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1. 发明授权

US12061142B2 Method for determining physicochemical properties of nanoscale systems (NSS) 有权
公开(公告)号：US12061142B2
公开(公告)日：2024-08-13
申请号：US17310592
申请日：2020-02-05
申请人： SMARTDYELIVERY GMBH
发明人： Christoph Englert , Marc Lehmann , Ivo Nischang , Ulrich Schubert
IPC分类号： G01N15/04 , G01N11/00 , G01N33/543 , G01N15/00
CPC分类号： G01N15/042 , G01N11/00 , G01N2015/0038 , G01N2015/045
摘要： The invention relates to a method for determining the physicochemical properties of a nanoscale system (NSS) using analytical ultracentrifugation), comprising the steps of generating a multi-dimensional sedimentation analysis map associated with the NSS of interest; selecting sample-dependent parameters; determining sedimentation coefficient value/parameter in the sample; inserting sample sedimentation coefficient values onto the multi-dimensional sedimentation analysis map to obtain a NSS sample map value; and inferring from the NSS sample map value the physicochemical properties of the NSS sample. Furthermore, the invention relates to a system for performing the method, a computer program product and a computer readable storage medium.

2. 发明授权

US10131747B2 Poly(ethylene imine)-based copolymers for bonding to and releasing genetic material, in particular DNA/RNA, and method for the production and use of same 有权
公开(公告)号：US10131747B2
公开(公告)日：2018-11-20
申请号：US15026882
申请日：2014-10-02
申请人： SmartDyeLivery GmbH
发明人： Christoph Englert , Lutz Tauhardt , Michael Gottschalk , Ulrich S. Schubert
IPC分类号： C08G73/02 , C08G81/00
摘要： New poly(ethylene imine)-based copolymers for bonding to and releasing genetic material, in particular DNA/RNA, and method for the production and use of same.The copolymers according to a compound of the general Formula I: can be produced at low costs and with little expenditure of time, are tailor-made and have a high functionality for universal effective uses without restriction of their bonding affinity to genetic material. The new copolymers are produced through a synthesis of the general Formula III:

3. 发明申请

US20210330677A1 PKC INHIBITORS FOR THE TREATMENT OF SEPTIC CHOLESTASIS WITH CTM TARGETING 有权
公开(公告)号：US20210330677A1
公开(公告)日：2021-10-28
申请号：US17271422
申请日：2019-08-26
申请人： SMARTDYELIVERY GMBH
发明人： Christoph ENZENSPERGER , Marc LEHMANN
IPC分类号： A61K31/553 , A61K47/54 , A61K31/7105 , A61K31/517 , A61K31/4025 , A61K31/4545 , A61K31/407 , A61K31/437 , A61K31/55 , A61K31/5377 , A61K31/52 , A61K31/501 , A61K31/4745 , A61K31/133 , A61K31/235 , A61K38/17 , A61K31/585 , A61K31/365 , A61K31/498 , A61P1/16 , A61K47/69
摘要： The invention relates to inhibitors of the PKC signaling pathway for use in the treatment of septic cholestasis, wherein the inhibitors are targeted into the liver by a selective nanostructured delivery system, wherein the selective nanostructured delivery system comprises at least one carbohydrate targeting moiety and at least one polymer and/or at least one lipid and/or at least one virus-like particle.

4. 发明申请

US20210315996A1 PKC INHIBITORS FOR THE TREATMENT OF SEPTIC CHOLESTASIS WITH POLYMETHINE DYE TARGETING 有权
公开(公告)号：US20210315996A1
公开(公告)日：2021-10-14
申请号：US17271411
申请日：2019-08-26
申请人： SMARTDYELIVERY GMBH
发明人： Christoph ENZENSPERGER , Marc LEHMANN
IPC分类号： A61K47/22 , A61K31/553 , A61K47/54 , A61K45/06 , A61K47/69 , C12N15/113
摘要： The invention relates to inhibitors of the PKC signaling pathway for use in the treatment of septic cholestasis, wherein the inhibitors are targeted into the liver by a selective nanostructured delivery system, wherein the selective nanostructured delivery system comprises at least one polymethine dye and at least one polymer and/or at least one lipid and/or at least one virus-like particle, wherein the at least one polymethine dye is a symmetrical or asymmetrical polymethine.

5. 发明授权

US09795688B2 Cell-specific targeting using nanostructured delivery systems 有权
公开(公告)号：US09795688B2
公开(公告)日：2017-10-24
申请号：US15021119
申请日：2014-09-11
申请人： SmartDyeLivery GmbH
发明人： Michael Bauer , Ulrich Schubert , Michael Gottschaldt , Anja Trager , Christian Pietsch , Falk Gonnert , Peter Recknagel , Adrian Press
IPC分类号： A61K9/00 , A61K47/48 , A61K49/00 , A61K45/06 , C12N15/113
CPC分类号： A61K47/6929 , A61K45/06 , A61K47/543 , A61K47/545 , A61K47/593 , A61K47/6911 , A61K47/6935 , A61K47/6937 , A61K49/0032 , A61K49/0084 , A61K49/0093 , C12N15/1137 , C12N2310/14 , C12N2320/32
摘要： The invention relates to a nanostructured delivery system comprising at least one polymer and/or at least one lipid and at least one polymethine dye, wherein the at least one polymethine dye acting as a targeting unit brings about the targeted transport of the nanostructured delivery system into a target issue. The invention also relates to a pharmaceutical composition and the uses of the nanostructured delivery system for transporting said system and, optionally, a pharmaceutical active ingredient into the target tissue, as well for treating liver and/or kidney diseases.

