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1. 发明授权

US07449492B2 Therapeutic agents—I 有权
标题翻译：治疗剂 - I
公开(公告)号：US07449492B2
公开(公告)日：2008-11-11
申请号：US10315288
申请日：2002-12-09
申请人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
发明人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
IPC分类号： A61K31/21
CPC分类号： A61K31/455 , A61K31/22 , A61K36/47 , C07C69/533 , Y02A50/401 , Y02A50/402 , Y02A50/409 , Y02A50/414 , Y02A50/415 , Y02A50/463 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , Y02A50/491 , Y02A90/26
摘要： The present invention relates generally to chemical agents useful in the treatment and prophylaxis of infection by pathogenic or potentially pathogenic entities, or entities capable of opportunistic infection in mammals, including humans and primates, non-mammalian animals and avian species. More particularly, the present invention provides a chemical agent of the macrocyclic diterpene family obtainable from a member of the Euphorbiaceae family of plants or botanical or horticultural relatives thereof or derivatives or chemical analogues or chemically synthetic forms of the agents for use in the treatment or prophylaxis of infection by pathogenic entities in mammalian, animal and avian subjects. The present invention further contemplates a method for the prophylaxis and/or treatment in mammalian, animal or avian subjects of infection or potential infection by pathogenic entities by the topical or systemic administration of a macrocyclic diterpene obtainable from a member of the Euphorbiaceae family of plants or their botanical or horticultural derivatives or a derivative, chemical analogue or chemically synthetic form of the agent. The chemical agent of the present invention may be in the form of a purified compound, mixture of compounds, a precursor form of one or more of the compounds capable of chemical transformation into a therapeutically active agent or in the form of a chemical fraction, sub-fraction, preparation or extract of the plant.
摘要翻译：本发明一般涉及用于治疗和预防致病或潜在致病实体或能够在包括人和灵长类动物，非哺乳动物和禽类物种在内的哺乳动物中机会感染的实体的感染的化学试剂。更具体地说，本发明提供了一种可从植物或植物或园艺亲属的大戟科家族成员获得的大环二萜类化合物或用于治疗或预防的药剂的衍生物或化学类似物或化学合成形式在哺乳动物，动物和禽类受试者中感染病原体。本发明进一步考虑了一种通过局部或全身施用可从植物大戟科植物的成员获得的大环二萜在哺乳动物，动物或禽类受试者中预防和/或治疗感染或潜在感染的方法，或其植物或园艺衍生物或衍生物，化学类似物或化学合成形式的药剂。本发明的化学试剂可以是纯化合物的形式，化合物的混合物，能够化学转化成治疗活性剂或以化学级分形式的一种或多种化合物的前体形式 - 植物的分离，制备或提取。

2. 发明申请

US20120041064A1 SKIN TREATMENT 审中-公开
标题翻译：皮肤治疗
公开(公告)号：US20120041064A1
公开(公告)日：2012-02-16
申请号：US13201331
申请日：2010-02-12
申请人： Steven Martin Ogbourne , David Thomas , Ryan Moseley , James Harrison Aylward
发明人： Steven Martin Ogbourne , David Thomas , Ryan Moseley , James Harrison Aylward
IPC分类号： A61K31/22 , A61P17/00 , A61K31/12
CPC分类号： A61K8/375 , A61Q17/04 , A61Q19/08
摘要： The present invention relates generally to the cosmetic treatment of aged skin. More specifically, the invention relates to the use of ingenol compounds, particularly ingenol angelates, in treating photo-aged and/or chronologically-aged skin.
摘要翻译：本发明一般涉及老化皮肤的美容治疗。更具体地，本发明涉及使用内酯化合物，特别是当归酸烯雌酚，用于治疗光老化和/或按时间顺序老化的皮肤。

