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1. 发明授权

US5679458A Antifogging abrasion resistant coating composition and synthetic resin article coated therewith 失效
公开(公告)号：US5679458A
公开(公告)日：1997-10-21
申请号：US638270
申请日：1996-04-26
申请人： Yong-Il Cho , Sung-Hoon Jang , Jung-Ok Park
发明人： Yong-Il Cho , Sung-Hoon Jang , Jung-Ok Park
IPC分类号： C08J7/04 , C08F265/04 , C09D4/00 , C09D4/02 , C09D4/06 , C09D5/00 , C09D133/00 , C09D133/04 , C09D163/00 , C09D183/04 , C09D183/06 , C09D183/08 , C09K3/18 , B32B9/04
CPC分类号： C09D4/06 , C08F265/04 , C09D4/00 , Y10T428/31507 , Y10T428/31511 , Y10T428/31663 , Y10T428/31667
摘要： A coating composition having excellent antifogging property, good abrasion resistance, improved adhesion to the substrate and good water resistance, which comprises an epoxy functional organosilane or the hydrolysate or condensate thereof; an amino functional organosilane or the hydrolysate or condensate thereof; a hydrophilic (meth)acrylate monomer, or a copolymer of two components selected from the hydrophilic (meth)acrylate monomer, another hydrophilic monomer and an organosilane and/or a terpolymer of the three components; a curing catalyst; and, optionally, a multi-functional (meth)acrylate monomer having at least two (meth)acryl groups and a radical polymerization initiator.

2. 发明授权

US5587388A Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof 失效
标题翻译：不可逆的HIV蛋白酶抑制剂，中间体，组合物及其制备方法
公开(公告)号：US5587388A
公开(公告)日：1996-12-24
申请号：US159382
申请日：1993-11-30
申请人： Sung C. Kim , Nakyen Choy , Chang S. Lee , Young C. Son , Ho I. Choi , Jong S. Koh , Heungsik Yoon , Chi H. Park , Sang S. Kim
发明人： Sung C. Kim , Nakyen Choy , Chang S. Lee , Young C. Son , Ho I. Choi , Jong S. Koh , Heungsik Yoon , Chi H. Park , Sang S. Kim
IPC分类号： A61K31/335 , A61K31/00 , A61K31/336 , A61K38/00 , A61P31/00 , A61P31/12 , A61P31/18 , C07C213/02 , C07C217/08 , C07C269/04 , C07C271/20 , C07C271/22 , C07D301/02 , C07D303/36 , C07D303/38 , C07D303/40 , C07D303/46 , C07D405/12 , C07D405/14 , C07D493/08 , C07K5/02 , C07K5/06 , C07K5/065 , C07K5/078 , C07K7/02 , C07D215/38 , A61K31/47
CPC分类号： C07D303/38 , C07C217/08 , C07C271/20 , C07C271/22 , C07D303/36 , C07D303/46 , C07D405/12 , C07D405/14 , C07D493/08 , C07K5/0207 , C07K5/06026 , C07K5/06078 , C07K5/06139 , C07K7/02 , A61K38/00 , C07C2101/14
摘要： The present invention provides cis-epoxide compounds represented by formula (I-1), (I-2) or (I-3) which are useful for treating or preventing diseases caused by HIV infection: ##STR1## wherein: A, B, D, E, R.sup.1, R.sup.10, R.sup.11, K, G, Q, r and J have the meanings as defined in the specification.
摘要翻译：本发明提供可用于治疗或预防由HIV感染引起的疾病的由式（I-1），（I-2）或（I-3）表示的顺式环氧化合物：（I-1）（I-2）（I-3）其中：A，B，D，E，R1，R10，R11，K，G，Q，r和J具有说明书中定义的含义。

