025 , B29C47/6031 , B29C47/6056 , B29C47/76 , B29C47/767 , B29K2069/00 , C08G64/307
摘要： Polycarbonate is prepared by reactive extrusion on a reactive extruder. A method incorporates the steps of introducing a polycarbonate oligomer, an activated carbonate, and a transesterification catalyst to the extruder through a feed section. The extruder has a feed section, a polycarbonate exit section, and a reaction section between the feed section and the polycarbonate exit section. The reaction section has one or more devolatilization units, wherein each devolatilization unit incorporates an array of vent-conveying sections and conveying sections arranged in a configuration of: (C V C)x(V)n, and/or (V C V)x(C)n. (V) is a vent-conveying section, (C) is a conveying section, x is 1 or more, and n is 1 or 0. The extruder screw in the vent-conveying sections and the conveying sections in each devolatilization unit have conveying elements or conveying elements and mixing elements and no elements that create a melt seal in the devolatilization unit. The method further includes the step of extruding the reaction components at a temperature in a range between 100° C. and 500° C., wherein during the extrusion of the reaction components, activated carbonate residue is removed through the vent-conveying sections.
摘要翻译：聚碳酸酯通过在反应性挤出机上的反应性挤出制备。一种方法包括通过进料段将聚碳酸酯低聚物，活性碳酸酯和酯交换催化剂引入挤出机的步骤。挤出机具有进料部分，聚碳酸酯出口部分和进料部分和聚碳酸酯出口部分之间的反应部分。反应部分具有一个或多个脱挥发单元，其中每个脱挥发单元结合一排排气输送部分和输送部分排列成：（CVC）x（V）n和/或（VCV）x（C） n。（V）是排气输送部，（C）是输送部，x为1以上，n为1或0.排气输送部中的挤出机螺杆和各脱挥发单元的输送部具有输送元件或输送元件和混合元件，并且没有在脱挥发单元中产生熔体密封的元件。该方法还包括在100℃和500℃之间的温度范围内挤出反应组分的步骤，其中在反应组分的挤出期间，通过排气输送段除去活性碳酸盐残余物。

3. 发明授权

US07482423B2 Polycarbonates and method of preparing same 有权
标题翻译：聚碳酸酯及其制备方法
公开(公告)号：US07482423B2
公开(公告)日：2009-01-27
申请号：US11427861
申请日：2006-06-30
申请人： Bernd Jansen , Jan Henk Kamps , Edward Kung , Patrick Joseph McCloskey , Paul Michael Smigelski, Jr.
发明人： Bernd Jansen , Jan Henk Kamps , Edward Kung , Patrick Joseph McCloskey , Paul Michael Smigelski, Jr.
IPC分类号： C08G64/00 , C08G63/02
CPC分类号： C08G64/307 , C08G64/04
摘要： Polycarbonates incorporating terminal carbonate groups derived from ester-substituted activated carbonates, for example terminal methyl salicyl carbonate (TMSC) derived from the use of BMSC as the activated carbonate in a transesterification process, have unfavorable properties with respect to color, hydrolytic stability and thermal stability, particularly when the polycarbonate containing such end groups is molded. The number of activated carbonate end groups formed during the melt transesterification formation of polycarbonate can be reduced, however, without sacrificing the benefits of using an activated diaryl carbonate, and without requiring a separate reaction or additional additives by reacting a dihydroxy compound with an activated diaryl carbonate in the presence of an esterification catalyst to produce a polycarbonate, wherein the molar ratio of activated diaryl carbonate to dihydroxy compound is less than 1 when expressed to at least three decimal places, for example 0.996 or less.
摘要翻译：由酯取代的活性碳酸酯衍生的末端碳酸酯基团的聚碳酸酯，例如在酯交换法中使用BMSC作为活性碳酸酯的末端甲基水杨酸碳酸酯（TMSC）在颜色，水解稳定性和热稳定性方面具有不利的性质特别是当含有这种端基的聚碳酸酯被模制时。然而，在聚碳酸酯的熔融酯交换形成期间形成的活化碳酸酯端基的数量可以降低，但不会牺牲使用活性碳酸二芳基酯的优点，并且不需要单独的反应或另外的添加剂，通过使二羟基化合物与活化的二芳基在酯化催化剂存在下制备碳酸酯以制备聚碳酸酯，其中活化的碳酸二芳酯与二羟基化合物的摩尔比当表示至少三位小数，例如0.996或更小时小于1。

