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1. 发明申请

US20190046397A1 Reinforced Gas Permeable Blood Storage Bags, and Methods of Preparation Thereof 审中-公开
公开(公告)号：US20190046397A1
公开(公告)日：2019-02-14
申请号：US15758785
申请日：2016-09-09
申请人： New Health Sciences, Inc.
发明人： Robert HARHEN , Peter PIGNONE , Narendran RENGANATHAN , Jancarlo SARITA , Jeffrey Karl SUTTON , Michael WOLF , Michael R. ZOCCHI
IPC分类号： A61J1/10 , A01N1/02 , A61J1/14 , A61M1/34
摘要： The present disclosure relates to improved collapsible blood containers comprising reinforced silicone for use in Oxygen Reduction Disposable kits (ORDKit), devices and methods. The improved collapsible blood containers and methods for the collection of blood and blood components provide for improved burst, tear, and puncture resistance.

2. 发明授权

US10136635B2 Irradiation of red blood cells and anaerobic storage 有权
公开(公告)号：US10136635B2
公开(公告)日：2018-11-27
申请号：US13289722
申请日：2011-11-04
申请人： Tatsuro Yoshida , Paul J. Vernucci
发明人： Tatsuro Yoshida , Paul J. Vernucci
IPC分类号： A61B19/00 , A01N1/02 , A61J1/10 , A61L2/08
摘要： A blood storage system comprising: a collection vessel for red blood cells; an oxygen or oxygen and carbon dioxide depletion device; a storage vessel for red blood cells; tubing connecting the collection vessel to the oxygen or oxygen and carbon dioxide depletion device and the oxygen or oxygen and carbon dioxide depletion device to the storage vessel; and a gamma or X-ray irradiating device is used to irradiate red blood cells stored in the vessel, storing red blood cells under anaerobic conditions.

3. 发明授权

US09977037B2 Capillary network devices and methods of use 有权
公开(公告)号：US09977037B2
公开(公告)日：2018-05-22
申请号：US14403365
申请日：2013-05-22
申请人： New Health Sciences, Inc. , The Administrators of the Tulane Educational Fund
发明人： Tatsuro Yoshida , Sergey S. Shevkoplyas , Jennie M. Burns
IPC分类号： G01N33/80 , B01L3/00
CPC分类号： G01N33/80 , B01L3/5027 , B01L3/502715 , B01L2300/0838 , B01L2300/0861 , B01L2300/0867
摘要： Artificial microvascular network (AMVN) devices are provided and related methods of making and methods of using such devices are provided. The present disclosure generally relates to an AMVN device comprising a substrate including a capillary network configured so as to simulate those actually encountered in the circulation of various humans and animal model systems. In certain aspects, the AMVN devices may be used, e.g., to investigate the effect of storing RBCs under aerobic and anaerobic conditions. However, the use of such AMVN devices is not so limited.

4. 发明申请

US20180133255A1 Methods for the Storage of Whole Blood, and Compositions Thereof 审中-公开
公开(公告)号：US20180133255A1
公开(公告)日：2018-05-17
申请号：US15575249
申请日：2016-05-18
申请人： New Health Sciences, Inc.
发明人： Tatsuro YOSHIDA
IPC分类号： A61K35/18
CPC分类号： A61K35/18 , A61K35/14 , A61M1/0272 , A61P7/00 , A61P43/00
摘要： Methods and compositions for improved clinical outcomes for trauma patients receiving whole blood transfusion. Methods and compositions for improved clinical outcomes for blood transfusions for cancer patients are also provided.

5. 发明申请

US20160007588A1 GAS DEPLETION AND GAS ADDITION DEVICES FOR BLOOD TREATMENT 有权
标题翻译：用于血液治疗的气体去除和气体添加装置
公开(公告)号：US20160007588A1
公开(公告)日：2016-01-14
申请号：US14771438
申请日：2014-02-28
申请人： NEW HEALTH SCIENCES, INC.
发明人： Steven F. LEVESQUE , Thomas R RUTH
IPC分类号： A01N1/02
CPC分类号： A01N1/0242 , A01N1/0263 , A61M1/0281 , B01D19/0031 , B01D2257/104
摘要： Devices for the preparation of depleted blood products that provide for the depletion of oxygen, carbon dioxide, or oxygen and carbon dioxide are described. In addition, devices for the replenishment of oxygen and other gases to an anaerobic blood product are described. Methods and systems incorporating depletion and addition devices are provided to optimize the preparation, storage and transfusion of blood products to a recipient are described.
摘要翻译：描述了用于制备耗氧血氧产物的装置，其中提供氧气，二氧化碳或氧气和二氧化碳的消耗。此外，还描述了用于将氧气和其它气体补充到厌氧血液制品的装置。提供了包含消耗和添加装置的方法和系统，以优化将血液制品制备，储存和输送给接受者。

6. 发明申请

US20150153367A1 CAPILLARY NETWORK DEVICES AND METHODS OF USE 有权
标题翻译：毛细网络设备及其使用方法
公开(公告)号：US20150153367A1
公开(公告)日：2015-06-04
申请号：US14403365
申请日：2013-05-22
申请人： New Health Sciences, Inc. , The Administrators of the Tulane Educational Fund
发明人： Tatsuro Yoshida , Sergey S. Shevkoplyas , Jennie M. Burns
IPC分类号： G01N33/80 , B01L3/00
CPC分类号： G01N33/80 , B01L3/5027 , B01L3/502715 , B01L2300/0838 , B01L2300/0861 , B01L2300/0867
摘要： Artificial microvascular network (AMVN) devices are provided and related methods of making and methods of using such devices are provided. The present disclosure generally relates to an AMVN device comprising a substrate including a capillary network configured so as to simulate those actually encountered in the circulation of various humans and animal model systems. In certain aspects, the AMVN devices may be used, e.g., to investigate the effect of storing RBCs under aerobic and anaerobic conditions. However, the use of such AMVN devices is not so limited.
摘要翻译：提供人造微血管网络（AMVN）装置，并提供相关的制造方法和使用这些装置的方法。本公开总体上涉及一种AMVN装置，其包括基底，该基底包括毛细管网络，该毛细管网被配置为模拟在各种人类和动物模型系统的循环中实际遇到的那些毛细管网络。在某些方面，可以使用AMVN装置，例如研究在需氧和厌氧条件下储存RBC的效果。然而，使用这样的AMVN设备并不限于此。

