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1. 发明申请

US20140228355A1 Novel D3 Dopamine Receptor Agonists to Treat Dyskinesia in Parkinson's Disease 有权
标题翻译：新型D3多巴胺受体激动剂治疗帕金森病的运动障碍
公开(公告)号：US20140228355A1
公开(公告)日：2014-08-14
申请号：US13764623
申请日：2013-02-11
申请人： Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine , University of Medicine and Dentistry New Jersey Medical School
发明人： Sandhya Kortagere , Eldo V. Kuzhikandahil
IPC分类号： A61K31/137 , C07C215/54 , C07C211/29 , C07C217/62 , C07D209/14 , C07D471/04 , C07D235/16 , A61K31/4045 , A61K31/4184 , A61K31/519 , A61K31/195 , A61K31/551 , A61K31/4985 , A61K31/48 , A61K31/428 , A61K31/404 , A61K31/506 , A61K31/437 , A61K31/473 , C07C215/08
摘要： The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.
摘要翻译：本发明提供了一种在患有帕金森病的患者中抑制，抑制或预防左旋多巴诱发的运动障碍的方法，包括向患者施用包含至少一种本发明化合物的药物组合物的步骤。本发明还提供了一种抑制，抑制或预防患者帕金森氏病的方法，包括向患者施用包含至少一种本发明化合物的药物组合物的步骤。

2. 发明申请

US20130143792A1 Use of CHEC Peptides to Treat Neurological and Cardiovascular Diseases and Disorders 有权
标题翻译：使用CHEC肽治疗神经和心血管疾病和疾病
公开(公告)号：US20130143792A1
公开(公告)日：2013-06-06
申请号：US13640192
申请日：2011-03-28
申请人： Timothy J. Cunningham
发明人： Timothy J. Cunningham
IPC分类号： A61K38/08
CPC分类号： A61K38/08
摘要： The present invention describes compositions and methods for treating and preventing non-degenerative neurological diseases and disorders associated with elevated sPLA2 activity as well as cardiovascular diseases using a CHEC peptide to inhibit sPLA2 activity.
摘要翻译：本发明描述了用于治疗和预防与升高的sPLA2活性相关的非退行性神经疾病和病症以及使用CHEC肽抑制sPLA2活性的心血管疾病的组合物和方法。

3. 发明申请

US20100216721A1 Inhibition of HIV-1 Infection by Potent Metallocene Conjugated Peptide Through Conformational Entrapment of Envelope GP120 审中-公开
标题翻译：通过包络GP120构象封闭强化金属茂共轭肽对HIV-1感染的抑制
公开(公告)号：US20100216721A1
公开(公告)日：2010-08-26
申请号：US12602073
申请日：2008-05-30
申请人： Hosahudya N. Gopi , Irwin M. Chaiken
发明人： Hosahudya N. Gopi , Irwin M. Chaiken
IPC分类号： A61K38/10 , A61K38/08 , C07K7/08 , C07K7/06 , C07K1/14
CPC分类号： A61K31/4192 , A61K38/00 , A61K47/64 , C07K7/06 , C07K7/08 , C07K14/005 , C12N2740/16122
摘要： The invention provides a peptide triazole conjugate and derivatives thereof, and methods of its use.
摘要翻译：本发明提供了肽三唑缀合物及其衍生物及其应用的方法。

4. 发明申请

US20100166794A1 PLASMODIUM LIVER STAGE ANTIGENS 有权
标题翻译： PLASMODIUM肝脏阶段抗原
公开(公告)号：US20100166794A1
公开(公告)日：2010-07-01
申请号：US12722439
申请日：2010-03-11
申请人： Patrick Duffy , Stefan H.I. Kappe , Urszula Krzych , Donald G. Heppner, JR. , Lawrence W. Bergman , Vladislav A. Malkov , Alice Tarun , Jason W. Wendler , Igor Bacik
发明人： Patrick Duffy , Stefan H.I. Kappe , Urszula Krzych , Donald G. Heppner, JR. , Lawrence W. Bergman , Vladislav A. Malkov , Alice Tarun , Jason W. Wendler , Igor Bacik
IPC分类号： A61K39/002 , C07K14/445 , C07H21/04 , A61P33/06
CPC分类号： C07K14/445 , A61K39/00 , Y02A50/412
摘要： The invention provides isolated liver stage Plasmodium polypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:1-48 and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the liver stage Plasmodium polypeptides of the invention, compositions comprising one or more liver stage Plasmodium polypeptides of the invention, methods for inducing an immune response against the liver stage Plasmodium polypeptides, and methods for treating and diagnosing liver stage malaria.
摘要翻译：本发明提供了分离的肝阶段疟原虫多肽，其包含选自SEQ ID NO：1-48的氨基酸序列及其免疫原性衍生物。本发明还提供编码本发明的肝阶段疟原虫多肽的分离的核酸分子，包含本发明的一种或多种肝阶段疟原虫多肽的组合物，诱导针对肝阶段的疟原虫多肽的免疫应答的方法，以及治疗和诊断方法肝阶段疟疾。

