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1. 发明申请

US20150044714A1 sPLA2 MONITORING STRIP 审中-公开
标题翻译： sPLA2监测条
公开(公告)号：US20150044714A1
公开(公告)日：2015-02-12
申请号：US14124430
申请日：2012-06-05
申请人： Timothy J. Cunningham , Katherine Marie Kollins Callaghan , Lihua Yao
发明人： Timothy J. Cunningham , Katherine Marie Kollins Callaghan , Lihua Yao
IPC分类号： C12Q1/44
CPC分类号： C12Q1/44 , C12Y301/01004 , G01N33/558 , G01N2333/916 , G01N2333/92 , G01N2405/04
摘要： A device and method for determining the presence or absence, or the level of, sPLA2 activity in a fluid sample. The device includes an absorbent matrix that defines a flow path for a fluid sample, a first region of the absorbent matrix for applying a fluid sample, where one of the components selected from a bioactive sPLA2 substrate and a label is dried onto or within the first region of the absorbent matrix, a second region of the absorbent matrix downstream of, and in fluid communication with, the first region for detecting an aggregated reaction product, where the other component not present in the first region is dried onto or within the second region of the absorbent matrix.
摘要翻译：用于确定流体样品中sPLA2活性的存在或不存在或水平的装置和方法。该装置包括限定流体样品的流动路径的吸收性基质，用于施加流体样品的吸收性基质的第一区域，其中选自生物活性sPLA2底物和标签的组分之一被干燥到第一所述吸收性基体的区域，所述吸收性基体的第二区域与所述第一区域的下游流体连通，用于检测聚集的反应产物，其中不存在于所述第一区域中的另一组分干燥到所述第二区域上或所述第二区域内的吸收性基体。

2. 发明申请

US20150038584A1 MATERIALS FOR DISINFECTION PRODUCED BY NON-THERMAL PLASMA 有权
标题翻译：非热等离子体消毒材料
公开(公告)号：US20150038584A1
公开(公告)日：2015-02-05
申请号：US13813750
申请日：2011-08-03
申请人： Gregory Fridman , Sin Park , Natalie Shainsky , Danil V. Dobrynin , Alexander Rabinovich , Gennady Friedman , Alexander Fridman , Moogega Cooper , Ari D. Brooks , Suresh G. Joshi , Alexander E. Poor , Utku K. Ercan , Mark Ingerman
发明人： Gregory Fridman , Sin Park , Natalie Shainsky , Danil V. Dobrynin , Alexander Rabinovich , Gennady Friedman , Alexander Fridman , Moogega Cooper , Ari D. Brooks , Suresh G. Joshi , Alexander E. Poor , Utku K. Ercan , Mark Ingerman
IPC分类号： A01N37/30 , A61L2/16
CPC分类号： A01N37/46 , A01N37/30 , A01N43/16 , A01N61/00 , A61L2/0011 , A61L2/14 , A61L2/16 , A61L2/22 , A61L2202/24 , A01N25/02 , A01N25/34
摘要： Aspects of the present subject matter are directed to a method comprising contacting an fluid, optionally containing an added organic material, with a non-thermal plasma to form a disinfection composition, wherein the disinfection composition is a liquid, and contacting a surface with the disinfection composition, wherein the surface is at least partially disinfected upon contact with the disinfection composition. Additional aspects of the present subject matter are directed to a method comprising forming a disinfection composition by contacting an organic material with a non-thermal plasma, wherein the disinfection composition is a liquid. A further aspect of the present subject matter is directed to a disinfection composition comprising an organic material contacted by a non-thermal plasma, wherein the disinfection composition is a liquid.
摘要翻译：本发明的方面涉及一种方法，其包括将任选地含有加入的有机材料的流体与非热等离子体接触以形成消毒组合物，其中消毒组合物是液体，并使表面与消毒接触组合物，其中所述表面在与消毒组合物接触时至少部分消毒。本发明的另外的方面涉及包括通过使有机材料与非热等离子体接触来形成消毒组合物的方法，其中消毒组合物是液体。本发明的另一方面涉及包含与非热等离子体接触的有机材料的消毒组合物，其中消毒组合物是液体。

3. 发明申请

US20150025418A1 SYSTEM AND METHOD FOR EVALUATING TISSUE 审中-公开
标题翻译：用于评估组织的系统和方法
公开(公告)号：US20150025418A1
公开(公告)日：2015-01-22
申请号：US14465520
申请日：2014-08-21
申请人： Wan Y. SHIH , Wei-Heng SHIH , Hakki YEGINGIL , Ari D. BROOKS
发明人： Wan Y. SHIH , Wei-Heng SHIH , Hakki YEGINGIL , Ari D. BROOKS
IPC分类号： A61B5/00
CPC分类号： A61B5/0053 , A61B5/4244 , A61B5/4312 , A61B5/4381 , A61B5/441 , A61B5/442 , A61B8/085 , A61B8/403 , A61B8/485 , G01N29/0672 , G01N2291/02475 , G01N2291/02827
摘要： A sensor system for measuring an elastic modulus and a shear modulus and a method for evaluating a tissue. The invention pertains to a method for determining the presence of and/or characterizing abnormal growths, using a piezoelectric finger sensor (PEFS) system. The PEFS system may be particularly useful for screening for tumors and various forms of cancer. Additionally, the PEFS system may be useful for various dermatological applications.
摘要翻译：用于测量弹性模量和剪切模量的传感器系统和用于评估组织的方法。本发明涉及使用压电手指传感器（PEFS）系统确定异常生长的存在和/或表征异常生长的方法。 PEFS系统可能特别适用于筛选肿瘤和各种形式的癌症。此外，PEFS系统可用于各种皮肤病学应用。

