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1. 发明申请

US20120183945A1 METHOD, DEVICE AND FLUID FOR TREATMENT OF A HEART AFTER HARVESTING 审中-公开
标题翻译：方法，设备和流体用于治疗心脏后收集
公开(公告)号：US20120183945A1
公开(公告)日：2012-07-19
申请号：US13498155
申请日：2010-09-22
申请人： Stig Steen , Audrius Paskevicius
发明人： Stig Steen , Audrius Paskevicius
IPC分类号： A01N1/02
CPC分类号： A01N1/0247 , A01N1/0226 , A01N1/0273
摘要： Method and device for treatment of a heart after harvesting and before transplantation. The device includes a container intended to comprise the heart; a first line for connection to an aorta of the heart; a fluid circuit comprising an oxygenator for oxygenating said fluid and a heater/cooler for regulating the temperature of said fluid; and a pump for perfusion of said fluid through the coronary blood vessels of the heart. The fluid includes an oncotic agent exerting an oncotic pressure larger than about 30 mmHg; and is cardioplegic by comprising a potassium concentration, which is between 15 mM and 30 mM. A control device is arranged for controlling the pump to perform said perfusion intermittently, whereby the perfusion time is less than half of the cycle time. The perfusion is performed at a pressure, which is at least 15 mmHg and at least 15 mmHg lower than said oncotic pressure.
摘要翻译：收集后和移植前治疗心脏的方法和装置。该装置包括旨在包括心脏的容器; 与心脏主动脉连接的第一条线流体回路，包括用于使所述流体充氧的氧合器和用于调节所述流体的温度的加热器/冷却器; 以及用于通过心脏的冠状动脉血液灌注所述流体的泵。流体包括施用大于约30mmHg的肿瘤压力的肿瘤剂; 并且通过包含在15mM和30mM之间的钾浓度来产生心脏停搏。控制装置被布置成用于控制泵间歇地执行所述灌注，由此灌注时间小于循环时间的一半。灌注在压力下进行，压力至少为15mmHg，并且比所述的起始压力低至少15mmHg。

2. 发明申请

US20160262634A1 AN AFTERLOAD DEVICE FOR A BEATING HEART DURING EXAMINATION THEREOF 审中-公开
标题翻译：用于在检查过程中佩戴心脏的后置装置
公开(公告)号：US20160262634A1
公开(公告)日：2016-09-15
申请号：US15031640
申请日：2014-10-24
申请人： VIVOLINE MEDICAL AB
发明人： Stig STEEN , Audrius PASKEVICIUS , Benjamin KING
IPC分类号： A61B5/02 , A01N1/02
CPC分类号： A61B5/02028 , A01N1/0247 , A61B5/0215 , A61B5/02158 , A61B5/02233 , A61B5/023 , A61B5/6876 , A61B2505/05 , G09B23/306
摘要： An examination device for a heart. An afterload device connected to the aorta provides a counterpressure by an annular space delimited between a rigid cylinder and an elastic tube inserted in the rigid cylinder. The annular space comprises a compressible medium, such as air, nitrogen gas or carbon dioxide and is connected to a reservoir providing a predetermined pressure corresponding to a diastolic pressure. The reservoir is connected to the annular space via a restriction and a back-flow valve. During diastole, the annular space is inflated by the reservoir and provides a diastolic counter pressure for providing coronary flow. During systole, the ejected fluid from the heart ventricle displaces the medium inside the annular space through the restriction to the reservoir, thereby removing energy from the fluid. The compressible medium forms a compliance. In addition, there is a preload device comprising a vertical collapsible tube forming a fluid column for preload of the atrium with a desired preload pressure without introducing air into the fluid. A pump delivers fluid to the preload device and removes fluid from the afterload device.
摘要翻译：心脏检查装置连接到主动脉的后负荷装置通过限定在刚性气缸和插入刚性气缸中的弹性管之间的环形空间提供反压力。环形空间包括诸如空气，氮气或二氧化碳的可压缩介质，并且连接到提供对应于舒张压的预定压力的储存器。储存器经由限制器和回流阀连接到环形空间。在舒张期间，环形空间被储存器充气，并提供用于提供冠状动脉血流的舒张压。在心脏收缩期间，来自心室的排出的液体将环形空间内的介质通过限制器移动到储存器，从而从流体中去除能量。可压缩介质形成顺应性。另外，还有一种预紧装置，它包括一个垂直的可折叠的管，形成一个流体柱，用于预先加载心房的预压力，而不会将空气引入到流体中。泵将流体输送到预载装置并从后负载装置中移除流体。