3. 发明申请

US20110213002A1 MACROCYCLIC DITERPENES FOR TREATING CONDITIONS ASSOCIATED WITH PROTEIN KINASE C 有权
标题翻译：用于处理与蛋白激酶C相关的条件的大分子化合物
公开(公告)号：US20110213002A1
公开(公告)日：2011-09-01
申请号：US13034172
申请日：2011-02-24
申请人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
发明人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
IPC分类号： A61K31/465 , A61K31/22 , A61P11/06 , A61P9/00 , A61P7/00 , A61P25/28 , A61P25/24 , A61P3/10 , A61P25/00 , A61P19/00 , A61P31/12 , A61P17/06 , A61K31/122
CPC分类号： A61K31/455 , A61K31/22 , A61K36/47 , C07C69/533 , Y02A50/401 , Y02A50/402 , Y02A50/409 , Y02A50/414 , Y02A50/415 , Y02A50/463 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , Y02A50/491 , Y02A90/26
摘要： The present invention relates generally to chemical agents useful in the treatment and prophylaxis of inflammatory conditions or in the amelioration of symptoms resulting from or facilitated by an inflammatory condition in a mammalian animal including human and primate, non-mammalian animal and avian species. More particularly, the present invention provides a chemical agent of the macrocyclic diterpene family obtaining from a member of the Euphorbiaceae family of plants or botanical or horticultural relatives thereof or derivatives or chemical analogues or chemically synthetic forms of the agents for use in the treatment or prophylaxis of an inflammatory condition or in the amelioration of symptoms resulting from or facilitated by an inflammatory condition in a mammal, animal or avian species. The present invention further contemplates a method for the prophylaxis or treatment of mammalian, animal or avian subjects for inflammatory conditions including chronic or transitory inflammatory conditions or for ameliorating the symptoms of an inflammatory condition by the topical or systemic administration of a macrocyclic diterpene obtainable from a member of the Euphorbiaceae family or botanical or horticultural relatives thereof or a derivative, chemical analogue or chemically synthetic form of the agent. The chemical agent of the present invention may be in the form of a purified compound, mixture of compounds, a precursor form of one or more of the compounds capable of chemical transformation into a therapeutically active agent or be in the form of a chemical fraction, sub-fraction or preparation or extract of the plant.
摘要翻译：本发明一般涉及用于治疗和预防炎性病症或改善由哺乳动物（包括人类和灵长类，非哺乳动物和禽类）物种中的炎性病症引起或促进的症状的化学试剂。更具体地说，本发明提供从大戟科植物或植物或园艺亲属的成员获得的大环二萜类家族化学试剂或用于治疗或预防的药剂的衍生物或化学类似物或化学合成形式的炎性病症或改善由哺乳动物，动物或禽类物种中的炎性病症引起或促进的症状。本发明进一步考虑了一种用于预防或治疗哺乳动物，动物或禽类受试者的炎症性疾病的方法，包括慢性或短暂性炎性病症或通过局部或全身给予大环二萜来改善炎症状态的症状，所述大环二萜可从大戟科的成员或植物或园艺亲属或衍生物，化学类似物或化学合成形式的药剂。本发明的化学试剂可以是纯化的化合物，化合物的混合物，能够化学转化成治疗活性剂或以化学级分形式的一种或多种化合物的前体形式，子部分或植物的制备或提取物。

4. 发明申请

US20100204318A1 TREATMENT OF VIRALLY INDUCED LESIONS 有权
标题翻译：治疗病毒性感染
公开(公告)号：US20100204318A1
公开(公告)日：2010-08-12
申请号：US12598102
申请日：2008-04-30
申请人： Steven Martin Ogbourne , Andreas Suhrbier , James Harrison Aylward
发明人： Steven Martin Ogbourne , Andreas Suhrbier , James Harrison Aylward
IPC分类号： A61K31/22 , A61P31/20
CPC分类号： A61K31/216 , A61K9/0031 , A61K9/0034 , A61K9/06 , A61K31/22 , A61K31/222 , A61K47/10 , A61K47/12 , A61K47/38
摘要： The present invention relates generally to the treatment of cutaneous lesions containing cells infected by a virus, as well as compositions for the treatment of such lesions. More specifically, the invention relates to the use of ingenol compounds, particularly ingenol angelates, in treating lesions caused by infection with a papilloma virus, such as a mammalian papilloma virus, in particular a Human Papilloma Virus.
摘要翻译：本发明一般涉及治疗含病毒感染细胞的皮肤病变，以及用于治疗这种病变的组合物。更具体地说，本发明涉及使用细胞因子化合物，特别是西诺芬当归，用于治疗由乳头瘤病毒感染引起的损伤，例如哺乳动物乳头状瘤病毒，特别是人乳头状瘤病毒。

