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1. 发明申请

US20160325230A1 ELECTROCHEMICAL CELL 审中-公开
公开(公告)号：US20160325230A1
公开(公告)日：2016-11-10
申请号：US15107663
申请日：2014-12-23
申请人： UNIVERSITÄT INNSBRUCK , MEDIZINISCHE UNIVERSITÄT INNSBRUCK
发明人： Markus Kofler , Julia Dumpfarth , Michael Grimm , Georg Grimm , Gulnara Fauland , Thomas Bechtold
IPC分类号： B01D61/42 , B01D61/46
CPC分类号： B01D61/427 , B01D61/422 , B01D61/46 , B01D2313/30 , B01D2313/345 , B01D2325/42 , G01N27/283 , G01N27/403
摘要： Electrochemical cell array for the treatment of a sample via electro-(end-)osmotic flow, comprising (i) an electrode chamber, comprising a cathodic compartment (CC) and an anodic compartment (AC), (ii) a cathode (C), being arranged in the cathodic compartment (CC), (iii) an anode (A), being arranged in the anodic compartment (AC), (iv) an intermediate cathodic compartment (C1) (v) an intermediate anodic compartment (A1) (iv) a first selective membrane (M1) being arranged between said cathodic compartment (CC) and said first intermediate cathodic compartment (C1) (v) a second selective membrane (M2) being arranged between said anodic compartment (AC) and said first intermediate anodic compartment (A1) (vi) a treatment compartment (T) for the sample being arranged between said intermediate cathodic compartment (C1) and said intermediate anodic compartment (A1), further comprising a first separator membrane (S1) between said treatment compartment (T) and said intermediate cathodic compartment (C1) and a second separator membrane (S2) arranged between said treatment compartment (T) and said intermediate anodic compartment (A1).

2. 发明授权

US11839394B2 Reflector for acoustic pressure wave head 有权
公开(公告)号：US11839394B2
公开(公告)日：2023-12-12
申请号：US17358344
申请日：2021-06-25
申请人： Medizinische Universität Innsbruck , Heart Regeneration Technologies GMBH
发明人： Christian Dorfmüller , Johannes Holfeld , Michael Grimm
IPC分类号： A61B17/225 , G10K11/28 , G10K15/04
CPC分类号： A61B17/225 , G10K11/28 , G10K15/043
摘要： The present invention relates to a reflector for an acoustic shock or pressure wave head, wherein the reflector comprises an acoustically reflective surface formed by a body of rotation, said body of rotation being formed by rotation of an elliptical segment about a rotation axis which extends through a focal point of the ellipse and encloses an angle α between 0.1° and 30° with the main axis of the ellipse.

3. 发明授权

US11674923B2 Means for the quantitative determination of sodium concentration and creatinine concentration 有权
公开(公告)号：US11674923B2
公开(公告)日：2023-06-13
申请号：US16603441
申请日：2018-03-20
申请人： UNIVERSITÄT INNSBRUCK , MEDIZINISCHE UNIVERSITÄT INNSBRUCK
发明人： Peter Heinz-Erian , Gerda Laura Fuhrmann
IPC分类号： G01N27/333 , A61B10/00 , G01N27/327 , G01N33/70
CPC分类号： G01N27/333 , A61B10/007 , G01N27/3275 , G01N33/70
摘要： The present invention relates to a single-use test-strip for the quantitative determination of sodium concentration and creatinine concentration and for the subsequent determination of their ratio, and to a non-invasive point-of-care (POC) device for detecting sodium depletion and/or sodium overload in a patient's body. Furthermore, the present invention relates to a method for simultaneously and quantitatively determining sodium concentration and creatinine concentration in a patient's urine sample and to a method of detecting sodium depletion and/or sodium overload in a patient's body.

4. 发明授权

US11096706B2 Reflector for acoustic pressure wave head 有权
公开(公告)号：US11096706B2
公开(公告)日：2021-08-24
申请号：US15521141
申请日：2015-10-21
申请人： Medizinische Universität Innsbruck , Christian Dorfmüller
发明人： Christian Dorfmüller , Johannes Holfeld , Michael Grimm
IPC分类号： A61B17/225 , G10K11/28 , G10K15/04
摘要： The present invention relates to a reflector for an acoustic shock or pressure wave head, wherein the reflector comprises an acoustically reflective surface formed by a body of rotation, said body of rotation being formed by rotation of an elliptical segment about a rotation axis which extends through a focal point of the ellipse and encloses an angle α between 0.1° and 30° with the main axis of the ellipse.