3. 发明授权

US09084416B2 Container and supporting structure for housing an organ 有权
标题翻译：集装箱和配套结构
公开(公告)号：US09084416B2
公开(公告)日：2015-07-21
申请号：US13498160
申请日：2010-09-24
申请人： Stig Steen , Audrius Paskevicius , Anna Beyer , Morgan Johansson , Benjamin King , Anna Soderlund , Anders Lindsten , Peter Sebelius , Maria Sperlingsson , Joakim Nilsson
发明人： Stig Steen , Audrius Paskevicius , Anna Beyer , Morgan Johansson , Benjamin King , Anna Soderlund , Anders Lindsten , Peter Sebelius , Maria Sperlingsson , Joakim Nilsson
IPC分类号： A01N1/00 , A01N1/02 , C12M3/00 , C12M1/36 , C12M1/38
CPC分类号： A01N1/0247 , A01N1/0273
摘要： An apparatus intended for evaluation, preservation and perfusion of an organ, such as a lung. The apparatus includes a container with a bottom portion, an insert portion and a lid portion. A pulmonary artery tube is intended to be connected to the lung pulmonary artery and a trachea tube is intended to be connected to the trachea of the lungs and bent tube connects the pulmonary artery tube to a circuit for providing a fluid to the pulmonary artery is provided. The circuit includes a pump, an oxygenator, an optional leukocyte-filter, and a holder for connecting the trachea tube to a source of respiration. There is an oxygenator tube set and a leukocyte-filter tube set. A supporting structure for the container comprises a recess sized for enclosing said container and a display panel. Moreover, there are two handles, which may be unfolded into a position for supporting a sterile cloth.
摘要翻译：用于评估，保存和灌注诸如肺的器官的装置。该装置包括具有底部，插入部分和盖部分的容器。肺动脉管旨在连接到肺肺动脉，气管连接到肺气管，弯管将肺动脉管连接到肺动脉提供流体的回路。电路包括泵，氧合器，可选的白细胞过滤器和用于将气管连接到呼吸源的保持器。有一个充氧器管组和一个白细胞过滤管组。用于容器的支撑结构包括用于封闭所述容器和显示面板的凹槽。此外，还有两个把手可以展开到支撑无菌布的位置。

4. 发明申请

US20150342178A1 CONTAINER AND SUPPORTING STRUCTURE FOR HOUSING AN ORGAN 有权
标题翻译：集装箱和支持结构的房屋
公开(公告)号：US20150342178A1
公开(公告)日：2015-12-03
申请号：US14801651
申请日：2015-07-16
申请人： Stig STEEN , Audrius Paskevicius , Anna Beyer , Morgan Johansson , Benjamin King , Anna Söderlund , Anders Lindsten , Peter Sebelius , Maria Sperlingsson , Joakim Nilsson
发明人： Stig STEEN , Audrius Paskevicius , Anna Beyer , Morgan Johansson , Benjamin King , Anna Söderlund , Anders Lindsten , Peter Sebelius , Maria Sperlingsson , Joakim Nilsson
IPC分类号： A01N1/02
CPC分类号： A01N1/0247 , A01N1/0273
摘要： An apparatus intended tor evaluation, preservation and perfusion of an organ, such as a lung. The apparatus includes a container with a bottom portion, an insert portion and a lid portion. A pulmonary artery tube is intended to be connected to the lung pulmonary artery and a trachea tube is intended to be connected to the trachea of the lungs and bent tube connects the pulmonary artery tube to a circuit for providing a fluid to the pulmonary artery is provided. The circuit includes a pump, an oxygenator, an optional leukocyte-filter, and a holder for connecting the trachea tube to a source of respiration. There is an oxygenator tube set and a leukocyte-filter tube set. A supporting structure for the container comprises a recess sized for enclosing said container and a display panel. Moreover, there are two handles, which may be unfolded into a position for supporting a sterile cloth.
摘要翻译：旨在评估，保存和灌注器官如肺的装置。该装置包括具有底部，插入部分和盖部分的容器。肺动脉管旨在连接到肺肺动脉，气管连接到肺气管，弯管将肺动脉管连接到肺动脉提供流体的回路。电路包括泵，氧合器，可选的白细胞过滤器和用于将气管连接到呼吸源的保持器。有一个充氧器管组和一个白细胞过滤管组。用于容器的支撑结构包括用于封闭所述容器和显示面板的凹槽。此外，还有两个把手可以展开到支撑无菌布的位置。

