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1. 发明授权

US4656281A Imidazo quinoline compounds useful as anti-allergy agents 失效
标题翻译：咪唑喹啉化合物可用作抗过敏剂
公开(公告)号：US4656281A
公开(公告)日：1987-04-07
申请号：US731689
申请日：1985-05-08
申请人： John H. Musser , Richard E. Brown
发明人： John H. Musser , Richard E. Brown
IPC分类号： C07D215/28 , C07D498/04 , C07D471/04
CPC分类号： C07D215/28
摘要： The quinoline compounds being of the formula: ##STR1## and salts thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, halo, trifluoromethyl, amino, lower alkyl amino, lower acylamino, cyano, aryl, aryl/lower alkylene, nitro, lower alkynyl, lower alkenyl, lower alkyl sulfinyl, lower alkyl sulfonyl, lower alkoxycarbonyl, carboxyl, lower alkoxy, lower alkanoyl, or lower alkenoyl,Y is nitrogen or R.sub.3 N wherein R.sub.3 is hydrogen, lower alkyl, alkenyl, alkynyl, aryl aralkyl, acyl, aminoalkyl, or carboxyalkyl,Z is nitrogen,X is cyano, carbalkoxyl, carboxyl, formyloximino, tetrazolyl, carbalkoxyalkyl or carboxyalkyl, andm is 0 or 1, are useful as medicinals, especially for treatment of asthma, and/or intermediates in the preparation of compounds useful for treating asthma.
摘要翻译：喹啉化合物具有下式：其中R1和R2独立地是氢，低级烷基，卤素，三氟甲基，氨基，低级烷基氨基，低级酰氨基，氰基，芳基，芳基/低级亚烷基，硝基低级炔基，低级烯基，低级烷基亚磺酰基，低级烷基磺酰基，低级烷氧基羰基，羧基，低级烷氧基，低级烷酰基或低级烯酰基，Y为氮或R3N，其中R3为氢，低级烷基，烯基，炔基，芳基芳烷基，酰基，氨基烷基或羧基烷基，Z是氮，X是氰基，甲酰氧基，羧基，甲酰肟基，四唑基，烷氧基烷基或羧基烷基，m是0或1，可用作药物，特别是用于治疗哮喘和/ 可用于治疗哮喘的化合物的制备。

2. 外观设计

USD286919S Pharmaceutical tablet 失效
公开(公告)号：USD286919S
公开(公告)日：1986-11-25
申请号：US646194
申请日：1984-08-31
申请人： James W. Flockhart , Joseph Barone
设计人： James W. Flockhart , Joseph Barone

3. 发明授权

US4578386A 7,8-Dihydroimidazo[1,5-a]pyrazin-8-ones 失效
标题翻译： 7,8-二氢咪唑并[1,5-a]吡嗪-8-酮
公开(公告)号：US4578386A
公开(公告)日：1986-03-25
申请号：US578916
申请日：1984-02-10
申请人： Thomas D. Lee
发明人： Thomas D. Lee
IPC分类号： A61K31/495 , A61P9/00 , C07D233/92 , C07D403/06 , C07D487/04 , A61K31/50 , A61K31/53 , C07D519/00
CPC分类号： C07D233/92 , C07D403/06 , C07D487/04
摘要： Provided are compounds of the structure: ##STR1## wherein R.sub.1, R.sub.3, R.sub.5 and R.sub.6 are independently H, alkyl, aralkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkenyl, alkynyl, hydroxy, hydroxyalkyl, alkoxy, mercapto, mercaptoalkyl, alkylthio, amino, alkylamino, aminoalkyl, formyl, carboxy and salts thereof, carbalkoxy, alkanoyl, cyano, nitro, halo, trifluoromethyl, alkylsulfonyl, aminosulfonyl, carbamoyl or cycloalkyl; andR.sub.7 is H, alkyl, aryl, aralkyl, oxo, or alkanoyl;wherein at least one of R.sub.1 R.sub.5 or R.sub.6 is an aryl, heteroaryl, or heteroaryl substituted with H, alkyl, halo, amino, trifluoromethyl or cyano.
摘要翻译：提供以下结构的化合物：其中R1，R3，R5和R6独立地为H，烷基，芳烷基，芳基，取代的芳基，杂芳基，取代的杂芳基，烯基，炔基，羟基，羟烷基，烷氧基，巯基，巯基烷基，烷硫基，氨基，烷基氨基，氨基烷基，甲酰基，羧基及其盐，烷氧基，烷酰基，氰基，硝基，卤素，三氟甲基，烷基磺酰基，氨基磺酰基，氨基甲酰基或环烷基; 并且R 7是H，烷基，芳基，芳烷基，氧代或烷酰基; 其中R 1 + L，R 5或R 6中的至少一个是被H，烷基，卤素，氨基，三氟甲基或氰基取代的芳基，杂芳基或杂芳基。

