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1. 发明授权

US11577208B2 Pressure vessel with high-pressure window 有权
公开(公告)号：US11577208B2
公开(公告)日：2023-02-14
申请号：US16529074
申请日：2019-08-01
申请人： MWT AG , Milestone S.r.l.
发明人： Werner Lautenschläger , Jens Lautenschläger , Werner Scholze
IPC分类号： B01J3/00 , G01N21/03 , G01J5/061 , G01J5/02 , B01J3/04 , B01F33/45
摘要： The present invention relates to a pressure vessel (1) having a pressure vessel wall (1a) which completely surrounds a reaction chamber (2) as a pressure space for the initiation and/or promotion of chemical and/or physical pressure reactions of a sample (P) to be heated which is accommodated in the reaction chamber (2), wherein the pressure vessel wall (1a) has an infrared-permeable high-pressure window (30) which extends away outward in a direction from the reaction chamber (2) and which is supported in the pressure vessel wall (1a) with respect to a pressure in the reaction chamber (2), wherein the pressure vessel (1) furthermore has an infrared to temperature sensor (40) which is situated directly opposite the high-pressure window (30), in order to measure the temperature of a sample (P), accommodated in the reaction chamber (2), during a pressure reaction through the high-pressure window (30).

2. 发明授权

US11085873B2 Spectrometer having a discharge lamp with a plurality of beam paths 有权
公开(公告)号：US11085873B2
公开(公告)日：2021-08-10
申请号：US16348684
申请日：2017-11-10
申请人： Mikrowellen Labor Technik AG , Milestone S.r.l.
发明人： Werner Lautenschläger , Jens Lautenschläger
IPC分类号： G01N21/31 , G01J3/42 , G01J3/18 , H01J61/06
摘要： The present invention relates a spectrometer (1) having a lamp (2) that extends in substantially tubular fashion for the purposes of forming a light emission zone (3) that extends in the direction of the tubular extent and between two points to the end of emitting a first light beam (L1) and a second light beam (L2) that have the same origin on the light emission zone (3), a sample container (6) that is arranged in the beam path of the first light beam (L1) for receiving a sample to be measured, a first detection apparatus (D1) that is arranged in the direction of the first light beam (L1) for quantitative and/or qualitative determination of the sample to be measured in the sample container (6) on the basis of an interaction between the sample to be measured and the first light beam (L1), and a second detection apparatus (D2) that is arranged in the direction of the second light beam (L2) for the purposes of referencing the quantitative and/are qualitative determination, on the basis of the second light beam (L2), of the sample to be measured. The invention further relates to a spectrometer (1′) having a lamp (2) that extends in substantially tubular fashion for the purposes of emitting at least two light beams (L1, L3), respectively one sample container (6, 16) arranged in the beam path of each light beam (L1, L3) for the purposes of receiving a sample to be measured, and a detection apparatus (D1, D3) that is arranged in the direction of each light beam (L1, L3) for the purposes of quantitative and/or qualitative determination of the sample to be measured in the respective sample container (6, 16) on the basis of an interaction between the sample to be measured and the respective light beam (L1, L3).

3. 发明申请

US20120276583A1 Method, Processor and Carrier for Processing Frozen Slices of Tissue of Biospecimens 审中-公开
标题翻译：用于处理生物样品组织冷冻切片的方法，处理器和载体
公开(公告)号：US20120276583A1
公开(公告)日：2012-11-01
申请号：US13439439
申请日：2012-04-04
申请人： Francesco Visinoni , Michele Bellini , Matteo Minuti
发明人： Francesco Visinoni , Michele Bellini , Matteo Minuti
IPC分类号： G01N1/30 , C12M1/00 , G01N1/28
CPC分类号： G01N1/30 , G01N1/312 , G01N1/42 , G01N2001/315
摘要： A method for processing frozen slices of tissue of biospecimens mounted on or adhered to glass slides, i.e. forming a frozen section (2), and arranged on a carrier (1), has the following steps: a.) immersing the frozen tissue slices in a fixative, b.) staining the tissue slice, c.) dehydrating the tissue slice, and d.) optionally clearing the tissue slice. Steps a.) to d.) are performed by automatically transferring the frozen sections (2) on the carrier (1) between and into and out of at least a container (C1) holding a fixative, at least one or optionally more, preferably two containers (C3, C5) holding a staining solution, a container (C6, C7) holding a dehydrating solution, and optionally a container (C8) holding a clearing solution. The transfer and the time duration during which the tissue slices are in said containers (C) are controlled by a control unit controlling an actuator (10).
摘要翻译：用于加工安装在玻璃载玻片上或附着于玻片上的冷冻切片组织的方法，即形成冷冻部分（2）并且布置在载体（1）上，具有以下步骤：a。将冷冻的组织切片浸入固定剂，b。）染色组织切片，c。）使组织切片脱水，以及d。）任选地清除组织切片。步骤a。）至d。）通过将载体（1）上的冷冻部分（2）自动转移到载体（1）之间并进入和移出至少一个容纳（C1）的容器（C1），至少一个或任选更多，优选地保持染色溶液的两个容器（C3，C5），保持脱水溶液的容器（C6，C7）和任选的容纳清洁溶液的容器（C8）。组织切片在所述容器（C）中的传送和持续时间由控制致动器（10）的控制单元控制。