5. 发明申请

US20100048698A1 MACROCYCLIC DITERPENES FOR TREATING CONDITIONS ASSOCIATED WITH PROTEIN KINASE C 审中-公开
标题翻译：用于处理与蛋白激酶C相关的条件的大分子化合物
公开(公告)号：US20100048698A1
公开(公告)日：2010-02-25
申请号：US12543087
申请日：2009-08-18
申请人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
发明人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
IPC分类号： A61K31/215 , A61P29/00
CPC分类号： A61K31/455 , A61K31/22 , A61K36/47 , C07C69/533 , Y02A50/401 , Y02A50/402 , Y02A50/409 , Y02A50/414 , Y02A50/415 , Y02A50/463 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/483 , Y02A50/491 , Y02A90/26
摘要： The present invention relates generally to chemical agents useful in the treatment and prophylaxis of inflammatory conditions or in the amelioration of symptoms resulting from or facilitated by an inflammatory condition in a mammalian animal including human and primate, non-mammalian animal and avian species. More particularly, the present invention provides a chemical agent of the macrocyclic diterpene family obtaining from a member of the Euphorbiaceae family of plants or botanical or horticultural relatives thereof or derivatives or chemical analogues or chemically synthetic forms of the agents for use in the treatment or prophylaxis of an inflammatory condition or in the amelioration of symptoms resulting from or facilitated by an inflammatory condition in a mammal, animal or avian species. The present invention further contemplates a method for the prophylaxis or treatment of mammalian, animal or avian subjects for inflammatory conditions including chronic or transitory inflammatory conditions or for ameliorating the symptoms of an inflammatory condition by the topical or systemic administration of a macrocyclic diterpene obtainable from a member of the Fuphorbiaceae family or botanical or horticultural relatives thereof or a derivative, chemical analogue or chemically synthetic form of the agent. The chemical agent of the present invention may be in the form of a purified compound, mixture of compounds, a precursor form of one or more of the compounds capable of chemical transformation into a therapeutically active agent or be in the form of a chemical fraction, sub-fraction or preparation or extract of the plant.
摘要翻译：本发明一般涉及用于治疗和预防炎性病症或改善由哺乳动物（包括人类和灵长类，非哺乳动物和禽类）物种中的炎性病症引起或促进的症状的化学试剂。更具体地说，本发明提供从大戟科植物或植物或园艺亲属的成员获得的大环二萜类家族化学试剂或用于治疗或预防的药剂的衍生物或化学类似物或化学合成形式的炎性病症或改善由哺乳动物，动物或禽类物种中的炎性病症引起或促进的症状。本发明进一步考虑了一种用于预防或治疗哺乳动物，动物或禽类受试者的炎症性疾病的方法，包括慢性或短暂性炎性病症或通过局部或全身给予大环二萜来改善炎症状态的症状，所述大环二萜可从大戟科（Fuphorbiaceae）家族的成员或其植物或园艺亲属，或代理人的衍生，化学类似物或化学合成形式。本发明的化学试剂可以是纯化的化合物，化合物的混合物，能够化学转化成治疗活性剂或以化学级分形式的一种或多种化合物的前体形式，子部分或植物的制备或提取物。

