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1. 发明申请

US20140228355A1 Novel D3 Dopamine Receptor Agonists to Treat Dyskinesia in Parkinson's Disease 有权
标题翻译：新型D3多巴胺受体激动剂治疗帕金森病的运动障碍
公开(公告)号：US20140228355A1
公开(公告)日：2014-08-14
申请号：US13764623
申请日：2013-02-11
申请人： Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine , University of Medicine and Dentistry New Jersey Medical School
发明人： Sandhya Kortagere , Eldo V. Kuzhikandahil
IPC分类号： A61K31/137 , C07C215/54 , C07C211/29 , C07C217/62 , C07D209/14 , C07D471/04 , C07D235/16 , A61K31/4045 , A61K31/4184 , A61K31/519 , A61K31/195 , A61K31/551 , A61K31/4985 , A61K31/48 , A61K31/428 , A61K31/404 , A61K31/506 , A61K31/437 , A61K31/473 , C07C215/08
摘要： The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.
摘要翻译：本发明提供了一种在患有帕金森病的患者中抑制，抑制或预防左旋多巴诱发的运动障碍的方法，包括向患者施用包含至少一种本发明化合物的药物组合物的步骤。本发明还提供了一种抑制，抑制或预防患者帕金森氏病的方法，包括向患者施用包含至少一种本发明化合物的药物组合物的步骤。

2. 发明申请

US20130143792A1 Use of CHEC Peptides to Treat Neurological and Cardiovascular Diseases and Disorders 有权
标题翻译：使用CHEC肽治疗神经和心血管疾病和疾病
公开(公告)号：US20130143792A1
公开(公告)日：2013-06-06
申请号：US13640192
申请日：2011-03-28
申请人： Timothy J. Cunningham
发明人： Timothy J. Cunningham
IPC分类号： A61K38/08
CPC分类号： A61K38/08
摘要： The present invention describes compositions and methods for treating and preventing non-degenerative neurological diseases and disorders associated with elevated sPLA2 activity as well as cardiovascular diseases using a CHEC peptide to inhibit sPLA2 activity.
摘要翻译：本发明描述了用于治疗和预防与升高的sPLA2活性相关的非退行性神经疾病和病症以及使用CHEC肽抑制sPLA2活性的心血管疾病的组合物和方法。

3. 发明申请

US20100216721A1 Inhibition of HIV-1 Infection by Potent Metallocene Conjugated Peptide Through Conformational Entrapment of Envelope GP120 审中-公开
标题翻译：通过包络GP120构象封闭强化金属茂共轭肽对HIV-1感染的抑制
公开(公告)号：US20100216721A1
公开(公告)日：2010-08-26
申请号：US12602073
申请日：2008-05-30
申请人： Hosahudya N. Gopi , Irwin M. Chaiken
发明人： Hosahudya N. Gopi , Irwin M. Chaiken
IPC分类号： A61K38/10 , A61K38/08 , C07K7/08 , C07K7/06 , C07K1/14
CPC分类号： A61K31/4192 , A61K38/00 , A61K47/64 , C07K7/06 , C07K7/08 , C07K14/005 , C12N2740/16122
摘要： The invention provides a peptide triazole conjugate and derivatives thereof, and methods of its use.
摘要翻译：本发明提供了肽三唑缀合物及其衍生物及其应用的方法。