3. 发明授权

US5569598A Extracellular aminopeptidase isolated from Streptococcus thermonitrificans culture 失效
标题翻译：从热球菌培养物中分离的胞外氨肽酶
公开(公告)号：US5569598A
公开(公告)日：1996-10-29
申请号：US261525
申请日：1994-06-17
申请人： Soon J. Park , Young M. Lee , Teug Y. Won , Soon C. Kwon , Seung J. Lee , Jung H. Kim , Bum J. Kim
发明人： Soon J. Park , Young M. Lee , Teug Y. Won , Soon C. Kwon , Seung J. Lee , Jung H. Kim , Bum J. Kim
IPC分类号： C12P21/00 , C07K14/61 , C12N9/48 , C12N15/09 , C12P21/02 , C12P21/06 , C12R1/465 , C12N1/20 , C12N9/52
CPC分类号： C12P21/06 , C07K14/61 , C12N9/48
摘要： An extracellular leucine aminopeptidase was isolated from the culture medium of Streptomyces therrnonitrificans which is a Zn.sup.2+ -dependent metalloenzyme which comprises an amino acid sequence Lys-Phe-Ser-Lys-Lys-Phe-Asn-Glu (SEQ ID NO: 3) at the N-terminal thereof, and amino acid sequences of Glu-Pro-Gly-Thr-Gly-Ala-Leu-Glu-Pro (SEQ ID NO: 4) and Asn-Pro-Asp-Ile-Val-Tyr (SEQ ID NO: 5) at other regions thereof. The aminopeptidase has a pH optimum of 7.5 to 9.0, a temperature optimum of 30.degree. to 50.degree. C., and an apparent molecular weight as determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis under reducing conditions of 41 to 45 kDa, and as determined by gel filtration under native state conditions of 36 to 40 kDa.
摘要翻译：从作为Zn 2+依赖性金属酶的链霉菌（Streptomyces thernnitrificans）的培养基中分离出细胞外亮氨酸氨基肽酶，其包含氨基酸序列Lys-Phe-Ser-Lys-Lys-Phe-Asn-Glu（SEQ ID NO：3） Glu-Pro-Gly-Thr-Gly-Ala-Leu-Glu-Pro（SEQ ID NO：4）和Asn-Pro-Asp-Ile-Val-Tyr的氨基酸序列（SEQ ID NO：：5）其他地区。氨基肽酶的pH最佳值为7.5〜9.0，最适温度为30〜50℃，表观分子量由十一烷基硫酸钠聚丙烯酰胺凝胶电泳法测定，在41〜45kDa的还原条件下测定，在36至40kDa的天然状态下进行凝胶过滤。

4. 发明授权

US5525730A Processes for preparation of sulfonylurea derivatives 失效
标题翻译：制备磺酰脲衍生物的方法
公开(公告)号：US5525730A
公开(公告)日：1996-06-11
申请号：US389042
申请日：1995-02-15
申请人： Jong K. Choi , In B. Chung , Jae C. Lee , Byoung W. Suh , Jong S. Sa , Tae H. Heo
发明人： Jong K. Choi , In B. Chung , Jae C. Lee , Byoung W. Suh , Jong S. Sa , Tae H. Heo
IPC分类号： C07D401/12 , A01N43/56 , B01J31/02 , C07B61/00 , C07D231/18 , C07D403/12 , C07D521/00
CPC分类号： C07D521/00 , C07D231/18 , C07D401/12
摘要： The present invention relates to a novel process for preparing sulfonylurea derivatives of formula (I) in a high purity and a high yield characterized in that a sulfonylchloride of formula (V) is reacted with 2-amino-4,6-dimethoxypyrimidine of formula (VII) in the presence of a metal cyanate and an organic base catalyst or a compound of formula (VIII) is reacted with 2-amino-4,6-dimethoxypyrimidine of formula (VII): ##STR1## wherein R.sup.1 represents hydrogen, C.sub.1 -C.sub.4 alkyl or phenyl, R.sup.2 represents hydrogen, C.sub.1 -C.sub.4 alkyl, allyl or propargyl and R.sup.3 represents hydrogen, methyl, ethyl or phenyl, and to a process for preparing the sulfonylchloride compound of formula (V) above and the compound of formula (VIII) above, both of which are useful as an intermediate compound for preparing the sulfonylurea derivative of formula (I) and to a novel intermediate compound of formula (VIII) as defined above.
摘要翻译：本发明涉及以高纯度和高产率制备式（I）的磺酰脲衍生物的新方法，其特征在于式（Ⅴ）磺酰氯与式（Ⅴ）的2-氨基-4,6-二甲氧基嘧啶反应， VII）在金属氰酸盐和有机碱催化剂或式（VIII）化合物存在下与式（VII）的2-氨基-4,6-二甲氧基嘧啶反应：（I） V）表示氢，C 1 -C 4烷基或苯基，R 2表示氢，C 1 -C 4烷基，烯丙基或炔丙基，R 3表示氢，甲基，乙基或苯基，以及制备上述式（Ⅴ）磺酰氯化合物的方法和上述式（VIII）化合物，它们都可用作制备式（I）的磺酰脲衍生物的中间体化合物和如上定义的新的式（Ⅷ）中间体化合物。