7. 发明申请

US20130333561A1 BLOOD STORAGE BAG SYSTEM AND DEPLETION DEVICES WITH OXYGEN AND CARBON DIOXIDE DEPLETION CAPABILITIES 有权
公开(公告)号：US20130333561A1
公开(公告)日：2013-12-19
申请号：US13969095
申请日：2013-08-16
申请人： New Health Sciences, Inc.
发明人： Tatsuro YOSHIDA , Paul J. Vernucci
IPC分类号： A61M1/34
CPC分类号： C12N5/0641 , A01N1/0221 , A01N1/0226 , A61K35/18 , A61M1/0209 , A61M1/0218 , A61M1/0231 , A61M1/0272 , A61M1/342 , A61M2202/0208 , A61M2202/0225 , B01D19/0031 , B01D53/22
摘要： A blood storage system. The system has a collection bag for red blood cells; an oxygen/carbon dioxide depletion device; a storage bag for red blood cells; and tubing connecting the collection bag to the depletion device and the depletion device to the storage bag. The depletion device includes a receptacle of a solid material having an inlet and an outlet adapted to receiving and expelling a flushing gas; a plurality of hollow fibers or gas-permeable films extending within the receptacle from an entrance to an exit thereof. The hollow fibers or gas-permeable films are adapted to receiving and conveying red blood cells.

8. 发明申请

US20030176788A1 Detecting, assessing, and diagnosing sleep apnea 审中-公开
标题翻译：检测，评估和诊断睡眠呼吸暂停
公开(公告)号：US20030176788A1
公开(公告)日：2003-09-18
申请号：US10352245
申请日：2003-01-28
申请人： New Health Sciences, Inc.
发明人： Kevin E. Crutchfield , B. Robert Mozayeni , Robert Beckman , Luke Beckman
IPC分类号： A61B008/00
CPC分类号： A61B8/06 , A61B5/4818 , A61B8/0808
摘要： The present invention comprises methods for detecting, assessing, diagnosing, and pre-diagnosing sleep apnea, and for assessing the efficacy of a treatment for sleep apnea. Methods for the detection, assessment, diagnosis and pre-diagnosis (screening) of sleep apnea and the assessment of a treatment for sleep apnea according to the present invention may be performed in the absence of a sleep study. The patients subject to these methods may remain awake during their performance. The invention may be applied to other vascular conditions besides sleep apnea, wherein the sleep apnea methods described herein are example methods for the application of the present invention to the detection, assessment, diagnosis and pre-diagnosis (screening) of other vascular conditions.
摘要翻译：本发明包括用于检测，评估，诊断和预诊断睡眠呼吸暂停的方法，以及用于评估治疗睡眠呼吸暂停的功效的方法。根据本发明的睡眠呼吸暂停的检测，评估，诊断和预诊断（筛选）和睡眠呼吸暂停治疗的评估方法可以在没有睡眠研究的情况下进行。患有这些方法的患者在执行过程中可能会保持清醒。本发明可以应用于除了睡眠呼吸暂停之外的其它血管疾病，其中本文所述的睡眠呼吸暂停方法是将本发明应用于其它血管病症的检测，评估，诊断和预诊断（筛选）的示例性方法。

9. 发明申请

US20180153157A1 GAS DEPLETION AND GAS ADDITION DEVICES FOR BLOOD TREATMENT 审中-公开
公开(公告)号：US20180153157A1
公开(公告)日：2018-06-07
申请号：US15842824
申请日：2017-12-14
申请人： NEW HEALTH SCIENCES, INC.
发明人： Steven F. LEVESQUE , Thomas R. RUTH
IPC分类号： A01N1/02 , B01D19/00 , A61M1/02
CPC分类号： A01N1/0242 , A01N1/0263 , A61M1/0281 , B01D19/0031 , B01D2257/104
摘要： Devices for the preparation of depleted blood products that provide for the depletion of oxygen, carbon dioxide, or oxygen and carbon dioxide are described. In addition, devices for the replenishment of oxygen and other gases to an anaerobic blood product are described. Methods and systems incorporating depletion and addition devices are provided to optimize the preparation, storage and transfusion of blood products to a recipient are described.

10. 发明授权

US09339025B2 Method for enhancing red blood cell quality and survival during storage 有权
标题翻译：储存期间提高红细胞质量和存活的方法
公开(公告)号：US09339025B2
公开(公告)日：2016-05-17
申请号：US13218114
申请日：2011-08-25
申请人： Tatsuro Yoshida , Larry J. Dumont
发明人： Tatsuro Yoshida , Larry J. Dumont
IPC分类号： A01N1/02 , A61M1/02
CPC分类号： A01N1/021 , A01N1/0242 , A61M1/0272 , C12N5/0641
摘要： The present invention is a method for enhancing the quality and survival of red blood cells during storage by depleting the red blood cells of both carbon dioxide and oxygen and maintaining 2,3-diphosphoglycerate acid levels.
摘要翻译：本发明是通过消耗二氧化碳和氧气的红细胞来提高储存期间红血细胞的质量和存活的方法，并维持2,3-二磷酸甘油酸的水平。

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