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1. 发明授权

US11491116B2 Adhesive patch 有权
公开(公告)号：US11491116B2
公开(公告)日：2022-11-08
申请号：US16085048
申请日：2016-03-16
申请人： LEAD CHEMICAL CO., LTD.
发明人： Takayasu Matsuzawa , Seijiro Yama , Naoki Murai
IPC分类号： A61K9/70 , A61F13/02 , A61F13/00
摘要： An adhesive patch comprising: a support; at least a pressure-sensitive adhesive layer provided on the support; and a release liner attached on the pressure-sensitive adhesive layer so as to cover the surface of the pressure-sensitive adhesive layer, in which the support is a 3D patterned sheet characterized in that a plurality of protruded lines and recessed lines parallelly and linearly extending are formed inside and outside lines in a plurality of figures partitioned by the lines, walls of the protruded lines and recessed lines in some of the figures are formed to be inclined by different inclination angles with respect to a base part, and the protruded lines have different heights from the base part, serving as physical parameters of the protruded lines and recessed lines, toward a predetermined direction in the sheet.

2. 发明申请

US20190046464A1 ADHESIVE PATCH 审中-公开
公开(公告)号：US20190046464A1
公开(公告)日：2019-02-14
申请号：US16085048
申请日：2016-03-16
申请人： LEAD CHEMICAL CO., LTD.
发明人： Takayasu MATSUZAWA , Seijiro YAMA , Naoki MURAI
IPC分类号： A61K9/70
摘要： An adhesive patch comprising: a support; at least a pressure-sensitive adhesive layer provided on the support; and a release liner attached on the pressure-sensitive adhesive layer so as to cover the surface of the pressure-sensitive adhesive layer, in which the support is a 3D patterned sheet characterized in that a plurality of protruded lines and recessed lines parallelly and linearly extending are formed inside and outside lines in a plurality of figures partitioned by the lines, walls of the protruded lines and recessed lines in some of the figures are formed to be inclined by different inclination angles with respect to a base part, and the protruded lines have different heights from the base part, serving as physical parameters of the protruded lines and recessed lines, toward a predetermined direction in the sheet.

3. 发明授权

US08841284B2 Compound having neurite-outgrowing activity 有权
标题翻译：化合物具有神经突向外生长活性
公开(公告)号：US08841284B2
公开(公告)日：2014-09-23
申请号：US13389105
申请日：2009-07-21
申请人： Hideo Nemoto , Yuji Matsuya
发明人： Hideo Nemoto , Yuji Matsuya
IPC分类号： A61K31/585 , C07J17/00 , C07J51/00
CPC分类号： A61K31/585 , C07J17/00 , C07J51/00
摘要： There is provided a novel compound having neurite-outgrowing activity that is useful for the prevention or the treatment of a neurodegenerative disease. A compound of Formula (I) [where X is OR or NR1R2, Y is OH, NR3R4, —NHC(═NH)NHR5, or —NHC(═NH)R5, and Z is a hydrogen atom, a linear or branched C1-5 alkyl group, or a 5- or 6-membered ring aryl group optionally having 1 or 2 nitrogen atom(s), sulfur atom(s), or oxygen atom(s)], or a pharmaceutically or veterinary-medically acceptable salt of the compound.
摘要翻译：提供了可用于预防或治疗神经退行性疾病的具有神经突变性活性的新化合物。式（I）化合物[其中X为OR或NR1R2，Y为OH，NR3R4，-NHC（= NH）NHR5或-NHC（= NH）R5），Z为氢原子，直链或支链C1 -5-烷基或任选具有1或2个氮原子的5或6元环芳基，硫原子或氧原子]或药学上或兽医学上可接受的盐的化合物。