5. 发明授权

US5342658A Abrasion resistant silicone coating composition 失效
标题翻译：耐磨硅胶涂料组合物
公开(公告)号：US5342658A
公开(公告)日：1994-08-30
申请号：US997207
申请日：1992-12-28
申请人： Young J. Hong , Jin B. Kim , Jong K. Yeo
发明人： Young J. Hong , Jin B. Kim , Jong K. Yeo
IPC分类号： C08J7/04 , B05D7/24 , C08G77/06 , C08J7/18 , C08K3/36 , C08K5/36 , C08L83/04 , C09D183/04 , G02B1/10 , C08G77/08 , C08G77/16 , C08J3/28
CPC分类号： C08J7/18 , C09D183/04
摘要： The present invention relates to an ultraviolet light curable coating composition having a shorter curing time and an excellent abrasion resistance, which comprises:(A) an aqueous-alcoholic base resin dispersion containing, based on the weight of the total solids present in the base resin dispersion,(a) 5 to 75% by weight of a colloidal silica and(b) 25 to 95% by weight of a partial condensate of a silanol of formula:R SI(OH).sub.3 whereinR is a C.sub.1-6 alkyl, C.sub.6-20 aryl or hydroxy group; and(B) an ultraviolet light curable catalyst of formulaAr.sub.3 S.sup.+ MX.sub.n.sup.- whereinAr.sub.3 is a triphenyl, tri(4-methoxy)phenyl, tri(3,5-dimethyl-4-hydroxyphenyl), diphenyl-2,5-dimethylphenyl or tri(4-methyl) phenyl group; andMX.sub.n.sup.- is a metallic halide anion.
摘要翻译：本发明涉及具有较短固化时间和优异耐磨性的紫外光固化涂料组合物，其包括：（A）一种含水醇基树脂分散液，其基于存在于基础树脂中的总固体的重量分散体，（a）5〜75重量％的胶体二氧化硅和（b）25〜95重量％的式：R SI（OH）3的硅烷醇的部分缩合物，其中R是C1-6烷基， C6-20芳基或羟基; 和（B）式Ar3S + MXn-的紫外光固化催化剂，其中Ar 3是三苯基，三（4-甲氧基）苯基，三（3,5-二甲基-4-羟基苯基），二苯基-2,5-二甲基苯基或三（4-甲基）苯基; 而MXn-是一种金属卤化物阴离子。

