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1. 发明申请

US20100040664A1 AABB-POLY(DEPSIPEPTIDE) BIODEGRADABLE POLYMERS AND METHODS OF USE 审中-公开
标题翻译： AABB-POLY（DEPSIPEPTIDE）可生物降解的聚合物及其使用方法
公开(公告)号：US20100040664A1
公开(公告)日：2010-02-18
申请号：US12540285
申请日：2009-08-12
申请人： Ramaz Katsarava , Natia Ochkhikdze , David Tugushi , Zaza D. Gomurashvili
发明人： Ramaz Katsarava , Natia Ochkhikdze , David Tugushi , Zaza D. Gomurashvili
IPC分类号： A61F2/00 , A61K9/14 , A61K38/07 , C07K5/10
CPC分类号： A61K31/785 , C08G69/44 , C08L77/12
摘要： The invention provides AABB-poly(depsipeptide)s (AABB-PDPs), a class of biodegradable polymers composed of α-amino and α-hydroxy acids with material properties suitable for biomedical applications. These AABB-PDPs belong to the family of amino acid-based poly(ester amide)s (PEAs), which are characterized by the presence of alternating ester and amide functionalities. Containing four ether groups per basic unit, these polymers degrade rapidly by biotic or abiotic hydrolytic action to release dispersed bioactive agents at a controlled delivery rate, are non-toxic, produce digestible breakdown products, and are easy to fabricate by solution polycondensation.
摘要翻译：本发明提供了一种由α-氨基和α-羟基酸组成的一类可生物降解的聚合物（AABB-PDPs），其具有适用于生物医学应用的材料性质。这些AABB-PDP属于基于氨基酸的聚（酯酰胺）（PEAs）家族，其特征在于存在交替的酯和酰胺官能团。每个基本单位含有四个醚基团，这些聚合物通过生物或非生物水解作用快速降解，以受控的输送速率释放分散的生物活性剂，是无毒的，产生可消化的分解产物，并且易于通过溶液缩聚制备。

2. 发明申请

US20090253809A1 BIOABSORBABLE ELASTOMERIC POLYMER NETWORKS, CROSS-LINKERS AND METHODS OF USE 有权
标题翻译：生物可塑弹性体聚合物网络，交联剂和使用方法
公开(公告)号：US20090253809A1
公开(公告)日：2009-10-08
申请号：US12058613
申请日：2008-03-28
申请人： Zaza D. Gomurashvili , Ramaz Katsarava , Giorgi Chumburdze , Nino Mumladze , David Tugushi
发明人： Zaza D. Gomurashvili , Ramaz Katsarava , Giorgi Chumburdze , Nino Mumladze , David Tugushi
IPC分类号： A61K47/42
CPC分类号： A61K31/74 , A61L27/18 , A61L27/58 , C08L77/12
摘要： The invention provides elastomeric polymer networks and semi-interpenetrating networks in which a linear PEA, PEUR or PEU polymer is crosslinked by ester or alpha-amino-acid containing cross-linkers that polymerize upon exposure to active species. Bioabsorbable elastomeric internal fixation devices fabricated using such polymer networks and semi-interpenetrating networks are useful for in vivo implant and delivery of a variety of different types of molecules in a time release fashion. Alpha-amino-acid containing ester amide cross-linkers are also provided by the invention.
摘要翻译：本发明提供弹性体聚合物网络和半互穿网络，其中线性PEA，PEUR或PEU聚合物通过酯或含有α-氨基酸的交联剂在暴露于活性物质时聚合而交联。使用这种聚合物网络和半互穿网络制造的生物可吸收的弹性内固定装置可用于以时间释放方式体内植入和递送多种不同类型的分子。含有α-氨基酸的酯酰胺交联剂也由本发明提供。