4. 发明授权

US07312352B2 Method of preparing ester-substituted diaryl carbonates 有权
标题翻译：酯取代的二芳基碳酸酯的制备方法
公开(公告)号：US07312352B2
公开(公告)日：2007-12-25
申请号：US10984318
申请日：2004-11-08
申请人： Paul William Buckley , James Silva , David Dardaris
发明人： Paul William Buckley , James Silva , David Dardaris
IPC分类号： C07C69/96
CPC分类号： C07C68/02 , C07C69/96
摘要： The present invention relates to an interfacial method of preparing ester-substituted diaryl carbonates. The method includes the steps of: forming a reaction mixture comprising phosgene, an ester-substituted phenol, an organic solvent, and a catalyst selected from the group consisting of a tertiary amine catalyst and a phase transfer catalyst, said reaction mixture having an organic phase and an aqueous phase, wherein said aqueous phase has a brine strength; allowing the reaction mixture to react wherein during the reaction, (i) the aqueous phase has a pH, and the pH is adjusted, if necessary, by the addition of an alkali metal hydroxide solution in amounts such that the pH is greater than or equal to 9.0 during at least some portion of the reaction, and (ii) the brine strength of the aqueous phase is adjusted, if necessary, by varying the concentration of the alkali metal hydroxide solution being added to maintain the pH such that the brine strength is between 15% and a saturated brine solution during at least some portion of the reaction: thereby forming an ester-substituted diaryl carbonate, wherein the reaction mixture is formed with less than 15% water of formulation, and wherein the brine strength is maintained at or above 15% and the pH is maintained at or above 9 for a sufficient portion of the process that the ester-substituted diaryl carbonate is formed with a conversion of at least 90% and a selectivity of at least 98%.
摘要翻译：本发明涉及制备酯取代的二芳基碳酸酯的界面方法。该方法包括以下步骤：形成包括光气，酯取代的酚，有机溶剂和选自叔胺催化剂和相转移催化剂的催化剂的反应混合物，所述反应混合物具有有机相和水相，其中所述水相具有盐水强度; 允许反应混合物反应，其中在反应期间，（i）水相具有pH，并且如果需要，通过加入碱金属氢氧化物溶液调节pH，使得pH大于或等于在反应的至少一部分期间至9.0，和（ii）如果需要，通过改变加入的碱金属氢氧化物溶液的浓度来调节水相的盐水强度，以保持pH使得盐水强度为在反应的至少一部分期间在15％和饱和盐水溶液之间，由此形成酯取代的碳酸二芳基酯，其中反应混合物由少于15％的制剂水形成，并且其中盐水强度保持在或高于15％，并且pH保持在或大于9，足够部分的方法是形成酯取代的碳酸二芳基酯，其转化率至少为90％，选择性为至少98％。

5. 发明授权

US07309730B2 Modified weatherable polyester molding composition 有权
标题翻译：改性耐候性聚酯模塑组合物
公开(公告)号：US07309730B2
公开(公告)日：2007-12-18
申请号：US11226172
申请日：2005-09-14
申请人： Sung Dug Kim
发明人： Sung Dug Kim
IPC分类号： C08L69/00 , C08L67/02
CPC分类号： C08L67/02 , C08K5/13 , C08L51/00 , C08L69/00 , C08L83/10 , C08L2666/02
摘要： A composition formed from (a) a polyester and polycarbonate blend; (b) an organopolysiloxane-polycarbonate block copolymer; (c) an acrylic core shell impact modifier; (d) titanium dioxide and (e) a flame retarding amount of a halogenated flame retardant has properties useful as a weatherable molding composition. It can suitably be used in articles such as encloses for electronic equipment such as communication devices.
摘要翻译：由（a）聚酯和聚碳酸酯共混物形成的组合物; （b）有机聚硅氧烷 - 聚碳酸酯嵌段共聚物; （c）丙烯酸核壳抗冲改性剂; （d）二氧化钛和（e）阻燃量的卤化阻燃剂具有用作耐候性模塑组合物的性质。它可以适用于诸如通信设备之类的电子设备的封闭物等物品。