6. 发明申请

US20050209192A1 Therapeutic agents - II 审中-公开
标题翻译：治疗剂 - II
公开(公告)号：US20050209192A1
公开(公告)日：2005-09-22
申请号：US11000712
申请日：2004-12-01
申请人： James Aylward , Peter Parsons , Andreas Suhrbier , Kathleen Turner
发明人： James Aylward , Peter Parsons , Andreas Suhrbier , Kathleen Turner
IPC分类号： A61K47/18 , A61K31/216 , A61K31/22 , A61K31/235 , A61K31/275 , A61K31/38 , A61K31/40 , A61K31/435 , A61K31/445 , A61K31/455 , A61K31/66 , A61K31/69 , A61K31/695 , A61K36/00 , A61K36/47 , A61K47/22 , A61K48/00 , A61P3/10 , A61P7/00 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/06 , A61P17/00 , A61P17/04 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/02 , A61P31/04 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , A61P33/00 , A61P35/00 , A61P37/04 , A61P37/06 , A61P37/08 , A61P39/02 , A61P43/00 , C07D213/80
CPC分类号： A61K31/455 , A61K31/22 , A61K36/47 , C07C69/533 , Y02A50/401 , Y02A50/402 , Y02A50/409 , Y02A50/414 , Y02A50/415 , Y02A50/463 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/483 , Y02A50/491 , Y02A90/26
摘要： The present invention relates generally to chemical agents useful in the treatment and prophylaxis of inflammatory conditions or in the amelioration of symptoms resulting from or facilitated by an inflammatory condition in a mammalian animal including human and primate, non-mammalian animal and avian species. More particularly, the present invention provides a chemical agent of the macrocyclic diterpene family obtaining from a member of the Euphorbiaceae family of plants or botanical or horticultural relatives thereof or derivatives or chemical analogues or chemically synthetic forms of the agents for use in the treatment or prophylaxis of an inflammatory condition or in the amelioration of symptoms resulting from or facilitated by an inflammatory condition in a mammal, animal or avian species. The present invention further contemplates a method for the prophylaxis or treatment of mammalian, animal or avian subjects for inflammatory conditions including chronic or transitory inflammatory conditions or for ameliorating. the symptoms of an inflammatory condition by the topical or systemic administration of a macrocyclic diterpene obtainable from a member of the Euphorbiaceae family or botanical or horticultural relatives thereof or a derivative, chemical analogue or chemically synthetic form of the agent. The chemical agent of the present invention may be in the form of a purified compound, mixture of compounds, a precursor form of one or more of the compounds capable of chemical transformation into a therapeutically active agent or be in the form of a chemical fraction, sub-fraction or preparation or extract of the plant.
摘要翻译：本发明一般涉及用于治疗和预防炎性病症或改善由哺乳动物（包括人类和灵长类，非哺乳动物和禽类）物种中的炎性病症引起或促进的症状的化学试剂。更具体地说，本发明提供从大戟科植物或植物或园艺亲属的成员获得的大环二萜类家族化学试剂或用于治疗或预防的药剂的衍生物或化学类似物或化学合成形式的炎性病症或改善由哺乳动物，动物或禽类物种中的炎性病症引起或促进的症状。本发明进一步考虑了用于预防或治疗哺乳动物，动物或禽类受试者的用于炎性病症（包括慢性或短暂性炎性病症）或用于改善的方法。通过局部或全身给药可从大戟科或其植物或园艺亲属获得的大环二萜或其衍生物，化学类似物或化学合成形式的炎症状态的症状。本发明的化学试剂可以是纯化的化合物，化合物的混合物，能够化学转化成治疗活性剂或以化学级分形式的一种或多种化合物的前体形式，子部分或植物的制备或提取物。

7. 发明申请

US20090215884A1 METHOD FOR WOUND HEALING 审中-公开
标题翻译：治疗方法
公开(公告)号：US20090215884A1
公开(公告)日：2009-08-27
申请号：US12094713
申请日：2006-11-24
申请人： Steven Martin Ogbourne , David Thomas , Ryan Moseley
发明人： Steven Martin Ogbourne , David Thomas , Ryan Moseley
IPC分类号： A61K31/335 , A61P17/02
CPC分类号： A61K31/22 , A61K31/222 , A61K31/235
摘要： The present invention relates generally to methods and compositions for promoting wound healing in a subject. In particular, the invention relates to the use of ingenol compounds, particularly ingenol angelates, in wound healing and compositions therefor which contain such compounds.
摘要翻译：本发明一般涉及用于促进受试者中伤口愈合的方法和组合物。特别地，本发明涉及在含有这些化合物的伤口愈合及其组合物中使用美烯酸酯化合物，特别是当归酸烯雌酚。

