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1. 发明授权

US12053501B2 Methods for treating symptoms of dry eye disease 有权
公开(公告)号：US12053501B2
公开(公告)日：2024-08-06
申请号：US17521366
申请日：2021-11-08
申请人： Tufts Medical Center , Trustees of Tufts College , On Target Therapeutics LLC
发明人： Charles Cohen , Krishna Kumar , Alan S. Kopin , Benjamin N. Harwood , Venkata S. Raman , Pedram Hamrah
IPC分类号： A61K38/08 , A61K9/00 , A61K38/00 , A61K47/54 , A61K47/60 , A61K47/65 , A61P27/02 , A61P29/00
CPC分类号： A61K38/08 , A61K9/0048 , A61K38/00 , A61K47/543 , A61P27/02 , A61P29/00 , A61K47/60 , A61K47/65
摘要： The present disclosure relates to, among other things, compositions and methods for treating an inflammatory condition including, but not limited to, ocular inflammation, dry eye disease, and ocular neuropathic pain. One aspect of the present disclosure relates to a composition comprising (a) chemerin or a fragment or analog thereof and (b) a lipid entity linked to the chemerin or fragment or analog thereof.

2. 发明申请

US20220135633A1 METHODS AND SYSTEMS FOR DESIGNING AND/OR CHARACTERIZING SOLUBLE LIPIDATED LIGAND AGENTS 有权
公开(公告)号：US20220135633A1
公开(公告)日：2022-05-05
申请号：US17525169
申请日：2021-11-12
申请人： Tufts Medical Center , Trustees of Tufts College , On Target Therapeutics LLC
发明人： Charles COHEN , Krishna KUMAR , Jamie Raudensky DOYLE , Alan S. KOPIN
IPC分类号： C07K14/47 , A61K47/54 , G01N33/92 , C07K7/06 , C07K7/08 , G01N33/50
摘要： The present application provides methods for preparing soluble lipidated ligand agents comprising a ligand entity and a lipid entity, and in some embodiments, provides relevant parameters of each of these components, thereby enabling appropriate selection of components to assemble active agents for any given target of interest.

3. 发明申请

US20110082493A1 MEDICAL CLOT TREATMENT DEVICE WITH DISTAL FILTER 有权
标题翻译：具有远程过滤器的医疗衣物处理设备
公开(公告)号：US20110082493A1
公开(公告)日：2011-04-07
申请号：US12966311
申请日：2010-12-13
申请人： Gene Samson , Harold F. Carrison
发明人： Gene Samson , Harold F. Carrison
IPC分类号： A61F2/01
CPC分类号： A61F2/013 , A61B17/221 , A61B90/39 , A61B2017/22034 , A61B2017/22045 , A61B2017/22084 , A61B2017/2212 , A61B2090/376 , A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61F2230/0071
摘要： This is a surgical device usually delivered through an intravascular catheter. It may be used in several ways. It may, for instance, be used to open a clear passageway adjacent thrombus to allow both blood and medication to bypass the clot. It may be used to pierce and to remove thrombus. These thrombus are often found in tortuous vasculature. The device includes several sections. The device has a core element, typically a core wire. Placed around the distal end of the core element is a collapsible but preferably self expanding proximal cage assembly and a distal filter, preferably a self-expanding cage assembly or other filter component. The various portions of those components are preferably radio-opaque. The proximal end of the proximal cage is typically is affixed to an actuator in such a way as to allow expansion of the cage after deployment. The proximal cage assembly may be used for collecting emboli or for displacing them to allow blood flow to resume, either with or without concurrent clot-dissolving drug treatment. The distal sector, whether a self-expanding cage or fan, is placed distally of the thrombus to collect portions of the thrombus which may loosen during the treatment or removal procedure.
摘要翻译：这是通常通过血管内导管递送的手术装置。它可以以几种方式使用。例如，它可以用于打开邻近血栓的清晰通道，以允许血液和药物绕过凝块。它可以用于刺穿和去除血栓。这些血栓通常在曲折的脉管系统中发现。该设备包括几个部分。该装置具有核心元件，通常为芯线。围绕芯元件的远端放置的是可折叠但优选自扩张的近端保持器组件和远端过滤器，优选自膨胀笼组件或其它过滤器部件。这些部件的各个部分优选地是不透射线的。近端保持架的近端通常被固定到致动器上，以允许在展开之后使笼膨胀。近端笼组件可用于收集栓塞或用于置换它们以允许血流恢复，无论是否伴有凝血溶解药物治疗。远端部分，无论是自膨胀笼或风扇，是否位于血栓的远端，以收集在治疗或移除手术过程中可能松动的部分血栓。

