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1. 发明授权

US07291112B2 Method and apparatus for control of non-invasive parameter measurements 有权
标题翻译：用于控制非侵入性参数测量的方法和装置
公开(公告)号：US07291112B2
公开(公告)日：2007-11-06
申请号：US10393660
申请日：2003-03-20
申请人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
发明人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/02028 , A61B5/024 , A61B5/684 , A61B5/6843 , A61B5/7203 , A61B5/7207 , A61B5/7264
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism, when such parameters are potentially affected by other concurrent events. In one exemplary embodiment, apparatus and methods for compensating for occlusive events (e.g., pressure cuff inflation) occurring ipsilateral to the location of parameter measurement are disclosed. Upon passive detection of signal degradation resulting from the event, the apparatus selectively enters a “wait state” wherein further processing of the hemodynamic data is suspended until the degrading event subsides. This behavior mitigates any adverse effects the event might have on the accuracy of the representation of the measured hemodynamic parameter generated by the system. In another exemplary embodiment, the measured data is analyzed in order to classify the type of event (e.g., occlusive or other), such classification allowing the system to appropriately tailor its response to the event.
摘要翻译：改进的方法和装置，用于非侵入性地评估与流体系统相关联的一个或多个参数，例如活体的循环系统，当这些参数可能受到其他并发事件的影响时。在一个示例性实施例中，公开了用于补偿与参数测量位置同侧出现的闭塞事件（例如，压力袖带充气）的装置和方法。在被动检测由事件导致的信号劣化时，该装置选择性地进入“等待状态”，其中暂停血液动力学数据的进一步处理，直到降解事件消退。该行为减轻了事件可能对由系统产生的测量的血液动力学参数的表示的准确性的任何不利影响。在另一个示例性实施例中，分析测量数据以便将事件的类型（例如，闭塞或其他）分类，允许系统适当地定制其对事件的响应。

2. 发明授权

US06974419B1 Method and apparatus for control of non-invasive parameter measurements 失效
标题翻译：用于控制非侵入性参数测量的方法和装置
公开(公告)号：US06974419B1
公开(公告)日：2005-12-13
申请号：US10211115
申请日：2002-08-01
申请人： Gregory I. Voss , Gregory J. Martin , Manouchehr Goharlaee
发明人： Gregory I. Voss , Gregory J. Martin , Manouchehr Goharlaee
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/02028 , A61B5/024 , A61B5/684 , A61B5/6843 , A61B5/7203 , A61B5/7207 , A61B5/7264
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism. In a first aspect, an improved method of continuously measuring pressure from a compressible vessel is disclosed, wherein a substantially optimal level of compression for the vessel is achieved and maintained using perturbations (e.g., modulation) of the compression level of the vessel. In one exemplary embodiment, the modulation is conducted according to a pseudo-random binary sequence (PBRS). In a second aspect, an improved apparatus for determining the blood pressure of a living subject is disclosed, the apparatus generally comprising a pressure sensor and associated processor with a computer program defining a plurality of operating states related to the sensed pressure data. Methods for pressure waveform correction and reacquisition, as well as treatment using the present invention, are also disclosed.
摘要翻译：用于非侵入性评估与诸如活体的循环系统的流体系统相关联的一个或多个参数的改进的方法和装置。在第一方面，公开了一种从可压缩容器连续测量压力的改进方法，其中使用容器的压缩水平的扰动（例如，调制）来实现和维持容器的基本上最佳的压缩水平。在一个示例性实施例中，根据伪随机二进制序列（PBRS）进行调制。在第二方面，公开了一种用于确定活体的血压的改进装置，所述装置通常包括压力传感器和与计算机程序相关联的处理器，所述计算机程序定义与感测的压力数据有关的多个操作状态。还公开了压力波形校正和再吸收的方法以及使用本发明的处理。