6. 发明授权

US5331046A Polyolefinic resin composition having superior paintability 失效
标题翻译：聚烯烃树脂组合物具有优异的可涂覆性
公开(公告)号：US5331046A
公开(公告)日：1994-07-19
申请号：US969329
申请日：1992-10-30
申请人： Suk K. Chang , In S. Seo , Dae W. Hong
发明人： Suk K. Chang , In S. Seo , Dae W. Hong
IPC分类号： C08L23/10 , C08K3/00 , C08L23/00 , C08L23/08 , C08L23/12 , C08L23/14 , C08L23/16 , C08L23/26 , C08L51/00 , C08L51/04 , C08L51/06 , C08L53/00 , C08L53/02
CPC分类号： C08L23/142 , C08L23/10 , C08L23/12 , C08L23/16 , C08L53/02 , C08L2205/02 , C08L2205/035 , C08L23/0869 , C08L2312/00 , C08L51/04 , C08L51/06
摘要： The present invention relates to a polyolefinic resin composition having superior paintability which comprises:(A) 40 to 80 parts by weight of a crystalline polypropylene resin;(B) 1 to 50 parts by weight of a thermoplastic olefinic rubber prepared by dynamic-crosslinking 10 to 70 parts by weight of a crystalline polypropylene resin with 90 to 30 parts by weight of an ethylene-.alpha.-olefin rubber;(C) 0.5 to 30 parts by weight of a polypropylene resin modified by grafting a polar monomer which has a physical affinity, but is not reactive, with an ethylene copolymer or ethylene copolymer rubber modified with .alpha.,.beta.-unsaturated carboxylic acid or a derivative thereof; and(D) 1 to 40 parts by weight of said modified ethylene copolymer or ethylene copolymer rubber based on 100 parts by weight of the total weight of the components (A),(B) and (C).
摘要翻译：本发明涉及具有优异可涂性的聚烯烃树脂组合物，其包含：（A）40至80重量份的结晶聚丙烯树脂; （B）1〜50重量份通过动态交联10〜70重量份的具有90〜30重量份乙烯-α-烯烃橡胶的结晶聚丙烯树脂制备的热塑性烯烃橡胶; （C）0.5〜30重量份通过用与α，β-不饱和羧酸或衍生物改性的乙烯共聚物或乙烯共聚物橡胶接枝具有物理亲和力但不具有反应性的极性单体改性的聚丙烯树脂的; 和（D）基于100重量份的组分（A），（B）和（C）的总重量，所述改性乙烯共聚物或乙烯共聚物橡胶为1至40重量份。

7. 发明授权

US5292733A Cephalosporin compounds 失效
标题翻译：头孢菌素化合物
公开(公告)号：US5292733A
公开(公告)日：1994-03-08
申请号：US866156
申请日：1992-04-09
申请人： Yong Z. Kim , Hun S. Oh , Jae H. Yeo , Jong C. Lim , Won S. Kim , Chan S. Bang , Hyeon J. Yim
发明人： Yong Z. Kim , Hun S. Oh , Jae H. Yeo , Jong C. Lim , Won S. Kim , Chan S. Bang , Hyeon J. Yim
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/00 , C07D501/04 , C07D501/36
CPC分类号： C07D501/00
摘要： The present invention relates to a cephalosporin compound including the pharmaceutically acceptable non-toxic salts, physiologically hydrolyzable esters, hydrates and solvates thereof of the formula(I) and its isomers: ##STR1## wherein: R.sup.1 is a C.sub.1-4 alkyl, C.sub.3-4 alkenyl, C.sub.3-4 alkynyl or --C(R.sup.3)(R.sup.4)COOH wherein R.sup.3 and R.sup.4, which may be the same or different, are hydrogen, C.sub.1-4 alkyl group, or constitute a C.sub.3-7 cycloalkyl group with the carbon atoms to which R.sup.3 and R.sup.4 are attached;R.sup.2, which may be attached to N.sup.a or N.sup.b, is a C.sub.1-4 alkyl, C.sub.3-4 alkenyl, C.sub.3-7 cycloalkyl, aryl or amino group; andQ.sub.1 and Q.sub.2, which may be the same or different, are CH or N.
摘要翻译：本发明涉及一种头孢菌素化合物，其包括式（I）的药学上可接受的无毒盐，生理上可水解的酯，水合物和溶剂化物及其异构体：（*化学结构*）（I）（*化学结构*）其中：R 1是C 1-4烷基，C 3-4烯基，C 3-4炔基或-C（R 3）（R 4）COOH，其中R 3和R 4可以相同或不同，是氢，C 1-4烷基或者构成与R3和R4相连的碳原子的C3-7环烷基; 可以连接到Na或Nb的R2是C1-4烷基，C3-4烯基，C3-7环烷基，芳基或氨基; 和可以相同或不同的Q1和Q2是CH或N.