3. 发明申请

US20090068743A1 CATIONIC ALPHA-AMINO ACID-CONTAINING BIODEGRADABLE POLYMER GENE TRANSFER COMPOSITIONS 审中-公开
标题翻译：含酸性氨基酸含氨基酸的生物可降解聚合物基因转移组合物
公开(公告)号：US20090068743A1
公开(公告)日：2009-03-12
申请号：US12197068
申请日：2008-08-22
申请人： William G. Turnell , Gina Ann Cruz-Aranda , Mark MinZhi Wu , Ronald Lee Chantung , Zaza D. Gomurashvili , Kristin M. DeFife
发明人： William G. Turnell , Gina Ann Cruz-Aranda , Mark MinZhi Wu , Ronald Lee Chantung , Zaza D. Gomurashvili , Kristin M. DeFife
IPC分类号： C12N15/87 , C12N15/11
CPC分类号： C12N15/111 , C08G69/44 , C12N15/87 , C12N2310/14 , C12N2320/32
摘要： The invention provides gene transfer compositions using as the gene carrier a biodegradable polymer that contains one or more cationic alpha amino acids, such as arginine or agmatine. The compositions form a tight soluble complex with a poly nucleic acid suitable for transfecting target cells to effect translation of the cargo poly nucleic acid by the target cell. Thus, such compounds are useful both in vitro and in vivo.
摘要翻译：本发明提供了使用含有一种或多种阳离子α-氨基酸的生物可降解聚合物作为基因载体的基因转移组合物，例如精氨酸或胍丁胺。组合物与适合于转染靶细胞的多核酸形成紧密的可溶性复合物，以实现靶细胞翻译货物多核酸。因此，这些化合物在体外和体内都是有用的。

4. 发明申请

US20060286064A1 Therapeutic polymers and methods 审中-公开
标题翻译：治疗性聚合物和方法
公开(公告)号：US20060286064A1
公开(公告)日：2006-12-21
申请号：US11446405
申请日：2006-06-02
申请人： William Turnell , Zaza Gomurashvili , Ramaz Katsarava
发明人： William Turnell , Zaza Gomurashvili , Ramaz Katsarava
IPC分类号： A61K31/785 , C08F20/00
CPC分类号： A61K31/785 , C07J1/0074
摘要： The present invention provides biodegradable therapeutic polymer compositions based on poly(ester amide) (PEA), poly(ester urethane) (PEUR), and poly(ester urea) (PEU) polymers useful for in vivo delivery of at least one therapeutic diol or di-acid incorporated into the backbone of the biodegradable polymer. The therapeutic polymer compositions biodegrade in vivo by enzymatic action to release therapeutic diols or di-acids from the polymer backbone in a controlled manner over time. The invention compositions are stable, can be lyophilized for transportation and storage, and can be redispersed for administration. Due to structural properties of the PEA and PEUR polymers used, the invention therapeutic polymer compositions provide for high loading of the therapeutic diol or di-acid, as well as optional bioactive agents.
摘要翻译：本发明提供了可用于体内递送至少一种治疗性二醇的聚（酯酰胺）（PEA），聚（酯聚氨酯）（PEUR）和聚（酯尿素）（PEU）聚合物的可生物降解的治疗性聚合物组合物，二酸掺入可生物降解聚合物的骨架中。治疗性聚合物组合物通过酶作用在体内生物降解，以随时间的控制方式从聚合物主链释放治疗性二醇或二酸。本发明组合物是稳定的，可以冻干运输和储存，并且可以再分散用于给药。由于所使用的PEA和PEUR聚合物的结构性质，本发明的治疗性聚合物组合物提供治疗性二醇或二酸的高负载量以及任选的生物活性剂。