4. 发明申请

US20110024025A1 Catheter With Knit Section 有权
标题翻译：导管与针织部分
公开(公告)号：US20110024025A1
公开(公告)日：2011-02-03
申请号：US12906872
申请日：2010-10-18
申请人： Jill M. McFadden , Earl Bardsley , Robert Garabedian
发明人： Jill M. McFadden , Earl Bardsley , Robert Garabedian
IPC分类号： B29C70/10
CPC分类号： A61M25/0045 , A61B5/6852 , A61M25/0053 , A61M25/0054 , Y10T29/49801
摘要： A catheter section comprising an elongate tubular member having a proximal end, a distal end, and a passageway defining a lumen extending between the proximal and distal ends. The elongate tubular member includes a knit tubular member and an inner tubular liner in coaxial relationship with the knit tubular member. The catheter section is for use as a distal section in a catheter having a relatively stiff proximal section.
摘要翻译：一种导管部分，包括细长的管状部件，其具有近端，远端以及限定在近端和远端之间延伸的内腔的通道。细长管状构件包括编织管状构件和与针织管状构件同轴关系的内部管状衬垫。导管部分用作具有相对刚性近端部分的导管中的远侧部分。

5. 发明授权

US07875050B2 Mechanical clot treatment device 有权
标题翻译：机械凝血治疗装置
公开(公告)号：US07875050B2
公开(公告)日：2011-01-25
申请号：US10082492
申请日：2002-02-22
申请人： Gene Samson , Harold F Carrison
发明人： Gene Samson , Harold F Carrison
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61B17/221 , A61B90/39 , A61B2017/22034 , A61B2017/22045 , A61B2017/22084 , A61B2017/2212 , A61B2090/376 , A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61F2230/0071
摘要： An embolism treatment device includes an elongated core wire having a coil tip coupled to the distal end of the core wire and a cage assembly substantially coaxial to the core wire, having a first deployment shape and a second expanded shape. The core wire is freely moveable axially through the cage assembly. The device additionally includes an inner coil surrounding the core wire within the cage assembly and an actuator element, having a first position and a second position, located proximally to the cage assembly, wherein when the actuator element is in the first position, the cage assembly is in the first deployment shape and when the actuator element is in the second position, the cage assembly is in the second expanded shape.
摘要翻译：栓塞治疗装置包括细长的芯线，其具有联接到芯线的远端的线圈末端和与芯线基本同轴的保持架组件，具有第一展开形状和第二扩张形状。芯线可以轴向自由移动通过保持架组件。该装置还包括围绕保持架组件内的芯线的内部线圈和具有位于保持架组件的近侧的第一位置和第二位置的致动器元件，其中当致动器元件处于第一位置时，保持架组件处于第一展开形状，并且当致动器元件处于第二位置时，保持架组件处于第二展开形状。

6. 发明申请

US20070049903A1 Catheter with composite stiffener 有权
标题翻译：导管与复合加强筋
公开(公告)号：US20070049903A1
公开(公告)日：2007-03-01
申请号：US11516061
申请日：2006-09-06
申请人： Lex Jansen , Thomas Chien , Perry Fukui , Jeffrey Sarge , Lawrence Alpert
发明人： Lex Jansen , Thomas Chien , Perry Fukui , Jeffrey Sarge , Lawrence Alpert
IPC分类号： A61M25/00
CPC分类号： A61M25/0053 , A61M25/005 , A61M25/0054
摘要： A catheter comprising an elongate tubular member having a proximal end, a distal end, and a passageway defining a lumen extending between the proximal and distal ends. The elongate tubular member comprises a relatively stiff proximal section and a relatively flexible distal section. The proximal section includes an inner tubular liner, a first stiffener comprising a metal alloy, and a second stiffener comprising a non-metal alloy. The first and second stiffeners are coaxially wound exterior to the proximal inner liner. The distal section includes a distal inner tubular liner and the second stiffener coaxially wound exterior to the distal inner liner. The first stiffener terminates before reaching the distal section.
摘要翻译：导管，其包括具有近端，远端和限定在所述近端和远端之间延伸的内腔的通道的细长管状构件。细长管状构件包括相对刚性的近端部分和相对柔性的远端部分。近端部分包括内部管状衬垫，包括金属合金的第一加强件和包括非金属合金的第二加强件。第一和第二加强件同轴地缠绕在近端内衬的外部。远侧部分包括远侧内部管状衬垫，并且第二加强件同轴地缠绕在远端内衬套的外部。第一加强件在到达远端部分之前终止。