4. 发明授权

US3838135A Oximo tetracyclic indoles 失效
标题翻译： OXIMO TETRACYCLIC INDOLES
公开(公告)号：US3838135A
公开(公告)日：1974-09-24
申请号：US29865872
申请日：1972-10-18
申请人： USV PHARMA CORP
发明人： MAGNIEN E , CABILIO J
IPC分类号： C07D471/06 , C07D33/50
CPC分类号： C07D471/06
摘要： COMPOUNDS OF THE STRUCTURE

1,2-(-(CH2)N-),6-(R3-N(-R4)-X-O-N=),R1,R2-5,6-DIHYDRO-4H-

PYRROLO(3,2,1-IJ)QUINOLINE

WHEREIN N IS AN INTEGER FROM 4-6, R1 IS HYDROGEN, LOWER ALKYL, LOWER ALKOXY, OR HALOGEN, R2 IS HYDROGEN OR LOWER ALKYL, R3 AND R4 ARE LOWER ALKYL OR CYCLOALKYL OR TAKEN TOGETHER WITH THE N TO WHICH THEY ARE ATTACHED, ARE PYRROLIDINO, PIPERIDINO, MORPHOLINO, OR PIPERAZINO, HAVE HYPOTENSIVE ACTIVITY.

5. 发明授权

US3823159A O-(substituted carbamoyl)-3-pyrrolidinopropio and butyrophenone oximes 失效
标题翻译： O-（取代的羰基）-3-吡咯烷酮和丁基酚氧化物
公开(公告)号：US3823159A
公开(公告)日：1974-07-09
申请号：US14137471
申请日：1971-05-07
申请人： USV PHARMA CORP
发明人： KARTEN M
IPC分类号： C07D295/125 , C07D27/04
CPC分类号： C07D295/125
摘要： COMPOUNDS OF THE FORMULA

X-Y-C(-R1)=N-O-CO-N(-R2)-R3

WHEREIN R1 AND R3 ARE LOWER ALIPHATIC, CYCLOALKYL, OR AROMATIC (INCLUDING HETERO), R2 IS HYDROGEN, AROMATIC, LOWER ALIPHATIC, OR PHENYL-LOWER ALKYL, Y IS AN ALKYLENE GROUP HAVING FROM 1-5 CARBON ATOMS, AND X IS A HETEROCYCLIC SECONDARY AMINO GROUP, AHVING POTENT ANALGESIC ACTIVITY.

6. 发明授权

US3793322A 1,4-disubstituted piperazines 失效
标题翻译： 1,4-取代的哌嗪
公开(公告)号：US3793322A
公开(公告)日：1974-02-19
申请号：US3793322D
申请日：1972-12-15
申请人： USV PHARMA CORP
发明人： SHROFF J , BANDURCO V
IPC分类号： C07D295/195 , C07D295/205 , C07D51/70
CPC分类号： C07D295/195 , C07D295/205 , Y10S514/866
摘要： PIPERAZINE DERIVATIVES OF THE FORMULA

1-((R,R''-PHENYL)-C(=N-R")-),4-R"''-PIPERAZINE

WHEREIN R AND R'' ARE HYDROGEN, HYDROXY, LOWER ALKYL, LOWER ALKOXY HALOGEN OR TRIFLUOROMETHYL, R" IS LOWER ALKYL, LOWER ALKENYL, CYCLOALKYL OR PHENYL OR R"'' IS HYDROGEN, LOWER ALKYL, LOWER ALKENYL, CARBOALKOXY, FORMYL, BENZYL, OR CINNAMYL HAVE POTENT HYPOGLYCEMIC ACTIVITY.

7. 发明授权

US3715396A N-amino-benzamidines 失效
标题翻译： N-氨基苯甲胺
公开(公告)号：US3715396A
公开(公告)日：1973-02-06
申请号：US3715396D
申请日：1969-11-04
申请人： USV PHARMA CORP
发明人： BANDURCO V , ELPERN B , SHROFF J
IPC分类号： C07C259/20 , C07C123/00
CPC分类号： C07C259/20
摘要： Compounds of the formula WHEREIN R is hydrogen, alkyl, acyl, phenyl-lower alkyl, carbamoyl, benzoyl, R1 is lower alkyl, pyridyl, naphthyl, or cycloalkyl, R2 is phenyl or substituted phenyl, and R3 and R4 are hydrogen, lower alkyl, phenyl or phenyl-lower alkyl, or taken together are alkylene, possess anti-inflammatory activity.
摘要翻译：式WHEREIN R的化合物是氢，烷基，酰基，苯基 - 低级烷基，氨基甲酰基，苯甲酰基，R1是低级烷基，吡啶基，萘基或环烷基，R2是苯基或取代的苯基，R3和R4是氢，，苯基或苯基 - 低级烷基，或一起为亚烷基，具有抗炎活性。

