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1. 发明授权

US08957076B2 Wound healing 有权
标题翻译：伤口愈合
公开(公告)号：US08957076B2
公开(公告)日：2015-02-17
申请号：US12643644
申请日：2009-12-21
申请人： Stephen M. Gunnigle
发明人： Stephen M. Gunnigle
IPC分类号： A61K31/497 , A61K9/70 , A61L15/16 , A61L15/44 , A61K31/00 , A61K38/19 , A61K45/06
CPC分类号： A61K39/3955 , A61K31/00 , A61K31/437 , A61K31/53 , A61K31/713 , A61K38/19 , A61K38/45 , A61K38/465 , A61K45/06 , A61L15/44 , A61L2300/412 , A61L2300/434 , A61L2300/45 , C07K16/40 , C12N15/1137 , C12N2310/11 , C12N2310/12 , C12Y207/00 , A61K2300/00
摘要： The present invention relates to the use of p38 MAP kinase inhibitors and p38 MAP kinase inhibition to promote wound healing.
摘要翻译：本发明涉及p38 MAP激酶抑制剂和p38MAP激酶抑制作用以促进伤口愈合的用途。

2. 发明授权

US08808754B2 Methods for the treatment of wounds 有权
标题翻译：伤口治疗方法
公开(公告)号：US08808754B2
公开(公告)日：2014-08-19
申请号：US11477307
申请日：2006-06-29
申请人： Patrick J. Trotter , Frank R. Cichocki, Jr.
发明人： Patrick J. Trotter , Frank R. Cichocki, Jr.
IPC分类号： A61K33/00 , A61P17/02 , A61M35/00 , A61H33/14
CPC分类号： A61M35/00 , A61H33/14
摘要： A method of treatment of a wound, said method comprising the step of injecting an effective amount of an oxygen-containing fluid into said wound at a location below a surface of said wound, said step of injecting being carried out through a conduit having one or more outlets for said fluid, wherein substantially all of said outlets are positioned below the surface of the wound during said step of injecting. Injection of oxygen directly into the wound tissue below the wound surface provides enhanced wound healing.
摘要翻译：一种治疗伤口的方法，所述方法包括在所述伤口表面下方的位置将有效量的含氧流体注入所述伤口的步骤，所述注射步骤通过具有一个或多个用于所述流体的更多出口，其中在所述注入步骤期间，基本上所有所述出口位于伤口表面下方。将注射氧气直接注入伤口表面下面的伤口组织提供增强的伤口愈合。

3. 发明授权

US07955572B2 Sample collection and testing device with swing arm 失效
标题翻译：带摇臂的样品收集和测试装置
公开(公告)号：US07955572B2
公开(公告)日：2011-06-07
申请号：US11913434
申请日：2007-03-02
申请人： Matthew Hannant , Stephen J. Irwin , Simon William Bayliff
发明人： Matthew Hannant , Stephen J. Irwin , Simon William Bayliff
IPC分类号： G01N21/01
CPC分类号： A61B10/0045 , A61B2010/0006
摘要： A sample collection and testing device comprising: An elongate housing (1) having a first end and a second end and a longitudinal axis; an analytical element (4) retained in the housing; a sample collector assembly extending from the first end of the housing and comprising a sample collector (24) in fluid communication with the analytical element (4); a swing arm (2) attached to the housing by a pivot fitting (44), said swing arm having proximal and distal ends; and a cap (40) at the distal end of the swing arm (2); wherein the device comprises a slide to allow limited linear movement of the cap (40) substantially along the longitudinal axis of the housing (1), and wherein the pivot fitting (44) allows the swing arm to rotate about a pivot axis substantially perpendicular to the said longitudinal axis, whereby the swing arm (2) is movable between a sample collection configuration in which the cap (40) is remote from the sample collector (24) and a sample analysis configuration in which the cap (40) encloses the sample collector (24).
摘要翻译：一种样品收集和测试装置，包括：细长壳体（1），其具有第一端和第二端以及纵向轴线; 保留在壳体中的分析元件（4）样品收集器组件，其从壳体的第一端延伸并且包括与分析元件（4）流体连通的样品收集器（24）; 通过枢轴配件（44）附接到壳体的摆臂（2），所述摆臂具有近端和远端; 以及在所述摆臂（2）的远端处的帽（40）; 其中所述装置包括滑块，以允许所述盖（40）基本上沿着所述壳体（1）的纵向轴线的有限线性运动，并且其中所述枢转配件（44）允许所述摆臂围绕基本垂直于所述纵向轴线，其中所述摆臂（2）可以在所述盖（40）远离所述样品收集器（24）的样品采集构型和样品分析结构之间移动，其中所述盖（40）包围所述样品收集器（24）。