4. 发明申请

US20100166794A1 PLASMODIUM LIVER STAGE ANTIGENS 有权
标题翻译： PLASMODIUM肝脏阶段抗原
公开(公告)号：US20100166794A1
公开(公告)日：2010-07-01
申请号：US12722439
申请日：2010-03-11
申请人： Patrick Duffy , Stefan H.I. Kappe , Urszula Krzych , Donald G. Heppner, JR. , Lawrence W. Bergman , Vladislav A. Malkov , Alice Tarun , Jason W. Wendler , Igor Bacik
发明人： Patrick Duffy , Stefan H.I. Kappe , Urszula Krzych , Donald G. Heppner, JR. , Lawrence W. Bergman , Vladislav A. Malkov , Alice Tarun , Jason W. Wendler , Igor Bacik
IPC分类号： A61K39/002 , C07K14/445 , C07H21/04 , A61P33/06
CPC分类号： C07K14/445 , A61K39/00 , Y02A50/412
摘要： The invention provides isolated liver stage Plasmodium polypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:1-48 and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the liver stage Plasmodium polypeptides of the invention, compositions comprising one or more liver stage Plasmodium polypeptides of the invention, methods for inducing an immune response against the liver stage Plasmodium polypeptides, and methods for treating and diagnosing liver stage malaria.
摘要翻译：本发明提供了分离的肝阶段疟原虫多肽，其包含选自SEQ ID NO：1-48的氨基酸序列及其免疫原性衍生物。本发明还提供编码本发明的肝阶段疟原虫多肽的分离的核酸分子，包含本发明的一种或多种肝阶段疟原虫多肽的组合物，诱导针对肝阶段的疟原虫多肽的免疫应答的方法，以及治疗和诊断方法肝阶段疟疾。

5. 发明申请

US20090181879A1 Methods for Monitoring Neuroinflammatory Destruction of Neurons and for Treating Diseases Having an Inflammatory component related to phospholipase A2 有权
标题翻译：监测神经炎症破坏神经元和治疗具有与磷脂酶A2相关的炎症成分的疾病的方法
公开(公告)号：US20090181879A1
公开(公告)日：2009-07-16
申请号：US11988253
申请日：2006-07-10
申请人： Timothy J. Cunningham , Lihua Yao , Jeffrey I. Greenstein
发明人： Timothy J. Cunningham , Lihua Yao , Jeffrey I. Greenstein
IPC分类号： A61K38/00 , G01N33/53 , C12Q1/00 , C12Q1/34
CPC分类号： G01N33/573 , G01N33/564 , G01N2333/918 , G01N2333/92 , G01N2800/285
摘要： The present invention relates to methods useful to monitor central and peripheral nervous system neuron/axon destruction resulting from an increase in acute phase inflammatory enzymes. The methods have applicability to monitoring the progress of neurological diseases, including multiple sclerosis and Alzheimer's disease, as well as neuroinflammatory damage that results from sports injuries, vigorous physical activity or any form of physical abuse. The invention further relates to methods of treating multiple sclerosis or other diseases with an inflammatory component related to phospholipase A2.
摘要翻译：本发明涉及用于监测由急性期炎症酶增加引起的中枢和周围神经系统神经元/轴突破坏的方法。该方法适用于监测包括多发性硬化和阿尔茨海默病在内的神经系统疾病的进展，以及运动损伤，体力活动或任何形式的身体虐待引起的神经炎症性损伤。本发明还涉及用与磷脂酶A2相关的炎性成分治疗多发性硬化症或其它疾病的方法。

6. 发明申请

US20150044714A1 sPLA2 MONITORING STRIP 审中-公开
标题翻译： sPLA2监测条
公开(公告)号：US20150044714A1
公开(公告)日：2015-02-12
申请号：US14124430
申请日：2012-06-05
申请人： Timothy J. Cunningham , Katherine Marie Kollins Callaghan , Lihua Yao
发明人： Timothy J. Cunningham , Katherine Marie Kollins Callaghan , Lihua Yao
IPC分类号： C12Q1/44
CPC分类号： C12Q1/44 , C12Y301/01004 , G01N33/558 , G01N2333/916 , G01N2333/92 , G01N2405/04
摘要： A device and method for determining the presence or absence, or the level of, sPLA2 activity in a fluid sample. The device includes an absorbent matrix that defines a flow path for a fluid sample, a first region of the absorbent matrix for applying a fluid sample, where one of the components selected from a bioactive sPLA2 substrate and a label is dried onto or within the first region of the absorbent matrix, a second region of the absorbent matrix downstream of, and in fluid communication with, the first region for detecting an aggregated reaction product, where the other component not present in the first region is dried onto or within the second region of the absorbent matrix.
摘要翻译：用于确定流体样品中sPLA2活性的存在或不存在或水平的装置和方法。该装置包括限定流体样品的流动路径的吸收性基质，用于施加流体样品的吸收性基质的第一区域，其中选自生物活性sPLA2底物和标签的组分之一被干燥到第一所述吸收性基体的区域，所述吸收性基体的第二区域与所述第一区域的下游流体连通，用于检测聚集的反应产物，其中不存在于所述第一区域中的另一组分干燥到所述第二区域上或所述第二区域内的吸收性基体。

