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1. 发明授权

US5194257A Kit and method for administration of bacillus calmette-guerin for the treatment of superficial bladder tumors 失效
标题翻译：用于治疗超声乳头肿瘤的BACILLUS CALMETTE-GUERIN的药盒和方法
公开(公告)号：US5194257A
公开(公告)日：1993-03-16
申请号：US619222
申请日：1990-11-28
申请人： Timothy L. Ratliff , M'Liss A. Hudson , Julie K. Ritchey
发明人： Timothy L. Ratliff , M'Liss A. Hudson , Julie K. Ritchey
IPC分类号： A61K9/00 , A61K35/74 , A61K47/02 , A61K47/18 , A61K47/20 , A61K47/22
CPC分类号： A61K47/22 , A61K35/74 , A61K47/02 , A61K47/183 , A61K47/20 , A61K9/0034
摘要： Improved treatment of superficial bladder tumors through the administration by intravesical instillation of bacillus Calmette-Guerin is realized through the use of therapeutic composition comprising bacillus Calmette-Guerin (BCG) suspended in a 0.15 M sodium chloride solution containing a buffer to maintain the pH of the solution in the range 6.6 to 7.4, preferably 7.0. A kit and method are provided whereby such a composition may be employed to maximize intravesical attachment of BCG for improved efficacy.

2. 发明授权

US5763480A Inhibitors of cell-medicated disorders 失效
公开(公告)号：US5763480A
公开(公告)日：1998-06-09
申请号：US196293
申请日：1994-02-14
申请人： Paul H. Schlesinger , Steven L. Teitelbaum , Harry C. Blair
发明人： Paul H. Schlesinger , Steven L. Teitelbaum , Harry C. Blair
IPC分类号： A61K31/198 , A61K31/28 , A61L24/02 , A61L27/02
CPC分类号： A61L27/025 , A61K31/198 , A61K31/28 , A61L24/02
摘要： The present invention provides a method for blocking a cellular proton pump that comprises contacting a cell with a cellular proton pump-blocking effective quantity of In-EDTA or Tl-EDTA. The present invention also provides a method of treating or preventing cell-mediated disorders in a vertebrate animal by administering In-EDTA or Tl-EDTA to the vertebrate animal, as well as a method for stopping the cellular proton pump-blocking effect of Group IIIa metals such as Ga, In, and Tl, through use of suitable chelating agents. Suitable compositions for use in the aforementioned methods are provided as well.

3. 发明授权

US5332669A Prostate-derived mitogen 失效
标题翻译：前列腺素有丝分裂原
公开(公告)号：US5332669A
公开(公告)日：1994-07-26
申请号：US356739
申请日：1989-05-24
申请人： Thomas F. Deuel
发明人： Thomas F. Deuel
IPC分类号： A61K35/55 , A61K38/00 , C07K1/20 , C07K14/00 , C07K14/475 , C12N5/00 , A61K37/36
CPC分类号： C07K14/475 , A61K38/00 , Y10S530/827 , Y10S530/854
摘要： A prostate-derived growth factor is disclosed which has a mol. wt. of about 28 kDa, an NH.sub.2 -terminal sequence substantially identical to the NH.sub.2 -terminal sequence of the 6 kDa mature rat EGF, potent mitogenic activity against NRK cells without additional carboxy terminal processing to the mature 6 kDa EGF molecular species, cross-reacts with antisera against rat EGF and its mitogenic activity is blocked by anti-EGF receptor antisera.
摘要翻译：公开了一种前列腺衍生生长因子，重量约28kDa，与6kDa成熟大鼠EGF的NH2-末端序列基本相同的NH2-末端序列，对NRK细胞有效的促有丝分裂活性，而对成熟6kDa EGF分子种类没有额外的羧基末端加工，与针对大鼠EGF的抗血清及其促有丝分裂活性被抗EGF受体抗血清阻断。