5. 发明申请

US20100096252A1 PHOTOLABILE DINITROINDOLINYL BASED COMPOUNDS 有权
标题翻译：可溶性丁基酚基酚化合物
公开(公告)号：US20100096252A1
公开(公告)日：2010-04-22
申请号：US12520924
申请日：2008-01-29
申请人： Graham Ellis-Davies
发明人： Graham Ellis-Davies
IPC分类号： C07D209/18 , B01J19/12
CPC分类号： C07F9/5728 , C07D209/08
摘要： The present invention relates to photolabile or photoreleasable compounds including a caging moiety linked to an effector moiety, wherein the compounds are capable of releasing the effector moiety on irradiation, typically by flash irradiation with light. These compounds are particularly suitable for focal 2-photon uncaging The photoreleasable compounds can be used to deliver effector moieties such as carboxylic acids, preferably, neuroactive amino acids to sites where their activity is required. In preferred embodiments of the invention, the caging moiety is based on 4-carboxymethoxy-5,7-dinitroinlinyl and derivatives thereof.
摘要翻译：本发明涉及光不稳定或光可释放化合物，其包括与效应子部分连接的笼蔽部分，其中所述化合物通常通过在光照射下通过照射而释放效应部分。这些化合物特别适用于焦点2光子褪色。可光致发光的化合物可用于将效应部分如羧酸，优选神经活性氨基酸递送至需要其活性的位点。在本发明的优选实施方案中，笼状部分基于4-羧基甲氧基-5,7-二硝基苯乙烯基及其衍生物。

6. 发明申请

US20090208926A1 DIAGNOSIS OF LIVER PATHOLOGY THROUGH ASSESSMENT OF PROTEIN GLYCOSYLATION 审中-公开
标题翻译：通过评估蛋白质糖蛋白来诊断肝病变
公开(公告)号：US20090208926A1
公开(公告)日：2009-08-20
申请号：US11913348
申请日：2006-05-05
申请人： Timothy M. Block , Anand Mehta , Mary Ann Comunale
发明人： Timothy M. Block , Anand Mehta , Mary Ann Comunale
IPC分类号： C12Q1/70 , C12Q1/00 , G01N33/68 , C12Q1/37 , G01N33/566
CPC分类号： G01N33/6893 , G01N33/57438 , G01N2333/4728 , G01N2800/08 , G01N2800/085 , G01N2800/7028
摘要： Methods for diagnosing pathology of the liver in a subject suspected of having such pathology are disclosed. The methods comprise quantifiably detecting glycosylation, and more specifically fucosylation, on proteins in biological fluids, and comparing the detected glycosylation with reference values for the glycosylation of such proteins in healthy or disease states.
摘要翻译：公开了用于诊断怀疑患有这种病理学的受试者的肝脏病理学的方法。所述方法包括定量检测生物流体中的蛋白质上的糖基化，更具体地岩藻糖基化，并将检测到的糖基化与在健康或疾病状态下这些蛋白质糖基化的参考值进行比较。

7. 发明申请

US20090181879A1 Methods for Monitoring Neuroinflammatory Destruction of Neurons and for Treating Diseases Having an Inflammatory component related to phospholipase A2 有权
标题翻译：监测神经炎症破坏神经元和治疗具有与磷脂酶A2相关的炎症成分的疾病的方法
公开(公告)号：US20090181879A1
公开(公告)日：2009-07-16
申请号：US11988253
申请日：2006-07-10
申请人： Timothy J. Cunningham , Lihua Yao , Jeffrey I. Greenstein
发明人： Timothy J. Cunningham , Lihua Yao , Jeffrey I. Greenstein
IPC分类号： A61K38/00 , G01N33/53 , C12Q1/00 , C12Q1/34
CPC分类号： G01N33/573 , G01N33/564 , G01N2333/918 , G01N2333/92 , G01N2800/285
摘要： The present invention relates to methods useful to monitor central and peripheral nervous system neuron/axon destruction resulting from an increase in acute phase inflammatory enzymes. The methods have applicability to monitoring the progress of neurological diseases, including multiple sclerosis and Alzheimer's disease, as well as neuroinflammatory damage that results from sports injuries, vigorous physical activity or any form of physical abuse. The invention further relates to methods of treating multiple sclerosis or other diseases with an inflammatory component related to phospholipase A2.
摘要翻译：本发明涉及用于监测由急性期炎症酶增加引起的中枢和周围神经系统神经元/轴突破坏的方法。该方法适用于监测包括多发性硬化和阿尔茨海默病在内的神经系统疾病的进展，以及运动损伤，体力活动或任何形式的身体虐待引起的神经炎症性损伤。本发明还涉及用与磷脂酶A2相关的炎性成分治疗多发性硬化症或其它疾病的方法。