5. 发明申请

US20060177416A1 Polymer particle delivery compositions and methods of use 审中-公开
标题翻译：聚合物颗粒递送组合物和使用方法
公开(公告)号：US20060177416A1
公开(公告)日：2006-08-10
申请号：US11344689
申请日：2006-01-31
申请人： William Turnell , Hong Li , Zaza Gomurashvili , Ramaz Katsarava
发明人： William Turnell , Hong Li , Zaza Gomurashvili , Ramaz Katsarava
IPC分类号： A61K48/00 , A61K31/785
CPC分类号： A61K9/1075 , A61K9/1647 , A61K9/5031 , A61K9/5153 , A61K47/34 , A61K47/59 , A61K47/593 , A61K47/595 , C07K16/2821 , C08L77/12 , C12N15/88 , Y10S977/773 , Y10S977/788 , Y10S977/906
摘要： The present invention provides biodegradable polymer particle delivery compositions based on polymers, such as polyester amide (PEA) and polyester urethane (PEUR) polymers, that contain amino acids in the polymer. The polymer particle delivery compositions can be formulated as a liquid dispersion of polymer particles with the bioactive agents dispersed in the particle or conjugated attached to polymer molecules or particle surfaces. The bioactive agents can include drugs, polypeptides, DNA and cells for cell-based therapies using particles sized for local, mucosal or circulatory delivery. Methods of treating a disease by administering to a subject the polymer particle delivery composition, which incorporates a bioactive agent suitable for treatment of the disease, or its symptoms, are also included.
摘要翻译：本发明提供了基于在聚合物中含有氨基酸的聚合物如聚酯酰胺（PEA）和聚酯聚氨酯（PEUR）聚合物的可生物降解的聚合物颗粒递送组合物。聚合物颗粒递送组合物可以配制成聚合物颗粒的液体分散体，其中分散在颗粒中的生物活性剂或缀合在聚合物分子或颗粒表面上。生物活性剂可以包括药物，多肽，DNA和细胞用于基于细胞的疗法，使用尺寸适合局部，粘膜或循环递送的颗粒。还包括通过向受试者施用包含适合于治疗该疾病的生物活性剂的聚合物颗粒递送组合物或其症状来治疗疾病的方法。

6. 发明申请

US20060024357A1 Wound healing polymer compositions and methods for use thereof 审中-公开
标题翻译：伤口愈合聚合物组合物及其使用方法
公开(公告)号：US20060024357A1
公开(公告)日：2006-02-02
申请号：US11128903
申请日：2005-05-12
申请人： Kenneth Carpenter , Huashi Zhang , Brendan McCarthy , Istvan Szinai , William Turnell , Sindhu Gopalan
发明人： Kenneth Carpenter , Huashi Zhang , Brendan McCarthy , Istvan Szinai , William Turnell , Sindhu Gopalan
IPC分类号： A61K9/14 , A61L15/00
CPC分类号： A61K35/44 , A61K9/0024 , A61K38/00 , A61K47/34 , A61K47/59 , A61K47/593 , A61K47/595 , A61L15/26 , A61L15/44 , A61L15/60 , A61L15/64 , A61L26/0019 , A61L26/0066 , A61L31/10 , A61L31/148 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/416 , A61L2300/604 , A61L2300/64 , C08L77/12 , C08L79/02
摘要： The present invention provides bioactive polymer compositions that can be formulated to release a wound healing agent at a controlled rate by adjusting the various components of the composition. The composition can be used in an external wound dressing, as a polymer implant for delivery of the wound healing agent to an internal body site, or as a coating on the surface of an implantable surgical device to deliver wound healing agents that are covalently attached to a biocompatible, biodegradable polymer and/or embedded within a hydrogel. Methods of using the invention bioactive polymer compositions to promote natural healing of wounds, especially chronic wounds, are also provided. Examples of biodegradable copolymer polyesters useful in forming the blood-compatible, hydrophilic layer or coating include copolyester amides, copolyester urethanes, glycolide-lactide copolymers, glycolide-caprolactone copolymers, poly-3-hydroxy butyrate-valerate copolymers, and copolymers of the cyclic diester monomer, 3-(S)[(alkyloxycarbonyl)methyl]-1,4-dioxane-2,5-dione, with L-lactide. The glycolide-lactide copolymers include poly(glycolide-L-lactide) copolymers formed utilizing a monomer mole ratio of glycolic acid to L-lactic acid ranging from 5:95 to 95:5 and preferably a monomer mole ratio of glycolic acid to L-lactic acid ranging from 45:65 to 95:5. The glycolide-caprolactone copolymers include glycolide and ε-caprolactone block copolymer, e.g., Monocryl or Poliglecaprone.
摘要翻译：本发明提供生物活性聚合物组合物，其可配制成通过调节组合物的各种组分以受控的速率释放伤口愈合剂。组合物可以用作外部伤口敷料，作为用于将伤口愈合剂递送到内部身体部位的聚合物植入物，或者作为可植入手术装置的表面上的涂层，以递送共价连接到生物相容的，可生物降解的聚合物和/或嵌入在水凝胶内。还提供了使用本发明生物活性聚合物组合物促进伤口，特别是慢性伤口的自然愈合的方法。可用于形成血液相容的亲水层或涂层的可生物降解的共聚物聚酯的实例包括共聚酯酰胺，共聚酯氨基甲酸酯，乙交酯 - 丙交酯共聚物，乙交酯 - 己内酯共聚物，聚-3-羟基丁酸酯 - 戊酸酯共聚物，以及环状二酯的共聚物单体，3-（S）[（烷氧基羰基）甲基] -1,4-二恶烷-2,5-二酮与L-丙交酯。乙交酯 - 丙交酯共聚物包括使用乙醇酸与L-乳酸的单体摩尔比为5:95至95:5的聚（乙交酯-L-丙交酯）共聚物，优选乙醇酸与L-乳酸的单体摩尔比，乳酸范围为45:65至95:5。乙交酯 - 己内酯共聚物包括乙交酯和ε-己内酯嵌段共聚物，例如Monocryl或Poliglecaprone。

