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1. 发明授权

US10905898B2 Methods and apparatuses for treating gland dysfunction 有权
公开(公告)号：US10905898B2
公开(公告)日：2021-02-02
申请号：US16375196
申请日：2019-04-04
申请人： TearScience, Inc.
发明人： Stephen M. Grenon , Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely
IPC分类号： A61N5/06 , A61H7/00 , A61F9/007 , A61N1/40 , A61N5/02 , A61B18/12 , A61B18/04 , A61F7/00 , A61H15/00 , A61N7/00 , A61N5/067
摘要： A method of treating dry eye includes delivering light energy from outside an eyelid toward the eyelid, and maintaining the delivery of the light energy toward the eyelid for a period of time to soften an obstruction of at least one meibomian gland. The light energy may be delivered specifically to the obstruction in the at least one meibomian gland without physically contacting the at least one meibomian gland, or the light energy delivered toward the eyelid may conductively apply heat to the meibomian gland to melt the obstruction. A corresponding apparatus includes a light energy source positionable outside an eyelid and configured to deliver the light energy from outside an eyelid toward the eyelid, and a controller configured to control the light energy source to maintain the delivery of the light energy toward the eyelid for a period of time to soften the obstruction.

2. 发明授权

US09795290B2 Ocular tear film peak detection and stabilization detection systems and methods for determining tear film layer characteristics 有权
公开(公告)号：US09795290B2
公开(公告)日：2017-10-24
申请号：US14543583
申请日：2014-11-17
申请人： TearScience, Inc.
发明人： Stephen M. Grenon , Scott Liddle , Donald R. Korb
IPC分类号： A61B3/10 , A61B3/00 , G01B11/06 , G06T7/00
CPC分类号： A61B3/101 , A61B3/0025 , G01B11/06 , G06T7/0012 , G06T2207/30041
摘要： Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for peak detection and/or determining stabilization of an ocular tear film. Embodiments disclosed herein also include various image capturing and processing methods and related systems for providing various information about a patient's ocular tear film (e.g., the lipid and aqueous layers) and a patient's meibomian glands that can be used to analyze tear film layer thickness(es) (TFLT), and related characteristics as it relates to dry eye.

3. 发明授权

US09719977B2 Methods and systems for treating meibomian gland dysfunction using radio-frequency energy 有权
公开(公告)号：US09719977B2
公开(公告)日：2017-08-01
申请号：US13590828
申请日：2012-08-21
申请人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely , Steven Bacich
发明人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely , Steven Bacich
IPC分类号： A61F7/08 , A61F9/00 , G01N33/22 , A61N1/40 , A61F9/007 , A61H7/00 , A61H9/00 , A61H23/02 , A61B5/00 , A61B18/12 , A61B18/04 , A61F7/00 , A61H39/08 , A61H15/00 , A61N7/00
CPC分类号： G01N33/227 , A61B5/4836 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61B2562/0247 , A61B2562/0271 , A61F9/007 , A61F9/00718 , A61F2007/0004 , A61F2007/0059 , A61H7/003 , A61H7/005 , A61H9/0057 , A61H9/0071 , A61H9/0078 , A61H23/0236 , A61H23/0245 , A61H23/0263 , A61H39/086 , A61H2015/0014 , A61H2201/0176 , A61H2201/0207 , A61H2201/0214 , A61H2201/5038 , A61H2201/5043 , A61H2205/024 , A61N1/403 , A61N7/00 , Y10T436/170769 , Y10T436/173076 , Y10T436/173845 , Y10T436/178459 , Y10T436/19 , Y10T436/206664
摘要： A method of treating meibomian gland dysfunction is disclosed. The method includes directing RF energy to an internal portion of a meibomian gland, selectively targeting an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction, and expressing the obstruction from the duct of the meibomian gland. An apparatus for treating meibomian gland dysfunction is also disclosed. The apparatus comprises at least one RF electrode configured to direct RF energy to an internal portion of a meibomian gland located in an eyelid of an eye, the at least one RF electrode further configured to selectively target an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction. The apparatus also comprises at least one expressor configured to express the obstruction from the duct of the meibomian gland.

4. 发明授权

US09662008B2 Ocular surface interferometry (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film 有权
公开(公告)号：US09662008B2
公开(公告)日：2017-05-30
申请号：US15143834
申请日：2016-05-02
申请人： TearScience Inc.
发明人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon
IPC分类号： A61B3/14 , A61B3/10 , A61B3/02 , A61B5/05 , A61B3/00 , G06T7/00
CPC分类号： A61B3/101 , A61B3/0025 , A61B3/0041 , A61B3/1005 , A61B3/14 , G06T7/0012 , G06T2207/30041
摘要： Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).