7. 发明申请

US20150038584A1 MATERIALS FOR DISINFECTION PRODUCED BY NON-THERMAL PLASMA 有权
标题翻译：非热等离子体消毒材料
公开(公告)号：US20150038584A1
公开(公告)日：2015-02-05
申请号：US13813750
申请日：2011-08-03
申请人： Gregory Fridman , Sin Park , Natalie Shainsky , Danil V. Dobrynin , Alexander Rabinovich , Gennady Friedman , Alexander Fridman , Moogega Cooper , Ari D. Brooks , Suresh G. Joshi , Alexander E. Poor , Utku K. Ercan , Mark Ingerman
发明人： Gregory Fridman , Sin Park , Natalie Shainsky , Danil V. Dobrynin , Alexander Rabinovich , Gennady Friedman , Alexander Fridman , Moogega Cooper , Ari D. Brooks , Suresh G. Joshi , Alexander E. Poor , Utku K. Ercan , Mark Ingerman
IPC分类号： A01N37/30 , A61L2/16
CPC分类号： A01N37/46 , A01N37/30 , A01N43/16 , A01N61/00 , A61L2/0011 , A61L2/14 , A61L2/16 , A61L2/22 , A61L2202/24 , A01N25/02 , A01N25/34
摘要： Aspects of the present subject matter are directed to a method comprising contacting an fluid, optionally containing an added organic material, with a non-thermal plasma to form a disinfection composition, wherein the disinfection composition is a liquid, and contacting a surface with the disinfection composition, wherein the surface is at least partially disinfected upon contact with the disinfection composition. Additional aspects of the present subject matter are directed to a method comprising forming a disinfection composition by contacting an organic material with a non-thermal plasma, wherein the disinfection composition is a liquid. A further aspect of the present subject matter is directed to a disinfection composition comprising an organic material contacted by a non-thermal plasma, wherein the disinfection composition is a liquid.
摘要翻译：本发明的方面涉及一种方法，其包括将任选地含有加入的有机材料的流体与非热等离子体接触以形成消毒组合物，其中消毒组合物是液体，并使表面与消毒接触组合物，其中所述表面在与消毒组合物接触时至少部分消毒。本发明的另外的方面涉及包括通过使有机材料与非热等离子体接触来形成消毒组合物的方法，其中消毒组合物是液体。本发明的另一方面涉及包含与非热等离子体接触的有机材料的消毒组合物，其中消毒组合物是液体。

8. 发明申请

US20150025418A1 SYSTEM AND METHOD FOR EVALUATING TISSUE 审中-公开
标题翻译：用于评估组织的系统和方法
公开(公告)号：US20150025418A1
公开(公告)日：2015-01-22
申请号：US14465520
申请日：2014-08-21
申请人： Wan Y. SHIH , Wei-Heng SHIH , Hakki YEGINGIL , Ari D. BROOKS
发明人： Wan Y. SHIH , Wei-Heng SHIH , Hakki YEGINGIL , Ari D. BROOKS
IPC分类号： A61B5/00
CPC分类号： A61B5/0053 , A61B5/4244 , A61B5/4312 , A61B5/4381 , A61B5/441 , A61B5/442 , A61B8/085 , A61B8/403 , A61B8/485 , G01N29/0672 , G01N2291/02475 , G01N2291/02827
摘要： A sensor system for measuring an elastic modulus and a shear modulus and a method for evaluating a tissue. The invention pertains to a method for determining the presence of and/or characterizing abnormal growths, using a piezoelectric finger sensor (PEFS) system. The PEFS system may be particularly useful for screening for tumors and various forms of cancer. Additionally, the PEFS system may be useful for various dermatological applications.
摘要翻译：用于测量弹性模量和剪切模量的传感器系统和用于评估组织的方法。本发明涉及使用压电手指传感器（PEFS）系统确定异常生长的存在和/或表征异常生长的方法。 PEFS系统可能特别适用于筛选肿瘤和各种形式的癌症。此外，PEFS系统可用于各种皮肤病学应用。

