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1. 发明授权

US11666578B2 Small molecule inhibitors of CDK12/CDK13 有权
公开(公告)号：US11666578B2
公开(公告)日：2023-06-06
申请号：US17053652
申请日：2019-05-07
申请人： The Scripps Research Institute
发明人： William R. Roush , Derek R. Duckett , Andrii Monastyrskyi
IPC分类号： A61K31/5377
CPC分类号： A61K31/5377
摘要： The invention provides compounds and methods of inhibiting a cyclin-dependent kinase, comprising contacting the cyclin-dependent kinase and an effective amount or concentration of a compound of formula (I) wherein variables are as defined herein. Compounds of formula (I) can be highly selective inhibitors of cyclin-dependent kinases such as CDK12/13, relative to other kinases such as casein kinases, such as CK1δ/ε. Compounds can be used in treatment of cancers, such as breast cancer, brain cancer and ovarian cancer.

2. 发明公开

US20240018228A1 ANTIBODIES SPECIFIC TO CCL21 AND METHODS OF USE 审中-公开
公开(公告)号：US20240018228A1
公开(公告)日：2024-01-18
申请号：US18043570
申请日：2021-08-27
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
发明人： Robert Hromas
IPC分类号： C07K16/24 , A61P1/00
CPC分类号： C07K16/24 , A61P1/00 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Disclosed herein are anti-CCL21 antibodies useful in treating autoimmune diseases, treating or preventing allograft transplant rejection, and treating metastatic cancer or preventing cancer metastasis in a subject.

3. 发明授权

US11649234B2 Nonmuscle myosin II inhibitors for substance use relapse 有权
公开(公告)号：US11649234B2
公开(公告)日：2023-05-16
申请号：US17250203
申请日：2019-06-13
申请人： The Scripps Research Institute
发明人： Courtney Miller , Patrick R. Griffin , Theodore Mark Kamenecka , Gavin Rumbaugh , Matthew Surman , Steve Young , Steven Duddy , Laszlo Radnai
IPC分类号： C07D471/04 , C07D471/14 , C07D495/14 , C07D519/00
CPC分类号： C07D471/04 , C07D471/14 , C07D495/14 , C07D519/00
摘要： The invention can provide compounds, analogs of blebbistatin, effective and selective inhibitors of nonmuscle myosin II relative to cardiac myosin II. Compounds can be used in the method of treating a disease, disorder, or medical condition in a patient, comprising modulating myosin II ATPase, such as treatment of substance abuse relapse disorder, or of renal disease, cancer and metastasis, benign prostate hyperplasia, hemostasis or thrombosis, nerve injury including retinal damage, lung fibrosis, liver fibrosis, arthrofibrosis, wound healing, spinal cord injury, periodontitis, glaucoma and immune-related diseases including multiple sclerosis; or wherein the disease, disorder, or medical condition comprises addiction including abuse of or addiction to anything classified as a Substance-Related or Addictive Disorder in the Diagnostic and Statistical Manual of Mental Disorders (DSM), such as, but not limited to, cocaine, opioids, amphetamines, ethanol, cannabis/marijuana, nicotine, and activities including gambling Compounds are of general formula (I) with substituents as defined herein.

