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1. 发明授权

US10492717B2 Methods, systems, and devices for determining and visually indicating demyelinated pathways 有权
公开(公告)号：US10492717B2
公开(公告)日：2019-12-03
申请号：US15034062
申请日：2014-11-04
申请人： The Research Foundation of State University of New York
发明人： Paul Jacob Maccabee , Lawrence Philip Eberle
IPC分类号： A61B5/00 , A61B5/0492 , A61B5/16 , A61B5/04 , A61B5/0488 , A61B5/11
CPC分类号： A61B5/4041 , A61B5/04012 , A61B5/0488 , A61B5/0492 , A61B5/162 , A61B5/4052 , A61B5/6877 , A61B5/742 , A61B5/1107
摘要： A method includes receiving multiple compound muscle action potential values (CMAPs), wherein each CMAP is an onset latency, a peak latency, a conduction velocity, or a response amplitude measured from a baseline; for each of the CMAPs and for each of a number parameters calculated from the CMAPs, determining a corresponding demyelinating boundary value using a normal value from a preselected population; determining whether each of the CMAPs and each of the parameters exceeds the corresponding demyelinating boundary value; determining one or more demyelinated nerve pathways based on which of the CMAPs and the parameters exceeds the corresponding demyelinating boundary value; indicating on a display which of the CMAPs and the parameters exceed the corresponding demyelinating boundary value; and displaying, in pictorial form, an anatomical diagram indicating the demyelinated nerve pathways.

2. 发明授权

US09945863B2 Coiled coil helix cristae morphology 1 (CHCM1) tumor marker and cancer therapeutic target 有权
公开(公告)号：US09945863B2
公开(公告)日：2018-04-17
申请号：US14107306
申请日：2013-12-16
申请人： The Research Foundation of State University of New York
发明人： M. Saeed Sheikh , Ying Huang , Jie An
IPC分类号： G01N33/574
CPC分类号： G01N33/57415 , G01N33/57419 , G01N33/5743 , G01N33/57484
摘要： Methods for diagnosing and treating a cancer or a tumor in a patient are provided. The methods can comprise the steps of obtaining a biological sample from the patient and analyzing the sample for the presence or absence of Coiled Coil Helix Cristae Morphology 1 protein (CHCM1). A patient is diagnosed with cancer or a tumor provided that CHCM1 is overexpressed. The diagnosed patient is treated by administering a cancer or tumor treatment. The methods can also comprise the steps of obtaining a sample of cancer or tumor cells from the patient, determining a level of CHCM1 expression in the sample of cancer or tumor cells, and administering to the patient a compound for reducing the expression of CHCM1 or for blocking or inhibiting function of CHCM1.

3. 发明申请

US20170044450A1 INCLINED ROTARY GASIFIER WASTE TO ENERGY SYSTEM 审中-公开
标题翻译：包装旋转燃气废物到能源系统
公开(公告)号：US20170044450A1
公开(公告)日：2017-02-16
申请号：US15305985
申请日：2015-04-21
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： David J. WAAGE
IPC分类号： C10J3/00 , C01B3/02 , C10J3/84
摘要： A gasifier system includes a reactor for receiving a wet feedstock which has a base and a container rotatably connected to the base such that a rotation of the container causes a mixing of the feedstock in an interior of the reactor. The interior is bounded by the base and the container. A space between the base and the container allows an entry of oxygen into the interior. The space has a dimension such that the feedstock is fully oxidized in a combustion area adjacent the base and such that the feedstock avoids combustion in a remainder of the interior. The reactor has a longitudinal axis inclined at an inclination angle relative to a horizontal line to promote the mixing of the feedstock in the interior.
摘要翻译：气化器系统包括用于接收湿原料的反应器，其具有基部和可旋转地连接到基部的容器，使得容器的旋转导致原料在反应器内部的混合。内部由基座和容器限定。基座和容器之间的空间允许氧进入内部。该空间具有这样的尺寸，使得原料在邻近基底的燃烧区域中被完全氧化，并且使得原料避免了在其余内部的燃烧。反应器具有相对于水平线倾斜倾斜的纵向轴线，以促进原料在内部的混合。