5. 发明授权

US09357915B2 Ocular surface interferometry (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film 有权
公开(公告)号：US09357915B2
公开(公告)日：2016-06-07
申请号：US14299504
申请日：2014-06-09
申请人： TearScience Inc.
发明人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon
IPC分类号： A61B3/14 , A61B3/10 , A61B3/02 , A61B5/05 , A61B3/00 , G06T7/00
摘要： Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).

6. 发明授权

US08915592B2 Apparatuses and methods of ocular surface interferometry (OSI) employing polarization and subtraction for imaging, processing, and/or displaying an ocular tear film 有权
标题翻译：使用偏振和减光进行成像，处理和/或显示眼泪膜的眼表干涉测量（OSI）的装置和方法
公开(公告)号：US08915592B2
公开(公告)日：2014-12-23
申请号：US13870054
申请日：2013-04-25
申请人： TearScience, Inc.
发明人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon
IPC分类号： A61B3/14 , A61B3/10 , A61B3/02 , A61B5/05 , A61B3/00 , G06T7/00 , G01B11/06 , G06T5/00 , G06T5/50
CPC分类号： A61B3/101 , A61B3/0025 , G01B11/0675 , G06T5/002 , G06T5/50 , G06T7/0012 , G06T2207/10016 , G06T2207/20224 , G06T2207/30041
摘要： Apparatuses and methods employing ocular surface interferometry (OSI) employing polarization and subtraction for imaging, processing, and/or displaying an ocular tear film are disclosed. The apparatuses and methods can be employed for measuring tear film layer thickness (TFLT) of the ocular tear film, which includes lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). An imaging device is focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device is focused on the lipid layer of the tear film to capture a second image containing background signal(s) in the first image. The second image can be subtracted from the first image to reduce and/or eliminate background signal(s) in the first image to produce a resulting image that can be analyzed to measure tear film layer thickness (TFLT).
摘要翻译：公开了使用用于成像，处理和/或显示眼泪膜的偏振和减影的眼表面干涉测量（OSI）的装置和方法。该装置和方法可用于测量眼泪膜的泪膜层厚度（TFLT），其包括脂质层厚度（LLT）和/或水层厚度（ALT）。成像装置集中在泪膜的脂质层上，以捕获与第一图像中的背景信号结合的来自泪膜的镜面反射光的光波干涉相互作用。成像装置聚焦在泪膜的脂质层上，以捕获包含第一图像中的背景信号的第二图像。可以从第一图像中减去第二图像以减少和/或消除第一图像中的背景信号，以产生可以被分析以测量泪膜层厚度（TFLT）的所得图像。

7. 发明授权

US08746883B2 Ocular surface interferometery (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film 有权
标题翻译：用于成像，加工和/或显示眼泪膜的眼表干涉仪（OSI）装置和系统
公开(公告)号：US08746883B2
公开(公告)日：2014-06-10
申请号：US12798275
申请日：2010-04-01
申请人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon
发明人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon
IPC分类号： A61B3/14 , A61B3/10 , A61B3/02 , A61B5/05
CPC分类号： A61B3/101 , A61B3/0025 , A61B3/0041 , A61B3/1005 , A61B3/14 , G06T7/0012 , G06T2207/30041
摘要： Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).
摘要翻译：公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼表干涉测量（OSI）装置，系统和方法。测量的TFLT可用于诊断干眼综合征（DES）。在某些公开的实施例中，可以控制多波长光源以照射眼泪膜。从多波长光源发射的光在泪膜中经历光波干涉相互作用。成像装置可以集中在泪膜的脂质层上，以捕获与第一图像中的背景信号结合的来自泪膜的镜面反射光的光波干涉相互作用。成像装置还可以聚焦在泪膜的脂质层上，以捕获包含存在于第一图像中的背景信号的第二图像。可以从第一图像中减去第二图像以减少和/或消除第一图像中的背景信号以产生所得图像。可以对所得图像进行处理和分析，以测量泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）。