5. 发明申请

US20130065218A1 MEDICAL FLUID, A METHOD OF TREATMENT AND USE OF THE FLUID 审中-公开
标题翻译：医用流体，治疗和使用流体的方法
公开(公告)号：US20130065218A1
公开(公告)日：2013-03-14
申请号：US13697839
申请日：2011-05-13
申请人： Stig Steen
发明人： Stig Steen
IPC分类号： A01N1/02
摘要： A medical fluid for a harvested organ, tissue or parts thereof, for evaluation and/or preservation. The fluid includes cocaine or a stimulating analogue thereof; nor-adrenalin; and/or adrenaline. In addition, the fluid includes an oncotic agent, such as dextran; hormones, such as thyroxin; triiodotyronine; cortisone, insulin; and electrolytes and optionally nutrients in substantially physiological concentrations in a physiologically acceptable medium. In addition, the medical fluid further includes albumin in a concentration not exceeding 5.0%, and an oxygen carrier, such as erythrocytes. Further components may be dopamine; hydrocortisone; methylprednisolone; and a vasopressor agent, such as desmopressin. The cocaine; adrenalin; and noradrenaline are present in concentrations of each about 0.010 μM to 0.100 μM, for example in a ratio of 1:1:1.
摘要翻译：用于收获的器官，组织或其部分的用于评估和/或保存的医用流体。流体包括可卡因或其刺激类似物; 肾上腺素; 和/或肾上腺素。此外，流体包括肿瘤剂，例如葡聚糖; 激素，如甲状腺素; 三碘青ine碱可的松，胰岛素; 以及在生理上可接受的介质中基本上生理浓度的电解质和任选的营养物质。此外，药液还含有浓度不超过5.0％的白蛋白和红细胞等氧载体。其他组分可以是多巴胺; 氢化可的松甲泼尼龙和血管加压素剂，如去氨加压素。可卡因肾上腺素和去甲肾上腺素以每种约0.010μM至0.100μM的浓度存在，例如以1:1:1的比例存在。