4. 发明申请

US20090275872A1 FLUID WOUND DRESSING COMPRISING PARTIALLY CURED POLYURETHANE 有权
标题翻译：流体包扎包裹部分固化的聚氨酯
公开(公告)号：US20090275872A1
公开(公告)日：2009-11-05
申请号：US12470620
申请日：2009-05-22
申请人： Deborah Addison , Edward Schonfeld , Peter Wachtel , Sally-Anne Stephens
发明人： Deborah Addison , Edward Schonfeld , Peter Wachtel , Sally-Anne Stephens
IPC分类号： A61F13/00 , A61L15/00
CPC分类号： A61L26/0019 , A61K31/155 , A61K31/167 , A61K31/555 , A61K31/7024 , A61K45/06 , A61L27/18 , A61K2300/00 , C08L75/04
摘要： A wound dressing composition comprising a partially cured polyurethane fluid. The composition can be injected directly into a wound, where it cures to form a wound filling dressing. Also provided is a wound dressing comprising such a composition. Also provided is a kit for the preparation of such wound dressings, the kit comprising (a) a polyurethane prepolymer; and (b) a curing agent for the polyurethane prepolymer. Preferably, the polyurethane components comprise reaction products of a diisocyanate with castor oil or a related ester of ricinoleic acid or its derivatives.
摘要翻译：一种包含部分固化的聚氨酯流体的伤口敷料组合物。组合物可以直接注射到伤口中，其中它固化以形成伤口填充敷料。还提供了包含这种组合物的伤口敷料。还提供了用于制备这种伤口敷料的试剂盒，试剂盒包含（a）聚氨酯预聚物; 和（b）聚氨酯预聚物的固化剂。优选地，聚氨酯组分包括二异氰酸酯与蓖麻油或蓖麻油酸或其衍生物的相关酯的反应产物。

5. 发明授权

US08377651B2 Method for detecting Escherichia coli 有权
标题翻译：检测大肠杆菌的方法
公开(公告)号：US08377651B2
公开(公告)日：2013-02-19
申请号：US12894212
申请日：2010-09-30
申请人： Gerard J. Colpas , Diane Ellis-Busby , Shite Sebastian , Mitchell C. Sanders
发明人： Gerard J. Colpas , Diane Ellis-Busby , Shite Sebastian , Mitchell C. Sanders
IPC分类号： C12Q1/37
CPC分类号： G01N33/573 , C12Q1/10 , C12Q1/37 , G01N33/52 , G01N33/54366 , G01N33/56916 , G01N2333/245
摘要： Described herein are methods of detecting an infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with an enzyme produced and/or secreted by the bacteria, and detecting modification or the absence of modification of the substrate, as an indicator of the presence or absence of the enzyme in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.
摘要翻译：本文描述的是检测感染和检测样品中存在或不存在微生物，例如伤口病原体的方法，通过使样品与细菌产生和/或分泌的酶接触，并检测是否存在作为样品中酶的存在或不存在的指示剂，修饰底物。本发明还具有用于检测样品中细菌存在或不存在的生物传感器。

