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1. 发明授权

US11458235B2 Sorbent for a dialysis device and dialysis system 有权
公开(公告)号：US11458235B2
公开(公告)日：2022-10-04
申请号：US16466138
申请日：2017-12-05
申请人： TEMASEK POLYTECHNIC , AWAK TECHNOLOGIES PTE LTD
发明人： Christian Gert Bluchel , Peter Haywood
IPC分类号： A61M1/16 , B01J39/17 , B01J20/02 , B01J20/24 , B01J47/02 , B01J47/04 , B01J20/20 , B01J39/12 , B01J41/10 , B01D15/08 , B01J47/024
摘要： The invention relates to a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a soluble source of sodium ions. The sorbent comprises an ion exchange system which converts urea to ammonium ions and which is configured to exchange ammonium ions for predominantly hydrogen ions and to exchange Ca, Mg, and K for predominantly sodium ions. The soluble source of sodium ions overcomes an initial drop in sodium concentration in regenerated dialysate. When used in conjunction with an infusion system configured to utilise exchange of Ca, Mg and K for sodium during dialysate regeneration a desired sodium ion concentration can be maintained.

2. 发明申请

US20140309584A1 DIALYSIS DEVICE AND METHOD OF DIALYSIS 审中-公开
标题翻译： DIALYSIS设备和DIALYSIS方法
公开(公告)号：US20140309584A1
公开(公告)日：2014-10-16
申请号：US13885273
申请日：2011-11-08
申请人： Christian Gert Bluchel , Liutong Lin
发明人： Christian Gert Bluchel , Liutong Lin
IPC分类号： A61M1/28
CPC分类号： A61M1/28 , A61M1/1658 , A61M1/1696 , A61M2205/121 , A61M2205/123 , A61M2205/126 , A61M2205/128 , A61M2205/33 , A61M2205/7518 , A61M2209/088
摘要： A dialysis device is provided comprising a disposable housing having a dialysate flow path along which dialysate received from a patient is subjected to contaminant removal when in operation, wherein said disposable housing comprises a storage chamber in fluid communication with the dialysate flow path for storing the dialysate therein; a controller for controlling the operation of said disposable housing; an interface means capable of operably coupling the controller and the disposable housing to enable the contaminant removal from the dialysate, and a fluid displacement means configured to move the dialysate along the dialysate flow path, wherein said fluid displacement means comprises a deformable diaphragm integrally formed with at least one wall of said storage chamber, wherein the flow path is fluidly sealed from the controller and interface means. A method of dialysis, a dialysis system and kits are also provided.
摘要翻译：提供了一种透析装置，其包括具有透析液流动通道的一次性外壳，沿着该透析液流路从患者接收的透析液在操作时经受污染物去除，其中所述一次性外壳包括与用于储存透析液的透析液流动路径流体连通的储存室其中用于控制所述一次性外壳的操作的控制器; 接口装置，其能够可操作地联接所述控制器和所述一次性外壳以使得能够从所述透析液中除去污染物;以及流体移动装置，其被配置为沿所述透析液流动路径移动所述透析液，其中所述流体移动装置包括可变形隔膜，所述储存室的至少一个壁，其中所述流动路径与所述控制器和接口装置流体密封。还提供透析方法，透析系统和试剂盒。

3. 发明授权

US08440441B2 Method of preparing a substrate for immobilization of functional substances thereon and the substrate obtained therefrom 有权
标题翻译：制备用于固定功能物质的基材的方法和由其获得的基材
公开(公告)号：US08440441B2
公开(公告)日：2013-05-14
申请号：US13580055
申请日：2011-02-18
申请人： Christian Bluchel , Yanmei Wang
发明人： Christian Bluchel , Yanmei Wang
IPC分类号： C12N11/02 , C02F1/00
CPC分类号： C12N11/12 , B01D61/243 , B01D67/0093 , B01D71/16 , B01J20/321 , B01J20/3212 , B01J20/3248 , B01J20/3251 , C12N11/06 , G01N33/54353
摘要： A substrate having compounds disposed thereon for immobilizing a functional molecule, each compound having a chain comprising: a moiety R that is chemically coupled to the substrate, said moiety R being selected from the group consisting of an ether, ester, carbonyl, carbonate ester, thioether, disulfide, sulfinyl, sulfonyl, and carbonothioyl; and an epoxide-containing moiety that is coupled to the moiety R by a linker comprising at least one nucleophilic group. Methods of preparing the substrate and use of the substrate are also disclosed.
摘要翻译：一种底物，其上设置有用于固定功能性分子的化合物，每种化合物具有包括：与基底化学偶联的部分R，所述部分R选自醚，酯，羰基，碳酸酯，硫醚，二硫化物，亚磺酰基，磺酰基和碳硫酰基; 和通过包含至少一个亲核基团的连接体与部分R偶联的含环氧化物的部分。还公开了制备基材和使用基材的方法。