3. 发明授权

US09949696B2 Apparatus and methods for computing cardiac output of a living subject via applanation tonometry 有权
公开(公告)号：US09949696B2
公开(公告)日：2018-04-24
申请号：US13829061
申请日：2013-03-14
申请人： Tensys Medical, Inc.
发明人： Oliver Goedje , Matthias Bohn , Patrick Hunziker , Oleksii Morozov , Felix Friedrich
IPC分类号： A61B5/00 , A61B3/16 , A61B5/02 , A61B5/021 , A61B5/024 , A61B5/029 , A61B5/0452 , A61B8/02 , A61B5/028 , A61B8/06 , A61B8/12 , A61B8/00 , A61B8/08
CPC分类号： A61B5/7278 , A61B3/165 , A61B5/02 , A61B5/021 , A61B5/02108 , A61B5/024 , A61B5/028 , A61B5/029 , A61B5/0452 , A61B5/742 , A61B8/02 , A61B8/06 , A61B8/065 , A61B8/12 , A61B8/4416 , A61B8/481 , A61B8/488 , G06F19/00
摘要： Apparatus and methods for calculating cardiac output (CO) of a living subject using applanation tonometry measurements. In one embodiment, the apparatus and methods build a nonlinear mathematical model to correlate physiologic source data vectors to target CO values. The source data vectors include one or more measurable or derivable parameters such as: systolic and diastolic pressure, pulse pressure, beat-to-beat interval, mean arterial pressure, maximal slope of the pressure rise during systole, the area under systolic part of the pulse pressure wave, gender (male or female), age, height and weight. The target CO values are acquired using various methods, across a plurality of individuals. Multidimensional nonlinear optimization is then used to find a mathematical model which transforms the source data to the target CO data. The model is then applied to an individual by acquiring physiologic data for the individual and applying the model to the collected data.

4. 发明授权

US08818731B2 Apparatus and method for interfacing time-variant signals 有权
标题翻译：用于连接时变信号的装置和方法
公开(公告)号：US08818731B2
公开(公告)日：2014-08-26
申请号：US12008060
申请日：2008-01-07
申请人： Ronald S. Conero
发明人： Ronald S. Conero
IPC分类号： A61B8/06
CPC分类号： A61B5/4839 , A61B5/021 , A61B8/04 , G01R31/024 , G06F19/00 , G16H40/63
摘要： An improved apparatus and method for interfacing a time variant waveform between two hardware environments. In one aspect, the invention comprises a circuit for accurately simulating the output of one or more types of sensing device (e.g., passive bridge pressure transducer) for use with a plurality of different monitoring and/or analysis devices, thereby obviating the need for specialized interface circuitry adapted to each different monitor/analyzer. In one exemplary embodiment, the sensing device comprises a non-invasive blood pressure monitor (NIBPM), which universally interfaces with prior art patient monitors via the interface circuit of the invention. In a second aspect of the invention, an improved NIBPM device incorporating the interface circuit is disclosed. An improved disconnect circuit adapted to sense the status of the electrical connection between the sensing device and monitor is also described.
摘要翻译：一种用于在两个硬件环境之间连接时变波形的改进的装置和方法。在一个方面，本发明包括用于精确模拟一种或多种类型的感测装置（例如，无源桥式压力传感器）的输出的电路，用于与多个不同的监测和/或分析装置一起使用，从而避免了专门的接口电路，适用于每个不同的监视器/分析器。在一个示例性实施例中，感测装置包括非侵入式血压监测器（NIBPM），其通过本发明的接口电路与现有技术的患者监护仪普遍接口。在本发明的第二方面，公开了一种结合了接口电路的改进的NIBPM器件。还描述了适于感测感测装置和监视器之间的电连接状态的改进的断开电路。