4. 发明授权

US5690907A Avidin-biotin conjugated emulsions as a site specific binding system 失效
标题翻译：亲和素 - 生物素缀合的乳液作为位点特异性结合系统
公开(公告)号：US5690907A
公开(公告)日：1997-11-25
申请号：US488743
申请日：1995-06-08
申请人： Gregory M. Lanza , Samuel A. Wickline
发明人： Gregory M. Lanza , Samuel A. Wickline
IPC分类号： A61K49/18 , A61K51/12 , G01N33/58 , A61K49/04 , A61K9/66 , B01D17/04 , G01N33/53
CPC分类号： G01N33/586 , A61K49/18 , A61K49/1812 , A61K51/1217 , Y10S514/937 , Y10S516/90 , Y10S516/907 , Y10T428/2984 , Y10T428/2989
摘要： A method for ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site-specific ligand activated with a biotin activating agent; (b) an avidin activating agent; and (c) lipid encapsulated particles activated with a biotin activating agent, whereby the ligand is conjugated to the particles through an avidin-biotin interaction and the resulting conjugate is bound to the molecular epitopes on such surface. The conjugate is effective for imaging by x-ray, ultrasound, magnetic resonance or positron emission tomography. Compositions for use in ultrasonic imaging of natural or synthetic surfaces and for enhancing the acoustic reflectivity thereof are also disclosed.
摘要翻译：在体内或体外，脂质包封的颗粒与表面上的分子表位配体基结合的方法包括依次施用（a）用生物素活化剂活化的位点特异性配体; （b）抗生物素蛋白活化剂; 和（c）用生物素活化剂活化的脂质包封的颗粒，由此配体通过抗生物素蛋白 - 生物素相互作用与颗粒缀合，并且所得到的缀合物结合到这种表面上的分子表位。该共轭物通过X射线，超声，磁共振或正电子发射断层扫描成像是有效的。还公开了用于天然或合成表面的超声成像和增强其声反射率的组合物。

5. 发明授权

US5618916A Purified protein which functions as a mycobacterial receptor for fibronectin 失效
标题翻译：用作纤连蛋白的分枝杆菌受体的纯化蛋白质
公开(公告)号：US5618916A
公开(公告)日：1997-04-08
申请号：US265450
申请日：1994-06-24
申请人： Timothy J. Ratliff , Eric J. Brown
发明人： Timothy J. Ratliff , Eric J. Brown
IPC分类号： A61K38/00 , C07K14/35 , C07K1/00 , A61K39/395
CPC分类号： C07K14/35 , A61K38/00 , Y10S530/825
摘要： A method for the treatment of superficial urinary tract tumors in a mammal involves administering a diagnostically effective amount of a liposomal composition comprising a liposome, a chemotherapeutic agent or immune activating drug carried by the liposome and a purified protein which functions as a mycobacterial receptor for fibronectin on the surface of the liposome whereby the liposomal composition becomes attached to and internalized in the cells of the tumors. In lieu of the purified protein an antibody to an integrin receptor on the surface of the cells of the tumors may be used or a delivery system composed of a conjugate of a chemotherapeutic agent or immune activating drug and an antibody to an integrin receptor may be employed.
摘要翻译：用于治疗哺乳动物的浅表性尿路肿瘤的方法包括给予诊断有效量的脂质体组合物，所述脂质体组合物包含由脂质体携带的脂质体，化学治疗剂或免疫活化药物和用作纤连蛋白的分枝杆菌受体的纯化蛋白质在脂质体的表面上，由此脂质体组合物附着于肿瘤的细胞内并被内化。可以使用纯化的蛋白质代替肿瘤细胞表面上的整联蛋白受体的抗体，或者可以使用由化学治疗剂或免疫活化药物的缀合物和抗整联蛋白受体的结合物组成的递送系统。

6. 发明授权

US5271636A Wheelchair travel restricting device and method 失效
标题翻译：轮椅行走限制装置及方法
公开(公告)号：US5271636A
公开(公告)日：1993-12-21
申请号：US790759
申请日：1991-11-12
申请人： Daniel P. Mohrman , Jerry W. Dell
发明人： Daniel P. Mohrman , Jerry W. Dell
IPC分类号： A61G5/10 , B60R25/02 , B60R25/00
CPC分类号： B60R25/021 , A61G5/10 , Y10T70/5841 , Y10T70/5845
摘要： A travel restricting device for use with a wheelchair of the type having a frame, a seat attached to the frame and wheels mounted for rotation on opposite sides of the frame. The device includes arms having longitudinally opposing outer ends, and hooks at the outer ends of the arms for engaging the wheels. The arms can be extended to move the hooks away from each other or retracted to move the hooks toward each other. A spring biasing the arms toward a retracted position secures the hooks in the wheels such that the device is supported by the wheels for movement with the wheels. The device as secured to the wheels engages the frame upon rotation of the wheels in a first direction for restricting travel of the wheelchair in the first direction and engages the surface supporting the wheelchair upon rotation of the wheels in a second direction for restricting travel of the wheelchair in a second direction.
摘要翻译：一种用于具有框架的轮椅的行驶限制装置，附接到框架的座椅和安装成用于在框架的相对侧上旋转的轮子。该装置包括具有纵向相对的外端的臂和在臂的外端处的钩，用于接合车轮。臂可以被延伸以使钩彼此远离或缩回以使钩朝向彼此移动。将臂朝着缩回位置偏置的弹簧将钩固定在车轮中，使得该装置由车轮支撑以与车轮一起移动。固定在车轮上的装置在车轮沿第一方向转动时接合框架，用于限制轮椅在第一方向上的行进，并且在轮子沿第二方向旋转时接合支撑轮椅的表面，以限制轮椅的行进轮椅在第二个方向。

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