4. 植物专利

USPP27128P2 Peach tree named ‘GulfAtlas’ 有权
标题翻译：桃树名为“GulfAtlas”
公开(公告)号：USPP27128P2
公开(公告)日：2016-09-06
申请号：US13998066
申请日：2013-09-27
申请人： The United States of America as represented by the Secretary of Agriculture , The University of Georgia Research Foundation , The University of Florida
发明人： Thomas G Beckman , Jose X Chaparro , Patrick J Conner
IPC分类号： A01H5/08
CPC分类号： A01H6/7463 , A01H5/08
摘要： A new and distinct variety of peach tree, denominated ‘GulfAtlas’, has a winter chilling requirement estimated at approximately 400 chill units (cu). The tree is medium size, moderately vigorous, and semi-spreading in growth habit. It bears showy, pink flowers, and leaves with reniform glands. Trees of ‘GulfAtlas’ are self-fertile and regularly bear heavy annual crops. Fruit are uniformly firm and have yellow, non-melting flesh. Fruit are nearly round, and uniform with substantially symmetrical shape, and have an attractive approximately 75% red skin. The fruit of ‘GulfAtlas’ typically ripen about 3 weeks after ‘Gulfcrimson’ in midJune at Attapulgus, Ga.
摘要翻译：一个新的和独特的桃树种类，称为“GulfAtlas”，冬季寒冷需求估计约为400冷藏单位（cu）。树的中等大小，适度生长，半生长的习惯。它具有华丽，粉红色的花朵和叶子与肾脏腺体。 “GulfAtlas”的树木是自给自足的，经常每年都会重播一年。果实均匀，果肉黄色，不融化。水果几乎圆形，均匀，形状基本对称，具有吸引力约75％的红色皮肤。 “GulfAtlas”的果实通常在加拿大Attapulgus的6月中旬在“Gulfcrimson”之后大约3周成熟。

5. 发明申请

US20090149414A1 rAAV EXPRESSION SYSTEMS AND COMPOSITIONS 审中-公开
标题翻译： rAAV表达系统和组成
公开(公告)号：US20090149414A1
公开(公告)日：2009-06-11
申请号：US12363514
申请日：2009-01-30
申请人： KENNETH H. WARRINGTON , SHAUN R. OPIE , NICHOLAS MUZYCZKA
发明人： KENNETH H. WARRINGTON , SHAUN R. OPIE , NICHOLAS MUZYCZKA
IPC分类号： A61K31/7088 , C12N15/00 , C12N5/06
CPC分类号： C12N15/86 , A61K48/00 , C12N2750/14143 , C12N2750/14145 , C12N2810/50
摘要： Disclosed are improved VP2-modified recombinant adeno-associated viral (rAAV) vectors, expression systems, and rAAV virions that are fully virulent, yet lack functional VP2 protein expression. Also disclosed are pharmaceutical compositions, virus particles, host cells, and pharmaceutical formulations that comprise these modified vectors useful in the expression of therapeutic proteins, polypeptides, peptides, antisense oligonucleotides and/or ribozymes in the cells and tissues of selected mammals, including, for example, human tissues and host cells.
摘要翻译：公开了改进的VP2修饰的重组腺相关病毒（rAAV）载体，表达系统和完全毒力但缺乏功能性VP2蛋白表达的rAAV病毒粒子。还公开了包含这些修饰的载体的药物组合物，病毒颗粒，宿主细胞和药物制剂，其用于在所选哺乳动物的细胞和组织中表达治疗性蛋白质，多肽，肽，反义寡核苷酸和/或核酶，包括用于例如，人体组织和宿主细胞。

6. 发明申请

US20090148949A1 rAAV Expression Systems and Methods of Use 审中-公开
标题翻译： rAAV表达系统和使用方法
公开(公告)号：US20090148949A1
公开(公告)日：2009-06-11
申请号：US12363469
申请日：2009-01-30
申请人： KENNETH H. WARRINGTON , SHAUN R. OPIE , NICHOLAS MUZYCZKA
发明人： KENNETH H. WARRINGTON , SHAUN R. OPIE , NICHOLAS MUZYCZKA
IPC分类号： C12N15/87
CPC分类号： C12N15/86 , A61K48/00 , C12N2750/14143 , C12N2750/14145 , C12N2810/50
摘要： Disclosed are improved VP2-modified recombinant adeno-associated viral (rAAV) vectors, expression systems, and rAAV virions that are fully virulent, yet lack functional VP2 protein expression. Also disclosed are pharmaceutical compositions, virus particles, host cells, and pharmaceutical formulations that comprise these modified vectors useful in the expression of therapeutic proteins, polypeptides, peptides, antisense oligonucleotides and/or ribozymes in the cells and tissues of selected mammals, including, for example, human tissues and host cells.
摘要翻译：公开了改进的VP2修饰的重组腺相关病毒（rAAV）载体，表达系统和完全毒力但缺乏功能性VP2蛋白表达的rAAV病毒粒子。还公开了包含这些修饰的载体的药物组合物，病毒颗粒，宿主细胞和药物制剂，其用于在所选哺乳动物的细胞和组织中表达治疗性蛋白质，多肽，肽，反义寡核苷酸和/或核酶，包括用于例如，人体组织和宿主细胞。