9. 发明申请

US20140249210A1 MODULATION OF PRE-MRNA USING SPLICE MODULATING OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS IN THE TREATMENT OF DISEASE 有权
标题翻译：在治疗疾病中使用作为治疗药物的粒子调节寡核苷酸的PRE-MRNA的调节
公开(公告)号：US20140249210A1
公开(公告)日：2014-09-04
申请号：US14188168
申请日：2014-02-24
申请人： Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine
发明人： Gordon J. Lutz , Melanie K. Tallent , Nicole Michele Lykens
IPC分类号： C12N15/11
CPC分类号： C12N15/1138 , A61K48/005 , C12N15/11 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/1137 , C12N2310/11 , C12N2320/33
摘要： The present invention encompasses a class of compounds known as splice modulating oligonucleotides (SMOs) that modulate pre-mRNA splicing, thereby affecting expression and functionality of a specific protein in a cell. The present invention further provides compositions and methods for modulating pre-mRNA splicing using a SMO of the invention to abrogate disease-causing mutations in a protein. Accordingly, the present invention provides compositions and methods of treating a subject at risk of, susceptible to, or having a disease, disorder, or condition associated with aberrant or unwanted target pre-mRNA expression or activity.
摘要翻译：本发明包括称为剪接调节寡核苷酸（SMO）的一类化合物，其调节前mRNA剪接，从而影响细胞中特定蛋白质的表达和功能。本发明还提供了使用本发明的SMO调节前mRNA剪接的组合物和方法，以消除蛋白质中的致病突变。因此，本发明提供了治疗患有与异常或不期望的靶mRNA表达或活性相关的疾病，病症或病症的风险易感或具有疾病，病症或病症的风险的受试者的组合物和方法。

10. 发明申请

US20140242707A1 Compositions and Methods for Diagnosing Hypercoagulability and Hypocoagulability 审中-公开
标题翻译：用于诊断高凝状态和低凝状态的组合物和方法
公开(公告)号：US20140242707A1
公开(公告)日：2014-08-28
申请号：US14233690
申请日：2012-07-19
申请人： Vance G. Nielsen , Keith Vosseller
发明人： Vance G. Nielsen , Keith Vosseller
IPC分类号： G01N33/86
CPC分类号： G01N33/86
摘要： The present invention provides a method for diagnosing hypercoagulability associated with carbon monoxide exposure in a subject. The method comprises obtaining a plasma sample from the subject, dividing the sample into at least two portions, and determining the clot strength of the first portion. The method further comprises exposing the second portion to an organic reductant, determining the clot strength of the second portion after exposure to the organic reductant, and comparing the clot strength of the first portion with the clot strength of the second portion. A diagnosis of hypercogulability associated with carbon monoxide exposure is made when the clot strength of the second portion is decreased compared with the cloth strength of the first portion.
摘要翻译：本发明提供了用于诊断与受试者中一氧化碳暴露有关的高凝状态的方法。该方法包括从受试者获得血浆样品，将样品分成至少两部分，并测定第一部分的凝块强度。该方法还包括将第二部分暴露于有机还原剂，在暴露于有机还原剂之后测定第二部分的凝块强度，并将第一部分的凝块强度与第二部分的凝块强度进行比较。当与第一部分的布强度相比，第二部分的凝块强度降低时，进行与一氧化碳暴露相关的高度凝固性的诊断。

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