7. 发明申请

US20030004461A1 Balloon catheter with delivery side holes 有权
公开(公告)号：US20030004461A1
公开(公告)日：2003-01-02
申请号：US10211399
申请日：2002-08-02
申请人： Target Therapeutics, Inc.
发明人： David Kupiecki
IPC分类号： A61M029/00
CPC分类号： A61M25/0075 , A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B17/12186 , A61B2017/1205 , A61M25/104 , A61M2025/1052 , A61M2025/1063
摘要： This is a medical catheter made up of a body having on its distal end portion an expandable balloon and, proximal of the balloon, a delivery lumen ending in a port through which therapeutic or diagnostic agents may be delivered. In one variation, a single inflation/wire lumen extends from the catheter proximal end to the catheter distal end, through which the balloon is inflated with pressurized fluid and through which a guide wire extends. The guide wire may have a valve plug for selectively seating against a valve seat of the catheter distal end to seal the inflation/wire lumen for balloon inflations. In another variation, a vaso-occlusive agent is disposable within a delivery lumen in a catheter coupled with a steerable guidewire. The delivery lumen ends in a delivery port near to and proximal of an expandable balloon located at the catheter's end. A single inflation/wire lumen may also be provided for facilitating both balloon inflation and guide wire tracking.

8. 发明授权

US6066158A Mechanical clot encasing and removal wire 失效
标题翻译：机械凝块包裹和去除线
公开(公告)号：US6066158A
公开(公告)日：2000-05-23
申请号：US686304
申请日：1996-07-25
申请人： Erik T. Engelson , Gene Samson
发明人： Erik T. Engelson , Gene Samson
IPC分类号： A61B17/22 , A61F2/958 , A61M29/00 , A61M29/02
CPC分类号： A61B17/3207 , A61B17/221 , A61B17/320725 , A61B17/32075 , A61B2017/22034 , A61B2017/22061 , A61B2017/2212 , A61M2025/1095 , A61M25/10 , A61M29/02
摘要： This is a surgical device usually delivered through an intravascular catheter. It is designed to pierce and remove emboli often found in tortuous vasculature. The device includes several sections. The device has a core element. Placed around the distal end of the core wire is a collapsible but self expanding embolism collection assembly. That collector assembly is typically joined to the core wire at its distal end. The collector assembly may have a generally conical distal portion when expanded and may have a proximal section having varied purposes, e.g. for centering the collector assembly in the vascular lumen. The assembly further may have an actuator which permits the collector assembly to expand after deployment.
摘要翻译：这是通常通过血管内导管递送的手术装置。它旨在刺穿和去除经常在弯曲脉管系统中发现的栓子。该设备包括几个部分。该设备具有核心元件。放置在芯线远端的是可折叠但自膨胀的栓塞收集组件。该集电器组件通常在其远端处连接到芯线。收集器组件可以在膨胀时具有大致锥形的远侧部分，并且可以具有不同目的的近端部分，例如，用于将收集器组件对准在血管腔中。组件还可以具有致动器，其允许收集器组件在展开之后膨胀。