4. 发明授权

US09530048B2 Automated facial action coding system 有权
标题翻译：自动面部动作编码系统
公开(公告)号：US09530048B2
公开(公告)日：2016-12-27
申请号：US14311814
申请日：2014-06-23
申请人： The Regents of the University of California , The Research Foundation of State University of New York
发明人： Marian Stewart Bartlett , Gwen Littlewort-Ford , Javier Movellan , Ian Fasel , Mark Frank
IPC分类号： G06K9/00 , G06K9/66 , G06K9/46 , G06K9/62
CPC分类号： G06K9/00335 , G06K9/00281 , G06K9/00288 , G06K9/00315 , G06K9/4652 , G06K9/6256 , G06K9/66
摘要： An automatic facial action coding system and method can include processing an image to identify a face in the image, to detect and align one or more facial features shown in the image, and to define one or more windows on the image. One or more distributions of pixels and color intensities can be quantified in each of the one or more windows to derive one or more two-dimensional intensity distributions of one or more colors within the window. The one or more two-dimensional intensity distributions can be processed to select image features appearing in the one or more windows and to classify one or more predefined facial actions on the face in the image. A facial action code score that includes a value indicating a relative amount of the predefined facial action occurring in the face in the image can be determined for the face in the image for each of the one or more predefined facial actions.
摘要翻译：自动面部动作编码系统和方法可以包括处理图像以识别图像中的脸部，以检测和对准图像中所示的一个或多个面部特征，并且定义图像上的一个或多个窗口。可以在一个或多个窗口中的每一个中量化像素和颜色强度的一个或多个分布，以导出窗口内的一种或多种颜色的一个或多个二维强度分布。可以处理一个或多个二维强度分布以选择出现在一个或多个窗口中的图像特征，并对图像中的脸部上的一个或多个预定义的面部动作进行分类。可以针对一个或多个预定义的面部动作中的每一个为图像中的面部确定包括指示出现在图像中的面部中的预定面部动作的相对量的值的面部动作代码分数。

5. 发明授权

US09365432B2 Titanate and titania nanostructures and nanostructure assemblies, and methods of making same 有权
公开(公告)号：US09365432B2
公开(公告)日：2016-06-14
申请号：US13872867
申请日：2013-04-29
申请人： The Research Foundation for The State University of New York
发明人： Stanislaus S. Wong , Yuanbing Mao
IPC分类号： C01G23/00 , C01D13/00 , C01G23/04 , C01G23/047 , C01G23/08 , C01B3/00 , C01B6/02 , C01B6/24 , B82Y30/00 , B32B18/00 , B82Y40/00
CPC分类号： C01G23/003 , B32B18/00 , B32B2311/18 , B82Y30/00 , B82Y40/00 , C01B3/0026 , C01B3/0031 , C01B6/02 , C01B6/24 , C01D13/00 , C01G23/005 , C01G23/04 , C01G23/043 , C01G23/047 , C01G23/08 , C01P2002/72 , C01P2002/82 , C01P2002/84 , C01P2002/85 , C01P2004/03 , C01P2004/04 , C01P2004/10 , C01P2004/13 , C01P2004/16 , C01P2004/32 , C01P2004/34 , C01P2004/50 , C01P2004/61 , C01P2004/62 , C01P2004/64 , Y02E60/327 , Y10S977/762 , Y10S977/773 , Y10S977/811 , Y10S977/896 , Y10T428/24058 , Y10T428/298
摘要： The invention relates to nanomaterials and assemblies including, a micrometer-scale spherical aggregate comprising: a plurality of one-dimensional nanostructures comprising titanium and oxygen, wherein the one-dimensional nanostructures radiate from a hollow central core thereby forming a spherical aggregate.