6. 发明申请

US20120135062A1 WOUND DRESSING MATERIALS 有权
标题翻译：绕线材料
公开(公告)号：US20120135062A1
公开(公告)日：2012-05-31
申请号：US13318938
申请日：2010-05-05
申请人： Lorraine Nisbet
发明人： Lorraine Nisbet
IPC分类号： A61L15/16 , A61K31/195 , A61B19/00 , A61K31/665
CPC分类号： A61L15/44 , A61F13/00063 , A61F13/0206 , A61L15/225 , A61L15/26 , A61L15/32 , A61L15/58 , A61L15/64 , A61L2300/214 , A61L2300/216 , A61L2300/40 , A61L2300/428 , A61L2300/45
摘要： A wound dressing material comprising: a wound dressing carrier, N-acetyl cysteine or a salt or derivative thereof, and a stabilized ascorbate. Suitably, the stabilized ascorbate comprises an ascorbate-2-polyphosphate. Also provided are wound dressing comprising the materials, methods of treatment with the materials, and methods of making the materials.
摘要翻译：一种伤口敷料，包括：伤口敷料载体，N-乙酰半胱氨酸或其盐或衍生物，以及稳定的抗坏血酸盐。适当地，稳定的抗坏血酸盐包含抗坏血酸-2-聚磷酸酯。还提供包括材料的伤口敷料，用该材料处理的方法以及制备材料的方法。

7. 发明授权

US08124826B2 Antioxidant and antimicrobial wound dressing materials 有权
标题翻译：抗氧化和抗菌伤口敷料
公开(公告)号：US08124826B2
公开(公告)日：2012-02-28
申请号：US10579850
申请日：2004-11-17
申请人： Deborah Addison , David Greenhalgh , Breda Mary Cullen
发明人： Deborah Addison , David Greenhalgh , Breda Mary Cullen
IPC分类号： A61F13/00
CPC分类号： A61L15/44 , A61F13/0203 , A61F13/0206 , A61F13/0209 , A61F13/0213 , A61F13/0226 , A61F13/0256 , A61L15/20 , A61L15/28 , A61L15/325 , A61L15/46 , A61L15/56 , A61L15/64 , A61L2300/21 , A61L2300/404 , B65B5/04 , B65B55/12 , C08L5/08 , C08L1/24
摘要： A wound dressing material comprising a polymeric substrate, a silver salt, and a dyestuff to photostabilize the silver salt. The substrate may comprise collagen and/or oxidized regenerated cellulose complexed to Ag+, and the dyestuff may for example be an aniline or acridine dye. Also provided are methods of making such materials, and wound dressings comprising such materials.
摘要翻译：一种伤口敷料，其包含聚合物基质，银盐和染料以使银盐光稳定。底物可以包含与Ag +络合的胶原和/或氧化的再生纤维，染料可以是例如苯胺或吖啶染料。还提供了制造这种材料的方法，以及包括这种材料的伤口敷料。

8. 发明授权

US08124370B2 Cationic anti-microbial peptides and methods of use thereof 失效
标题翻译：阳离子抗微生物肽及其使用方法
公开(公告)号：US08124370B2
公开(公告)日：2012-02-28
申请号：US10543523
申请日：2004-01-30
申请人： Mitchell C. Sanders , Gerard J. Colpas , Shite Sebastian , Diane Ellis-Busby
发明人： Mitchell C. Sanders , Gerard J. Colpas , Shite Sebastian , Diane Ellis-Busby
IPC分类号： C12Q1/37
CPC分类号： G01N33/54366 , C12Q1/04
摘要： Described herein are methods of detecting a wound infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with a cationic anti-microbial peptide that is degradable by an enzyme produced and/or secreted by a microorganism, and detecting degradation or the absence of degradation of the peptide, as an indicator of the presence or absence of the enzyme in the sample, and thus indicative of the presence or absence of a microorganism in the sample. The present invention also features a biosensor for detecting the presence or absence of a microorganism in a sample.
摘要翻译：本文描述的是检测伤口感染并检测样品中存在或不存在微生物，例如伤口病原体的方法，通过将样品与可产生和/或分泌的酶降解的阳离子抗微生物肽接触通过微生物检测降解或不降解肽，作为样品中酶的存在或不存在的指标，因此表明样品中存在或不存在微生物。本发明还具有用于检测样品中微生物的存在或不存在的生物传感器。

