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    • 1. 发明申请
    • METHOD OF SELECTING APTAMERS
    • 选择APTAMERS的方法
    • US20100304991A1
    • 2010-12-02
    • US12739087
    • 2008-10-22
    • Clive Gavin Brown
    • Clive Gavin Brown
    • C40B30/04
    • C12N15/1048C12Q1/6811C12Q2541/101
    • The present invention is a method for the identification of one or more aptamers to at least one target molecule, the method comprising: selecting candidate aptamer sequences that bind to a target molecule, assigning to the bound sequences a measure (fitness function) of each sequence's aptameric potential, allowing evolution of some or all of the sequences to create a new mixture of candidate sequences, and repeating the method with the newly created candidate aptamer pool until the aggregate aptameric potential of the candidate pool reaches a plateau, wherein sequences present in the final pool are optimal aptamers to the target molecule.
    • 本发明是用于鉴定至少一种靶分子的一种或多种适体的方法,所述方法包括:选择与靶分子结合的候选适体序列,向所述结合序列分配每个序列的测量(适应度函数) 允许进行一些或所有序列以产生候选序列的新混合物,并且用新产生的候选适体池重复该方法,直到候选池的总体适体潜力达到平台,其中存在于 最终池是靶分子的最佳适体。