5. 发明授权

US08506497B2 Continuous positioning apparatus and methods 有权
公开(公告)号：US08506497B2
公开(公告)日：2013-08-13
申请号：US11803559
申请日：2007-05-14
申请人： Andrew S. Katayama , Todd A. Keitel , Manouchehr Goharlaee , Stuart L. Gallant , Warren B. Craycroft
发明人： Andrew S. Katayama , Todd A. Keitel , Manouchehr Goharlaee , Stuart L. Gallant , Warren B. Craycroft
IPC分类号： A61B5/02
CPC分类号： A61B5/0225 , A61B5/021 , A61B5/02233 , A61B5/6843 , A61B5/72
摘要： Improved apparatus and methods for non-invasively assessing one or more parameters associated with systems such as fluidic circulating systems (e.g., the circulatory system of a living organism). In a first aspect, an improved method of continuously measuring pressure from a compressible vessel is disclosed, wherein a substantially optimal level of compression for the vessel is achieved and maintained using dynamically applied dither perturbations (e.g., modulation) on the various axes associated with the vessel. In a second aspect, an improved apparatus and method are provided for monitoring hemodynamic parameters, such as blood pressure, in a continuous and non-invasive manner while operating under a single unifying scheme. One variant of this scheme using a simulated annealing (SA) type approach to determining and maintaining an optimal operating state.

6. 发明授权

US07048691B2 Method and apparatus for assessing hemodynamic parameters within the circulatory system of a living subject 有权
公开(公告)号：US07048691B2
公开(公告)日：2006-05-23
申请号：US09815080
申请日：2001-03-22
申请人： Frank R. Miele , Ronald Mucci , Stuart L. Gallant
发明人： Frank R. Miele , Ronald Mucci , Stuart L. Gallant
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61B5/0053 , A61B5/02028 , A61B5/02116 , A61B8/06 , A61B8/0858 , A61B2562/0247
摘要： An improved method and apparatus for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises a method of measuring a hemodynamic parameter by measuring a non-calibrated value of the parameter non-invasively, and inducing a stress of the circulatory system while measuring a second parameter. The response of the circulatory system to the stress is determined directly from the subject, and a calibration function is derived from the response and applied to the non-calibrated measured value to produce a calibrated measure of the actual value of the hemodynamic parameter. Methods of using backscattered acoustic energy for determination of hemodynamic markers are also disclosed.

7. 发明授权

US09655530B2 Apparatus and methods for non-invasively measuring physiologic parameters of one or more subjects 有权
公开(公告)号：US09655530B2
公开(公告)日：2017-05-23
申请号：US13098344
申请日：2011-04-29
申请人： Dave Eshbaugh , Oliver Goedje , Matthias Bohn
发明人： Dave Eshbaugh , Oliver Goedje , Matthias Bohn
IPC分类号： A61B5/02 , A61B5/021 , A61B5/00
CPC分类号： A61B5/02141 , A61B5/6824 , A61B5/684 , A61B2560/0406 , A61B2562/16
摘要： Improved apparatus and methods for non-invasively assessing one or more physiologic (e.g., hemodynamic) parameters associated with a living organism. In one embodiment, the invention comprises an apparatus adapted to automatically and accurately place and maintain a sensor (e.g., tonometric pressure sensor) with respect to the anatomy of the subject. The apparatus is comprised of a sensor device removably coupled to a host device which is used to position the sensor during measurements. Methods for positioning the alignment apparatus and sensor, and operating the apparatus, are also disclosed.