7. 发明授权

US08652504B2 Solid polymer delivery compositions and methods for use thereof 有权
标题翻译：固体聚合物输送组合物及其使用方法
公开(公告)号：US08652504B2
公开(公告)日：2014-02-18
申请号：US11525491
申请日：2006-09-21
申请人： Hong Li , William G. Turnell , Yumin Yuan , Geoffrey C. Landis , Ryan L. Knoy
发明人： Hong Li , William G. Turnell , Yumin Yuan , Geoffrey C. Landis , Ryan L. Knoy
IPC分类号： A61K48/00 , A61K39/395 , C08F20/00 , A61F2/02
CPC分类号： C08G69/44 , A61K9/0024 , A61K47/34 , A61L27/34 , A61L31/10 , C08L77/12 , C08L2666/02
摘要： The present invention provides an implantable solid polymer delivery composition that can be formulated to release a bioactive agent to an interior body site at a controlled rate over an extended period of time by adjusting the various components of the composition. The controlled delivery of the composition avoids an initial drug spike, resulting in a smooth delivery profile over time. Polymer layers in the composition can be porous and are both biodegradable in water and body enzymes and biocompatible. Methods of making the implantable solid polymer compositions and methods of delivering a bioactive agent at a controlled rate to an interior body site are also provided.
摘要翻译：本发明提供了一种可植入的固体聚合物递送组合物，其可通过调节组合物的各种成分而配制成在长时间内以受控的速率将生物活性剂释放到内部身体部位。组合物的受控输送避免了初始药物尖峰，导致随着时间的顺利递送。组合物中的聚合物层可以是多孔的，并且在水和身体酶中都是可生物降解的并且是生物相容的。还提供了制造可植入固体聚合物组合物的方法和将受控速率递送至内部身体部位的生物活性剂的方法。

8. 发明申请

US20100004390A1 BIODEGRADABLE METAL-CHELATING POLYMERS AND VACCINES 审中-公开
标题翻译：生物可降解金属螯合聚合物和疫苗
公开(公告)号：US20100004390A1
公开(公告)日：2010-01-07
申请号：US12437435
申请日：2009-05-07
申请人： William G. Turnell , Zaza D. Gomurashvill , Benjamin W. Parcher , Jonathan Hughes , Jeffrey N. Anderl
发明人： William G. Turnell , Zaza D. Gomurashvill , Benjamin W. Parcher , Jonathan Hughes , Jeffrey N. Anderl
IPC分类号： A61K47/48 , C08G69/44 , C08L77/12
CPC分类号： C08F283/04 , A61K47/593 , A61K47/595 , A61K47/60 , A61K47/6935 , A61K49/0047 , A61K49/0093 , A61K49/128 , C08G69/44 , C08G73/028 , C08L77/12 , C08L79/02
摘要： The invention provides metal-chelating poly(ether amide) polymers useful in preparation of polymer compositions for delivering a variety of cargo molecules, such as bioactive agents. In solution metal ions and cargo molecules, such as vaccine epitopes, that include metal avid amino acids can be loaded into the polymer compositions and held in a non-covalent complex. Nanoparticles of such polymer compositions can also be prepared directly from the solution.
摘要翻译：本发明提供了可用于制备用于递送各种货物分子的生物活性剂的聚合物组合物的金属螯合聚（醚酰胺）聚合物。在溶液中，金属离子和货物分子，如疫苗表位，包括金属氨基酸，可加载到聚合物组合物中并保持在非共价复合物中。这种聚合物组合物的纳米颗粒也可以直接从溶液制备。

