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1. 发明授权

US5726158A Peptide derivatives 失效
公开(公告)号：US5726158A
公开(公告)日：1998-03-10
申请号：US467333
申请日：1995-06-06
申请人： Philip Duke Edwards , John Anthony Schwartz , Mark Morris Stein , Diane Amy Trainor , Richard Alan Wildonger
发明人： Philip Duke Edwards , John Anthony Schwartz , Mark Morris Stein , Diane Amy Trainor , Richard Alan Wildonger
IPC分类号： A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/4433 , A61K31/535 , A61K38/00 , A61K38/55 , A61P9/10 , A61P11/00 , A61P29/00 , A61P43/00 , C07C205/02 , C07C205/26 , C07C205/43 , C07D207/16 , C07D213/26 , C07D333/00 , C07D401/12 , C07D403/12 , C07D409/12 , C07K1/113 , C07K5/04 , C07K5/06 , C07K5/08 , C07K5/093 , C07K14/81 , C12N9/99 , A61K38/06 , A61K38/07
CPC分类号： C07C205/26 , C07C205/02 , C07C205/43 , C07K5/06191 , C07K5/0819 , C07K5/0827 , A61K38/00
摘要： The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out hereinafter, and salts thereof, which are inhibitors of human leukocyte elastase. Also described herein are pharmaceutical compositions containing a peptide derivative and processes and intermediates for use in the manufacture of the peptide derivatives.

2. 发明授权

US5723442A Peptide derivatives 失效
标题翻译：肽衍生物
公开(公告)号：US5723442A
公开(公告)日：1998-03-03
申请号：US043616
申请日：1993-04-07
申请人： Donald John Wolanin
发明人： Donald John Wolanin
IPC分类号： C12N9/99 , A61K38/00 , A61P11/00 , A61P43/00 , C07K1/02 , C07K1/06 , C07K1/113 , C07K5/06 , C07K14/81 , A61K38/06 , A61K38/05
CPC分类号： C07K5/06191 , A61K38/00
摘要： The present invention relates to certain peptide derivatives, as described herein, which are human leukocyte elastase (HLE) inhibitors making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated, including treatment of tissue degenerative diseases such as pulmonary emphysema. The invention also includes intermediates useful in the synthesis of these peptide derivatives, processes for preparing them, pharmaceutical compositions containing such peptide derivatives and methods for their use.
摘要翻译：本发明涉及如本文所述的某些肽衍生物，其是人类白细胞弹性蛋白酶（HLE）抑制剂，其使得当需要这种抑制时它们是有用的，例如用于药理学，诊断和相关研究中的研究工具以及用于治疗疾病的涉及HLE的哺乳动物，包括治疗组织退行性疾病如肺气肿。本发明还包括可用于合成这些肽衍生物的中间体，其制备方法，含有这些肽衍生物的药物组合物及其使用方法。

3. 发明授权

US5449658A Biocidal compositions comprising polyhexamethylene biguanide and EDTA, and methods for treating commercial and recreational water 失效
标题翻译：包含聚六亚甲基双胍和EDTA的杀生物组合物，以及用于处理商业和娱乐用水的方法
公开(公告)号：US5449658A
公开(公告)日：1995-09-12
申请号：US163448
申请日：1993-12-07
申请人： Michael J. Unhoch , Peter S. K. Lee , David G. Chasin
发明人： Michael J. Unhoch , Peter S. K. Lee , David G. Chasin
IPC分类号： A01N47/44 , A01N61/00 , C02F1/50 , C02F1/72 , A01N37/04 , A01N59/00 , A01N59/14
CPC分类号： C02F1/722 , A01N47/44 , A01N61/00 , C02F1/50 , C02F1/505 , C02F2103/42
摘要： The growth of algae, fungi and pathogenic organisms in commercial and recreational waters, such as cooling towers, swimming pools and spas, may be controlled by adding to the water a primary sanitizing agent, preferably poly(hexamethylene biguanide) ("PHMB"), and a potentiating adjuvant comprising a calcium ion-chelating agent, preferably ethylenediamine tetraacetic acid ("EDTA"), in amounts such that the adjuvant renders the composition algicidal and fungicidal in water. The water may be further treated with a peroxy salt as a backup agent, preferably sodium perborate, or the calcium ion-chelating agent and peroxy salt may be combined as a shock treatment to water being treated with the primary sanitizing agent.
摘要翻译：在商业和休闲水域如冷却塔，游泳池和水疗中的藻类，真菌和致病生物的生长可以通过向水中加入主要消毒剂，优选聚（六亚甲基双胍）（“PHMB”），和包含钙离子螯合剂，优选乙二胺四乙酸（“EDTA”）的增效佐剂，其量使得助剂使组合物在水中具有杀藻和杀真菌作用。水可以用过氧盐作为备用剂，优选过硼酸钠，或钙离子螯合剂和过氧盐进一步处理，作为用初级消毒剂处理的水的休克处理。