8. 发明申请

US20130308095A1 APPARATUSES AND METHODS OF OCULAR SURFACE INTERFEROMETRY (OSI) EMPLOYING POLARIZATION AND SUBTRACTION FOR IMAGING, PROCESSING, AND/OR DISPLAYING AN OCULAR TEAR FILM 有权
标题翻译：用于成像，处理和/或显示眼睛电影的极化表面干涉（OSI）的装置和方法进行偏振和分离
公开(公告)号：US20130308095A1
公开(公告)日：2013-11-21
申请号：US13870054
申请日：2013-04-25
申请人： TearScience, Inc.
发明人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon
IPC分类号： A61B3/10
CPC分类号： A61B3/101 , A61B3/0025 , G01B11/0675 , G06T5/002 , G06T5/50 , G06T7/0012 , G06T2207/10016 , G06T2207/20224 , G06T2207/30041
摘要： Apparatuses and methods employing ocular surface interferometry (OSI) employing polarization and subtraction for imaging, processing, and/or displaying an ocular tear film are disclosed. The apparatuses and methods can be employed for measuring tear film layer thickness (TFLT) of the ocular tear film, which includes lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). An imaging device is focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device is focused on the lipid layer of the tear film to capture a second image containing background signal(s) in the first image. The second image can be subtracted from the first image to reduce and/or eliminate background signal(s) in the first image to produce a resulting image that can be analyzed to measure tear film layer thickness (TFLT).
摘要翻译：公开了使用用于成像，处理和/或显示眼泪膜的偏振和减影的眼表面干涉测量（OSI）的装置和方法。该装置和方法可用于测量眼泪膜的泪膜层厚度（TFLT），其包括脂质层厚度（LLT）和/或水层厚度（ALT）。成像装置集中在泪膜的脂质层上，以捕获与第一图像中的背景信号结合的来自泪膜的镜面反射光的光波干涉相互作用。成像装置聚焦在泪膜的脂质层上，以捕获包含第一图像中的背景信号的第二图像。可以从第一图像中减去第二图像以减少和/或消除第一图像中的背景信号，以产生可以被分析以测量泪膜层厚度（TFLT）的所得图像。

9. 发明授权

US08585204B2 Tear film measurement 有权
标题翻译：撕裂膜测量
公开(公告)号：US08585204B2
公开(公告)日：2013-11-19
申请号：US13455628
申请日：2012-04-25
申请人： Benjamin T. Gravely , Donald R. Korb
发明人： Benjamin T. Gravely , Donald R. Korb
IPC分类号： A61B3/10 , A61B3/14
CPC分类号： A61B3/101
摘要： A method for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye. Light is directed to the lipid layer of a patient's eye with an illuminator that is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. The specularly reflected light is collected and focused using a collector such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis.
摘要翻译：用于测量眼表面上的角膜前泪膜的脂质层成分的相对厚度的方法。光被引导到患者眼睛的脂质层，其中照射器是覆盖可见区域的宽光谱光源，并且是透明光发射器，使得光源被镜面反射从脂质层并经历建构性和相消干涉脂质层。使用收集器收集和聚焦镜面反射光，使得可以观察到泪膜脂质层上的干涉图案。集电极还产生代表镜面反射光的输出信号，适用于进一步的分析。

10. 发明授权

US08545017B2 Ocular surface interferometry (OSI) methods for imaging, processing, and/or displaying an ocular tear film 有权
标题翻译：用于成像，处理和/或显示眼泪膜的眼表干涉测量（OSI）方法
公开(公告)号：US08545017B2
公开(公告)日：2013-10-01
申请号：US12798325
申请日：2010-04-01
申请人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon
发明人： Donald R. Korb , William L. Weber , Randal B. Chinnock , Benjamin T. Gravely , Stephen M. Grenon
IPC分类号： A61B3/14 , A61B3/10
CPC分类号： A61B3/101 , A61B3/0025 , A61B3/0041 , A61B3/1005 , A61B3/14 , G06T7/0012 , G06T2207/30041
摘要： Ocular surface interferometry (OSI) devices, systems, and methods are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT). The measured TFLT can be used to diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in a first image. The imaging device can also be focused on the lipid layer of the tear film to capture a second image containing the background signal(s) present in the first image. The second image can be subtracted from the first image to reduce and/or eliminate the background signal(s) in the first image to produce a resulting image. The resulting image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).
摘要翻译：公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼表干涉测量（OSI）装置，系统和方法。测量的TFLT可用于诊断干眼综合征（DES）。在某些公开的实施例中，可以控制多波长光源以照射眼泪膜。从多波长光源发射的光在泪膜中经历光波干涉相互作用。成像装置可以集中在泪膜的脂质层上，以捕获与第一图像中的背景信号结合的来自泪膜的镜面反射光的光波干涉相互作用。成像装置还可以聚焦在泪膜的脂质层上，以捕获包含存在于第一图像中的背景信号的第二图像。可以从第一图像中减去第二图像以减少和/或消除第一图像中的背景信号以产生所得图像。可以对所得图像进行处理和分析，以测量泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）。

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