6. 发明授权

US07297409B2 Multilayer, weatherable compositions and method of manufacture thereof 有权
标题翻译：多层，耐候性组合物及其制造方法
公开(公告)号：US07297409B2
公开(公告)日：2007-11-20
申请号：US09682749
申请日：2001-10-12
申请人： Safwat E. Tadros , Peter H. Th. Vollenberg
发明人： Safwat E. Tadros , Peter H. Th. Vollenberg
IPC分类号： B32B27/36 , B38B7/00
CPC分类号： B32B27/08 , B32B27/18 , C08K5/34 , C08K5/3435 , C08K5/3492 , Y02P20/582 , Y10T428/31507 , Y10T428/31786
摘要： A weatherable composition comprising an upper layer that comprises a polymer system consisting essentially of a cycloaliphatic polyester resin, and an additive composition comprising an hindered amine light stabilizer and a low volatility, hydroxyphenyl triazine or pyrimidine UV absorber; an intermediate layer that comprises a polymer system consisting essentially of a cycloaliphatic polyester, and optionally, an additive composition comprising TiO2, dyes, pigments, and special effects additives; and a polymeric substrate, wherein the intermediate layer is disposed between and in intimate contact with the upper layer and the substrate. The composition finds utility in articles such as automotive parts.
摘要翻译：一种耐候性组合物，其包含上层，其包含基本上由脂环族聚酯树脂组成的聚合物体系，和包含受阻胺光稳定剂和低挥发性羟基苯基三嗪或嘧啶紫外线吸收剂的添加剂组合物; 中间层，其包含基本上由脂环族聚酯组成的聚合物体系，以及任选的包含TiO 2，染料，颜料和特殊效果添加剂的添加剂组合物; 和聚合物基材，其中中间层设置在上层和基底之间并与之紧密接触。该组合物可用于诸如汽车部件的物品中。

7. 外观设计

USD545438S1 Analyte meter 有权
标题翻译：分析仪
公开(公告)号：USD545438S1
公开(公告)日：2007-06-26
申请号：US29226834
申请日：2005-04-01
申请人： Eileen Huang , Joseph Flaherty , Sonny Vu
设计人： Eileen Huang , Joseph Flaherty , Sonny Vu

8. 发明授权

US07230066B2 Polycarbonate—ultem block copolymers 有权
标题翻译：聚碳酸酯 - 最终嵌段共聚物
公开(公告)号：US07230066B2
公开(公告)日：2007-06-12
申请号：US11015216
申请日：2004-12-16
申请人： Farid Khouri , Julia Lee , Sheldon Shafer
发明人： Farid Khouri , Julia Lee , Sheldon Shafer
IPC分类号： C08G63/02
CPC分类号： C08G64/18 , C08G73/16
摘要： The present invention provides novel block copolycarbonates comprising residues from a hydroxy terminated polyetherimide or polyimide, residues from a dihydroxy compound, and residues from an activated carbonate. In a preferred embodiment of the present invention the polyetherimide or polyimide blocks exhibit high Mw while the resulting block copolycarbonate exhibits a single Tg. The novel block copolycarbonates of the present invention are produced under melt polymerization conditions in the presence an activated carbonate source.
摘要翻译：本发明提供新的嵌段共聚碳酸酯，其包含羟基封端的聚醚酰亚胺或聚酰亚胺的残基，二羟基化合物的残基和活化的碳酸酯的残基。在本发明的优选实施方案中，聚醚酰亚胺或聚酰亚胺嵌段表现出高的摩尔比，而所得的嵌段共聚碳酸酯表现出单一的T N。本发明的新型嵌段共聚碳酸酯在熔融聚合条件下在活性碳酸酯源存在下制备。