4. 发明授权

US5338734A Heterocyclic amide derivatives and pharmaceutical use thereof 失效
标题翻译：杂环酰胺衍生物及其药物用途
公开(公告)号：US5338734A
公开(公告)日：1994-08-16
申请号：US981718
申请日：1992-11-25
申请人： Peter R. Bernstein , Frederick J. Brown , Victor G. Matassa , Ying K. Yee
发明人： Peter R. Bernstein , Frederick J. Brown , Victor G. Matassa , Ying K. Yee
IPC分类号： C07D209/12 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/535 , A61K31/5355 , A61K31/536 , A61K31/538 , A61K31/54 , A61K31/541 , A61K31/5415 , A61P9/00 , A61P11/00 , A61P11/14 , A61P17/00 , A61P27/16 , A61P29/00 , A61P37/04 , A61P37/08 , A61P43/00 , C07D209/08 , C07D209/18 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D249/18 , C07D265/36 , C07D275/04 , C07D279/16 , C07D333/52 , C07D333/56 , C07D333/58 , C07D333/60 , C07D401/12 , C07D403/10 , C07D405/12 , C07D409/10 , C07D409/12 , C07D413/10 , C07D413/12
CPC分类号： C07D231/56 , C07D209/18 , C07D235/04 , C07D249/18 , C07D265/36 , C07D333/60 , C07D403/10
摘要： The invention concerns novel, pharmaceutically useful, amide derivatives of certain benzoheterocyclylalkanoic acids (and related tetrazoles and acylsulphonamides) of the formula I and salts thereof, wherein the radicals R.sup.1, R.sup.2, L, X, Y, Z, A.sup.1, Q, A.sup.2 and M have the meanings set out in the specification. The invention also includes pharmaceutical compositions incorporating a formula I compound or a salt thereof, a process for the manufacture of the said compound, together with intermediates for use in the latter process. ##STR1##
摘要翻译：本发明涉及式I的某些苯并杂环基链烷酸（和相关的四唑和酰基磺酰胺）及其盐的新颖的，药学上可用的酰胺衍生物，其中R1，R2，L，X，Y，Z，A1，Q，A2和 M具有说明书中列出的含义。本发明还包括掺入式I化合物或其盐的药物组合物，制备所述化合物的方法，以及用于后一方法的中间体。我

5. 发明授权

US5334762A Method for accelerating oxime production 失效
标题翻译：加速肟生产的方法
公开(公告)号：US5334762A
公开(公告)日：1994-08-02
申请号：US13278
申请日：1993-02-04
申请人： James P. Neilan , Donald J. Gosciniak
发明人： James P. Neilan , Donald J. Gosciniak
IPC分类号： C07C249/08
CPC分类号： C07C249/08
摘要： A method for preparing oximes where an aldehyde or ketone is reacted with hydroxylamine or its salt in the presence of a catalytic amount of an organotin(IV) compound such as monoalkyltin(IV), dialkyltin(IV) and aryltin(IV). The organotin(IV) compound is represented by the formula I:(R.sup.1).sub.n SnX.sub.m-n (I)where R.sup.1 is independently selected from alkyl of 1 to 18 carbons or aryl, X is halogen, oxygen, hydroxyl, OR.sup.1, R.sup.2 CO.sub.2 --, R.sup.2 O.sub.2 C--(Z).sub.y --CO.sub.2 -- or R.sup.2 CO.sub.2 (CH.sub.2).sub.y S--, R.sup.2 is alkyl of 1 to 18 carbons or aryl, Z is selected from CH.sub.2 or CH.dbd.CH, where y is 0 to 6, n is 1 or 2 and m is 4 except that when X is oxygen, n is 2 and m is 3. Exemplary of the organotin(IV) compounds are butyltin tris(2-ethylhexanoate), dibutyltin diacetate and diphenyltin dichloride.
摘要翻译：一种制备肟的方法，其中醛或酮与羟胺或其盐在催化量的有机锡（IV）化合物如单烷基锡（IV），二烷基锡（IV）和芳基锡（IV））存在下反应。有机锡（IV）化合物由式I表示：（R1）nSnXm-n（I）其中R1独立地选自1至18个碳的烷基或芳基，X是卤素，氧，羟基，OR1，R2CO2-， R2O2C-（Z）y-CO2-或R2CO2（CH2）yS-，R2是1至18个碳原子的烷基或芳基，Z选自CH 2或CH = CH，其中y为0至6，n为1或2 有机锡（IV）化合物为三（2-乙基己酸）丁基锡，二乙酸二丁基锡和二苯基锡二氯化锡，其中m为4，不同之处在于X为氧时n为2且m为3。