8. 发明申请

US20130156761A1 Compounds Useful for Inhibiting Metastasis from Cancer and Methods Using Same 有权
标题翻译：用于抑制癌症转移的化合物和使用其的方法
公开(公告)号：US20130156761A1
公开(公告)日：2013-06-20
申请号：US13776220
申请日：2013-02-25
申请人： Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine , Alliance Discovery, Inc.
发明人： Alessandro Fatatis , Joseph M. Salvino , Olimpla Meucci , Whitney L. Jamieson
IPC分类号： A61K39/395 , A61K31/7088 , A61K31/451 , A61K31/453 , C07K16/28 , C07D403/04
CPC分类号： C07D487/04 , A61K31/451 , A61K31/453 , A61K31/7088 , A61K39/3955 , C07D403/04 , C07K16/28
摘要： The present invention includes compositions that are useful in preventing or treating metastasis in a subject diagnosed with cancer. The present invention also includes methods of preventing or treating metastasis in a subject diagnosed with cancer, wherein the method comprises administering to the subject in need thereof an effective amount of a pharmaceutical formulation comprising at least one pharmaceutically acceptable carrier and at least one CX3CR1 or fractalkine antagonist.
摘要翻译：本发明包括可用于预防或治疗患有癌症的受试者的转移的组合物。本发明还包括预防或治疗患有癌症的受试者的转移的方法，其中所述方法包括向有需要的受试者施用有效量的药物制剂，其包含至少一种药学上可接受的载体和至少一种CX3CR1或fractalkine 拮抗剂。

9. 发明申请

US20110256538A1 EPIGENOMIC DNA MODIFICATIONS FOR TISSUE TYPING, EARLY CANCER DETECTION, AND DISEASE MANAGEMENT 审中-公开
标题翻译：用于组织类型，早期癌症检测和疾病管理的原始DNA修饰
公开(公告)号：US20110256538A1
公开(公告)日：2011-10-20
申请号：US13087029
申请日：2011-04-14
申请人： Ying-Hsiu Su , Surbhi Jain
发明人： Ying-Hsiu Su , Surbhi Jain
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/156 , C12Q2600/16
摘要： Provided herein is a suitable method for detecting the presence or absence of a cancer in an individual, by determining the level of methylation of the sense strand of a selected regulatory region of a tumor suppressor gene. Also provided herein is a method of detecting the presence or absence a cancer in an individual by determining if there is an apparent 100% methylation by assay of the CpG sites in the anti-sense strand of a selected regulatory region of a tumor suppressor gene. Also provided herein is a method of tissue typing by determining the level of methylation of the anti-sense strand of a selected regulatory region of a tumor suppressor gene indicating an enhanced likelihood that a tissue is liver.
摘要翻译：本文提供了通过确定肿瘤抑制基因选定的调节区域的有义链的甲基化水平来检测个体中癌症存在或不存在的合适方法。本文还提供了通过测定肿瘤抑制基因的选定调节区的反义链中CpG位点是否存在明显的100％甲基化来检测个体中癌症存在或不存在的方法。本文还提供了通过确定肿瘤抑制基因的所选调节区的反义链的甲基化水平来指示组织为肝脏的可能性增加的组织分型方法。

10. 发明申请

US20100094149A1 Noninvasive Ultrasound Cardiac Pacemaker and Defibrillator 审中-公开
标题翻译：无创超声心脏起搏器和除颤器
公开(公告)号：US20100094149A1
公开(公告)日：2010-04-15
申请号：US12558294
申请日：2009-09-11
申请人： Andrew R. Kohut , Peter B. Kurnik , Peter A. Lewin , Christopher Vecchio
发明人： Andrew R. Kohut , Peter B. Kurnik , Peter A. Lewin , Christopher Vecchio
IPC分类号： A61B5/0472 , A61N7/00
CPC分类号： A61B5/0472 , A61N7/00 , A61N2007/0026 , A61N2007/0078
摘要： A device for providing extracorporeal cardiac pacing. The device includes an ultrasound transducer mountable to the external thorax of a patient and an ultrasound generator for transmitting ultrasound pulses to the ultrasound transducer. The heart rate of a patient is monitored by the device. A controller evaluates the heartbeat as compared with threshold criteria for stimulation of the heart and causes the ultrasound generator to deliver ultrasound pulses to the ultrasound transducer at a prescribed intensity, frequency, and pulse duration.
摘要翻译：用于提供体外心脏起搏的装置。该装置包括可安装到患者的外部胸部的超声波换能器和用于将超声波脉冲发射到超声换能器的超声波发生器。患者的心率由设备监测。与心脏刺激的阈值标准相比，控制器对心跳进行评估，并使超声波发生器以规定的强度，频率和脉冲持续时间将超声波脉冲传送到超声换能器。

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