4. 发明申请

US20100062121A1 Microwave Hydrodiffusion for Isolation of Natural Products 审中-公开
标题翻译：微波加氢扩散用于天然产物的分离
公开(公告)号：US20100062121A1
公开(公告)日：2010-03-11
申请号：US12523680
申请日：2008-01-21
申请人： Chemat Farid , Maryline Vian , Francesco Visinoni
发明人： Chemat Farid , Maryline Vian , Francesco Visinoni
IPC分类号： B01D17/06 , A23L3/01 , A23L3/015
CPC分类号： B01D5/0006 , B01D5/0057 , B01D11/0211 , C11B9/02
摘要： The present invention relates to the isolation of biological materials by hydrodiffusion by microwave irradiation, to an apparatus suitable for carrying out present method and to a system for carrying out the present method continuously.
摘要翻译：本发明涉及通过微波照射的水扩散对生物材料的分离，适用于实施本方法的装置和连续地进行本方法的系统。

5. 发明授权

US07075045B2 Automatic, microwave assisted tissue histoprocessor 有权
标题翻译：自动微波辅助组织处理器
公开(公告)号：US07075045B2
公开(公告)日：2006-07-11
申请号：US11066577
申请日：2005-02-25
申请人： Franco Visinoni
发明人： Franco Visinoni
IPC分类号： H05B6/64
CPC分类号： G01N1/44 , G01N1/30 , G01N1/31
摘要： A system and for automatic histoprocessing of organic tissue specimens using microwaves, two cavities and automatic fluid and specimen transfer between the two cavities.
摘要翻译：一种系统，用于使用微波进行有机组织标本的自动组织处理，两个腔和两个腔之间的自动流体和样品转移。

6. 发明授权

US06949227B2 Device for implementing chemical reactions and processes in high frequency fields 失效
标题翻译：用于实现高频场化学反应和工艺的装置
公开(公告)号：US06949227B2
公开(公告)日：2005-09-27
申请号：US09980026
申请日：2001-03-27
申请人： Werner Lautenschläger , Bernd Ondruschka , Matthias Nüchter
发明人： Werner Lautenschläger , Bernd Ondruschka , Matthias Nüchter
IPC分类号： B01J19/12 , H05B6/64 , B01J19/08
CPC分类号： H05B6/806 , B01J19/126 , B01J2219/1215 , B01J2219/1218 , B01J2219/1254 , B01J2219/126 , B01J2219/1293 , H05B6/6408
摘要： A devise for carrying out chemical reactions and processes in high-frequency fields, comprises a high-frequency chamber 2 for irradiating a solid, liquid or gaseous substance while under pressure with at least one radiation source and a reactor for exposing to a high-frequency field. The reactor being connectively coupled to the upper wall 4 of the high-frequency chamber 2 through a sealable connection 3. Rail elements 5 are provided around the reactor, and configured to form a pressure-resistant cage. The rail elements 5 each have a guide 11 for holding a crown-shaped holder 12. The holder 12 is fixed in its position by the guides 11 of the rail elements 5. Multiple reaction chambers can be incorporated as a batch reactor system.
摘要翻译：用于在高频场中进行化学反应和过程的设备包括用于在至少一个辐射源和用于暴露于高频的反应器的压力下照射固体，液体或气体物质的高频室2 领域。反应器通过可密封的连接3连接到高频室2的上壁4。轨道元件5设置在反应器周围，并构造成形成耐压保持架。轨道元件5各自具有用于保持冠状保持器12的引导件11。保持器12通过轨道元件5的引导件11固定在其位置。可以将多个反应室作为间歇反应器系统并入。