8. 外观设计

USD290412S Pharmaceutical tablet 失效
公开(公告)号：USD290412S
公开(公告)日：1987-06-16
申请号：US649884
申请日：1984-09-13
申请人： Stephen C. Downs
设计人： Stephen C. Downs

9. 发明授权

US4605675A Polyene compounds useful in the treatment of allergic responses 失效
标题翻译：可用于治疗过敏反应的多烯化合物
公开(公告)号：US4605675A
公开(公告)日：1986-08-12
申请号：US787843
申请日：1985-10-16
申请人： Bernard Loev , Wan-Kit Chan
发明人： Bernard Loev , Wan-Kit Chan
IPC分类号： A61K31/05 , A61K31/075 , A61K31/085
CPC分类号： C07C403/02 , C07C2101/16
摘要： Polyene compounds represented by the formula ##STR1## in which R is H or an alkyl group of from 1 to 5 carbon atoms, R.sub.1 is H, lower alkyl of from 1 to 8 carbon atoms or aralkyl, and the pharmaceutically acceptable salts thereof.The foregoing compounds have been found active in regulating phospholipases and as such possess therapeutic value in the treatment of inflammatory conditions.
摘要翻译：其中R为H或1至5个碳原子的烷基，R 1为H，1至8个碳原子的低级烷基或芳烷基，其化学式为“IMAGE”的多烯化合物及其药学上可接受的盐。已经发现前述化合物在调节磷脂酶中是有活性的，因此具有治疗炎性病症的治疗价值。

10. 发明授权

US4588734A Blood pressure lowering n-pyridyl-, n-quinolyl-, and n-piperdyl-n-acyl amino acid derivatives and method 失效
标题翻译：血压降低正丁基 - 正正喹啉基和正 - 哌啶基-N-酰基氨基酸衍生物及方法
公开(公告)号：US4588734A
公开(公告)日：1986-05-13
申请号：US672645
申请日：1984-11-19
申请人： John T. Suh , Jerry W. Skiles , Bruce E. Williams , Alfred Schwab
发明人： John T. Suh , Jerry W. Skiles , Bruce E. Williams , Alfred Schwab
IPC分类号： A61K31/445 , C07D207/08 , C07D211/26 , C07D213/40 , C07D213/75 , C07D217/22 , C07D219/14 , C07D235/30 , C07D239/42 , C07D277/46 , C07D307/52 , C07D307/66 , C07D307/82 , C07D309/14 , C07D317/66 , C07D319/18 , C07D333/20 , C07D333/36 , C07D333/48 , A61K31/47 , C07D215/38
CPC分类号： C07D213/40 , C07C327/00 , C07D207/08 , C07D211/26 , C07D213/75 , C07D217/22 , C07D219/14 , C07D235/30 , C07D239/42 , C07D277/46 , C07D307/52 , C07D307/66 , C07D307/82 , C07D309/14 , C07D317/66 , C07D319/18 , C07D333/20 , C07D333/36 , C07D333/48
摘要： Compounds of the structure: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, or cycloalkyl,n is an integer from 0 to 4 inclusive,M is heterocyclic or heterocyclic alkyl,Y is hydroxy, alkoxy, amino, or substituted amino, amino-alkanoyl, aryloxy, aminoalkoxy, or hydroxyalkoxy, andR.sub.7 is hydrogen, alkanoyl, carboxylalkanoyl, hydroxyalkanoyl, amino-alkanoyl, cyano, amidino, carbalkoxy, ZS, or ##STR2## wherein Z is hydrogen, alkyl, hydroxyalkyl, aminoalkyl or the radical ##STR3## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, n, M and Y are as described above; and where Y is hydroxy their nontoxic, pharmaceutically acceptable alkali metal, alkaline earth metal, and amine salts.These compounds possess antihypertensive and angiotensin converting enzyme inhibitory activity.
摘要翻译：结构化合物：其中R 1，R 2，R 3，R 4，R 5和R 6为氢，烷基，烯基，炔基，苯基 - 烷基或环烷基，n为0-4的整数，或杂环烷基，Y是羟基，烷氧基，氨基或取代的氨基，氨基 - 烷酰基，芳氧基，氨基烷氧基或羟基烷氧基，R7是氢，烷酰基，羧基烷酰基，羟基烷酰基，氨基 - 烷酰基，氰基，脒基，或其中Z是氢，烷基，羟基烷基，氨基烷基或基团，其中R 1，R 2，R 3，R 4，R 5，R 6，n，M和Y如上所述; 并且其中Y是羟基，它们是无毒的，药学上可接受的碱金属，碱土金属和胺盐。这些化合物具有抗高血压和血管紧张素转换酶的抑制活性。

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