4. 发明申请

US20140249210A1 MODULATION OF PRE-MRNA USING SPLICE MODULATING OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS IN THE TREATMENT OF DISEASE 有权
标题翻译：在治疗疾病中使用作为治疗药物的粒子调节寡核苷酸的PRE-MRNA的调节
公开(公告)号：US20140249210A1
公开(公告)日：2014-09-04
申请号：US14188168
申请日：2014-02-24
申请人： Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine
发明人： Gordon J. Lutz , Melanie K. Tallent , Nicole Michele Lykens
IPC分类号： C12N15/11
CPC分类号： C12N15/1138 , A61K48/005 , C12N15/11 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/1137 , C12N2310/11 , C12N2320/33
摘要： The present invention encompasses a class of compounds known as splice modulating oligonucleotides (SMOs) that modulate pre-mRNA splicing, thereby affecting expression and functionality of a specific protein in a cell. The present invention further provides compositions and methods for modulating pre-mRNA splicing using a SMO of the invention to abrogate disease-causing mutations in a protein. Accordingly, the present invention provides compositions and methods of treating a subject at risk of, susceptible to, or having a disease, disorder, or condition associated with aberrant or unwanted target pre-mRNA expression or activity.
摘要翻译：本发明包括称为剪接调节寡核苷酸（SMO）的一类化合物，其调节前mRNA剪接，从而影响细胞中特定蛋白质的表达和功能。本发明还提供了使用本发明的SMO调节前mRNA剪接的组合物和方法，以消除蛋白质中的致病突变。因此，本发明提供了治疗患有与异常或不期望的靶mRNA表达或活性相关的疾病，病症或病症的风险易感或具有疾病，病症或病症的风险的受试者的组合物和方法。

5. 发明申请

US20140242707A1 Compositions and Methods for Diagnosing Hypercoagulability and Hypocoagulability 审中-公开
标题翻译：用于诊断高凝状态和低凝状态的组合物和方法
公开(公告)号：US20140242707A1
公开(公告)日：2014-08-28
申请号：US14233690
申请日：2012-07-19
申请人： Vance G. Nielsen , Keith Vosseller
发明人： Vance G. Nielsen , Keith Vosseller
IPC分类号： G01N33/86
CPC分类号： G01N33/86
摘要： The present invention provides a method for diagnosing hypercoagulability associated with carbon monoxide exposure in a subject. The method comprises obtaining a plasma sample from the subject, dividing the sample into at least two portions, and determining the clot strength of the first portion. The method further comprises exposing the second portion to an organic reductant, determining the clot strength of the second portion after exposure to the organic reductant, and comparing the clot strength of the first portion with the clot strength of the second portion. A diagnosis of hypercogulability associated with carbon monoxide exposure is made when the clot strength of the second portion is decreased compared with the cloth strength of the first portion.
摘要翻译：本发明提供了用于诊断与受试者中一氧化碳暴露有关的高凝状态的方法。该方法包括从受试者获得血浆样品，将样品分成至少两部分，并测定第一部分的凝块强度。该方法还包括将第二部分暴露于有机还原剂，在暴露于有机还原剂之后测定第二部分的凝块强度，并将第一部分的凝块强度与第二部分的凝块强度进行比较。当与第一部分的布强度相比，第二部分的凝块强度降低时，进行与一氧化碳暴露相关的高度凝固性的诊断。

6. 发明申请

US20130236972A1 Liver Sinusoid Model 审中-公开
标题翻译：肝正弦模型
公开(公告)号：US20130236972A1
公开(公告)日：2013-09-12
申请号：US13413679
申请日：2012-03-07
申请人： Hongseok Noh , Michael Bouchard
发明人： Hongseok Noh , Michael Bouchard
IPC分类号： C12N5/071 , C12M3/00
CPC分类号： C12N5/067 , C12N2533/54 , C12N2535/00
摘要： A liver sinusoid model includes a generally planar substrate having first and second generally parallel microchannels formed therein. A microporous membrane is disposed between and separating the first and second generally parallel microchannels. A first layer of cells lines one side of the membrane in the first microchannel. The first layer of cells are all a first common cell type. A second layer of cells extends parallel to the first layer of cells in one of the first microchannel and the second microchannel. The second layer of cells is all of a second common cell type. A liver sinusoid bioreactor utilizing the inventive model is also disclosed.
摘要翻译：肝窦状模型包括具有在其中形成的第一和第二大致平行的微通道的大致平面的基底。微孔膜设置在第一和第二大致平行的微通道之间并分离。第一层细胞在第一微通道中排列膜的一侧。第一层细胞都是第一种细胞类型。细胞的第二层平行于第一微通道和第二微通道之一中的第一细胞层延伸。第二层细胞都是第二种细胞类型。还公开了利用本发明模型的肝窦状生物反应器。