7. 发明授权

US11629793B2 Valve 有权
公开(公告)号：US11629793B2
公开(公告)日：2023-04-18
申请号：US17090175
申请日：2020-11-05
申请人： MILESTONE S.r.l.
发明人： Francesco Visinoni , Matteo Minuti , Michele Bellini
IPC分类号： F16K15/14
摘要： The invention relates to a valve (1) for mounting to a surface (2) and for use in a flow path, which flows through said surface (2), for permitting flow in said flow path in a first direction and for preventing flow in said flow path in a second direction being opposite to the first direction. The valve (1) comprises: one or more ports (21) defined by a plurality of lips (22), wherein each lip (22) is resiliently deformable from a first position, in which the lips (22) are in contact with one another in order to close the respective port (21), to a second position, in which the respective port (21) is opened in order to permit flow in the first direction, and one or more contacting structures (30) arranged to mechanically contact the surface (2), when the valve is mounted to the surface (2), such that the one or more contacting structures (30) bias the lips (22) into the first position.

8. 发明授权

US11584556B2 System and method for filling a closed container with a fixative solution 有权
公开(公告)号：US11584556B2
公开(公告)日：2023-02-21
申请号：US17378865
申请日：2021-07-19
申请人： Milestone S.r.l.
发明人： Francesco Visinoni , Matteo Minuti , Marco Bellini , Michele Bellini , Michele Martinelli
IPC分类号： B65B31/02 , A61J1/14 , B65B3/00 , B65B3/26 , A01N1/02
摘要： The present invention relates to a method and a system (400) for filling a closed container (200) with a fixative solution. The system comprises a container (200) comprising a container body (230) for receiving a biological specimen, a lid (220) for selectively closing the container body (230) and a port (100) forming a unidirectional barrier in a direction from the inside (IC) to the outside (OC) of the closed container (200). The system further comprises a dispensing apparatus (500) having a filling nozzle (300) for dispensing the fixative solution. The filling nozzle (300) is relatively moveable with respect to the container (200) between a retracted position and a filling position to fill the container (200) with the fixative solution.

9. 发明申请

US20210011552A1 System and Method for Medical Gross Examination 有权
公开(公告)号：US20210011552A1
公开(公告)日：2021-01-14
申请号：US16925429
申请日：2020-07-10
申请人： MILESTONE S.r.l.
发明人： Francesco Visinoni , Marco Bellini , Mattia Salvi
IPC分类号： G06F3/01 , G06T11/00 , H04R1/08 , H04N5/232 , H04N7/18
摘要： The present invention relates to a system (100) for medical gross examination. The system (100) comprises an examination area (200) for receiving biospecimens (TS), a camera device (300) for visual inspection of the examination area (200) and for providing images captured during visual inspection, and a display device (400) for displaying the captured images. The system (100) further comprises an eye-tracking device (500) for detecting eye information based on the point of gaze (505) or eye movement of a user's (OP) eye and a controller (600) for controlling the system (100) based on the detected eye information.
Furthermore, the invention relates to a method for the control of a system (100) for medical gross examination, comprising the steps of placing a biospecimen (TS) in an examination area (200), visually inspecting the examination area (200), capturing images thereof and displaying the captured images. The method further comprises the steps of detecting eye information based on the point of gaze (505) or eye movement of a user (OP) and controlling the system (100) based on the detected eye information.

10. 发明授权

US10109376B2 Measuring apparatus 有权
公开(公告)号：US10109376B2
公开(公告)日：2018-10-23
申请号：US15489999
申请日：2017-04-18
申请人： MILESTONE S.r.l.
发明人： Francesco Visinoni , Matteo Minuti , Michele Martinelli
IPC分类号： G06F19/00 , G16H40/20 , G06K7/10 , G06Q10/08 , G01N35/00 , G01B11/00 , G01N33/483 , G01N1/31 , G01N33/50 , G01N33/569
摘要： Measuring apparatus (1) for tracking human and/or animal tissues comprising: a working area (2) for receiving a tissue; a detecting unit (5) configured to detect a unique tissue code provided with the tissue placed on the working area (2); a measuring unit (9) configured to automatically measure quantitative properties of the tissue placed on the working area (2); and a processing and storing unit (22) configured to automatically link the quantitative properties with the tissue code and to automatically store the so linked quantitative properties and tissue code such that the quantitative properties can be retrieved based on the tissue code.

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