6. 发明申请

US20110270215A1 COMPOSITION COMPRISING NOR-ADRENALINE AND A NET INHIBITOR FOR ADMINISTERING TO A BRAIN-DEAD, HEART-BEATING POTENTIAL ORGAN DONOR 审中-公开
标题翻译：包含非 - 肾上腺素和网络抑制剂的组合物用于治疗脑死亡，心脏发生潜在有机组成
公开(公告)号：US20110270215A1
公开(公告)日：2011-11-03
申请号：US13142727
申请日：2009-12-30
申请人： Stig Steen
发明人： Stig Steen
IPC分类号： A61M5/142 , A61K38/08 , A61P43/00 , A61K31/46
CPC分类号： A61K31/46 , A01N1/0226 , A61K9/0019 , A61K31/135 , A61K31/137 , A61K31/198 , A61K31/55 , A61K31/573 , A61K38/095 , A61K45/06 , A61M5/142 , A61M5/172 , A61K2300/00
摘要： A composition, an infusion solution, a method for treatment, and a kit for intravascular administration for treatment of a brain-dead, heart-beating, respirated, potential organ donor. The composition has a non-adrenaline and NET inhibitor for noradrenaline. The NET inhibitor may be cocaine or an analogue thereof or a tricyclic antidepressant. The composition may in addition include adrenaline, hydrocortisone, thyroxin, insulin, triiodotyronine, dopamine, a vasopressor agent, such as desmopressin, and methylprednisolone. The ratio between the NET inhibitor and nor-adrenaline is about 1:1. The composition may be dissolved in pure water, Ringer's acetate solution or physiological sodium chloride solution. The composition is infused in such an amount as to maintain a mean arterial pressure of about 60 mmHg. The composition may be infused by a pump at a rate of about 1.7 ml/hour decreasing dose-dependent to about 0.4 ml/hour after 24 hours.
摘要翻译：组合物，输液溶液，治疗方法和血管内给药用于治疗脑死亡，心跳，呼吸，潜在的器官供体的试剂盒。该组合物具有用于去甲肾上腺素的非肾上腺素和NET抑制剂。 NET抑制剂可以是可卡因或其类似物或三环抗抑郁药。组合物还可以包括肾上腺素，氢化可的松，甲状腺素，胰岛素，三碘青ron碱，多巴胺，血管加压剂，如去氨加压素和甲基强的松龙。 NET抑制剂与非肾上腺素之间的比例约为1:1。组合物可溶于纯水，林格氏醋酸溶液或生理氯化钠溶液。该组合物以维持约60mmHg的平均动脉压的量输注。组合物可以以约1.7ml /小时的速率输注泵，24小时后剂量依赖于约0.4ml /小时。

7. 发明授权

US10357029B2 Insert for an organ transport device 有权
公开(公告)号：US10357029B2
公开(公告)日：2019-07-23
申请号：US15108942
申请日：2014-12-29
申请人： VIVOLINE MEDICAL AB
发明人： Stig Steen , Audrius Paskevicius , Anna Beyer , Benjamin King
IPC分类号： A01N1/02
摘要： A device for arranging a harvested heart to be stored in an enclosure before transplantation, whereby the heart is connected to a tube for supply of a medical fluid to the heart. A cylindrical insert intended to be arranged in a enclosure for the heart, comprises a fixture for immobilizing the tube in a central position of the insert. The fixture comprises an arm extending from the periphery of the fixture to the center of the fixture; and a jaw device for gripping the tube and maintaining the tube and the organ hanging in the tube in a predetermined height position.

8. 发明申请

US20120184024A1 Container and Supporting Structure for Housing an Organ 有权
标题翻译：住房机构的集装箱和配套结构
公开(公告)号：US20120184024A1
公开(公告)日：2012-07-19
申请号：US13498160
申请日：2010-09-24
申请人： Stig Steen , Audrius Paskevicius , Anna Beyer , Morgan Johansson , Benjamin King , Anna Soderlund , Anders Lindsten , Peter Sebelius , Maria Sperlingsson , Joakim Nilsson
发明人： Stig Steen , Audrius Paskevicius , Anna Beyer , Morgan Johansson , Benjamin King , Anna Soderlund , Anders Lindsten , Peter Sebelius , Maria Sperlingsson , Joakim Nilsson
IPC分类号： A01N1/02 , B01L9/00
CPC分类号： A01N1/0247 , A01N1/0273
摘要： An apparatus intended for evaluation, preservation and perfusion of an organ, such as a lung. The apparatus includes a container with a bottom portion, an insert portion and a lid portion. A pulmonary artery tube is intended to be connected to the lung pulmonary artery and a trachea tube is intended to be connected to the trachea of the lungs and bent tube connects the pulmonary artery tube to a circuit for providing a fluid to the pulmonary artery is provided. The circuit includes a pump, an oxygenator, an optional leukocyte-filter, and a holder for connecting the trachea tube to a source of respiration. There is an oxygenator tube set and a leukocyte-filter tube set. A supporting structure for the container comprises a recess sized for enclosing said container and a display panel. Moreover, there are two handles, which may be unfolded into a position for supporting a sterile cloth.
摘要翻译：用于评估，保存和灌注诸如肺的器官的装置。该装置包括具有底部，插入部分和盖部分的容器。肺动脉管旨在连接到肺肺动脉，气管连接到肺气管，弯管将肺动脉管连接到肺动脉提供流体的回路。电路包括泵，氧合器，可选的白细胞过滤器和用于将气管连接到呼吸源的保持器。有一个充氧器管组和一个白细胞过滤管组。用于容器的支撑结构包括用于封闭所述容器和显示面板的凹槽。此外，还有两个把手可以展开到支撑无菌布的位置。

