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1. 发明授权

US11841265B2 Heterogeneous subsurface imaging systems and methods 有权
公开(公告)号：US11841265B2
公开(公告)日：2023-12-12
申请号：US16598468
申请日：2019-10-10
申请人： Massachusetts Institute of Technology , The Trustees of Boston University
发明人： Stephen Brown , Thomas Szabo , Daniel R. Burns , Michael Fehler
IPC分类号： G01H9/00 , G01S13/86 , G01S13/88 , G01V11/00 , G01V1/00 , G01V3/12
CPC分类号： G01H9/002 , G01S13/86 , G01S13/885 , G01V1/003 , G01V3/12 , G01V11/00 , G01V2210/1299
摘要： A system for near-surface subsurface imaging for detecting and characterizing subsurface heterogeneities comprises a non-contact acoustic source that senses a plurality of acoustic waves that travel through a surface; an instrument that outputs probing electromagnetic signals through the surface that interact and are affected by scattered signals of the acoustic waves and further senses vibrational modes of a subsurface below the surface; an imaging device that dynamically generates a time sequence of images of properties of the acoustic waves and maps elastic wave fields of the acoustic waves; and a processor that analyzes dynamic multi-wave data of the images to quantify spatial variations in the mechanical and viscoelastic properties of the subsurface.

2. 发明授权

US10613076B2 Optoelectronic control of solid-state nanopores 有权
公开(公告)号：US10613076B2
公开(公告)日：2020-04-07
申请号：US14775217
申请日：2014-03-14
申请人： The Trustees of Boston University
发明人： Amit Meller , Nicolas Di Fiori
IPC分类号： G01N33/00 , G01N33/487 , C12Q1/6869 , G01N21/63 , G01N27/49
CPC分类号： G01N33/48721 , C12Q1/6869 , G01N21/63 , G01N27/49 , G01N2201/06113 , C12Q1/6869 , C12Q2565/631
摘要： Optoelectronic control of solid-state nanopores and applications thereof. Nanopores are extremely sensitive single-molecule sensors. Electron beams have been used to fabricate synthetic nanopores in thin solid-state membranes with sub-nanometer resolution. Methods for controlling the translocation speed of biopolymers through solid-state nanopores and methods for unblocking clogged pores by illuminating nanopores are described.

3. 发明授权

US09903820B2 Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof 有权
公开(公告)号：US09903820B2
公开(公告)日：2018-02-27
申请号：US14815727
申请日：2015-07-31
申请人： The Trustees of Boston University
发明人： Amit Meller , Meni Wanunu
IPC分类号： G01N25/18 , G01N21/64 , B82Y15/00 , G01N33/487 , C12Q1/68
CPC分类号： G01N21/6428 , B82Y15/00 , C12Q1/6869 , G01N33/48721 , G01N2021/6439 , Y10T428/2982 , Y10T436/143333 , C12Q2521/543 , C12Q2565/631
摘要： Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof. Nanopores are extremely sensitive single-molecule sensors. Recently, electron beams have been used to fabricate synthetic nanopores in thin solid-state membranes with sub-nanometer resolution. A new class of chemically modified nanopore sensors are provided with two approaches for monolayer coating of nanopores by: (1) self-assembly from solution, in which nanopores −10 nm diameter can be reproducibly ceased, and (2) self-assembly under voltage driven electrolyte flow, in which 5 nm nanopore may be coated. Applications of chemically modified nanopore are provided including, the detection of biopolymers such as DNA and RNA, immobilizing enzymes or other proteins for detection or for generating chemical gradients; and localized pH sensing.

4. 发明申请

US20160033471A1 Optoelectronic Control Of Solid-State Nanopores 审中-公开
标题翻译：固态纳米孔的光电子控制
公开(公告)号：US20160033471A1
公开(公告)日：2016-02-04
申请号：US14775217
申请日：2014-03-14
申请人： THE TRUSTEES OF BOSTON UNIVERSITY
发明人： Amit MELLER , Nicolas Di FIORI
IPC分类号： G01N33/487 , G01N21/63 , G01N27/49
CPC分类号： G01N33/48721 , C12Q1/6869 , G01N21/63 , G01N27/49 , G01N2201/06113 , C12Q2565/631
摘要： Optoelectronic control of solid-state nanopores and applications thereof. Nanopores are extremely sensitive single-molecule sensors. Electron beams have been used to fabricate synthetic nanopores in thin solid-state membranes with sub-nanometer resolution. Methods for controlling the translocation speed of biopolymers through solid-state nanopores and methods for unblocking clogged pores by illuminating nanopores are described.
摘要翻译：固态纳米孔的光电子控制及其应用。纳米孔是非常敏感的单分子传感器。电子束已被用于制备具有亚纳米分辨率的薄固态膜中的合成纳米孔。描述了通过固态纳米孔控制生物聚合物的转运速度的方法以及通过照射纳米孔解除堵塞的孔的方法。