6. 发明授权

US4950323A Herbicidal bis-formyl-N-aryl-N'-alkyl ureas and methods of use 失效
标题翻译：除草双-2-甲酰基-N-芳基-N'-烷基脲和使用方法
公开(公告)号：US4950323A
公开(公告)日：1990-08-21
申请号：US2465
申请日：1987-01-12
申请人： Charles Kezerian
发明人： Charles Kezerian
IPC分类号： A01N47/34 , C07C275/50
CPC分类号： C07C275/50 , A01N47/34
摘要： Herbicidal bis-formyl-N-aryl-N'-alkyl ureas having the formula ##STR1## in which X and Y are the same or different and are selected from the group consisting of trifluoromethyl, chloro, bromo, fluoro, hydrogen, cyano, alkyl, thioalkyl, halothioalkyl, alkoxy and sulfonylalkyl, wherein the alkyl groups have from one to four carbon atoms; andR is alkyl wherein the alkyl groups have from one to four carbon atoms and methods of use are disclosed and claimed.
摘要翻译：具有式“IMAGE”的除草双 - 甲酰基-N-芳基-N'-烷基脲类，其中X和Y相同或不同，并且选自三氟甲基，氯，溴，氟，氢，氰基，烷基，硫代烷基，卤代烷基，烷氧基和磺酰基烷基，其中烷基具有1至4个碳原子; 并且R是烷基，其中烷基具有1-4个碳原子，并且公开并要求保护其使用方法。

7. 发明授权

US3929866A Diesters of tetrabromophthalic anhydride 失效
公开(公告)号：US3929866A
公开(公告)日：1975-12-30
申请号：US36147673
申请日：1973-05-18
申请人： ICI AMERICA INC
发明人： BALDINO JAMES P , FELTZIN JOSEPH
IPC分类号： C08G18/00 , C07C69/80 , C08G18/38 , C08G18/46 , C08G18/50
CPC分类号： C08G18/5075 , C08G18/381 , C08G18/4607 , C08G18/5012
摘要： Diesters comprising the reaction product of tetrabromophthalic anhydride and a polyhydroxy compound containing at least 3 hydroxyl groups are disclosed. The diesters are prepared, in one step, by reacting tetrabromophthalic anhydride with the polyhydroxy compound at a temperature of from about 130*C. to about 190*C. in the presence of an alkaline material. The diesters are especially useful in the preparation of fireretardant, self-extinguishing, polyurethane foams.