4. 发明申请

US20120190841A1 COMPOUND HAVING NEURITE-OUTGROWING ACTIVITY 有权
标题翻译：具有神经递质活性的化合物
公开(公告)号：US20120190841A1
公开(公告)日：2012-07-26
申请号：US13389105
申请日：2009-07-21
申请人： Hideo Nemoto , Yuji Matsuya
发明人： Hideo Nemoto , Yuji Matsuya
IPC分类号： C07J17/00
CPC分类号： A61K31/585 , C07J17/00 , C07J51/00
摘要： There is provided a novel compound having neurite-outgrowing activity that is useful for the prevention or the treatment of a neurodegenerative disease. A compound of Formula (I) [where X is OR or NR1R2, Y is OH, NR3R4, —NHC(═NH)NHR5, or —NHC(═NH)R5, and Z is a hydrogen atom, a linear or branched C1-5 alkyl group, or a 5- or 6-membered ring aryl group optionally having 1 or 2 nitrogen atom(s), sulfur atom(s), or oxygen atom(s)], or a pharmaceutically or veterinary-medically acceptable salt of the compound.
摘要翻译：提供了可用于预防或治疗神经退行性疾病的具有神经突变性活性的新化合物。式（I）化合物[其中X为OR或NR1R2，Y为OH，NR3R4，-NHC（= NH）NHR5或-NHC（= NH）R5），Z为氢原子，直链或支链C1 -5-烷基或任选具有1或2个氮原子的5或6元环芳基，硫原子或氧原子]或药学上或兽医学上可接受的盐的化合物。

5. 发明申请

US20100239508A1 ULTRAVIOLET ABSORBER 有权
标题翻译：超紫外线吸收剂
公开(公告)号：US20100239508A1
公开(公告)日：2010-09-23
申请号：US12677900
申请日：2008-04-02
申请人： Masao Mori , Haruo Saito
发明人： Masao Mori , Haruo Saito
IPC分类号： A61K8/37 , C07C69/736 , C09D5/00 , C08K5/101
CPC分类号： C07C69/734 , A61K8/37 , A61Q17/04
摘要： There is provided an ultraviolet absorber having a strong absorptive capacity in the UVA range and an absorptive capacity in the UVB range to have an ultraviolet inhibitory effect in a wide range of wavelength, increasing in an ultraviolet absorptive capacity over the course of ultraviolet irradiation time in both the UVA and the UVB ranges and having an excellent solubility. An ultraviolet absorber comprising, as an active ingredient, a compound of General Formula I: (where —OA is an alkoxy group) that exhibits an ultraviolet A wave absorptive capacity which increases over time and that has an ultraviolet B wave absorptive capacity.
摘要翻译：提供了在UVA范围内具有强吸收能力的紫外线吸收剂和在UVB范围内的吸收能力，在宽波长范围内具有紫外线抑制作用，在紫外线照射时间内增加紫外线吸收能力 UVA和UVB两者都具有优异的溶解性。一种紫外线吸收剂，其特征在于，含有通式I的化合物（其中-OA为烷氧基），其表现出随时间而增加并具有紫外线B吸收能力的紫外线A吸收能力。

6. 发明授权

US07361785B2 Compound protecting against ultraviolet rays 有权
标题翻译：化合物防紫外线
公开(公告)号：US07361785B2
公开(公告)日：2008-04-22
申请号：US10533202
申请日：2002-11-05
申请人： Masao Mori , Haruo Saito , Masako Nakagawa , Atsushi Nishida
发明人： Masao Mori , Haruo Saito , Masako Nakagawa , Atsushi Nishida
IPC分类号： C07C63/36 , C07C205/06
CPC分类号： C07C233/55 , A61K8/37 , A61K8/40 , A61K8/42 , A61K8/445 , A61K8/69 , A61Q17/04 , C07C69/76 , C07C69/92 , C07C205/43
摘要： An ultraviolet ray protection agent including a compound having an ultraviolet ray protection effect as an active ingredient. The compound is expressed by general formula I′: wherein X represents NH or O; Y′ represents a vinyl group substituted by a methyl group or a phenyl group, or a phenyl group substituted by a methoxy group or a fluorine atom, or a naphthyl group; and Z represents a phenyl group substituted by a methyl group, a carboxyl group or a nitro group, or a naphthyl group. The compound represented by the general formula I′ includes both novel compounds of the present invention and known compounds. The ultraviolet ray protection agent of the present invention offers outstanding ultraviolet ray protection effectiveness and is very safe.
摘要翻译：包含具有紫外线保护作用的化合物作为有效成分的紫外线防护剂。该化合物由通式I'表示：其中X表示NH或O; Y'表示被甲基或苯基取代的乙烯基或被甲氧基或氟原子取代的苯基或萘基; Z表示被甲基，羧基或硝基取代的苯基或萘基。由通式I'表示的化合物包括本发明的新化合物和已知化合物。本发明的紫外线防护剂提供优异的紫外线防护效果，且非常安全。