5. 发明授权

US08758949B2 Waste to hydrogen conversion process and related apparatus 有权
标题翻译：废氢转化过程及相关设备
公开(公告)号：US08758949B2
公开(公告)日：2014-06-24
申请号：US13632672
申请日：2012-10-01
申请人： The Trustees of Boston University
发明人： Uday B. Pal , Srikanth Gopalan
IPC分类号： H01M8/06 , H01M4/36 , H01M8/10 , H01M4/92 , C25C7/00
CPC分类号： C25B9/14 , C01B3/50 , C01B2203/0495 , C25B1/06 , H01M4/8621 , H01M4/90 , H01M4/9041 , H01M8/1246 , H01M8/186 , H01M2004/8684 , Y02E60/366 , Y02E60/525 , Y02E60/528 , Y02P70/56
摘要： A reversible electrochemical system includes a first electrode comprising liquid silver metal and a second electrode, said first and second electrodes separated by a oxygen ion-conducting solid electrolyte; a conduit for directing a first reactive material across the second electrode; and a conduit for contacting second reactive material with the first liquid silver electrode, wherein the cell is capable of steam electrolysis when the polarity of the electrodes is selected such that the liquid silver is an anode and the cell is capable of electrical energy generation when the polarity of the electrodes is selected such that the liquid silver is a cathode.
摘要翻译：可逆电化学系统包括包含液态银金属和第二电极的第一电极，所述第一和第二电极由氧离子导电固体电解质分离; 用于引导第一反应性材料穿过第二电极的导管; 以及用于使第二反应性材料与第一液体银电极接触的导管，其中当选择电极的极性使得电池能够进行蒸汽电解，使得液体银是阳极，并且当电池能够产生电能时选择电极的极性使得液体银是阴极。

6. 发明申请

US20140121363A1 Bioreactive Agents 失效
标题翻译：生物反应剂
公开(公告)号：US20140121363A1
公开(公告)日：2014-05-01
申请号：US13616499
申请日：2012-09-14
申请人： Kenneth J. Rothschild , Sanjay M. Sonar , Jarzy Olejelk
发明人： Kenneth J. Rothschild , Sanjay M. Sonar , Jarzy Olejelk
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , A61K38/00 , A61K41/0042 , C07C205/45 , C07C205/57 , C07D207/404 , C07D311/16 , C07D405/12 , C07D495/04 , C07H19/04 , C07H21/00 , C07K1/1077 , C07K1/13 , C12P21/00 , C12Q1/6823 , G01N33/5306 , G01N33/532 , G01N33/58 , C12Q2523/319
摘要： This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, and nascent proteins from translation reactions. The invention also relates to targets isolated with conjugates which may be useful as pharmaceutical agents or compositions that can be administered to humans and other mammals. The invention further relates to kits comprised of agents and conjugates that can be used for the detection of diseases, disorders and individual substances in a complex background of substances.
摘要翻译：本发明涉及可用于从复杂混合物检测和分离靶组分的试剂和缀合物，例如来自生物样品的核酸，来自体液的细胞和来自翻译反应的新生蛋白。本发明还涉及用缀合物分离的靶，其可用作可以施用于人和其它哺乳动物的药剂或组合物。本发明还涉及包含可用于检测物质复杂背景中的疾病，病症和个体物质的试剂和缀合物的试剂盒。

7. 发明申请

US20130183597A1 SYSTEM AND METHOD FOR ENERGY STORAGE AND RECOVERY 有权
标题翻译：能量储存和恢复系统与方法
公开(公告)号：US20130183597A1
公开(公告)日：2013-07-18
申请号：US13700095
申请日：2011-05-24
申请人： Uday B. Pal , Srikanth Gopalan
发明人： Uday B. Pal , Srikanth Gopalan
IPC分类号： H01M8/12 , H01M8/06
CPC分类号： H01M8/12 , C25B1/04 , C25B11/0457 , C25B15/08 , H01M8/0656 , H01M8/0662 , H01M8/186 , H01M2008/1293 , Y02E60/366 , Y02E60/528
摘要： System and method for energy storage and recovery is described. More particularly, system and method using tungsten based materials to electrochemically store and recover energy is described. In certain embodiments, the system includes a reversible solid oxide electrochemical cell (RSOEC) having a porous cathode, a porous anode, and an electrolyte capable of transporting oxygen ion. The system further includes a reactor comprising tungsten, tungsten oxide, or combinations thereof. To store the energy, the RSOEC is capable of receiving electricity to electrolyze H2O to generate H2 and O2 and the reactor is operably connected to the RSOEC to receive the generated H2 and convert tungsten oxide to tungsten thereby storing electrical energy. To recover the energy, reactor is capable of receiving H2O to convert tungsten to tungsten oxide and generate H2 and the RSOEC is operably connected to the reactor to receive the generated H2 and generate electrical energy.
摘要翻译：描述了用于储能和回收的系统和方法。更具体地，描述了使用钨基材料电化学存储和回收能量的系统和方法。在某些实施方案中，该系统包括具有多孔阴极，多孔阳极和能够输送氧离子的电解质的可逆固体氧化物电化学电池（RSOEC）。该系统还包括包含钨，氧化钨或其组合的反应器。为了存储能量，RSOEC能够接收电以电解H 2 O以产生H 2和O 2，并且反应器可操作地连接到RSOEC以接收所产生的H 2并将氧化钨转换成钨从而存储电能。为了回收能量，反应器能够接收H 2 O以将钨转化为氧化钨并产生H 2并且RSOEC可操作地连接到反应器以接收生成的H 2并产生电能。