9. 发明申请

US20070128250A1 Poly(ester urea) polymers and methods of use 有权
标题翻译：聚（酯脲）聚合物和使用方法
公开(公告)号：US20070128250A1
公开(公告)日：2007-06-07
申请号：US11584143
申请日：2006-10-19
申请人： Ramaz Katsarava , David Tugushi , Zaza Gomurashvili
发明人： Ramaz Katsarava , David Tugushi , Zaza Gomurashvili
IPC分类号： A61K31/56 , C08F20/00 , A61F2/02
CPC分类号： A61K31/56 , A61L27/18 , A61L31/06 , C08G71/04 , C08G2230/00 , C08G2250/00 , C08L75/02
摘要： The invention provides high molecular weight, crystalline or semi crystalline biodegradable and biocompatible poly(ester urea) (PEU) polymers useful for making vascular stents and hard tissue replacement implants, such as bone substitutes. The PEU polymers are based on α amino acids and are made by a polycondensation reaction. PEU polymer compositions can contain a therapeutic diol incorporated into the polymer backbone that is released from such an implant in situ. Bioactive agents, such as analgesics, antibiotics, and the like, can also be covalently attached to certain PEU polymers for release into tissue surrounding an implant during biodegradation of the polymer.
摘要翻译：本发明提供了可用于制备血管支架和硬组织置换植入物例如骨代用品的高分子量，结晶或半结晶可生物降解和生物相容的聚（酯尿素）（PEU）聚合物。 PEU聚合物基于α氨基酸，并通过缩聚反应制备。 PEU聚合物组合物可以含有掺入聚合物骨架中的治疗性二醇，其从原位从这种植入物释放。生物活性剂，例如止痛剂，抗生素等也可以共价连接到某些PEU聚合物，以在聚合物的生物降解期间释放到植入物周围的组织中。

10. 发明申请

US20060188469A1 Vaccine delivery compositions and methods of use 审中-公开
标题翻译：疫苗输送组合物和使用方法
公开(公告)号：US20060188469A1
公开(公告)日：2006-08-24
申请号：US11345021
申请日：2006-01-31
申请人： William Turnell , Vassil Vassilev , Kristin DeFife , Hong Li , Zaza Gomurashvili , Ramaz Katsarava
发明人： William Turnell , Vassil Vassilev , Kristin DeFife , Hong Li , Zaza Gomurashvili , Ramaz Katsarava
IPC分类号： A61K39/00
CPC分类号： A61K39/385 , A61K39/12 , A61K39/145 , A61K39/21 , A61K2039/544 , A61K2039/6093 , A61K2039/64 , C07K14/005 , C12N2740/16022 , C12N2740/16034 , C12N2760/16122 , C12N2760/16134
摘要： The present invention provides synthetic vaccine delivery compositions based on polyester amide (PEA), polyester urethane (PEUR), and polyester urea (PEU) polymers for stimulating an immune response to a variety of pathogenic organisms and tumor cells in humans and other mammals. The vaccine delivery compositions are formulated as a liquid dispersion of polymer particles or molecules including class I or class II antigen peptides derived from organism or tumor cell proteins, which are taken up by antigen presenting cells of the mammal to induce an immune response in the mammal. Methods of inducing an immune response to the pathogenic organism or tumor cells in the invention compositions are also included.
摘要翻译：本发明提供了基于聚酯酰胺（PEA），聚酯聚氨酯（PEUR）和聚酯尿素（PEU）聚合物的合成疫苗递送组合物，用于刺激人和其它哺乳动物中各种致病生物体和肿瘤细胞的免疫应答。疫苗递送组合物被配制为聚合物颗粒或分子的液体分散体，包括衍生自生物或肿瘤细胞蛋白的I类或II类抗原肽，其被哺乳动物的抗原呈递细胞吸收以在哺乳动物中诱导免疫应答。还包括诱导本发明组合物中致病生物或肿瘤细胞的免疫应答的方法。

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