7. 发明申请

US20130165489A1 Small Molecule Modulators of HIV-1 Capsid Stability and Methods Thereof 审中-公开
标题翻译： HIV-1衣壳稳定性的小分子调节剂及其方法
公开(公告)号：US20130165489A1
公开(公告)日：2013-06-27
申请号：US13643392
申请日：2011-04-25
申请人： Simon Cocklin , Sandhya Kortagere , Amos B. Smith, III
发明人： Simon Cocklin , Sandhya Kortagere , Amos B. Smith, III
IPC分类号： C07D417/12 , C07D405/10 , A61K31/4164 , A61K45/06 , A61K31/4178 , A61K31/427 , C07D405/14 , C07D233/64
CPC分类号： A61K31/33 , A61K31/415 , Y02A50/385 , Y02A50/393
摘要： The present invention includes a method of inhibiting, suppressing or preventing a viral infection in a subject, comprising administering to the subject a pharmaceutical composition comprising one or more of the compounds useful within the invention.
摘要翻译：本发明包括抑制，抑制或预防受试者中的病毒感染的方法，其包括向所述受试者施用包含一种或多种本发明中有用的化合物的药物组合物。

8. 发明申请

US20090099441A1 BRAIDED ELECTRODES 审中-公开
标题翻译： BRAIDED电极
公开(公告)号：US20090099441A1
公开(公告)日：2009-04-16
申请号：US12065697
申请日：2006-09-08
申请人： Simon Giszter , Frank K. Ko , Ubong Ime Udoekwere , Heejae Yang
发明人： Simon Giszter , Frank K. Ko , Ubong Ime Udoekwere , Heejae Yang
IPC分类号： A61N1/05 , A61B5/042
CPC分类号： A61N1/0529 , A61N1/0551 , Y10T29/49194
摘要： Electrodes for intracorporeal and other uses are provided. The invention features sterilizable, braided electrodes which are formed of or include conductive elements in electronic communication with a plurality of sites for electrical stimulation or sensing. Other active elements may be included in the braided electrodes.
摘要翻译：提供体内和其他用途的电极。本发明的特征在于可灭菌的编织电极，其由多个用于电刺激或感测的部位电连接形成或包括导电元件。编织电极中可以包括其它有源元件。

9. 发明申请

US20140228355A1 Novel D3 Dopamine Receptor Agonists to Treat Dyskinesia in Parkinson's Disease 有权
标题翻译：新型D3多巴胺受体激动剂治疗帕金森病的运动障碍
公开(公告)号：US20140228355A1
公开(公告)日：2014-08-14
申请号：US13764623
申请日：2013-02-11
申请人： Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine , University of Medicine and Dentistry New Jersey Medical School
发明人： Sandhya Kortagere , Eldo V. Kuzhikandahil
IPC分类号： A61K31/137 , C07C215/54 , C07C211/29 , C07C217/62 , C07D209/14 , C07D471/04 , C07D235/16 , A61K31/4045 , A61K31/4184 , A61K31/519 , A61K31/195 , A61K31/551 , A61K31/4985 , A61K31/48 , A61K31/428 , A61K31/404 , A61K31/506 , A61K31/437 , A61K31/473 , C07C215/08
摘要： The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.
摘要翻译：本发明提供了一种在患有帕金森病的患者中抑制，抑制或预防左旋多巴诱发的运动障碍的方法，包括向患者施用包含至少一种本发明化合物的药物组合物的步骤。本发明还提供了一种抑制，抑制或预防患者帕金森氏病的方法，包括向患者施用包含至少一种本发明化合物的药物组合物的步骤。

10. 发明申请

US20130143792A1 Use of CHEC Peptides to Treat Neurological and Cardiovascular Diseases and Disorders 有权
标题翻译：使用CHEC肽治疗神经和心血管疾病和疾病
公开(公告)号：US20130143792A1
公开(公告)日：2013-06-06
申请号：US13640192
申请日：2011-03-28
申请人： Timothy J. Cunningham
发明人： Timothy J. Cunningham
IPC分类号： A61K38/08
CPC分类号： A61K38/08
摘要： The present invention describes compositions and methods for treating and preventing non-degenerative neurological diseases and disorders associated with elevated sPLA2 activity as well as cardiovascular diseases using a CHEC peptide to inhibit sPLA2 activity.
摘要翻译：本发明描述了用于治疗和预防与升高的sPLA2活性相关的非退行性神经疾病和病症以及使用CHEC肽抑制sPLA2活性的心血管疾病的组合物和方法。

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