8. 发明申请

US20130030330A1 Control and Integration of Sensory Data 有权
标题翻译：感官数据的控制和整合
公开(公告)号：US20130030330A1
公开(公告)日：2013-01-31
申请号：US13567975
申请日：2012-08-06
申请人： Conrad Wall, III , Lars I.E. Oddsson , Peter Francis Meyer
发明人： Conrad Wall, III , Lars I.E. Oddsson , Peter Francis Meyer
IPC分类号： A61H1/00 , A63B69/00 , A61N1/36
CPC分类号： A61B5/1116 , A61B5/1036 , A61B5/1123 , A61B5/4023 , A61B5/486 , A61B5/6807 , A61B5/6823 , A61B2560/0242 , A61N1/36003
摘要： A sensory data integration system for integrating sensory data generated by a first sensory substitution device and sensory data generated by a second sensory substitution device. The system includes a processor configured to generate an orientation signal indicative of a difference between a subject's orientation and an acceptable orientation. The orientation signal is based on the sensory data generated by the first sensory substitution device and the sensory data generated by the second sensory substitution device.
摘要翻译：一种用于整合由第一感官替代装置产生的感觉数据和由第二感官替代装置产生的感觉数据的感觉数据集成系统。该系统包括处理器，其被配置为产生指示被摄体的取向与可接受取向之间的差异的取向信号。取向信号基于由第一感官置换装置生成的感觉数据和由第二感官置换装置生成的感觉数据。

9. 发明申请

US20130026032A1 WASTE TO HYDROGEN CONVERSION PROCESS AND RELATED APPARATUS 有权
公开(公告)号：US20130026032A1
公开(公告)日：2013-01-31
申请号：US13632672
申请日：2012-10-01
申请人： The Trustees of Boston University
发明人： Uday B. PAL , Srikanth GOPALAN
IPC分类号： C25B9/14
CPC分类号： C25B9/14 , C01B3/50 , C01B2203/0495 , C25B1/06 , H01M4/8621 , H01M4/90 , H01M4/9041 , H01M8/1246 , H01M8/186 , H01M2004/8684 , Y02E60/366 , Y02E60/525 , Y02E60/528 , Y02P70/56
摘要： A reversible electrochemical system includes a first electrode comprising liquid silver metal and a second electrode, said first and second electrodes separated by a oxygen ion-conducting solid electrolyte; a conduit for directing a first reactive material across the second electrode; and a conduit for contacting second reactive material with the first liquid silver electrode, wherein the cell is capable of steam electrolysis when the polarity of the electrodes is selected such that the liquid silver is an anode and the cell is capable of electrical energy generation when the polarity of the electrodes is selected such that the liquid silver is a cathode.

10. 发明申请

US20120190035A1 Detection Of Disease Related Genes 失效
标题翻译：疾病相关基因检测
公开(公告)号：US20120190035A1
公开(公告)日：2012-07-26
申请号：US13437589
申请日：2012-04-02
申请人： Kenneth J. Rothschild , Sanjay M. Sonar , Jerzy Olejnik
发明人： Kenneth J. Rothschild , Sanjay M. Sonar , Jerzy Olejnik
IPC分类号： C12Q1/68
CPC分类号： A61K41/0042 , A61K38/00 , C07C205/45 , C07C205/57 , C07D207/404 , C07D311/16 , C07D405/12 , C07D495/04 , C07H19/04 , C07H21/00 , C07K1/1077 , C07K1/13 , C12P21/00 , C12Q1/6883 , G01N33/58
摘要： The invention is directed to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system. tRNA molecules are misaminoacylated with non-radioactive markers which may be non-native amino acids, amino acid analogs or derivatives, or substances recognized by the protein synthesizing machinery. Markers may comprise cleavable moieties, detectable labels, reporter properties wherein markers incorporated into protein can be distinguished from unincorporated markers, or coupling agents which facilitate the detection and isolation of nascent protein from other components of the translation system. The invention also comprises proteins prepared using misaminoacylated tRNAs which can be utilized in pharmaceutical compositions for the treatment of diseases and disorders in humans and other maninials, and kits which may be used for the detection of diseases and disorders.
摘要翻译：本发明涉及用于在细胞或无细胞翻译系统中翻译的新生蛋白的非放射性标记，检测，定量和分离的方法。 tRNA分子被非放射性标记物错氨基酰化，其可以是非天然氨基酸，氨基酸类似物或衍生物，或由蛋白质合成机理识别的物质。标记可以包含可切割部分，可检测标记，报告基因特性，其中掺入蛋白质的标记可以与非组合标记物或促进从翻译系统的其他组分检测和分离新生蛋白质的偶联剂区别。本发明还包括使用可以用于治疗人类和其他肌肉疾病和病症的药物组合物中的使用错氨基酰化tRNA制备的蛋白质，以及可用于检测疾病和病症的试剂盒。

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