6. 发明授权

US09325014B2 Branched nanostructures for battery electrodes 有权
标题翻译：用于电池电极的分支纳米结构
公开(公告)号：US09325014B2
公开(公告)日：2016-04-26
申请号：US13817289
申请日：2011-08-23
申请人： Jae Ho Lee , Isaac Lund
发明人： Jae Ho Lee , Isaac Lund
IPC分类号： H01M4/75 , H01M4/52 , H01M4/70 , H01M4/13 , H01M4/134 , H01M4/139 , H01M4/1395 , H01M4/66 , H01M4/78 , H01M10/052 , H01M4/04 , H01M4/36
CPC分类号： H01M4/70 , H01M4/0402 , H01M4/13 , H01M4/134 , H01M4/139 , H01M4/1395 , H01M4/366 , H01M4/66 , H01M4/661 , H01M4/662 , H01M4/663 , H01M4/664 , H01M4/667 , H01M4/78 , H01M10/052 , Y02E60/122 , Y02T10/7011
摘要： The invention relates to electrochemical electrodes containing branched nanostructures having increased surface area and flexibility. These branched nanostructures allow for higher anode density, resulting in the creation of smaller, longer-lasting, more efficient batteries which require less area for the same charging capacity. Also disclosed are methods for creating said branched nanostructures and electrodes.
摘要翻译：本发明涉及具有增加的表面积和柔韧性的支化纳米结构的电化学电极。这些分支的纳米结构允许更高的阳极密度，导致产生更小，更持久，更有效的电池，这对于相同的充电容量需要较少的面积。还公开了用于产生所述支化纳米结构和电极的方法。

7. 发明授权

US09150612B2 RNA targeting compounds and methods for making and using same 有权
标题翻译： RNA靶向化合物及其制备和使用方法
公开(公告)号：US09150612B2
公开(公告)日：2015-10-06
申请号：US12072291
申请日：2008-02-25
申请人： Matthew D. Disney
发明人： Matthew D. Disney
IPC分类号： C07K4/00 , C07D249/04 , A61K31/7008 , C07K9/00 , C07K14/00
CPC分类号： C07K4/00 , A61K31/7008 , C07D249/04 , C07K9/00 , C07K14/001 , Y10T436/143333
摘要： Disclosed are RNA targeting compounds having the formula: wherein j is an integer from 1 to 100; each i is the same or different and is zero or an integer from 1 to 100; each Z1 represents the same or different linking moiety; each R1 is the same or different and represents an alkyl group or an aryl group; each Q1 represents the same or different RNA binding ligand; Q2 is an alkyl group; Q3 is a halogen, an alkyl group, an aryl group, or an amine. Also disclosed are RNA targeting compounds that include a polymer backbone and two or more pendant RNA binding ligands that are bound to the polymer backbone. Methods for using the subject RNA targeting compounds to treat myotonic dystrophy and other diseases are also disclosed, as are compounds that can be used to prepare the subject RNA targeting compounds.
摘要翻译：公开了具有下式的RNA靶向化合物：其中j是1至100的整数; 每个i相同或不同，为零或1至100的整数; 每个Z 1代表相同或不同的连接部分; 每个R 1相同或不同，表示烷基或芳基; 每个Q1代表相同或不同的RNA结合配体; Q2是烷基; Q3是卤素，烷基，芳基或胺。还公开了包含聚合物主链和结合至聚合物主链的两个或更多个侧挂RNA结合配体的RNA靶向化合物。还公开了使用目标RNA靶向化合物治疗肌强直性营养不良和其他疾病的方法，以及可用于制备目标RNA靶向化合物的化合物。