9. 发明授权

US07794925B2 Diagnosis of clinical infection of a wound 有权
标题翻译：伤口临床感染诊断
公开(公告)号：US07794925B2
公开(公告)日：2010-09-14
申请号：US10494507
申请日：2002-11-05
申请人： Breda Mary Cullen
发明人： Breda Mary Cullen
IPC分类号： C12Q1/00
CPC分类号： C12Q1/37 , G01N33/573 , G01N33/6893 , G01N2333/78
摘要： A method of predicting or diagnosing clinical infection of a wound comprising measuring the concentration of a marker associated with an inflammatory response in wound fluid, wherein the marker is a fibronectin fragment, a neutrophil protease or a macrophage protease. Also provided is a use of a wound dressing or biosensor comprising components of an assay system for measuring the concentration of a marker associated with an inflammatory response, wherein the marker is a fibronectin fragment, a neutrophil protease or a macrophage protease, for use in the manufacture of a medicament for predicting the likelihood of clinical infection of the wound or for diagnosing clinical infection of a wound.
摘要翻译：一种预测或诊断伤口的临床感染的方法，包括测量与伤口液中的炎症反应相关的标志物的浓度，其中所述标记是纤连蛋白片段，嗜中性粒细胞蛋白酶或巨噬细胞蛋白酶。还提供伤口敷料或生物传感器的用途，所述创伤敷料或生物传感器包括用于测量与炎症反应相关的标志物的浓度的测定系统的组分，其中所述标记是纤连蛋白片段，嗜中性粒细胞蛋白酶或巨噬细胞蛋白酶，用于制造用于预测伤口的临床感染的可能性或用于诊断伤口的临床感染的药物。

10. 发明授权

US07601546B2 Diagnostic test devices 失效
标题翻译：诊断测试设备
公开(公告)号：US07601546B2
公开(公告)日：2009-10-13
申请号：US10590248
申请日：2005-02-23
申请人： Simon W. Bayloff , Michelle Del Bono , Maurice C. Biott , Sylvia Lindsay-Watt
发明人： Simon W. Bayloff , Michelle Del Bono , Maurice C. Biott , Sylvia Lindsay-Watt
IPC分类号： G01N33/53
CPC分类号： A61B10/0045 , A61B10/0096 , A61B10/02 , A61B10/0266 , A61B17/32053 , A61B2010/0006 , A61F13/38 , B01L3/5029 , B01L3/50825 , B01L2300/0663 , B01L2300/0681 , B01L2300/0864 , B01L2400/0406 , B01L2400/0487 , G01N1/02 , G01N2001/028 , Y10T436/25
摘要： A diagnostic test apparatus comprising: a shaft having a first end and a second end; a swab or a biopsy punch mounted on the first end of a shaft; and a cap for fitting over the first end of the shaft, said cap containing at least one diagnostic test reagent; wherein the shaft comprises at least one cap engagement element located proximate to the first end, said element extending radially outwardly of the swab or the biopsy punch for engagement with the cap to retain the cap on the shaft. Also provided are diagnostic caps for use in the test apparatus having a small internal volume and at least one diagnostic test reagent located in or on an absorbent plug inside the cap. Also provided are diagnostic caps for use in the test apparatus having a housing extending from a sample receiving port, said housing defining a lateral flow path for the sample. Also provided is a test system comprising a swab shaft, a biopsy punch shaft and a diagnostic cap in accordance with the invention, wherein the cap can be used interchangeably between the two different shafts.
摘要翻译：一种诊断测试装置，包括：具有第一端和第二端的轴; 安装在轴的第一端上的拭子或活检冲头; 以及用于装配在所述轴的第一端上的盖，所述盖包含至少一个诊断试剂; 其中所述轴包括靠近所述第一端定位的至少一个帽接合元件，所述元件沿所述拭子或所述活检穿孔径向向外延伸，用于与所述帽接合以将所述帽保持在所述轴上。还提供了用于具有小内部容积的测试装置中的诊断帽和位于帽内的吸收塞内或中的至少一个诊断测试试剂。还提供了用于在测试装置中使用的诊断帽，其具有从样本接收端口延伸的壳体，所述壳体限定用于样品的侧向流动路径。还提供了一种包括根据本发明的拭子轴，活检穿刺轴和诊断帽的测试系统，其中所述盖可以在两个不同的轴之间互换使用。

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