7. 发明授权

US08287900B2 Medicated patch comprising 5-methyl-1-phenyl-2-(1H)-pyridone 有权
标题翻译：药物贴剂包含5-甲基-1-苯基-2-（1H） - 吡啶酮
公开(公告)号：US08287900B2
公开(公告)日：2012-10-16
申请号：US12451646
申请日：2008-05-26
申请人： Takayasu Matsuzawa , Tamaki Horiuchi , Seijiro Yama , Tetsukazu Hamamoto , Sunao Takeuchi , Daisuke Ichimatsu
发明人： Takayasu Matsuzawa , Tamaki Horiuchi , Seijiro Yama , Tetsukazu Hamamoto , Sunao Takeuchi , Daisuke Ichimatsu
IPC分类号： A61L15/16 , A61F13/00 , A61K9/70 , A61K9/14 , A61L15/00
CPC分类号： A61K9/7023 , A61K9/7053 , A61K9/7061 , A61K31/44 , A61K31/4418 , A61L15/42 , A61L15/44 , A61L2300/204
摘要： There is provided a medicated patch including 5-methyl-1-phenyl-2-(1H)-pyridone. A medicated patch comprising a percutaneously absorbable preparation layer, wherein the percutaneously absorbable preparation layer includes 5-methyl-1-phenyl-2-(1H)-pyridone or a pharmaceutically acceptable salt thereof as an active component, a dissolving agent and an aqueous base material (or a rubber-type base material), and the active component is contained in an amount of 0.1 to 30 mass % relative to the total amount of the percutaneously absorbable preparation layer.
摘要翻译：提供包含5-甲基-1-苯基-2-（1H） - 吡啶酮的药物贴片。一种药物贴剂，其包含经皮吸收制剂层，其中所述经皮吸收制剂层包含作为活性成分的5-甲基-1-苯基-2-（1H） - 吡啶酮或其药学上可接受的盐，溶解剂和水性基质材料（或橡胶类基材），相对于经皮吸收性制剂层的总量，活性成分的含量为0.1〜30质量％。

8. 发明申请

US20110293670A1 ADHESIVE MATERIAL CONTAINING 5-METHYL-1-PHENYL-2-(1H)-PYRIDONE 有权
标题翻译：含有5-甲基-1-苯基-2-（1H） - 吡啶酮的粘合材料
公开(公告)号：US20110293670A1
公开(公告)日：2011-12-01
申请号：US13130461
申请日：2009-11-20
申请人： Takayasu Matsuzawa , Tamaki Horiuchi , Seijiro Yama , Sunao Takeuchi , Makoto Takeuchi
发明人： Takayasu Matsuzawa , Tamaki Horiuchi , Seijiro Yama , Sunao Takeuchi , Makoto Takeuchi
IPC分类号： A61K9/00 , A61K31/4412
CPC分类号： A61K9/7038 , A61K31/4412 , A61K31/4418
摘要： There is provided an adhesive preparation containing 5-methyl-1-phenyl-2-(1H)-pyridone. The adhesive preparation is a 5-methyl-1-phenyl-2-(1H)-pyridone-containing adhesive preparation including an active medicinal ingredient-containing layer, characterized in that the active medicinal ingredient-containing layer contains an lipophilic base, a dissolving agent (except glycerin and a medium-chain aliphatic acid triglyceride), and 5-methyl-1-phenyl-2-(1H)-pyridone or medically acceptable salts thereof.
摘要翻译：提供含有5-甲基-1-苯基-2-（1H） - 吡啶酮的粘合剂。粘合剂是含有活性药物成分含有层的含5-甲基-1-苯基-2-（1H） - 吡啶酮的粘合剂制剂，其特征在于含活性药物成分层含有亲脂性基质，溶解性（甘油和中链脂肪酸甘油三酸酯除外）和5-甲基-1-苯基-2-（1H） - 吡啶酮或其医药上可接受的盐。