7. 发明授权

US07514249B2 Biomimetic organic/inorganic composites 有权
标题翻译：仿生有机/无机复合材料
公开(公告)号：US07514249B2
公开(公告)日：2009-04-07
申请号：US10691002
申请日：2003-10-22
申请人： Laurie B. Gower , Matthew J. Olszta , Elliot P. Douglas , Sivakumar Munisamy , Donna L. Wheeler
发明人： Laurie B. Gower , Matthew J. Olszta , Elliot P. Douglas , Sivakumar Munisamy , Donna L. Wheeler
IPC分类号： C12N11/00 , C12N11/02 , C12N11/10 , C12N11/12 , C12N11/08 , C07K17/04 , C07K17/10 , C07K17/12 , C07K17/08 , A61K9/00 , C12N11/04 , A61F2/00
CPC分类号： A61L27/24 , A61L27/446 , A61L27/46 , A61L31/127 , A61L31/128 , A61L31/146 , Y10S530/811 , Y10S530/812 , Y10S530/813 , Y10S530/814 , Y10S530/815 , Y10S530/817
摘要： The subject invention concerns a composite comprising an organic fluid-swellable, fibrous matrix, such as collagen, and a mineral phase, such as calcium carbonate or phosphate mineral phase, for use as a biomimetic of bone. In another aspect, the subject invention concerns a process for making a composite involving the inclusion of acidic polymers to a supersaturated mineralizing solution, in order to induce an amorphous liquid-phase precursor to the inorganic mineral, which is then absorbed (pulled by capillary action) into the organic matrix. Advantageously, once solidified, a high mineral content can be achieved, with the inorganic mineral crystals embedded within the collagen fibers (intrafibrillarly) and oriented such that they are aligned along the long axes of the fibers of the organic matrix, thereby closely mimicking the natural structure of bone. The present invention further concerns a method of treating a patient suffering from a bone defect by applying a biomimetic composite to the bone defect site.
摘要翻译：本发明涉及一种复合材料，其包含有机流体 - 可溶胀的纤维基质如胶原和矿物相如碳酸钙或磷酸盐矿物相用作骨仿生体。在另一方面，本发明涉及一种制备涉及将酸性聚合物包含在过饱和矿化溶液中的复合物的方法，以便诱导无机矿物的无定形液相前体，然后将其吸收（通过毛细作用拉动）进入有机基质。有利地，一旦固化，可以实现高矿物质含量，其中无机矿物晶体嵌入胶原纤维内（纤维内）并定向成使得它们沿着有机基质的纤维的长轴排列，从而紧密地模仿天然骨结构。本发明还涉及通过将仿生复合材料应用于骨缺损部位来治疗患有骨缺损的患者的方法。

8. 发明申请

US20090074723A1 Method of Treating or Retarding the Development of Blindness 审中-公开
标题翻译：治疗或阻碍盲症发展的方法
公开(公告)号：US20090074723A1
公开(公告)日：2009-03-19
申请号：US12253955
申请日：2008-10-18
申请人： Gregory M. Acland , Gustavo D. Aguirre , Jean Bennett , William W. Hauswirth , Samuel G. Jacobson , Albert M. Maguire
发明人： Gregory M. Acland , Gustavo D. Aguirre , Jean Bennett , William W. Hauswirth , Samuel G. Jacobson , Albert M. Maguire
IPC分类号： A61K48/00 , A61K31/7088 , A61K35/12 , A61K35/76 , A61P27/02
CPC分类号： A61K48/0058 , A61K9/0048 , A61K31/70 , A61K38/00 , A61K38/465 , A61K38/51 , A61K38/52 , A61K48/00 , A61K48/005 , A61K48/0075 , C07K14/705 , C12N7/00 , C12N15/86 , C12N15/8645 , C12N2750/14132 , C12N2750/14142 , C12N2750/14143 , C12N2750/14171 , C12N2830/008 , C12N2830/85 , C12N2840/203 , C12Y301/01064
摘要： A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method.
摘要翻译：用于治疗人或动物对象的眼细胞中缺陷或不存在正常基因的眼部疾病的方法包括通过视网膜下注射给予受试者有效量的携带核酸序列的重组腺相关病毒编码在表达基因在眼细胞中的产物的启动子序列控制下的正常基因。眼细胞优选为视网膜色素上皮细胞（RPE），该基因优选为RPE特异性基因，例如RPE65。启动子是可以在RPE细胞中表达基因产物的启动子。视网膜下给药的组合物在该方法中是有用的。