8. 发明授权

US09247886B2 Compact apparatus and methods for non-invasively measuring hemodynamic parameters 有权
标题翻译：用于非侵入性测量血液动力学参数的紧凑装置和方法
公开(公告)号：US09247886B2
公开(公告)日：2016-02-02
申请号：US13113794
申请日：2011-05-23
申请人： Simon E. Finburgh , Mark W. Perona , Russell D. Hempstead
发明人： Simon E. Finburgh , Mark W. Perona , Russell D. Hempstead
IPC分类号： A61B5/00 , A61B5/022 , A61B5/06
CPC分类号： A61B5/022 , A61B5/061 , A61B5/681
摘要： Improved apparatus and methods for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises spatially compact “bracelet” embodiment adapted to accurately place and maintain a sensor (e.g., tonometric pressure sensor) with respect to the anatomy of the subject, including an optional alignment apparatus which moveably captures the sensor to, inter alia, facilitate coupling thereof to an actuator used to position the sensor during measurements. The alignment apparatus also advantageously allows the sensor position to be maintained when the fixture is removed from the subject, such as during patient transport. A completely autonomous variant of the bracelet apparatus having internal power supply and wireless interfaces is also disclosed. Methods for positioning the alignment apparatus and sensor and providing treatment to the subject are also described.
摘要翻译：用于非侵入性评估与生物体的循环系统相关的一个或多个血液动力学参数的改进的装置和方法。在一个方面，本发明包括空间紧凑的“手镯”实施例，其适于相对于被检体的解剖结构精确地放置和维持传感器（例如，压力传感器），包括可移动地将传感器捕获到特别地，有助于将其耦合到用于在测量期间定位传感器的致动器。对准装置还有利地允许当夹具从受试者移除时（例如在患者运送期间）保持传感器位置。还公开了具有内部电源和无线接口的手镯装置的完全自主的变型。还描述了用于将对准装置和传感器定位并向对象提供治疗的方法。

9. 发明授权

US08777862B2 Apparatus and methods for non-invasively measuring a patient's arterial blood pressure 有权
标题翻译：用于非侵入性测量患者动脉血压的装置和方法
公开(公告)号：US08777862B2
公开(公告)日：2014-07-15
申请号：US12287630
申请日：2008-10-09
申请人： Simon E. Finburgh , Andrew S. Katayama , Ronald J. Vidischak , Anthony T. Butler , Kurt Blessinger
发明人： Simon E. Finburgh , Andrew S. Katayama , Ronald J. Vidischak , Anthony T. Butler , Kurt Blessinger
IPC分类号： A61B5/02
CPC分类号： A61B5/6843 , A61B5/0205 , A61B5/02141 , A61B5/022 , A61B5/061 , A61B5/489 , A61B5/6841 , A61B2562/0247 , A61B2562/043
摘要： Improved apparatus and methods for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises an apparatus adapted to automatically and accurately place and maintain a sensor (e.g., tonometric pressure sensor) with respect to the anatomy of the subject. The apparatus comprised of a sensor device removably coupled to an actuator which is used to position the sensor during measurements. Methods for positioning the alignment apparatus and sensor, and operating the apparatus, are also disclosed.
摘要翻译：用于非侵入性评估与生物体的循环系统相关的一个或多个血液动力学参数的改进的装置和方法。一方面，本发明包括适于相对于受试者的解剖结构自动且精确地放置和维持传感器（例如，压力计传感器）的装置。该装置包括可拆卸地联接到致动器的传感器装置，其用于在测量期间定位传感器。还公开了用于定位对准装置和传感器以及操作该装置的方法。

10. 发明授权

US08597195B2 Method and apparatus for non-invasively measuring hemodynamic parameters using parametrics 失效
公开(公告)号：US08597195B2
公开(公告)日：2013-12-03
申请号：US12987928
申请日：2011-01-10
申请人： Stuart L. Gallant , Gregory I. Voss , William H. Markle
发明人： Stuart L. Gallant , Gregory I. Voss , William H. Markle
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61B5/6843 , A61B2562/02 , A61B2562/0247 , G06F19/00
摘要： An improved method and apparatus for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises a method of measuring a hemodynamic parameter (e.g., arterial blood pressure) by applanating or compressing portions of tissue proximate to the blood vessel of concern until a desired condition is achieved, and then measuring the hemodynamic parameter. Such applanation effectively mitigates transfer and other losses created by the tissue proximate to the blood vessel, thereby facilitating accurate and robust tonometric measurement. An algorithm adapted to maintain optimal levels of applanation is also described. Methods and apparatus for scaling such hemodynamic parameter measurements based on subject physiology, and providing treatment to the subject based on the measured parameters, are also disclosed.

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