9. 发明授权

US07211562B2 Methods for enhancing the efficacy of cytotoxic agents through the use of HSP90 inhibitors 有权
标题翻译：通过使用HSP90抑制剂来提高细胞毒性剂功效的方法
公开(公告)号：US07211562B2
公开(公告)日：2007-05-01
申请号：US10415878
申请日：2001-11-01
申请人： Neal Rosen , Pamela Nathalie Munster
发明人： Neal Rosen , Pamela Nathalie Munster
IPC分类号： A61K35/00 , A61K41/00 , A61K38/00
CPC分类号： A61K33/24 , A61K31/282 , A61K31/337 , A61K31/365 , A61K31/395 , A61K31/505 , A61K31/704 , A61K2300/00
摘要： The administration of cytotoxic agents followed by the administration of heat shock protein 90 inhibitors, such as ansamycins, has a synergistic effect on the growth inhibition of cells. This synergy occurs at doses of each cytotoxic agent that normally only causes minimal growth inhibition of cells. Such combination therapy thus allows one to use lower doses of cytotoxic agents to avoid or reduce their respective toxicity to patients without compromising their growth inhibitory effects. Thus, these combinations can be used for the treatment of an animal, preferably a mammal, that has a cell proliferative disorder, whether the cells have wild-type Rb or are Rb deficient or Rb negative. One such method, directed to treating cell proliferative disorders includes the step of administering a therapeutic effective amount of a cytotoxic agent followed by administering a therapeutic effective amount of a heat shock protein 90 inhibitor. The cytotoxic agent may be a microtubule-affecting agent, topoisomerase II inhibitor, a platinum complex, paclitaxel, or a paclitaxel derivative. The HSP90 inhibitor may be an ansamycin, radicicol or a synthetic compound that binds to the ATP-binding site of HSP90.
摘要翻译：细胞毒性剂的施用，然后施用热休克蛋白90抑制剂，例如安莎霉素，对细胞的生长抑制具有协同作用。这种协同作用发生在通常仅引起细胞生长抑制最小的各细胞毒剂剂量。因此，这样的组合疗法允许使用较低剂量的细胞毒剂以避免或降低其对患者的相应毒性而不损害其生长抑制作用。因此，这些组合可用于治疗具有细胞增殖性疾病的动物，优选哺乳动物，细胞是否具有野生型Rb或Rb缺陷或Rb阴性。针对治疗细胞增殖性疾病的一种这样的方法包括施用治疗有效量的细胞毒性剂的步骤，然后施用治疗有效量的热休克蛋白90抑制剂。细胞毒性剂可以是微管影响剂，拓扑异构酶II抑制剂，铂络合物，紫杉醇或紫杉醇衍生物。 HSP90抑制剂可以是结合HSP90的ATP结合位点的安莎霉素，根霉素或合成化合物。

10. 发明授权

US07534773B1 TRPM-2 antisense therapy 失效
标题翻译： TRPM-2反义治疗
公开(公告)号：US07534773B1
公开(公告)日：2009-05-19
申请号：US09913325
申请日：2000-02-25
申请人： Martin Gleave , Paul S. Rennie , Hideaki Miyake , Colleen Nelson
发明人： Martin Gleave , Paul S. Rennie , Hideaki Miyake , Colleen Nelson
IPC分类号： A61K31/70 , C07H21/04
CPC分类号： C12N15/1135 , A61K31/00 , A61K31/337 , A61K31/66 , A61K31/704 , A61K41/0038 , A61K45/06 , A61K48/00 , C07H21/00 , C07K14/775 , C12N15/113 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , A61K2300/00 , C12N2310/3525
摘要： Antisense therapy which reduces the expression of TRPM-2 provides therapeutic benefits in the treatment of cancer for example prostate cancer and renal cell cancer. Antisense TRPM-2 ODN treatment of prostatic tumor cells in vivo is effective for delaying the onset of androgen independence and can be used in combination with androgen-withdrawal to induce apoptotic cell death of prostatic tumor cells in the individual. Combined use of antisense TRPM-2 and taxanes synergistically enhances cytotoxic chemosensitivity of androgen-independent prostate cancer. Radiation sensitivity is also enhanced when cells expressing TRPM-2 are treated with antisense TRPM-2 ODN. Thus, the antisense TRPM-2 ODNs can be used to enhance hormone sensitivity, chemosensitivity and radiation sensitivity of a variety of cancer types in which expression of TRPM-2 has been observed.
摘要翻译：降低TRPM-2表达的反义疗法在治疗癌症中具有治疗益处，例如前列腺癌和肾细胞癌。反义TRPM-2 ODN治疗前列腺肿瘤细胞在体内是有效的延迟雄激素独立的发作，可以与雄激素停用联合使用以诱导个体前列腺肿瘤细胞的凋亡性细胞死亡。结合使用反义TRPM-2和紫杉烷类物质协同增强雄激素依赖性前列腺癌的细胞毒性化学敏感性。当用反义TRPM-2 ODN处理表达TRPM-2的细胞时，放射敏感性也增强。因此，反义TRPM-2 ODN可用于增强已经观察到TRPM-2表达的各种癌症类型的激素敏感性，化学敏感性和辐射敏感性。

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