9. 发明申请

US20110065169A1 APPARATUS FOR HOUSING AN ORGAN DURING EVALUATION AND PRESERVATION 审中-公开
标题翻译：用于在评估和保存期间容纳一个有机体的装置
公开(公告)号：US20110065169A1
公开(公告)日：2011-03-17
申请号：US12991273
申请日：2009-05-06
申请人： Stig Steen , Audrius Paskevicius , Benjamin Martin King
发明人： Stig Steen , Audrius Paskevicius , Benjamin Martin King
IPC分类号： A01N1/02 , C12M1/34
CPC分类号： A01N1/02 , A01N1/0242 , A01N1/0247
摘要： A vessel for housing an organ such as lungs from a mammal ex-vivo, for evaluation or preservation. A liquid solution suitable for evaluation or preservation of the lungs surrounds the organ, at least partly. The solution is circulated via an outlet and an inlet. Two pressure chambers are arranged between the walls of the vessel and the organ. A gas is introducible to the pressure chamber in order to expand the pressure chamber for occupying the spaces surrounding the organ. Then, the pressure inside the pressure chambers is increased in order to push the solution to a higher level so that the organ is immersed in the solution without necessitating addition of further solution. Alternatively, the vessel is exposed to an under pressure and the pressure chambers are open to the atmosphere. In a further alternative embodiment, a solution collection space has variable volume.
摘要翻译：用于容纳来自哺乳动物的器官如肺的器官，用于评估或保存。适于评估或保护肺的液体溶液至少部分地包围器官。溶液通过出口和入口循环。两个压力室布置在容器的壁和器官之间。气体可以被引入压力室，以便扩大用于占据器官周围空间的压力室。然后，增加压力室内的压力以便将溶液推到更高的水平，使得器官浸入溶液中，而不需要添加另外的溶液。或者，容器暴露于低压下，并且压力室对大气敞开。在另一替代实施例中，解集合空间具有可变容量。

10. 发明授权

US09596842B2 Container and supporting structure for housing an organ 有权
公开(公告)号：US09596842B2
公开(公告)日：2017-03-21
申请号：US14801651
申请日：2015-07-16
申请人： Stig Steen , Audrius Paskevicius , Anna Beyer , Morgan Johansson , Benjamin King , Anna Söderlund , Anders Lindsten , Peter Sebelius , Maria Sperlingsson , Joakim Nilsson
发明人： Stig Steen , Audrius Paskevicius , Anna Beyer , Morgan Johansson , Benjamin King , Anna Söderlund , Anders Lindsten , Peter Sebelius , Maria Sperlingsson , Joakim Nilsson
IPC分类号： A01N1/02
CPC分类号： A01N1/0247 , A01N1/0273
摘要： An apparatus intended for evaluation, preservation and perfusion of an organ, such as a lung. The apparatus includes a container with a bottom portion, an insert portion and a lid portion. A pulmonary artery tube is intended to be connected to the lung pulmonary artery and a trachea tube is intended to be connected to the trachea of the lungs and bent tube connects the pulmonary artery tube to a circuit for providing a fluid to the pulmonary artery is provided. The circuit includes a pump, an oxygenator, an optional leukocyte-filter, and a holder for connecting the trachea tube to a source of respiration. There is an oxygenator tube set and a leukocyte-filter tube set. A supporting structure for the container comprises a recess sized for enclosing said container and a display panel. Moreover, there are two handles, which may be unfolded into a position for supporting a sterile cloth.

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