5. 发明授权

US08058015B2 Markers for chronic kidney disease 有权
标题翻译：慢性肾脏疾病的标志物
公开(公告)号：US08058015B2
公开(公告)日：2011-11-15
申请号：US12523625
申请日：2008-01-21
申请人： Florian Kronenberg , Barbara Kollerits , Danilo Fliser
发明人： Florian Kronenberg , Barbara Kollerits , Danilo Fliser
IPC分类号： G01N33/53
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/118
摘要： The present invention relates to a method for the determination or prediction of the progression of chronic kidney disease in a subject suspected to suffer from chronic kidney disease, said method comprising the step of determining the expression levels of at least one marker selected from (a) FGF23; and (b) adiponectin in a biological sample. Furthermore, the present invention relates to a use of a specific detection molecule for FGF23 or use of a specific detection molecule for adiponectin for the preparation of a diagnostic composition for the detection of chronic kidney disease or the progression of chronic kidney diseases in a subject suspected to suffer from said disease. In particular, the present invention also provides for use of FGF23 and/or of adiponectin as an in vitro marker for the presence, absence or progression of a chronic kidney disease and kits comprising a specific detection molecule for FGF23 or a specific detection molecule for adiponectin for use in the method of the present invention.
摘要翻译：本发明涉及一种用于确定或预测疑似患有慢性肾脏疾病的受试者的慢性肾脏疾病进展的方法，所述方法包括确定选自（a）的至少一种标志物的表达水平的步骤， FGF23; 和（b）生物样品中的脂联素。此外，本发明涉及用于FGF23的特异性检测分子的用途或者用于脂联素的特异性检测分子的用途，用于制备用于检测受试者的慢性肾脏疾病或慢性肾脏疾病进展的诊断组合物患有所述疾病。特别地，本发明还提供使用FGF23和/或脂连蛋白作为慢性肾脏疾病的存在，不存在或进展的体外标记物，以及包含用于FGF23的特异性检测分子或脂联素特异性检测分子的试剂盒用于本发明的方法中。

6. 发明公开

US20230408474A1 DEVICE AND PROCESS FOR ANALYSING GAS EFFECTS IN SAMPLES 审中-公开
公开(公告)号：US20230408474A1
公开(公告)日：2023-12-21
申请号：US18250790
申请日：2021-10-21
申请人： Medizinische Universität Innsbruck , EURAC RESEARCH
发明人： Simon Woyke , Thomas Haller
IPC分类号： G01N33/00 , G01J3/02
CPC分类号： G01N33/0062 , G01N33/0031 , G01N33/0036 , G01J3/0202
摘要： The invention provides a device and a process for analysing the effect of a concentration of a gas on a sample, especially measurement of the gas concentration within a sample, and/or measurement of the effect of the absorption and/or desorption of a gas by the sample, using spectrophotometric detection of a gas-sensitive and optically detectable analyte of the sample while measuring the concentration of the gas in a gas composition that is continuously delivered to each sample well in order to contact the samples with a gas having a predetermined and/or measured concentration, respectively a pre-determined and/or measured partial pressure.

7. 发明公开

US20240091390A1 IMPROVED CHOLECYSTOKININ-2 RECEPTOR (CCK2R) TARGETING FOR DIAGNOSIS AND THERAPY 审中-公开
公开(公告)号：US20240091390A1
公开(公告)日：2024-03-21
申请号：US18263797
申请日：2022-02-02
申请人： Medizinische Universität Innsbruck
发明人： Elisabeth VON GUGGENBERG ZU RIEDHOFEN , Anton Amadeus HÖRMANN
IPC分类号： A61K51/08 , A61P35/00 , C07K7/02
CPC分类号： A61K51/088 , A61P35/00 , C07K7/02 , A61K2121/00 , A61K2123/00
摘要： The present invention provides valuable peptidomimetics for therapeutic and diagnostic purposes as well as compositions, methods, uses and kits based on these peptidomimetics. In particular, the peptidomimetics of the present invention are incorporated by CCK2R expressing cells, for instance, cancer cells. This allows, for instance, to selectively destroy cancer cells or to selectively image cancer cells that express CCK2R.