8. 发明授权

US08969200B2 Apparatus and method for integration of through substrate vias 有权
标题翻译：通过衬底通孔整合的装置和方法
公开(公告)号：US08969200B2
公开(公告)日：2015-03-03
申请号：US13445636
申请日：2012-04-12
申请人： Jeremiah Hebding , Megha Rao , Colin McDonough , Matthew Smalley , Douglas Duane Coolbaugh , Joseph Piccirillo, Jr. , Stephen G. Bennett , Michael Liehr , Daniel Pascual
发明人： Jeremiah Hebding , Megha Rao , Colin McDonough , Matthew Smalley , Douglas Duane Coolbaugh , Joseph Piccirillo, Jr. , Stephen G. Bennett , Michael Liehr , Daniel Pascual
IPC分类号： H01L21/44
CPC分类号： H01L25/0652 , H01L21/76229 , H01L21/768 , H01L21/76802 , H01L21/76898 , H01L24/05 , H01L24/06 , H01L24/13 , H01L24/80 , H01L24/94 , H01L25/50 , H01L2224/02372 , H01L2224/0401 , H01L2224/05548 , H01L2224/06181 , H01L2224/08145 , H01L2224/131 , H01L2224/80097 , H01L2224/80203 , H01L2224/80205 , H01L2224/80895 , H01L2224/9205 , H01L2224/94 , H01L2224/97 , H01L2225/06524 , H01L2225/06541 , H01L2924/1461 , H01L2924/014 , H01L2924/00014 , H01L2224/80 , H01L2924/00
摘要： An apparatus and method are provided for integrating TSVs into devices prior to device contacts processing. The apparatus includes a semiconducting layer; one or more CMOS devices mounted on a top surface of the semiconducting layer; one or more TSVs integrated into the semiconducting layer of the device wafer; at least one metal layer applied over the TSVs; and one or more bond pads mounted onto a top layer of the at least one metal layer, wherein the at least one metal layer is arranged to enable placement of the one or more bond pads at a specified location for bonding to a second device wafer. The method includes obtaining a wafer of semiconducting material, performing front end of line processing on the wafer; providing one or more TSVs in the wafer; performing middle of line processing on the wafer; and performing back end of line processing on the wafer.
摘要翻译：提供了一种在设备接触处理之前将TSV集成到设备中的装置和方法。该装置包括半导体层; 安装在半导体层的顶表面上的一个或多个CMOS器件; 集成到器件晶片的半导体层中的一个或多个TSV; 在TSV上施加至少一个金属层; 以及安装在所述至少一个金属层的顶层上的一个或多个接合焊盘，其中所述至少一个金属层被布置成能够将所述一个或多个接合焊盘放置在用于结合到第二器件晶片的指定位置。该方法包括获得半导体材料晶片，在晶片上进行线前处理; 在晶片中提供一个或多个TSV; 在晶片上进行中间线处理; 并在晶片上执行线路处理的后端。

9. 发明申请

US20140277293A1 METHODS FOR IN VITRO INHIBITION OF FIBROBLAST PROLIFERATION 有权
标题翻译：用于纤维蛋白原增殖的体外抑制的方法
公开(公告)号：US20140277293A1
公开(公告)日：2014-09-18
申请号：US14207114
申请日：2014-03-12
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Jared Jagdeo , Roslyn Rivkah Isseroff , Andrew Mamalis , Neil Brody , Daniel Siegel , Hadar Lev-Tov
IPC分类号： A61N5/06
CPC分类号： A61N5/0616 , A61N2005/0651 , A61N2005/0659 , A61N2005/0663
摘要： Methods for LED generated low-level light therapy (LLLT) in the red, blue, and IR ranges are described to effectively inhibit fibroblast proliferation in vitro without altering viability, and may be used as therapy for the treatment of scars and other proliferative skin diseases.
摘要翻译：描述了红色，蓝色和红外范围内LED产生低水平光疗法（LLLT）的方法，可有效抑制体外成纤维细胞增殖而不改变活力，可用作治疗瘢痕和其他增生性皮肤病的治疗方法。

10. 发明申请

US20140272342A1 CONDUCTIVE FILMS AND DEVICES COMPRISED THEREOF 有权
标题翻译：导电膜及其装置
公开(公告)号：US20140272342A1
公开(公告)日：2014-09-18
申请号：US14212559
申请日：2014-03-14
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： William E. Bernier , Nicholas A. Ravvin , Wayne E. Jones, JR. , Kenneth H. Skorenko
IPC分类号： C09D181/02
CPC分类号： C09D181/02 , Y10T428/24942
摘要： Embodiments of films and material layers comprising PEDOT. These embodiments are the result of methods that utilize polymerization processes including vapor phase polymerization (VPP) to form the conductive film comprising PEDOT. In one embodiment, the film can result from a method that includes steps for depositing a coating solution onto a substrate, exposing the substrate to a monomer source, and cleaning the subsrate after polymerization. The coating solution can comprise an initiating oxidant, which facilitates growth of PEDOT from 3,4 ethylenedioxythiophene (EDOT), as well as a quenching agent that neutralizes acid that results from polymerization.
摘要翻译：包括PEDOT的膜和材料层的实施方案。这些实施方案是利用包括气相聚合（VPP）在内的聚合方法形成包含PEDOT的导电膜的方法的结果。在一个实施方案中，膜可以由包括将涂布溶液沉积到基材上的步骤的方法产生，将基材暴露于单体源，并在聚合后清洗该沉淀物。涂层溶液可以包含引发氧化剂，其促进PEDOT从3,4-亚乙二氧噻吩（EDOT）的生长，以及中和聚合产生的酸的淬灭剂。

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