6. 发明授权

US11344859B2 Reactor for the preparation of a formulation 有权
公开(公告)号：US11344859B2
公开(公告)日：2022-05-31
申请号：US16697454
申请日：2019-11-27
申请人： SmartDyeLivery GmbH
发明人： Christoph Englert , Marc Lehmann
IPC分类号： B01J19/18 , B01J19/00
摘要： The invention discloses a reactor for preparing a formulation. The reactor comprises at least two apertures, a base and at least one sidewall extending flush therefrom, wherein the base and the sidewall together define a mixing chamber with a height hM and at least one axis of symmetry arranged substantially perpendicular to the base and at least one distance r from the sidewall. A first aperture is arranged within the base or adjacent to the base in the sidewall of the mixing chamber at a height hA ranging from 0.6 to 0.0 hM in order to introduce free-flowing materials and/or mixtures to the mixing chamber. The first aperture is configured with a non-return valve disposed therein or adjacent thereto, the non-return valve permitting the introduction of free-flowing materials to the mixing chamber through the aperture, but preventing outflow of free-flowing materials from the mixing chamber through the aperture. The first aperture is formed with an aperture area extending in a range between a minimum and a maximum, the minimum area being 0.05 mm2 and the maximum area being determined by a value resulting from Volumemixing chamber [cm3]/Areafirst aperture [cm2]≈5500.

7. 发明申请

US20220099547A1 METHOD FOR DETERMINING PHYSICOCHEMICAL PROPERTIES OF NANOSCALE SYSTEMS (NSS) 有权
公开(公告)号：US20220099547A1
公开(公告)日：2022-03-31
申请号：US17310592
申请日：2020-02-05
申请人： SMARTDYELIVERY GMBH
发明人： Christoph ENGLERT , Marc LEHMANN , Ivo NISCHANG , Ulrich SCHUBERT
IPC分类号： G01N15/04 , G01N11/00
摘要： The invention relates to a method for determining the physicochemical properties of a nanoscale system (NSS) using analytical ultracentrifugation), comprising the steps of generating a multi-dimensional sedimentation analysis map associated with the NSS of interest; selecting sample-dependent parameters; determining sedimentation coefficient value/parameter in the sample; inserting sample sedimentation coefficient values onto the multi-dimensional sedimentation analysis map to obtain a NSS sample map value; and inferring from the NSS sample map value the physicochemical properties of the NSS sample. Furthermore, the invention relates to a system for performing the method, a computer program product and a computer readable storage medium.

8. 发明申请

US20210154639A1 Reactor for the preparation of a formulation 有权
公开(公告)号：US20210154639A1
公开(公告)日：2021-05-27
申请号：US16697454
申请日：2019-11-27
申请人： SmartDyeLivery GmbH
发明人： Christoph Englert , Marc Lehmann
IPC分类号： B01J19/18 , B01J19/00
摘要： The invention discloses a reactor for preparing a formulation. The reactor comprises at least two apertures, a base and at least one sidewall extending flush therefrom, wherein the base and the sidewall together define a mixing chamber with a height hM and at least one axis of symmetry arranged substantially perpendicular to the base and at least one distance r from the sidewall. A first aperture is arranged within the base or adjacent to the base in the sidewall of the mixing chamber at a height hA ranging from 0.6 to 0.0 hM in order to introduce free-flowing materials and/or mixtures to the mixing chamber. The first aperture is configured with a non-return valve disposed therein or adjacent thereto, the non-return valve permitting the introduction of free-flowing materials to the mixing chamber through the aperture, but preventing outflow of free-flowing materials from the mixing chamber through the aperture. The first aperture is formed with an aperture area extending in a range between a minimum and a maximum, the minimum area being 0.05 mm2 and the maximum area being determined by a value resulting from Volumemixing chamber [cm3]/Areafirst aperture [cm2]≈5500.

9. 发明授权

US09671340B2 Measurement method for determining an organ function 有权
公开(公告)号：US09671340B2
公开(公告)日：2017-06-06
申请号：US13813391
申请日：2010-07-30
申请人： Michael Bauer , Falk A. Gonnert , Peter Recknagel
发明人： Michael Bauer , Falk A. Gonnert , Peter Recknagel
IPC分类号： G01N21/64 , A61K49/10 , A61B5/00 , A61K49/00
CPC分类号： G01N21/64 , A61B5/0071 , A61K49/0032 , A61K49/0034
摘要： The invention relates to a method for acquiring data in order to determine organ function, in particular the liver or kidney function, comprising one or more polymethine fluorescent dyes having a fluorescence emission maximum, measured in ethanol, of less than or equal to 820 nm, and to the use of dyes as markers for acquiring data in order to determine the organ function. The invention further relates to a kit for determining an organ function with a marker dye, and to a device for acquiring data in the method.

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