8. 发明申请

US20210363545A1 GENETIC SELECTION MARKERS BASED ON ENZYMATIC ACTIVITIES OF THE PYRIMIDINE SALVAGE PATHWAY 有权
公开(公告)号：US20210363545A1
公开(公告)日：2021-11-25
申请号：US17252164
申请日：2019-06-07
申请人： Medizinische Universität Innsbruck
发明人： Fabio GSALLER , Hubertus HAAS
IPC分类号： C12N15/90 , C12N15/65
摘要： The present invention relates to a method of site-directed integration into a genetic locus encoding at least one activity of the pyrimidine salvage pathway in a host cell, wherein said activity of the pyrimidine salvage pathway is purine/cytosine permease (FcyB), cytosine deaminase (FcyA), uracil-phosphoribosyl-transferase (Uprt), concentrative nucleoside transporter (CntA) or uridine kinase (UK), comprising: a) providing a host cell comprising a functional copy of the genetic locus encoding at least one activity of the pyrimidine salvage pathway; (b) introducing a gene or sequence of interest into said host cell via transformation of an integrative nucleic acid construct which comprises 3′ and/or 5′ of the gene or sequence of interest flanks being homologous to said genetic locus or which carries a sequence being homologous to said genetic locus of the pyrimidine salvage pathway and thus allowing for a homologous recombination at said genetic locus, wherein said homologous recombination is capable of causing an inactivation or reduction of the activity encoded by said genetic locus; (c) growing a transformed host cell under selective medium conditions, wherein said medium comprises an efficient amount of 5-flucytosine (5-FC), 5-fluorouracil (5-FU) or 5-fluorouridine (5-FUR); and (d) selecting a host cell which is capable of growing under the medium conditions of step (c). Also envisaged is a host cell, comprising at least one gene or sequence of interest in one or more genetic loci encoding an activity of the pyrimidine salvage pathway wherein said gene or sequence of interest replaces or partially replaces the sequence encoding said at least one activity of the pyrimidine salvage pathway at said locus, the use of such a host cell for the production of several activities, as well as the use of a genetic locus encoding at least one activity of the pyrimidine salvage pathway in a host cell in a process of transforming said host cell or a process of genetically modifying said host cell.

9. 发明申请

US20110189252A1 PHARMACEUTICAL COMPOSITIONS COMPRISING LIGNANS AND THEIR DERIVATIVES FOR TREATING HYPERPLASTIC DISEASES 有权
标题翻译：包含LIGNANS及其用于治疗高血压疾病的衍生物的药物组合物
公开(公告)号：US20110189252A1
公开(公告)日：2011-08-04
申请号：US13054385
申请日：2009-07-17
申请人： Hermann Stuppner , Stefan Schwaiger , David Bernhard , Günther Laufer
发明人： Hermann Stuppner , Stefan Schwaiger , David Bernhard , Günther Laufer
IPC分类号： A61K9/00 , A61K31/341 , A61K31/381 , A61K31/40 , A01N1/02 , A61P35/00
CPC分类号： A61K31/341
摘要： The present invention relates to a pharmaceutical composition comprising specific compounds which may be obtained from Leontopodium alpinum Cass. (Edelweiss). A preferred compound is leoligin (=(2S,3R,4R)-4-(3,4-dimethoxybenzyl)-2-(3,4-dimethoxyphenyl)tetrahydrofuran-3-yl]methyl(2Z)-2-methylbut-2-enoat]). Corresponding means and methods in respect of medical uses of the compounds are described. The present invention also provides a medical device comprising, containing or having been contacted with the compound. The compounds provided herein may particularly be used in the treatment of hyperplastic diseases, in particular intimal hyperplasia, e.g. stenosis, restenosis, atherosclerosis and the like. Also envisaged herein is the use of these compounds in the treatment of proliferative diseases, such as leukemia, prostate cancer and lung cancer.
摘要翻译：本发明涉及一种药物组合物，其包含可从Leontopodium alpinum Cass获得的特定化合物。（Edelweiss）。优选的化合物是leoligin（=（2S，3R，4R）-4-（3,4-二甲氧基苄基）-2-（3,4-二甲氧基苯基）四氢呋喃-3-基]甲基（2Z）-2-甲基丁-2- -enoat]）。描述了关于化合物的医疗用途的相应手段和方法。本发明还提供了包含或含有该化合物的医疗装置。本文提供的化合物可特别用于治疗增生性疾病，特别是内膜增生，例如内膜增生。狭窄，再狭窄，动脉粥样硬化等。本文还设想使用这些化合物来治疗增殖性疾病，例如白血病，前列腺癌和肺癌。

10. 发明授权

US12049518B2 Pharmacokinetics and cholecystokinin-2 receptor (CCK2R) targeting for diagnosis and therapy 有权
公开(公告)号：US12049518B2
公开(公告)日：2024-07-30
申请号：US16620403
申请日：2018-06-08
申请人： Medizinische Universitat Innsbruck
发明人： Elisabeth Von Guggenberg Zu Riedhofen , Maximilian Klingler
IPC分类号： C07K7/08 , A61K38/08 , A61K51/08 , C07K7/06 , A61K38/00
CPC分类号： C07K7/08 , A61K38/08 , A61K51/088 , C07K7/06 , A61K38/00
摘要： The present invention provides valuable peptidomimetics for therapeutic and diagnostic purposes as well as compositions, methods, uses and kits based on these peptidomimetics. In particular, the peptidomimetics of the present invention are incorporated by CCK2R expressing cells, for instance, cancer cells. This allows, for instance, to selectively destroy cancer cells or to selectively image cancer cells that express CCK2R.

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