8. 发明授权

US3872923A Use of radiation-induced polymers as temporary or permanent diverting agent 失效
标题翻译：使用辐射诱导的聚合物作为临时或永久转移剂
公开(公告)号：US3872923A
公开(公告)日：1975-03-25
申请号：US30373772
申请日：1972-11-06
申请人： ICI AMERICA INC
发明人： KNIGHT BRUCE L , RHUDY JOHN S , GOGARTY WILLIAM B
IPC分类号： C09K8/508 , E21B43/24 , E21B33/138 , E21B43/27
CPC分类号： E21B43/2403 , C09K8/5083
摘要： Temporary or permanent permeability reduction or plugging of porous medium to the flow of fluids is effected by treating, preferably by injecting under pressure into the pores, the porous medium with an aqueous solution containing a water-soluble polymer obtained as a product of radiation-induced polymerization of acrylamide and/or methacrylamide and acrylic acid, methacrylic acid, and/or alkali metal salts thereof. The polymer has sufficient properties to effect substantial permeability reduction of the porous medium. The polymerization is preferably carried out in 10-60 percent aqueous monomer solution with gamma radiation. A mixture of monomers, before radiation, preferably contain 25-99 percent acrylamide and 75-1 percent sodium acrylate. Permeability can be restored by subsequently treating the porous medium with a chemical to break down the polymer, e.g., hydrazine hypochlorite solution, strong mineral acids, or bases.
摘要翻译：多孔介质对流体流动的临时或永久渗透性降低或堵塞通过优选通过将含有作为辐射诱导的产物获得的水溶性聚合物的水溶液处理，优选通过在压力下向孔中注入多孔介质来实现丙烯酰胺和/或甲基丙烯酰胺和丙烯酸，甲基丙烯酸和/或其碱金属盐的聚合。聚合物具有足够的性能以实现多孔介质的显着的渗透率降低。聚合优选在具有γ辐射的10-60％单体水溶液中进行。在辐射之前，单体的混合物优选含有25-99％的丙烯酰胺和75-1％的丙烯酸钠。通过随后用化学品处理多孔介质以分解聚合物，例如次氯酸肼溶液，强无机酸或碱，可以恢复渗透性。

9. 发明授权

US3856830A Polymerizable urethane compounds 失效
标题翻译：可聚合的URETHANE化合物
公开(公告)号：US3856830A
公开(公告)日：1974-12-24
申请号：US21167071
申请日：1971-12-23
申请人： ATLAS CHEM IND
发明人： KUEHN E
IPC分类号： C08F20/00 , C07C67/00 , C07C239/00 , C07C269/02 , C07C271/20 , C07C275/62 , C08F20/34 , C08F283/01 , C08F290/00 , C08F299/00 , C08G18/00 , C08G18/67 , C07C125/06
CPC分类号： C08G18/6725 , C07C275/62 , C08F20/34 , C08F283/01 , C08G18/672 , C08F220/36
摘要： Ethylenically unsaturated urethane monomers containing three or more double bonds per molecule and addition polymers and copolymers of these compounds are disclosed.
摘要翻译：公开了每分子含有三个或更多个双键的烯键式不饱和聚氨酯单体和这些化合物的加成聚合物和共聚物。

10. 发明授权

US3850819A Low fuming spin finish for nylon weaving yarns 失效
标题翻译：用于尼龙织物纱的低真空旋涂
公开(公告)号：US3850819A
公开(公告)日：1974-11-26
申请号：US28392872
申请日：1972-08-25
申请人： ICI AMERICA INC
发明人： SHAY B
IPC分类号： D06M13/46 , D06M13/02 , D06M13/144 , D06M13/224 , D06M13/322 , D06M13/47 , D06M13/473 , D06M15/263 , D06M15/273 , D06M15/53 , D06M101/00 , D06M101/16 , D06M101/30 , D06M101/34
CPC分类号： D06M15/53 , C10M2201/02 , C10M2207/281 , C10M2207/282 , C10M2207/283 , C10M2207/286 , C10M2207/40 , C10M2207/404 , C10M2209/104 , C10M2215/224 , C10M2219/042 , C10N2240/62 , D06M7/00 , D06M13/224 , D06M13/473 , D06M2200/40
摘要： A lubricating composition useful in the processing of nylon yarns consisting of 30 to 50 percent vegetable oils and trimethylolalkane esters of fatty acids having 8 to 10 carbon atoms, 10 to 30 percent imidazolinium alkyl sulfates, and 20 to 60 percent of an emulsifier selected from a group consisting of alkoxylated fatty acid esters of sorbitan and sorbitol and alkoxylated alkyl phenols.
摘要翻译：用于加工尼龙纱线的润滑组合物，其由30至50％的植物油和具有8至10个碳原子的脂肪酸的三羟甲基烷烃酯，10至30％的咪唑烷烷基硫酸盐和20至60％的选自以下的乳化剂组成：由脱水山梨糖醇和山梨糖醇的烷氧基化脂肪酸酯和烷氧基化烷基酚组成的组。

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