9. 发明申请

US20080113010A1 Nonaqueous Preparation for Percutaneous Absorption Containing Nonsteroidal Anti-Inflammatory Analgesic 有权
标题翻译：含非甾体抗炎镇痛剂的经皮吸收非水制剂
公开(公告)号：US20080113010A1
公开(公告)日：2008-05-15
申请号：US11666624
申请日：2004-11-05
申请人： Seijirou Yama , Naoki Murai
发明人： Seijirou Yama , Naoki Murai
IPC分类号： A61K31/192 , A61F13/02
CPC分类号： A61K45/06 , A61K9/7053 , A61K9/7076 , A61K31/192 , A61K33/42 , A61K2300/00
摘要： The present invention relates to nonaqueous preparation for percutaneous absorption prepared by laminating an adhesive layer comprising a nonsteroidal anti-inflammatory analgesic in an alkali metal salt form, and an inorganic acid which is strongly acidic compared with the nonsteroidal anti-inflammatory analgesic in a free form, together with a nonaqueous base, on a support. According to the present invention, drug-releasing characteristics and skin penetration in a nonaqueous preparation for percutaneous absorption can be improved because the addition of an inorganic acid in a nonaqueous base containing a drug in an alkali metal salt form leads to an improvement in the solubility of the drug in the base, and a good partitioning of the drug to skin surface. In addition, as the inorganic acid has no alcoholic hydroxy group in the structure, the inorganic acid does not react with the drug, therefore it causes no lowering in the stability of the drug by esterification.
摘要翻译：本发明涉及通过层压含有碱金属盐形式的非甾族抗炎止痛剂的粘合剂层和与游离形式的非甾体抗炎止痛剂相比强酸性的无机酸制备的用于经皮吸收的非水性制剂，与非水性基质一起在载体上。根据本发明，通过在含有碱金属盐形式的药物的非水性碱中添加无机酸，能够提高用于经皮吸收的非水系制剂中的药物释放特性和皮肤渗透性，从而提高溶解性的药物在基础上，并且药物与皮肤表面的良好分配。此外，由于无机酸在结构中不含醇羟基，所以无机酸不与药物反应，因此通过酯化不会降低药物的稳定性。

10. 发明授权

US5695779A Release controlled transdermal therapeutic system 失效
标题翻译：释放受控透皮治疗系统
公开(公告)号：US5695779A
公开(公告)日：1997-12-09
申请号：US638565
申请日：1996-04-26
申请人： Masao Mori
发明人： Masao Mori
IPC分类号： A61K9/70 , A61F13/02
CPC分类号： A61K9/7053 , A61K9/7076 , A61K9/7092 , A61K9/5026 , A61K9/5036 , A61K9/5047 , A61K9/5057 , A61K9/5084
摘要： A release controlled transdermal therapeutic system having excellent storage stability and capable of optionally controlling the release rate of drugs, comprising a rubbery adhesive, microcapsules comprising a water-soluble wall material and encapsulating drugs as core material, and a water-insoluble, rubber- and rubber solvent-insoluble, water absorbing resin powder, such as starch-polyacrylic acid salt copolymers, the microcapsules and the resin powder being dispersed in the rubbery adhesive.
摘要翻译：一种释放控制的透皮治疗系统，其具有优异的储存稳定性并且能够任选地控制药物的释放速率，包括橡胶粘合剂，包含水溶性壁材料和包封药物作为核心材料的微胶囊，以及水不溶性橡胶和橡胶溶剂不溶性，吸水树脂粉末，如淀粉 - 聚丙烯酸盐共聚物，微胶囊和树脂粉末分散在橡胶粘合剂中。

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