8. 发明申请

US20060105994A1 Treatment of prostate cancer 有权
公开(公告)号：US20060105994A1
公开(公告)日：2006-05-18
申请号：US11324587
申请日：2006-01-03
申请人： James Aylward , Peter Parsons
发明人： James Aylward , Peter Parsons
IPC分类号： A61K31/695 , A61K31/69 , A61K31/66 , A61K31/22
CPC分类号： A61K36/47 , A61K31/222 , A61K31/235 , A61K31/455 , A61K47/54 , A61K47/548
摘要： A chemical agent of the diterpene family obtained from a member of the Euphorbiaceae family of plants for use in the treatment of prophylaxis of prostate cancer or a related cancer or condition.

9. 发明授权

US07838555B2 Macrocyclic diterpenes for the treatment and prophylaxis of acne vulgaris 有权
标题翻译：用于治疗和预防寻常型痤疮的大环二萜类
公开(公告)号：US07838555B2
公开(公告)日：2010-11-23
申请号：US10315318
申请日：2002-12-09
申请人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
发明人： James Harrison Aylward , Peter Gordon Parsons , Andreas Suhrbier , Kathleen Anne Turner
IPC分类号： A61K31/21
CPC分类号： A61K31/455 , A61K31/22 , A61K36/47 , C07C69/533 , Y02A50/401 , Y02A50/402 , Y02A50/409 , Y02A50/414 , Y02A50/415 , Y02A50/463 , Y02A50/465 , Y02A50/469 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , Y02A50/491 , Y02A90/26
摘要： The present invention relates to the treatment of acne vulgaris in a subject by administering to the subject an ingenane of the formula wherein R24-R26 are herein defined.
摘要翻译：本发明涉及通过向受试者施用下式其中R 24 -R 26在本文中定义的甲氰菊酯来治疗受试者中的寻常痤疮。

10. 发明授权

US07410656B2 Anti-cancer compounds 有权
标题翻译：抗癌化合物
公开(公告)号：US07410656B2
公开(公告)日：2008-08-12
申请号：US10896811
申请日：2004-07-22
申请人： James Harrison Aylward
发明人： James Harrison Aylward
IPC分类号： A61K36/00 , A61K31/12 , A61K31/045
CPC分类号： A61K36/47 , A61K31/225 , A61K2300/00
摘要： This invention relates to a compound or group of compounds present in an active principle derived from plants of species Euphorbia peplus, Euphorbia hirta and Euphorbia drummondii, and to pharmaceutical compositions comprising these compounds. Extracts from these plants have been found to show selective cytotoxicity against several different cancer cell lines. The compounds are useful in effective treatment of cancers, particularly malignant melanomas and squamous cell carcinomas (SCCs). In a preferred embodiment of the invention, the compound is selected from the group consisting of jatrophanes, pepluanes, paralianes and ingenanes, andpharmaceutically-acceptable salts or esters thereof, and more particularly jatrophanes of Conformation II.
摘要翻译：本发明涉及存在于源自大戟属植物，大戟属和大戟属植物的活性成分中的化合物或一组化合物，以及包含这些化合物的药物组合物。已经发现这些植物的提取物显示出对几种不同癌细胞系的选择性细胞毒性。该化合物可有效治疗癌症，特别是恶性黑素瘤和鳞状细胞癌（SCC）。在本发明的一个优选实施方案中，该化合物选自由琼脂糖，胡椒酰，对氨基苯甲酸和嵌合物组成的组，及其药学上可接受的盐或酯，更特别是构象II的麻风病毒。

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