8. 发明授权

US5744621A Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof 失效
标题翻译：不可逆的HIV蛋白酶抑制剂，中间体，组合物及其制备方法
公开(公告)号：US5744621A
公开(公告)日：1998-04-28
申请号：US667888
申请日：1996-06-20
申请人： Sung Chun Kim , Nakyen Choy , Chang Sun Lee , Young Chan Son , Ho Il Choi , Jong Sung Koh , Heungsik Yoon , Chi Hyo Park , Sang Soo Kim
发明人： Sung Chun Kim , Nakyen Choy , Chang Sun Lee , Young Chan Son , Ho Il Choi , Jong Sung Koh , Heungsik Yoon , Chi Hyo Park , Sang Soo Kim
IPC分类号： A61K31/335 , A61K31/00 , A61K31/336 , A61K38/00 , A61P31/00 , A61P31/12 , A61P31/18 , C07C213/02 , C07C217/08 , C07C269/04 , C07C271/20 , C07C271/22 , C07D301/02 , C07D303/36 , C07D303/38 , C07D303/40 , C07D303/46 , C07D405/12 , C07D405/14 , C07D493/08 , C07K5/02 , C07K5/06 , C07K5/065 , C07K5/078 , C07K7/02 , C07D303/08 , C07D215/38 , C07D265/30
CPC分类号： C07D303/38 , C07C217/08 , C07C271/20 , C07C271/22 , C07D303/36 , C07D303/46 , C07D405/12 , C07D405/14 , C07D493/08 , C07K5/0207 , C07K5/06026 , C07K5/06078 , C07K5/06139 , C07K7/02 , A61K38/00 , C07C2101/14
摘要： Cis-epoxide compounds of formula (I-1) and pharmaceutically acceptable salts, hydrates and solvates thereof: ##STR1## wherein: R.sup.1 is a cycloalkyl, or aryl-substituted lower alkyl group; A is a functionalized acyl group of the formula ##STR2## wherein R.sup.2 is a C.sub.1-4 alkyl, or amide-substituted C.sub.1-2 alkyl group; R.sup.3 is a C.sub.1-4 alkoxy, aryloxyalkyl or arylalkoxy, or a nitrogen-containing aromatic radical, or a lower alkoxy group substituted with a nitrogen-containing aromatic radical, or a radical having the formula of ##STR3## wherein R.sup.4 is a hydrogen or a methyl group and R.sup.5 is an alkyl group substituted with a nitrogen-containing aromatic radical; and m is 0 or 1; and B is a functionalized amino group of the formula ##STR4## wherein R.sup.8 and R.sup.9 are independently a C.sub.1-4 alkyl group optionally substituted with an aromatic radical, or an aromatic group.
摘要翻译：式（I-1）的顺式环氧化合物及其药学上可接受的盐，水合物和溶剂合物：其中：R1是环烷基或芳基取代的低级烷基; A是下式的官能化酰基：其中R 2是C 1-4烷基或酰胺取代的C 1-2烷基; R 3是C 1-4烷氧基，芳氧基烷基或芳基烷氧基或含氮芳族基团，或被含氮芳族基团取代的低级烷氧基或具有下式的基团：其中R 4是氢或甲基，R 5为被含氮芳族基团取代的烷基; m为0或1; 并且B是式“IMAGE”的官能化氨基，其中R 8和R 9独立地是任选被芳族基团或芳族基团取代的C 1-4烷基。