9. 发明授权

US6056761A System for detaching an occlusive device within a body using a solderless, electrolytically severable joint 失效
标题翻译：用于使用无焊料，可分解电解的接头来拆卸身体内的闭塞装置的系统
公开(公告)号：US6056761A
公开(公告)日：2000-05-02
申请号：US743494
申请日：1996-11-04
申请人： Son Gia , Hong Doan , Pete Phong Pham , Ivan Sepetka , U. Hiram Chee , Michael Mariant , David Kupiecki
发明人： Son Gia , Hong Doan , Pete Phong Pham , Ivan Sepetka , U. Hiram Chee , Michael Mariant , David Kupiecki
IPC分类号： A61F2/82 , A61B17/00 , A61B17/12 , A61F2/06 , A61F2/84 , A61B17/08
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B2017/00017 , A61B2017/00292 , A61B2017/12063 , A61B2018/1495 , A61F2/95
摘要： A solderless sacrificial link between a detachable member which is placed at and is intended to remain at a desired site within the mammalian body and the core wire used to introduce the detachable member. The detachable member device may be one used to create emboli in the vascular system or may be of any other type deliverable into the human body and detached into an ionic aqueous environment, either for later removal or permanent placement.
摘要翻译：放置在哺乳动物体内的期望部位并且旨在保持在哺乳动物体内的期望部位的可拆卸部件与用于引入可拆卸部件的芯线之间的无焊接牺牲连接。可拆卸构件装置可以是用于在血管系统中产生栓塞的构件装置，或者可以是可输送到人体内并且分离成离子水性环境的任何其它类型的装置，用于随后的移除或永久放置。

10. 发明授权

US6036720A Sheet metal aneurysm neck bridge 失效
标题翻译：钣金动脉瘤颈桥
公开(公告)号：US6036720A
公开(公告)日：2000-03-14
申请号：US990314
申请日：1997-12-15
申请人： Robert M. Abrams , Daniel R. Kurz
发明人： Robert M. Abrams , Daniel R. Kurz
IPC分类号： A61B17/12 , A61B17/08
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12172 , A61B2017/12063
摘要： This is a device for bridging the necks of wide-necked or narrow-necked aneurysms in the vasculature. It is a device which may be used by itself to bridge the neck of an aneurysm or used to stabilize the presence of other vaso-occlusive devices such as helically wound coils in that aneurysm. The included vaso-occlusive devices may be delivered to the aneurysm in a variety of different ways, e.g., by a core wire which is linked to the coils by an electrolytically severable or mechanically detachable joint. The vaso-occlusive devices may also be simply pushed into the aneurysm. The aneurysm neck bridge may also be delivered in a variety of ways, but preferably is attached to an electrolytically severable joint for its deployment. The inventive neck bridge may contain one or two sections: a first or inner section to be placed within the aneurysm and an optional second or outer section suitably placed outside the aneurysm. The first section typically has a number of array elements which are intended to be resident within the aneurysm after the device is deployed from the distal end of a catheter. The optional second or outer section has one or more array elements which are to be placed outside the aneurysm. The array elements typically extend from and are attached to an attachment area, often centrally located. The inventive device is at least partially formed of thin, usually metallic, sheets. After deployment of this retainer, the aneurysm may be partially filled with vaso-occlusive devices such as helically wound coils.
摘要翻译：这是用于桥接脉管系统中的宽颈或窄颈动脉瘤颈部的装置。它是一种本身可以用于桥接动脉瘤颈部或用于稳定其他血管闭塞装置的存在的装置，例如在该动脉瘤中螺旋缠绕的线圈。包括的血管闭塞装置可以以各种不同的方式递送到动脉瘤，例如通过芯线，其通过可电解分离或机械可拆卸的关节连接到线圈。血管闭塞装置也可以简单地推入动脉瘤。动脉瘤颈桥还可以以各种方式递送，但是优选地附接到用于其展开的电解分离的接头。本发明的颈桥可以包含一个或两个部分：放置在动脉瘤内的第一或内部部分和适当地放置在动脉瘤外部的任选的第二或外部部分。第一部分通常具有多个阵列元件，其在装置从导管的远端部署之后旨在驻留在动脉瘤内。可选的第二或外部部分具有一个或多个排列在动脉瘤外部的阵列元件。阵列元件通常从附接区域延伸并且附接到通常位于中心的附接区域。本发明的装置至少部分地由薄的，通常是金属的片材形成。在展开该保持器之后，动脉瘤可以部分地填充有血管闭塞装置，例如螺旋卷绕的线圈。

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