4. 发明公开

US20240058514A1 DIALYSATE REGENERATOR COMPRISING REVERSIBLE RETAINER 审中-公开
公开(公告)号：US20240058514A1
公开(公告)日：2024-02-22
申请号：US17918818
申请日：2021-04-13
申请人： TEMASEK POLYTECHNIC
发明人： Christian Gert BLUECHEL , Cathy Padua SAGUN , Puay Meng TANG , Liutong LIN, I , Hua ZHANG , Keng Hong LEE
IPC分类号： A61M1/16 , A61M1/14 , A61M1/26 , B01D15/16 , B01D15/18 , B01D15/36 , B01J39/02 , B01J39/10 , B01J47/018 , B01J47/12
CPC分类号： A61M1/1696 , A61M1/1563 , A61M1/1605 , A61M1/267 , B01D15/166 , B01D15/18 , B01D15/362 , B01D15/363 , B01J39/02 , B01J39/10 , B01J47/018 , B01J47/12 , A61M2205/3331
摘要： An aspect of the disclosure relates to a dialysate regenerator, including: a purification means; at least one reversible retainer including an ion reservoir; a dialysate flow path including a dialysate inlet for receiving a dialysate, a dialysate outlet for dispensing the dialysate, the purification means and the at least one reversible retainer: a pump connected to the dialysate flow path and configured to generate a flow of the dialysate from the dialysate inlet via the reversible retainer and the purification means to the dialysate outlet, wherein a direction of the dialysate flow path through the reversible retainer is reversible.

5. 发明授权

US11600830B2 Plate member for a cell stack 有权
公开(公告)号：US11600830B2
公开(公告)日：2023-03-07
申请号：US17005481
申请日：2020-08-28
申请人： Temasek Polytechnic
发明人： Ming Han , Yunzhong Chen , Lei Wang , Chun Yu Ling
IPC分类号： H01M8/0254 , H01M8/0258 , H01M8/1004
摘要： A plate member for a cell stack, a cell stack assembly, a method of forming a plate member for a cell stack and a method of assembling a cell stack may be provided, and the plate member includes a channel sheet with at least one peak and one trough for forming fluid flow channels; two alignment parts, each alignment part including a main body and one or more alignment members or holes, the main body having a through hole provided within the main body; and wherein the alignment part is capable of aligning the channel sheet parallel to a plane of the main body and the alignment member is capable of aligning the alignment member to another corresponding alignment member along an axis passing through the alignment member; and further wherein the channel sheet is disposed between the two alignment parts.

6. 发明授权

US11590272B2 Sorbent for a dialysis device 有权
公开(公告)号：US11590272B2
公开(公告)日：2023-02-28
申请号：US16792774
申请日：2020-02-17
申请人： TEMASEK POLYTECHNIC
发明人： Christian Gert Bluchel , Yanmei Wang , Kim Cheng Tan
IPC分类号： A61M1/36 , A61M1/28 , B01J20/06 , B01J20/20 , B01J20/22 , B01J20/28 , B01J39/12 , B01J41/10 , A61M1/16 , B01D15/20 , B01D15/36
摘要： There is provided a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a layer of immobilized uremic toxin-treating enzyme particles intermixed with cation exchange particles.