9. 发明授权

US5674941A Antifogging abrasion resistant coating composition and synthetic resin article coated therewith 失效
标题翻译：防雾耐磨涂料组合物及其涂覆的合成树脂制品
公开(公告)号：US5674941A
公开(公告)日：1997-10-07
申请号：US335002
申请日：1994-04-15
申请人： Yong-Il Cho , Sung-Hoon Jang , Jung-Ok Park
发明人： Yong-Il Cho , Sung-Hoon Jang , Jung-Ok Park
IPC分类号： C08J7/04 , C08F265/04 , C09D4/00 , C09D4/02 , C09D4/06 , C09D5/00 , C09D133/00 , C09D133/04 , C09D163/00 , C09D183/04 , C09D183/06 , C09D183/08 , C09K3/18 , C09D143/04
CPC分类号： C09D4/06 , C08F265/04 , C09D4/00 , Y10T428/31507 , Y10T428/31511 , Y10T428/31663 , Y10T428/31667
摘要： A coating composition having excellent antifogging property, good abrasion resistance, improved adhesion to the substrate and good water resistance, which comprises an epoxy functional organosilane or the hydrolysate or condensate thereof; an amino functional organosilane or the hydrolysate or condensate thereof; a hydrophilic (meth)acrylate monomer, or a copolymer of two components selected from the hydrophilic (meth)acrylate monomer, another hydrophilic monomer and an organosilane and/or a terpolymer of the three components; a curing catalyst; and, optionally, a multi-functional (meth)acrylate monomer having at least two (meth)acryl groups and a radical polymerization initiator.
摘要翻译：包含环氧官能的有机硅烷或其水解产物或缩合物的涂料组合物具有优异的防雾性，良好的耐磨性，改善的与基材的粘合性和良好的耐水性。氨基官能的有机硅烷或其水解产物或缩合物; 亲水性（甲基）丙烯酸酯单体或选自亲水性（甲基）丙烯酸酯单体，其他亲水性单体和有机硅烷和/或三种成分的三元共聚物的两种成分的共聚物; 固化催化剂; 和任选的具有至少两个（甲基）丙烯酰基的多官能（甲基）丙烯酸酯单体和自由基聚合引发剂。

10. 发明授权

US5612420A Process for preparing a polymeric gloss modifier 失效
标题翻译：制备聚合物光泽调节剂的方法
公开(公告)号：US5612420A
公开(公告)日：1997-03-18
申请号：US211946
申请日：1994-04-21
申请人： Jin N. Yoo , Dong O. Kim , Yeong R. Chang , Jong K. Yeo
发明人： Jin N. Yoo , Dong O. Kim , Yeong R. Chang , Jong K. Yeo
IPC分类号： C08F257/00 , C08F2/22 , C08F6/22 , C08F257/02 , C08F265/00 , C08F265/04 , C08F265/08 , C08K3/24 , C08L27/06 , C08L51/00 , C08L51/06 , C08F265/06
CPC分类号： C08F257/02 , C08F265/04 , C08F6/22 , C08L27/06 , C08L51/003
摘要： Polymeric glass modifier having a partially crosslinked structure capable of effectively reducing the surface gloss of a thermoplastic resin, is prepared by (a) emulsion polymerizing an acrylic monomer, an ethylenically unsaturated cyanide compound end, optionally, an aromatic vinyl monomer to obtain a copolymer latex of a linear structure; (b) conducting a crosslinking emulsion polymerization of the resultant linear copolymer latex obtained in step (a) with an addition of the same monomers used in step (a), an acrylamide inter-particle crosslinking agent and an ethylenically unsaturated crosslinking agent to produce a partially crosslinked latex; and (c) coagulating and interparticle crosslinking the partially crosslinked latex obtained in step (b) with an addition of an acid to obtain the polymeric gloss modifier.
摘要翻译： PCT No.PCT / KR93 / 00081 Sec。 371日期1994年04月21日 102（e）日期1994年4月21日PCT提交1993年9月7日PCT公布。出版物WO94 / 05715 日期：1994年3月17日通过（a）将丙烯酸单体，烯键式不饱和氰化物末端，任选的芳族乙烯基单体乳液聚合，制备具有能够有效降低热塑性树脂表面光泽度的部分交联结构的聚合玻璃改性剂得到线性结构的共聚物胶乳; （b）通过添加步骤（a）中使用的相同单体，丙烯酰胺颗粒间交联剂和烯键式不饱和交联剂，对步骤（a）获得的所得线性共聚物胶乳进行交联乳液聚合，部分交联胶乳; 和（c）通过加入酸使步骤（b）中获得的部分交联的胶乳凝结和颗粒间交联以获得聚合物光泽改性剂。

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