9. 发明申请

US20070103628A1 Transflective LCD using multilayer dielectric film transflector 有权
标题翻译：透反液晶显示器采用多层介质膜透射反射器
公开(公告)号：US20070103628A1
公开(公告)日：2007-05-10
申请号：US11635718
申请日：2006-12-07
申请人： Shin-Tson Wu , Qiong-Hua Wang , Thomas Wu , Xinyu Zhu , Zhibing Ge
发明人： Shin-Tson Wu , Qiong-Hua Wang , Thomas Wu , Xinyu Zhu , Zhibing Ge
IPC分类号： G02F1/1335
CPC分类号： G02F1/133555 , G02F2001/133557 , G02F2202/42
摘要： A novel transflective liquid crystal display (LCD) is provided with a multilayer dielectric film transflector. The dielectric transflector is composed of alternating high and low refractive index dielectric material layers deposited directly on the inner side of the LCD substrate to avoid parallax. The transmittance of the dielectric transflector can vary from approximately 5% to approximately 95% by simply adjusting the individual dielectric layer thickness and the arrangement of layers. The thickness of the 10-layer film is approximately 700 nm, which does not affect the voltage drop on the LC. Two structures of the dielectric film using different positions of the materials of construction are provided and demonstrated. Such a transflective LCD exhibits outstanding features, such as, robust dielectric film, single cell gap, no parallax, and a simple fabrication process.
摘要翻译：一种新型半透射液晶显示器（LCD）具有多层电介质膜透射反射器。介电透射反射器由直接沉积在LCD基板的内侧上的交替的高折射率和低折射率介电材料层组成，以避免视差。通过简单地调节单个介电层厚度和层的布置，介电透射反射器的透射率可以在约5％至约95％之间变化。 10层膜的厚度约为700nm，不影响LC上的电压降。提供并展示了使用构造材料的不同位置的电介质膜的两个结构。这种透反射液晶显示器具有突出的特征，例如坚固的电介质膜，单电池间隙，无视差，以及简单的制造工艺。

10. 发明授权

US06969512B2 Devices and methods for eliminating termite colonies 失效
公开(公告)号：US06969512B2
公开(公告)日：2005-11-29
申请号：US10268356
申请日：2002-10-10
申请人： Philip Frederick Brode, III , Garry Steven Garrett , Leo Timothy Laughlin , Randall Stryker Matthews
发明人： Philip Frederick Brode, III , Garry Steven Garrett , Leo Timothy Laughlin , Randall Stryker Matthews
IPC分类号： A01M1/02 , A01M1/20 , A01N20060101 , A01N25/00 , A01N25/02 , A01N25/08 , A01N31/00 , A01N33/02 , A01N35/06 , A01N37/00 , A01N37/06 , A01N43/16 , A01N43/40 , A01N43/54 , A01N43/66 , A01N61/00 , C07H9/06 , C07H15/203 , A01N43/50 , A01N25/34 , A01N43/52
CPC分类号： A01M1/026 , A01M1/2011 , A01M2200/011 , A01N25/006 , A01N35/06 , A01N43/16 , A01N61/00 , C07H9/06 , C07H15/203 , Y10S424/11 , A01N2300/00
摘要： This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such that the termiticide causes death to about 50 to about 100% of termites within about 24 to about 84 days after the termites begin to ingest the termiticide or the bait matrix comprising the termiticide, b) a cellulose containing material, and c) water. The termiticidal bait matrix can be used in a bait station installed in the ground. The kits are suitable to be used by consumers in their homes.

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