7. 发明授权

US11186482B2 Hydrogen generating system 有权
公开(公告)号：US11186482B2
公开(公告)日：2021-11-30
申请号：US16430142
申请日：2019-06-03
申请人： TEMASEK POLYTECHNIC
发明人： Lei Wang , Ming Han , Yunzhong Chen , Ee Ho Gareth Tang
IPC分类号： C01B3/06 , B01J7/02 , B01J21/18 , B01J23/42 , B01J31/06 , C01B3/00 , H01M8/065 , H01M8/1018
摘要： The present invention relates to a solid fuel, a system and a method for generating hydrogen. The solid fuel comprises sodium borohydride, catalyst loaded fibres and a binder, wherein the catalyst loaded fibres and the binder form a scaffold structure within which the sodium borohydride is positioned. The system comprises a fuel cartridge containing the solid fuel of the present invention for generating hydrogen gas, a reactor configured to house the fuel cartridge, a tank for storing water, a pump and a liquid conduit for conveying water from the tank to the fuel cartridge housed within the reactor to induce a hydrolysis reaction of the solid fuel contained in the fuel cartridge and a controller for regulating flow of the water.

8. 发明申请

US20210205522A1 DIALYSIS DEVICE AND METHOD OF DIALYSIS 有权
公开(公告)号：US20210205522A1
公开(公告)日：2021-07-08
申请号：US17209439
申请日：2021-03-23
申请人： TEMASEK POLYTECHNIC
发明人： Christian Gert Bluchel , Liutong Lin
IPC分类号： A61M1/28 , A61M1/16
摘要： A dialysis device is provided including a disposable housing having a flow path along which dialysate received from a patient is subjected to contaminant removal when in operation. The device includes a controller for controlling the operation of the disposable housing and an interface capable of operably coupling the controller and the disposable housing to enable the contaminant removal from the dialysate. The flow path is fluidly sealed from the controller and interface.

9. 发明授权

US10763518B2 Plate member for a cell stack 有权
公开(公告)号：US10763518B2
公开(公告)日：2020-09-01
申请号：US15571845
申请日：2016-04-29
申请人： TEMASEK POLYTECHNIC
发明人： Ming Han , Yunzhong Chen , Lei Wang , Chun Yu Ling
IPC分类号： H01M8/0254 , H01M8/0258 , H01M8/248 , H01M8/2483 , H01M8/2465 , H01M8/1018
摘要： A plate member for a cell stack, a cell stack assembly, a method of forming a plate member for a cell stack and a method of assembling a cell stack may be provided, and the plate member comprises a channel sheet comprising at least one peak and one trough for forming fluid flow channels; two alignment parts, each alignment part comprising a main body and one or more alignment members, the main body having a through hole provided within the main body; and wherein the alignment part is capable of aligning the channel sheet parallel to a plane of the main body and the alignment member is capable of aligning the alignment member to another corresponding alignment member along an axis passing through the alignment member; and further wherein the channel sheet is disposed between the two alignment parts.

10. 发明申请

US20190302022A1 BIOMARKER DETECTION SYSTEM 审中-公开
公开(公告)号：US20190302022A1
公开(公告)日：2019-10-03
申请号：US16318946
申请日：2017-07-21
申请人： Temasek Polytechnic , Agency for Science, Technology and Research , Tan Tock Seng Hospital Pte Ltd
发明人： Ling Ling Sun , Willie Ng , Xiaodong Zhou , Ten It Wong , Yee Sin Leo
IPC分类号： G01N21/552 , G01N21/01 , G01N33/74
摘要： Disclosed is a localised surface plasmon resonance (LSPR) nanopillar assembly. The LSPR assembly is for use in sensing the presence of a biomarker when attached to a quantum dot. The LSPR assembly comprises a substrate and an array. The array comprises a LSPR nanopillar and a polymer spacer attached to the nanopillar. The LSPR assembly further comprises an antibody attached to the at least one polymer spacer. In the LSPR assembly, a combined height of the polymer spacer and antibody is selected by varying the number of monomer units of the polymer spacer, so that, when in use with the biomarker and the quantum dot, the quantum dot is at a predetermined distance from the nanopillar.

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